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Aliases for GKAP1 Gene

Aliases for GKAP1 Gene

  • G Kinase Anchoring Protein 1 2 3
  • CGMP-Dependent Protein Kinase-Anchoring Protein Of 42 KDa 3 4
  • CGMP-Dependent Protein Kinase Anchoring Protein 42kDa 2 3
  • GKAP42 3 4
  • Protein Kinase Anchoring Protein GKAP42 3
  • G Kinase-Anchoring Protein 1 3
  • FKSG21 3

External Ids for GKAP1 Gene

Previous GeneCards Identifiers for GKAP1 Gene

  • GC09M081812
  • GC09M083583
  • GC09M085544
  • GC09M086354
  • GC09M056179

Summaries for GKAP1 Gene

Entrez Gene Summary for GKAP1 Gene

  • This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for GKAP1 Gene

GKAP1 (G Kinase Anchoring Protein 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GKAP1 Gene

Genomics for GKAP1 Gene

Regulatory Elements for GKAP1 Gene

Genomic Location for GKAP1 Gene

83,739,421 bp from pter
83,829,516 bp from pter
90,096 bases
Minus strand

Genomic View for GKAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GKAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GKAP1 Gene

Proteins for GKAP1 Gene

  • Protein details for GKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G kinase-anchoring protein 1
    Protein Accession:
    Secondary Accessions:
    • Q96LI0
    • Q9BYI1
    • Q9BYI2
    • Q9H225

    Protein attributes for GKAP1 Gene

    366 amino acids
    Molecular mass:
    42078 Da
    Quaternary structure:
    • Interacts with PRKG1.
    • Sequence=BAB71712.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70734.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16011.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW62665.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GKAP1 Gene


neXtProt entry for GKAP1 Gene

Proteomics data for GKAP1 Gene at MOPED

Post-translational modifications for GKAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GKAP1 Gene

Antibody Products

No data available for DME Specific Peptides for GKAP1 Gene

Domains for GKAP1 Gene

Protein Domains for GKAP1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GKAP1 family.
  • Belongs to the GKAP1 family.
genes like me logo Genes that share domains with GKAP1: view

No data available for Gene Families for GKAP1 Gene

Function for GKAP1 Gene

Gene Ontology (GO) - Molecular Function for GKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with GKAP1: view

Animal Model Products

miRNA for GKAP1 Gene

miRTarBase miRNAs that target GKAP1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for GKAP1 Gene

Localization for GKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GKAP1 Gene

Golgi apparatus.

Subcellular locations from

Jensen Localization Image for GKAP1 Gene COMPARTMENTS Subcellular localization image for GKAP1 gene
Compartment Confidence
golgi apparatus 4
nucleus 3
mitochondrion 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus ISS --
genes like me logo Genes that share ontologies with GKAP1: view

Pathways for GKAP1 Gene

SuperPathways for GKAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction ISS --
GO:0016310 phosphorylation --
genes like me logo Genes that share ontologies with GKAP1: view

No data available for Pathways by source for GKAP1 Gene

Transcripts for GKAP1 Gene

Unigene Clusters for GKAP1 Gene

G kinase anchoring protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GKAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GKAP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for GKAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GKAP1 Gene

mRNA expression in normal human tissues for GKAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GKAP1 Gene

This gene is overexpressed in Testis (11.9).

Protein differential expression in normal tissues for GKAP1 Gene

This gene is overexpressed in Testis (61.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GKAP1 Gene

SOURCE GeneReport for Unigene cluster for GKAP1 Gene Hs.522255

genes like me logo Genes that share expressions with GKAP1: view

Expression partners for GKAP1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GKAP1 Gene

Orthologs for GKAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GKAP1 35
  • 93.48 (n)
  • 95.32 (a)
GKAP1 36
  • 95 (a)
(Canis familiaris)
Mammalia GKAP1 35
  • 94.77 (n)
  • 96.69 (a)
GKAP1 36
  • 96 (a)
(Mus musculus)
Mammalia Gkap1 35
  • 85.34 (n)
  • 87.98 (a)
Gkap1 16
Gkap1 36
  • 88 (a)
(Pan troglodytes)
Mammalia GKAP1 35
  • 100 (n)
  • 100 (a)
GKAP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gkap1 35
  • 85.7 (n)
  • 90.44 (a)
(Monodelphis domestica)
Mammalia GKAP1 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia GKAP1 36
  • 74 (a)
(Gallus gallus)
Aves GKAP1 35
  • 78.48 (n)
  • 76.92 (a)
GKAP1 36
  • 76 (a)
(Anolis carolinensis)
Reptilia GKAP1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gkap1 35
  • 68.99 (n)
  • 66.02 (a)
Str.10774 35
African clawed frog
(Xenopus laevis)
Amphibia gkap42-pending-prov 35
(Danio rerio)
Actinopterygii gkap1 35
  • 63.76 (n)
  • 65.17 (a)
wufi16a08 35
gkap1 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10015 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for GKAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GKAP1 Gene

Gene Tree for GKAP1 (if available)
Gene Tree for GKAP1 (if available)

Paralogs for GKAP1 Gene

No data available for Paralogs for GKAP1 Gene

Variants for GKAP1 Gene

Sequence variations from dbSNP and Humsavar for GKAP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs167181 -- 83,819,180(+) TGCAG(A/T)ATCTA upstream-variant-2KB
rs182408 -- 83,804,657(+) gcccc(A/G)tccgg intron-variant
rs186099 -- 83,804,811(+) gcccc(A/T)ctgcc intron-variant
rs295268 -- 83,814,390(+) TTTAT(C/T)CCTCA intron-variant
rs295269 -- 83,815,472(+) GCACA(C/T)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GKAP1 Gene

Variant ID Type Subtype PubMed ID
nsv893513 CNV Gain 21882294
nsv469859 CNV Complex 16826518
esv7015 CNV Loss 19470904
esv2738668 CNV Deletion 23290073
esv2672912 CNV Deletion 23128226
dgv2394e1 CNV Complex 17122850

Relevant External Links for GKAP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GKAP1 Gene

Disorders for GKAP1 Gene

No disorders were found for GKAP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GKAP1 Gene

Publications for GKAP1 Gene

  1. Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. (PMID: 16015647) Sweetser D.A. … Daly S.B. (Genes Chromosomes Cancer 2005) 3 4
  2. Binding and phosphorylation of a novel male germ cell-specific cGMP- dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. (PMID: 10671526) Yuasa K. … Yanaka N. (J. Biol. Chem. 2000) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for GKAP1 Gene

Sources for GKAP1 Gene

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