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Aliases for GK5 Gene

Aliases for GK5 Gene

  • Glycerol Kinase 5 (Putative) 2 3 5
  • EC 4 58
  • ATP:Glycerol 3-Phosphotransferase 5 4
  • Glycerokinase 5 4
  • GK 5 4

External Ids for GK5 Gene

Previous GeneCards Identifiers for GK5 Gene

  • GC03M143359
  • GC03M141876
  • GC03M139249

Summaries for GK5 Gene

GeneCards Summary for GK5 Gene

GK5 (Glycerol Kinase 5 (Putative)) is a Protein Coding gene. Among its related pathways are triacylglycerol biosynthesis and glycerol degradation. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and glycerol kinase activity. An important paralog of this gene is GK.

Additional gene information for GK5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GK5 Gene

Genomics for GK5 Gene

Regulatory Elements for GK5 Gene

Enhancers for GK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H141310 1.7 Ensembl ENCODE dbSUPER 19.9 +913.3 913325 3 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 GK5 ZBTB38 YWHAQP6 LOC100289442
GH03H141364 1.4 ENCODE dbSUPER 20.8 +857.7 857672 7.1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 RASA2 GK5 ZBTB38 YWHAQP6 ENSG00000249417 KRT18P35
GH03H142849 1.5 Ensembl ENCODE dbSUPER 11.2 -625.0 -625018 2 PKNOX1 FOXA2 ATF1 ARNT ARID4B TCF12 ATF7 RUNX3 SP5 KAT8 PBX2P1 XRN1 PCOLCE2 GK5 ATR LOC100507389 RPL8P3
GH03H142026 1.2 ENCODE dbSUPER 11.5 +197.4 197367 3.9 HDAC1 TBP PKNOX1 TBL1XR1 SIN3A BMI1 FEZF1 ZBTB40 BATF CHAMP1 RNU6-425P GK5 ATP1B3 RPL19P6 PIR46950
GH03H142022 1.2 Ensembl ENCODE 11.5 +203.0 203037 0.9 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 RUNX3 NCOA1 RNU6-425P GK5 RPL19P6 PIR46950
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GK5 on UCSC Golden Path with GeneCards custom track

Promoters for GK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159425 207 1600 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143

Genomic Locations for GK5 Gene

Genomic Locations for GK5 Gene
68,081 bases
Minus strand

Genomic View for GK5 Gene

Genes around GK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GK5 Gene

Proteins for GK5 Gene

  • Protein details for GK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative glycerol kinase 5
    Protein Accession:
    Secondary Accessions:
    • B2R9I2
    • D3DNG2
    • Q8N2A7
    • Q8N5E6

    Protein attributes for GK5 Gene

    529 amino acids
    Molecular mass:
    59156 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GK5 Gene


neXtProt entry for GK5 Gene

Selected DME Specific Peptides for GK5 Gene


Post-translational modifications for GK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GK5 Gene

Gene Families for GK5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FGGY kinase family.
  • Belongs to the FGGY kinase family.
genes like me logo Genes that share domains with GK5: view

Function for GK5 Gene

Molecular function for GK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Enzyme Numbers (IUBMB) for GK5 Gene

Phenotypes From GWAS Catalog for GK5 Gene

Gene Ontology (GO) - Molecular Function for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004370 glycerol kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016773 phosphotransferase activity, alcohol group as acceptor IEA --
genes like me logo Genes that share ontologies with GK5: view
genes like me logo Genes that share phenotypes with GK5: view

miRNA for GK5 Gene

miRTarBase miRNAs that target GK5

Clone Products

  • Addgene plasmids for GK5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GK5 Gene

Localization for GK5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GK5 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with GK5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GK5 Gene

