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Aliases for GKN1 Gene

Aliases for GKN1 Gene

  • Gastrokine 1 2 3 5
  • 18 KDa Antrum Mucosa Protein 3 4
  • BRICHOS Domain Containing 1 2 3
  • AMP-18 3 4
  • AMP18 3 4
  • CA11 3 4
  • Protein CA11 4
  • Foveolin 3
  • BRICD1 3
  • FOV 3

External Ids for GKN1 Gene

Previous GeneCards Identifiers for GKN1 Gene

  • GC02P069176
  • GC02P069114

Summaries for GKN1 Gene

Entrez Gene Summary for GKN1 Gene

  • The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]

GeneCards Summary for GKN1 Gene

GKN1 (Gastrokine 1) is a Protein Coding gene. Diseases associated with GKN1 include gastric cancer. GO annotations related to this gene include growth factor activity. An important paralog of this gene is GKN2.

UniProtKB/Swiss-Prot for GKN1 Gene

  • Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.

Gene Wiki entry for GKN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GKN1 Gene

Genomics for GKN1 Gene

Regulatory Elements for GKN1 Gene

Genomic Location for GKN1 Gene

Chromosome:
2
Start:
68,974,573 bp from pter
End:
68,980,980 bp from pter
Size:
6,408 bases
Orientation:
Plus strand

Genomic View for GKN1 Gene

Genes around GKN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GKN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GKN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GKN1 Gene

Proteins for GKN1 Gene

  • Protein details for GKN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS71-GKN1_HUMAN
    Recommended name:
    Gastrokine-1
    Protein Accession:
    Q9NS71
    Secondary Accessions:
    • Q8IUA9

    Protein attributes for GKN1 Gene

    Size:
    199 amino acids
    Molecular mass:
    21999 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN75447.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN75449.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89409.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GKN1 Gene

Proteomics data for GKN1 Gene at MOPED

Post-translational modifications for GKN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GKN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GKN1 Gene

Domains & Families for GKN1 Gene

Gene Families for GKN1 Gene

Protein Domains for GKN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GKN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS71

UniProtKB/Swiss-Prot:

GKN1_HUMAN :
  • Contains 1 BRICHOS domain.
  • Belongs to the gastrokine family.
Domain:
  • Contains 1 BRICHOS domain.
Family:
  • Belongs to the gastrokine family.
genes like me logo Genes that share domains with GKN1: view

Function for GKN1 Gene

Molecular function for GKN1 Gene

UniProtKB/Swiss-Prot Function:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
genes like me logo Genes that share phenotypes with GKN1: view

Animal Models for GKN1 Gene

MGI Knock Outs for GKN1:
  • Gkn1 tm1.1(KOMP)Vlcg

Animal Model Products

miRNA for GKN1 Gene

miRTarBase miRNAs that target GKN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GKN1 Gene

Localization for GKN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GKN1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GKN1 Gene COMPARTMENTS Subcellular localization image for GKN1 gene
Compartment Confidence
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GKN1: view

Pathways & Interactions for GKN1 Gene

SuperPathways for GKN1 Gene

No Data Available

Interacting Proteins for GKN1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367172%0d%0a9606.ENSP00000434614%0d%0a
Selected Interacting proteins: ENSP00000367172 for GKN1 Gene via STRING

Symbol External ID(s) Details
CDC27

Gene Ontology (GO) - Biological Process for GKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion NAS 10835488
GO:0042127 regulation of cell proliferation IBA --
genes like me logo Genes that share ontologies with GKN1: view

No data available for Pathways by source and SIGNOR curated interactions for GKN1 Gene

Drugs & Compounds for GKN1 Gene

No Compound Related Data Available

Transcripts for GKN1 Gene

mRNA/cDNA for GKN1 Gene

Unigene Clusters for GKN1 Gene

Gastrokine 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GKN1 Gene

No ASD Table

Relevant External Links for GKN1 Gene

GeneLoc Exon Structure for
GKN1
ECgene alternative splicing isoforms for
GKN1

Expression for GKN1 Gene

mRNA expression in normal human tissues for GKN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GKN1 Gene

This gene is overexpressed in Stomach (x52.7).

