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Aliases for GKN1 Gene

Aliases for GKN1 Gene

  • Gastrokine 1 2 3 5
  • 18 KDa Antrum Mucosa Protein 3 4
  • BRICHOS Domain Containing 1 2 3
  • AMP-18 3 4
  • AMP18 3 4
  • CA11 3 4
  • Gastrokine-1 3
  • Protein CA11 4
  • Foveolin 3
  • BRICD1 3
  • FOV 3

External Ids for GKN1 Gene

Previous GeneCards Identifiers for GKN1 Gene

  • GC02P069176
  • GC02P069114

Summaries for GKN1 Gene

Entrez Gene Summary for GKN1 Gene

  • The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]

GeneCards Summary for GKN1 Gene

GKN1 (Gastrokine 1) is a Protein Coding gene. Diseases associated with GKN1 include Gastric Cancer. GO annotations related to this gene include growth factor activity. An important paralog of this gene is GKN2.

UniProtKB/Swiss-Prot for GKN1 Gene

  • Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.

Gene Wiki entry for GKN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GKN1 Gene

Genomics for GKN1 Gene

Regulatory Elements for GKN1 Gene

Enhancers for GKN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F068994 0.9 Ensembl ENCODE 11.3 +20.5 20493 0.3 ZNF263 ZNF362 MAX ZNF384 ATF2 ZNF366 BCL11A FOXP2 ZNF18 ZBTB17 GKN1 PNO1 ANTXR1
GH02F068943 0.8 Ensembl ENCODE 10.4 -30.7 -30662 1.0 CTCF SAP130 MLX ARID4B ZIC2 ZNF644 RAD21 ZNF143 SMC3 HNF4G ANTXR1 GKN1 GKN2 GKN3P
GH02F069026 0.2 ENCODE 10.4 +51.6 51591 0.1 ELF3 CTCF ARID4B CEBPG ZNF644 RAD21 TEAD3 ZNF143 SMC3 NR2F6 GKN1 GKN2 ANTXR1 MIR3126
GH02F069011 1 FANTOM5 ENCODE 10.2 +39.2 39151 3.7 SIN3A DMAP1 ZNF48 FOS ZNF263 REST ZNF518A KAT8 GLIS1 MXD3 RNA5SP96 RNU6-1216P GKN2 GKN1 ANTXR1 MIR3126
GH02F069240 1.2 FANTOM5 ENCODE 10.1 +267.6 267572 4.1 KLF1 RFX1 PKNOX1 ZIC2 ZNF843 GLIS1 NFE2 MAFK RNU6-1216P RNA5SP96 GKN1 GKN2 PCBP1-AS1 ANXA4 LOC100421347
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GKN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GKN1 Gene

68,974,573 bp from pter
68,980,980 bp from pter
6,408 bases
Plus strand

Genomic View for GKN1 Gene

Genes around GKN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GKN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GKN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GKN1 Gene

Proteins for GKN1 Gene

  • Protein details for GKN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8IUA9

    Protein attributes for GKN1 Gene

    199 amino acids
    Molecular mass:
    21999 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAN75447.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN75449.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89409.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GKN1 Gene

Post-translational modifications for GKN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GKN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GKN1 Gene

Domains & Families for GKN1 Gene

Gene Families for GKN1 Gene

Protein Domains for GKN1 Gene


Suggested Antigen Peptide Sequences for GKN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BRICHOS domain.
  • Belongs to the gastrokine family.
  • Contains 1 BRICHOS domain.
  • Belongs to the gastrokine family.
genes like me logo Genes that share domains with GKN1: view

Function for GKN1 Gene

Molecular function for GKN1 Gene

UniProtKB/Swiss-Prot Function:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.

