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Aliases for GKAP1 Gene

Aliases for GKAP1 Gene

  • G Kinase Anchoring Protein 1 2 3 5
  • CGMP-Dependent Protein Kinase-Anchoring Protein Of 42 KDa 3 4
  • CGMP-Dependent Protein Kinase Anchoring Protein 42kDa 2 3
  • GKAP42 3 4
  • Protein Kinase Anchoring Protein GKAP42 3
  • FKSG21 3

External Ids for GKAP1 Gene

Previous GeneCards Identifiers for GKAP1 Gene

  • GC09M081812
  • GC09M083583
  • GC09M085544
  • GC09M086354
  • GC09M056179

Summaries for GKAP1 Gene

Entrez Gene Summary for GKAP1 Gene

  • This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for GKAP1 Gene

GKAP1 (G Kinase Anchoring Protein 1) is a Protein Coding gene. GO annotations related to this gene include kinase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GKAP1 Gene

Genomics for GKAP1 Gene

Regulatory Elements for GKAP1 Gene

Genomic Location for GKAP1 Gene

Chromosome:
9
Start:
83,739,421 bp from pter
End:
83,829,516 bp from pter
Size:
90,096 bases
Orientation:
Minus strand

Genomic View for GKAP1 Gene

Genes around GKAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GKAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GKAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GKAP1 Gene

Proteins for GKAP1 Gene

  • Protein details for GKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VSY0-GKAP1_HUMAN
    Recommended name:
    G kinase-anchoring protein 1
    Protein Accession:
    Q5VSY0
    Secondary Accessions:
    • Q96LI0
    • Q9BYI1
    • Q9BYI2
    • Q9H225

    Protein attributes for GKAP1 Gene

    Size:
    366 amino acids
    Molecular mass:
    42078 Da
    Quaternary structure:
    • Interacts with PRKG1.
    SequenceCaution:
    • Sequence=BAB71712.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70734.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16011.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW62665.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GKAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GKAP1 Gene

Proteomics data for GKAP1 Gene at MOPED

Post-translational modifications for GKAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GKAP1 Gene

No data available for DME Specific Peptides for GKAP1 Gene

Domains & Families for GKAP1 Gene

Protein Domains for GKAP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VSY0

UniProtKB/Swiss-Prot:

GKAP1_HUMAN :
  • Belongs to the GKAP1 family.
Family:
  • Belongs to the GKAP1 family.
genes like me logo Genes that share domains with GKAP1: view

No data available for Gene Families for GKAP1 Gene

Function for GKAP1 Gene

genes like me logo Genes that share phenotypes with GKAP1: view

Animal Model Products

miRNA for GKAP1 Gene

miRTarBase miRNAs that target GKAP1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GKAP1 Gene

Localization for GKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GKAP1 Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GKAP1 Gene COMPARTMENTS Subcellular localization image for GKAP1 gene
Compartment Confidence
golgi apparatus 4
nucleus 4
cytosol 3
cytoskeleton 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for GKAP1 Gene

Pathways & Interactions for GKAP1 Gene

SuperPathways for GKAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GKAP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GKAP1 Gene

Drugs & Compounds for GKAP1 Gene

No Compound Related Data Available

Transcripts for GKAP1 Gene

Unigene Clusters for GKAP1 Gene

G kinase anchoring protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GKAP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2:
SP3: -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for GKAP1 Gene

GeneLoc Exon Structure for
GKAP1
ECgene alternative splicing isoforms for
GKAP1

Expression for GKAP1 Gene

mRNA expression in normal human tissues for GKAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GKAP1 Gene

This gene is overexpressed in Testis (x11.9).

Protein differential expression in normal tissues from HIPED for GKAP1 Gene

This gene is overexpressed in Testis (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GKAP1 Gene



SOURCE GeneReport for Unigene cluster for GKAP1 Gene Hs.522255

genes like me logo Genes that share expression patterns with GKAP1: view

Protein tissue co-expression partners for GKAP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GKAP1 Gene

Orthologs for GKAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GKAP1 35
  • 93.48 (n)
  • 95.32 (a)
GKAP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GKAP1 35
  • 94.77 (n)
  • 96.69 (a)
GKAP1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gkap1 35
  • 85.34 (n)
  • 87.98 (a)
Gkap1 16
Gkap1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GKAP1 35
  • 100 (n)
  • 100 (a)
GKAP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gkap1 35
  • 85.7 (n)
  • 90.44 (a)
oppossum
(Monodelphis domestica)
Mammalia GKAP1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GKAP1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GKAP1 35
  • 78.48 (n)
  • 76.92 (a)
GKAP1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GKAP1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gkap1 35
  • 68.99 (n)
  • 66.02 (a)
Str.10774 35
African clawed frog
(Xenopus laevis)
Amphibia gkap42-pending-prov 35
zebrafish
(Danio rerio)
Actinopterygii gkap1 35
  • 63.76 (n)
  • 65.17 (a)
wufi16a08 35
gkap1 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10015 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for GKAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GKAP1 Gene

ENSEMBL:
Gene Tree for GKAP1 (if available)
TreeFam:
Gene Tree for GKAP1 (if available)

Paralogs for GKAP1 Gene

No data available for Paralogs for GKAP1 Gene

Variants for GKAP1 Gene

Sequence variations from dbSNP and Humsavar for GKAP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs4750 -- 83,739,596(-) TTTTT(C/G)TTGAA utr-variant-3-prime
rs182408 -- 83,804,657(+) gcccc(A/G)tccgg intron-variant
rs186099 -- 83,804,811(+) gcccc(A/T)ctgcc intron-variant
rs390893 -- 83,804,097(+) cccgg(C/G)agccg intron-variant
rs295268 -- 83,814,390(+) TTTAT(C/T)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GKAP1 Gene

Variant ID Type Subtype PubMed ID
nsv893513 CNV Gain 21882294
nsv469859 CNV Complex 16826518
esv7015 CNV Loss 19470904
esv2738668 CNV Deletion 23290073
esv2672912 CNV Deletion 23128226
dgv2394e1 CNV Complex 17122850

Variation tolerance for GKAP1 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GKAP1 Gene

HapMap Linkage Disequilibrium report
GKAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GKAP1 Gene

Disorders for GKAP1 Gene

Relevant External Links for GKAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GKAP1

No disorders were found for GKAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GKAP1 Gene

Publications for GKAP1 Gene

  1. Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. (PMID: 16015647) Sweetser D.A. … Daly S.B. (Genes Chromosomes Cancer 2005) 3 4 67
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PMID: 18654987) Thalappilly S. … Dusetti N.J. (Proteomics 2008) 3

Products for GKAP1 Gene

Sources for GKAP1 Gene

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