Protein differential expression in normal tissues from HIPED for GKN1 Gene

This gene is overexpressed in Cardia (44.3) and Stomach (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GKN1 Gene



SOURCE GeneReport for Unigene cluster for GKN1 Gene Hs.69319

mRNA Expression by UniProt/SwissProt for GKN1 Gene

Q9NS71-GKN1_HUMAN
Tissue specificity: Expressed in stomach. No expression is detected in cancer tissue or gastric cancer cell lines.
genes like me logo Genes that share expression patterns with GKN1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for GKN1 Gene

Orthologs for GKN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GKN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GKN1 35
  • 98.99 (n)
  • 98.49 (a)
GKN1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOV 36
  • 70 (a)
OneToOne
GKN1 35
  • 82.52 (n)
  • 69.73 (a)
dog
(Canis familiaris)
Mammalia GKN1 35
  • 79.89 (n)
  • 73.37 (a)
GKN1 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gkn1 16
Gkn1 36
  • 64 (a)
OneToOne
Gkn1 35
  • 72.16 (n)
  • 62.09 (a)
oppossum
(Monodelphis domestica)
Mammalia GKN1 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GKN1 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gkn1 35
  • 72.01 (n)
  • 60.22 (a)
chicken
(Gallus gallus)
Aves GKN1 35
  • 51.83 (n)
  • 31.79 (a)
GKN1 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GKN1 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486889 35
  • 54.72 (n)
  • 42.2 (a)
Species with no ortholog for GKN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GKN1 Gene

ENSEMBL:
Gene Tree for GKN1 (if available)
TreeFam:
Gene Tree for GKN1 (if available)

Paralogs for GKN1 Gene

Paralogs for GKN1 Gene

(4) SIMAP similar genes for GKN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GKN1: view

Variants for GKN1 Gene

Sequence variations from dbSNP and Humsavar for GKN1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035923 A breast cancer sample
rs4430980 -- 68,974,850(+) CACAC(C/T)AGGTC intron-variant
rs4072127 -- 68,974,079(-) CTCAG(C/T)CTGAC upstream-variant-2KB
rs4458243 -- 68,972,779(+) TGTAT(C/G)TATCT upstream-variant-2KB
rs4462818 -- 68,981,170(+) TCCAA(G/T)ACTCT downstream-variant-500B

Variation tolerance for GKN1 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GKN1 Gene

HapMap Linkage Disequilibrium report
GKN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GKN1 Gene

Disorders for GKN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GKN1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
- elite association - COSMIC cancer census association via MalaCards
Search GKN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GKN1

Genetic Association Database (GAD)
GKN1
Human Genome Epidemiology (HuGE) Navigator
GKN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GKN1
genes like me logo Genes that share disorders with GKN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GKN1 Gene

Publications for GKN1 Gene

  1. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. (PMID: 12851218) Martin T.E. … Toback F.G. (Am. J. Physiol. 2003) 2 3 4 23 67
  2. AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins. (PMID: 15961882) Walsh-Reitz M.M. … Toback F.G. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005) 3 23
  3. Human stomach-specific gene, CA11, is down-regulated in gastric cancer. (PMID: 11562744) Shiozaki K. … Monden M. (Int. J. Oncol. 2001) 2 3
  4. Decreased expression of gastrokine 1 in gastric mucosa of gastric cancer patients. (PMID: 25469040) Guo X.Y. … Shi A.M. (World J. Gastroenterol. 2014) 3
  5. Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer. (PMID: 25344918) Yoon J.H. … Park W.S. (Oncotarget 2014) 3

Products for GKN1 Gene

Sources for GKN1 Gene

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