Gene Ontology (GO) - Molecular Function for GKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GKN1: view
genes like me logo Genes that share phenotypes with GKN1: view

Animal Models for GKN1 Gene

MGI Knock Outs for GKN1:
  • Gkn1 tm1.1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for GKN1

miRNA for GKN1 Gene

miRTarBase miRNAs that target GKN1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GKN1 Gene

Localization for GKN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GKN1 Gene


Subcellular locations from

Jensen Localization Image for GKN1 Gene COMPARTMENTS Subcellular localization image for GKN1 gene
Compartment Confidence
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with GKN1: view

Pathways & Interactions for GKN1 Gene

SuperPathways for GKN1 Gene

No Data Available

Interacting Proteins for GKN1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000367172 Q9NS71-GKN1_HUMAN for GKN1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion NAS 10835488
GO:0042127 regulation of cell proliferation IBA --
GO:0051781 positive regulation of cell division IEA --
genes like me logo Genes that share ontologies with GKN1: view

No data available for Pathways by source and SIGNOR curated interactions for GKN1 Gene

Transcripts for GKN1 Gene

mRNA/cDNA for GKN1 Gene

Unigene Clusters for GKN1 Gene

Gastrokine 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GKN1 Gene

No ASD Table

Relevant External Links for GKN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GKN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GKN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GKN1 Gene

This gene is overexpressed in Stomach (x52.7).

Protein differential expression in normal tissues from HIPED for GKN1 Gene

This gene is overexpressed in Cardia (44.3) and Stomach (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GKN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GKN1 Gene:


SOURCE GeneReport for Unigene cluster for GKN1 Gene:


mRNA Expression by UniProt/SwissProt for GKN1 Gene:

Tissue specificity: Expressed in stomach. No expression is detected in cancer tissue or gastric cancer cell lines.
genes like me logo Genes that share expression patterns with GKN1: view

Primer Products

No data available for Protein tissue co-expression partners for GKN1 Gene

Orthologs for GKN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GKN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GKN1 34 35
  • 98.99 (n)
(Bos Taurus)
Mammalia GKN1 34
  • 82.52 (n)
FOV 35
  • 70 (a)
(Canis familiaris)
Mammalia GKN1 34 35
  • 79.89 (n)
(Mus musculus)
Mammalia Gkn1 34 16 35
  • 72.16 (n)
(Rattus norvegicus)
Mammalia Gkn1 34
  • 72.01 (n)
(Monodelphis domestica)
Mammalia GKN1 35
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia GKN1 35
  • 32 (a)
(Gallus gallus)
Aves GKN1 34 35
  • 51.83 (n)
(Anolis carolinensis)
Reptilia GKN1 35
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486889 34
  • 54.72 (n)
Species where no ortholog for GKN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GKN1 Gene

Gene Tree for GKN1 (if available)
Gene Tree for GKN1 (if available)

Paralogs for GKN1 Gene

Paralogs for GKN1 Gene

(4) SIMAP similar genes for GKN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GKN1: view

Variants for GKN1 Gene

Sequence variations from dbSNP and Humsavar for GKN1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035923 A breast cancer sample
rs111339376 -- 68,979,313(+) ATGAA(A/G)ATAGA intron-variant
rs112221233 -- 68,980,463(+) GCTAA(G/T)AGAAT intron-variant
rs112304683 -- 68,972,787(+) TCTAT(C/G)TATCT upstream-variant-2KB
rs112491379 -- 68,974,087(+) GAGAA(A/G)AAAGG upstream-variant-2KB

Variation tolerance for GKN1 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GKN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GKN1 Gene

Disorders for GKN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GKN1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
- elite association - COSMIC cancer census association via MalaCards
Search GKN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GKN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GKN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GKN1 Gene

Publications for GKN1 Gene

  1. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. (PMID: 12851218) Martin T.E. … Toback F.G. (Am. J. Physiol. 2003) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins. (PMID: 15961882) Walsh-Reitz M.M. … Toback F.G. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for GKN1 Gene

  • Cloud-Clone Corp. Antibodies for GKN1
  • Cloud-Clone Corp. Proteins for GKN1
  • Cloud-Clone Corp Assay Kits for GKN1

Sources for GKN1 Gene

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