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Aliases for GKN2 Gene

Aliases for GKN2 Gene

  • Gastrokine 2 2 3 5
  • Trefoil Factor Interactions(Z) 1 3 4
  • BRICHOS Domain Containing 1B 2 3
  • Blottin 3 4
  • TFIZ1 3 4
  • GDDR 3 4
  • Down Regulated In Gastric Cancer GDDR 2
  • Down-Regulated In Gastric Cancer GDDR 3
  • Down-Regulated In Gastric Cancer 4
  • Gastrokine-2 3
  • BRICD1B 3
  • VLTI465 3
  • PRO813 3
  • BLOT 4

External Ids for GKN2 Gene

Previous GeneCards Identifiers for GKN2 Gene

  • GC02M069025
  • GC02M069172

Summaries for GKN2 Gene

Entrez Gene Summary for GKN2 Gene

  • The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]

GeneCards Summary for GKN2 Gene

GKN2 (Gastrokine 2) is a Protein Coding gene. Diseases associated with GKN2 include Gastric Cancer and Internuclear Ophthalmoplegia. An important paralog of this gene is GKN1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GKN2 Gene

Genomics for GKN2 Gene

Regulatory Elements for GKN2 Gene

Enhancers for GKN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F069305 1.6 FANTOM5 Ensembl ENCODE 9.5 -355.6 -355633 5.9 HDGF WRNIP1 ARID4B SIN3A ZNF48 ZNF2 GLIS2 ZNF143 KLF7 ZNF263 GFPT1 ANTXR1 PCBP1-AS1 GMCL1 RNA5SP96 RNU6-1216P GKN2 PIR40340 LOC100421347
GH02F068906 1.3 Ensembl ENCODE 10.3 +44.4 44370 4.0 PKNOX1 ELK1 ZNF143 FOS DEK SP3 REST MEF2D MAFF SMARCA4 BMP10 ENSG00000237576 APLF FBXO48 GKN2 GKN3P LOC105374792
GH02F069011 1.3 FANTOM5 ENCODE 10.3 -60.8 -60754 3.7 SIN3A DMAP1 ZNF48 FOS ZNF263 REST ZNF518A KAT8 GLIS1 MXD3 RNA5SP96 RNU6-1216P GKN2 GKN1 ANTXR1 MIR3126
GH02F069174 1.3 Ensembl ENCODE 9.5 -224.8 -224791 6.1 MLX ZFP64 ARID4B DMAP1 SLC30A9 CBX5 ZNF143 FOS SP5 ZHX2 GKN2 RNA5SP96 GC02M069149
GH02F068857 1.2 FANTOM5 Ensembl ENCODE 9.6 +94.8 94786 2.0 GATA3 NFE2 FOS ENSG00000237576 PLEK FBXO48 GKN2 APLF BMP10 LINC01890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GKN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GKN2 Gene

68,945,232 bp from pter
68,952,970 bp from pter
7,739 bases
Minus strand

Genomic View for GKN2 Gene

Genes around GKN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GKN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GKN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GKN2 Gene

Proteins for GKN2 Gene

  • Protein details for GKN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UWS6

    Protein attributes for GKN2 Gene

    184 amino acids
    Molecular mass:
    20487 Da
    Quaternary structure:
    • Interacts with TFF2 (By similarity). Heterodimer with TFF1; disulfide linked.

neXtProt entry for GKN2 Gene

Post-translational modifications for GKN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GKN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GKN2 Gene

Domains & Families for GKN2 Gene

Gene Families for GKN2 Gene

Protein Domains for GKN2 Gene

Suggested Antigen Peptide Sequences for GKN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BRICHOS domain.
  • Contains 1 BRICHOS domain.
genes like me logo Genes that share domains with GKN2: view

Function for GKN2 Gene

genes like me logo Genes that share phenotypes with GKN2: view

Animal Models for GKN2 Gene

MGI Knock Outs for GKN2:
  • Gkn2 tm1.1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for GKN2

miRNA for GKN2 Gene

miRTarBase miRNAs that target GKN2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GKN2 Gene

