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Aliases for GKAP1 Gene

Aliases for GKAP1 Gene

  • G Kinase Anchoring Protein 1 2 3 5
  • CGMP-Dependent Protein Kinase-Anchoring Protein Of 42 KDa 3 4
  • CGMP-Dependent Protein Kinase Anchoring Protein 42kDa 2 3
  • GKAP42 3 4
  • Protein Kinase Anchoring Protein GKAP42 3
  • G Kinase-Anchoring Protein 1 3
  • FKSG21 3

External Ids for GKAP1 Gene

Previous GeneCards Identifiers for GKAP1 Gene

  • GC09M081812
  • GC09M083583
  • GC09M085544
  • GC09M086354
  • GC09M056179

Summaries for GKAP1 Gene

Entrez Gene Summary for GKAP1 Gene

  • This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for GKAP1 Gene

GKAP1 (G Kinase Anchoring Protein 1) is a Protein Coding gene. GO annotations related to this gene include kinase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GKAP1 Gene

Genomics for GKAP1 Gene

Regulatory Elements for GKAP1 Gene

Enhancers for GKAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F083885 1.2 Ensembl ENCODE 7.4 -56.5 -56542 1.7 ZSCAN9 RARA RCOR1 FOS MIXL1 THAP11 ZNF362 CEBPB PPARG MIER3 KIF27 IDNK GKAP1 LOC105376335 ENSG00000231616
GH09F083816 0.9 ENCODE 8.3 +11.0 11006 3.3 HDGF ZNF76 SIN3A ZNF2 ZNF48 RAD21 ZBTB40 GLIS2 EGR1 ZNF366 KIF27 GKAP1 ENSG00000231616 LOC105376114 LOC101927552
GH09F083977 1.1 ENCODE 5.3 -150.5 -150541 5.5 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 C9orf64 KIF27 LOC105376116 IDNK RMI1 GKAP1 MIR7-1 ENSG00000235298
GH09F083620 1.6 FANTOM5 Ensembl ENCODE 1.4 +206.1 206098 5.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 ZNF143 KLF7 LOC105376114 IDNK KIF27 UBQLN1 GKAP1 GC09M083666
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GKAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GKAP1 Gene

Chromosome:
9
Start:
83,739,421 bp from pter
End:
83,829,516 bp from pter
Size:
90,096 bases
Orientation:
Minus strand

Genomic View for GKAP1 Gene

Genes around GKAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GKAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GKAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GKAP1 Gene

Proteins for GKAP1 Gene

  • Protein details for GKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VSY0-GKAP1_HUMAN
    Recommended name:
    G kinase-anchoring protein 1
    Protein Accession:
    Q5VSY0
    Secondary Accessions:
    • Q96LI0
    • Q9BYI1
    • Q9BYI2
    • Q9H225

    Protein attributes for GKAP1 Gene

    Size:
    366 amino acids
    Molecular mass:
    42078 Da
    Quaternary structure:
    • Interacts with PRKG1.
    SequenceCaution:
    • Sequence=BAB71712.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70734.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16011.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW62665.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GKAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GKAP1 Gene

Post-translational modifications for GKAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GKAP1 Gene

Domains & Families for GKAP1 Gene

Protein Domains for GKAP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VSY0

UniProtKB/Swiss-Prot:

GKAP1_HUMAN :
  • Belongs to the GKAP1 family.
Family:
  • Belongs to the GKAP1 family.
genes like me logo Genes that share domains with GKAP1: view

No data available for Gene Families for GKAP1 Gene

Function for GKAP1 Gene

Gene Ontology (GO) - Molecular Function for GKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with GKAP1: view
genes like me logo Genes that share phenotypes with GKAP1: view

Animal Model Products

miRNA for GKAP1 Gene

miRTarBase miRNAs that target GKAP1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GKAP1 Gene

Localization for GKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GKAP1 Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GKAP1 gene
Compartment Confidence
nucleus 4
golgi apparatus 4
cytosol 3
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for GKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus ISS --
genes like me logo Genes that share ontologies with GKAP1: view