Localization for GKN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GKN2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GKN2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0045178 basal part of cell IEA --
genes like me logo Genes that share ontologies with GKN2: view

Pathways & Interactions for GKN2 Gene

No Data Available

Interacting Proteins for GKN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000329292 Q86XP6-GKN2_HUMAN for GKN2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042127 regulation of cell proliferation IBA --
genes like me logo Genes that share ontologies with GKN2: view

No data available for Pathways by source and SIGNOR curated interactions for GKN2 Gene

Transcripts for GKN2 Gene

mRNA/cDNA for GKN2 Gene

Unigene Clusters for GKN2 Gene

Gastrokine 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GKN2 Gene

No ASD Table

Relevant External Links for GKN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GKN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GKN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GKN2 Gene

This gene is overexpressed in Stomach (x50.2).

Protein differential expression in normal tissues from HIPED for GKN2 Gene

This gene is overexpressed in Cardia (51.4) and Stomach (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GKN2 Gene

Protein tissue co-expression partners for GKN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GKN2 Gene:


SOURCE GeneReport for Unigene cluster for GKN2 Gene:


mRNA Expression by UniProt/SwissProt for GKN2 Gene:

Tissue specificity: Expressed in gastric mucosa.
genes like me logo Genes that share expression patterns with GKN2: view

Primer Products

Orthologs for GKN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GKN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GKN2 34 35
  • 98.91 (n)
(Bos Taurus)
Mammalia GKN2 34 35
  • 83.88 (n)
(Canis familiaris)
Mammalia GKN2 34 35
  • 81.4 (n)
(Rattus norvegicus)
Mammalia Gkn2 34
  • 77.54 (n)
(Mus musculus)
Mammalia Gkn2 34 16 35
  • 76.45 (n)
(Monodelphis domestica)
Mammalia GKN2 35
  • 71 (a)
(Gallus gallus)
Aves GKN2 34 35
  • 55.49 (n)
Species where no ortholog for GKN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GKN2 Gene

Gene Tree for GKN2 (if available)
Gene Tree for GKN2 (if available)

Paralogs for GKN2 Gene

Paralogs for GKN2 Gene

(2) SIMAP similar genes for GKN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GKN2: view

Variants for GKN2 Gene

Sequence variations from dbSNP and Humsavar for GKN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10048657 -- 68,948,201(+) agatc(A/G)cacca intron-variant
rs10048698 -- 68,945,779(+) GCCAC(A/G)TTTAG intron-variant
rs10175263 -- 68,951,984(+) GCTGA(C/T)AGTCT intron-variant
rs10175379 -- 68,952,123(+) TGCAA(C/T)GTGGA intron-variant
rs10530973 -- 68,953,577(+) GATTG(-/A)AAAAA upstream-variant-2KB

Variation tolerance for GKN2 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GKN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GKN2 Gene

Disorders for GKN2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GKN2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
internuclear ophthalmoplegia
- elite association - COSMIC cancer census association via MalaCards
Search GKN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GKN2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GKN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GKN2 Gene

Publications for GKN2 Gene

  1. Identification of blottin: a novel gastric trefoil factor family-2 binding protein. (PMID: 16888721) Otto W.R. … Oien K.A. (Proteomics 2006) 2 3 4 22 64
  2. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP- C. (PMID: 15924415) Westley B.R. … May F.E.B. (Biochemistry 2005) 2 3 4 22 64
  3. Study on novel gene GDDR related to gastric cancer. (PMID: 15774165) Du J.J. … Gao Z.Q. (Zhonghua Wai Ke Za Zhi 2005) 2 4 22 64
  4. The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer. (PMID: 18722547) May F.E. … Westley B.R. (Int. J. Biochem. Cell Biol. 2009) 3 22 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for GKN2 Gene

Sources for GKN2 Gene

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