Pathways & Interactions for GKAP1 Gene

SuperPathways for GKAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,ISS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with GKAP1: view

No data available for Pathways by source and SIGNOR curated interactions for GKAP1 Gene

Transcripts for GKAP1 Gene

Unigene Clusters for GKAP1 Gene

G kinase anchoring protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GKAP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2:
SP3: -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for GKAP1 Gene

GeneLoc Exon Structure for
GKAP1
ECgene alternative splicing isoforms for
GKAP1

Expression for GKAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GKAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GKAP1 Gene

This gene is overexpressed in Testis (x11.9).

Protein differential expression in normal tissues from HIPED for GKAP1 Gene

This gene is overexpressed in Testis (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GKAP1 Gene



Protein tissue co-expression partners for GKAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GKAP1 Gene:

GKAP1

SOURCE GeneReport for Unigene cluster for GKAP1 Gene:

Hs.522255
genes like me logo Genes that share expression patterns with GKAP1: view

No data available for mRNA Expression by UniProt/SwissProt for GKAP1 Gene

Orthologs for GKAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GKAP1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia GKAP1 34 35
  • 94.77 (n)
cow
(Bos Taurus)
Mammalia GKAP1 34 35
  • 93.48 (n)
rat
(Rattus norvegicus)
Mammalia Gkap1 34
  • 85.7 (n)
mouse
(Mus musculus)
Mammalia Gkap1 34 16 35
  • 85.34 (n)
oppossum
(Monodelphis domestica)
Mammalia GKAP1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GKAP1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GKAP1 34 35
  • 78.48 (n)
lizard
(Anolis carolinensis)
Reptilia GKAP1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gkap1 34
  • 68.99 (n)
Str.10774 34
African clawed frog
(Xenopus laevis)
Amphibia gkap42-pending-prov 34
zebrafish
(Danio rerio)
Actinopterygii gkap1 34 35
  • 63.76 (n)
wufi16a08 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10015 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for GKAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GKAP1 Gene

ENSEMBL:
Gene Tree for GKAP1 (if available)
TreeFam:
Gene Tree for GKAP1 (if available)

Paralogs for GKAP1 Gene

No data available for Paralogs for GKAP1 Gene

Variants for GKAP1 Gene

Sequence variations from dbSNP and Humsavar for GKAP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10116542 -- 83,770,992(+) GCATT(A/T)CCTCT intron-variant
rs10118300 -- 83,812,302(+) ATATA(C/T)GTATA intron-variant
rs10125556 -- 83,770,869(+) ATTAC(A/G)TTTTA intron-variant
rs10435945 -- 83,801,397(+) ttgtg(G/T)ttttt intron-variant
rs10453251 -- 83,794,803(+) TATTC(A/C)TAGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GKAP1 Gene

Variant ID Type Subtype PubMed ID
nsv982312 CNV duplication 23825009
nsv469859 CNV gain 16826518
nsv1137473 CNV deletion 24896259
esv7015 CNV loss 19470904
esv3620905 CNV loss 21293372
esv3620904 CNV gain 21293372
esv2761538 CNV gain 21179565
esv2759701 CNV gain 17122850
esv2738668 CNV deletion 23290073
esv2672912 CNV deletion 23128226

Variation tolerance for GKAP1 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GKAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GKAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GKAP1 Gene

Disorders for GKAP1 Gene

Relevant External Links for GKAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GKAP1

No disorders were found for GKAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GKAP1 Gene

Publications for GKAP1 Gene

  1. Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. (PMID: 16015647) Sweetser D.A. … Daly S.B. (Genes Chromosomes Cancer 2005) 3 4 64
  2. Binding and phosphorylation of a novel male germ cell-specific cGMP- dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. (PMID: 10671526) Yuasa K. … Yanaka N. (J. Biol. Chem. 2000) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64

Products for GKAP1 Gene

Sources for GKAP1 Gene

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