Pathways & Interactions for GK5 Gene

genes like me logo Genes that share pathways with GK5: view

Pathways by source for GK5 Gene

2 BioSystems pathways for GK5 Gene

UniProtKB/Swiss-Prot Q6ZS86-GLPK5_HUMAN

  • Pathway: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Gene Ontology (GO) - Biological Process for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006071 glycerol metabolic process IBA --
GO:0006641 triglyceride metabolic process IBA --
GO:0016310 phosphorylation IEA --
GO:0019563 glycerol catabolic process IEA --
genes like me logo Genes that share ontologies with GK5: view

No data available for SIGNOR curated interactions for GK5 Gene

Drugs & Compounds for GK5 Gene

(2) Drugs for GK5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Approved, Investigational Pharma 253
ATP Nutra Agonist 0

(2) Additional Compounds for GK5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
glycerol 3-phosphate
  • 1-(Dihydrogen phosphate) Glycerol
  • 1-Glycerophosphate
  • 1-Glycerophosphorate
  • 1-Glycerophosphoric acid
  • 3-Glycerophosphate
genes like me logo Genes that share compounds with GK5: view

Transcripts for GK5 Gene

Unigene Clusters for GK5 Gene

Glycerol kinase 5 (putative):
Representative Sequences:

Clone Products

  • Addgene plasmids for GK5

Alternative Splicing Database (ASD) splice patterns (SP) for GK5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - - - - - -

Relevant External Links for GK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GK5 Gene

This gene is overexpressed in Fetal gut (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GK5 Gene

Protein tissue co-expression partners for GK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of GK5 Gene:


SOURCE GeneReport for Unigene cluster for GK5 Gene:


Evidence on tissue expression from TISSUES for GK5 Gene

  • Nervous system(4.2)
  • Kidney(4.1)
  • Blood(4)
genes like me logo Genes that share expression patterns with GK5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GK5 Gene

Orthologs for GK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GK5 33 34
  • 98.06 (n)
(Canis familiaris)
Mammalia GK5 33 34
  • 89.27 (n)
(Bos Taurus)
Mammalia GK5 33 34
  • 89.23 (n)
(Mus musculus)
Mammalia Gk5 33 16 34
  • 83.61 (n)
(Rattus norvegicus)
Mammalia Gk5 33
  • 83.43 (n)
(Monodelphis domestica)
Mammalia GK5 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia GK5 34
  • 82 (a)
(Gallus gallus)
Aves GK5 33 34
  • 69.78 (n)
(Anolis carolinensis)
Reptilia GK5 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gk5 33
  • 66.27 (n)
(Danio rerio)
Actinopterygii gk5 33 34
  • 63.78 (n)
wufc06f04 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007581 33
  • 48.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1271 33 34
  • 47.78 (n)
(Caenorhabditis elegans)
Secernentea C55B6.1 33 34
  • 49.64 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUT1 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.533 33
Species where no ortholog for GK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GK5 Gene

Gene Tree for GK5 (if available)
Gene Tree for GK5 (if available)

Paralogs for GK5 Gene

Paralogs for GK5 Gene

(3) SIMAP similar genes for GK5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GK5: view

Variants for GK5 Gene

Sequence variations from dbSNP and Humsavar for GK5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000004815 -- 142,182,069(+) GTTAG(A/G)GGAAA intron-variant
rs1000067798 -- 142,188,284(+) CCCAG(C/T)ACTTT intron-variant
rs1000087489 -- 142,195,213(+) CCATA(C/T)TAATT intron-variant
rs1000197648 -- 142,218,847(+) ACATA(C/T)CCAGC intron-variant
rs1000210995 -- 142,220,850(+) ATGCC(A/G)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GK5 Gene

Variant ID Type Subtype PubMed ID
nsv523945 CNV gain 19592680
nsv1011175 CNV gain 25217958
nsv1008873 CNV gain 25217958
nsv1002953 CNV loss 25217958
esv3598001 CNV gain 21293372
esv3597996 CNV gain 21293372
esv3597995 CNV gain 21293372
esv34483 CNV gain 17911159
esv2763767 CNV gain 21179565
esv2759182 CNV gain 17122850
esv2751979 CNV gain 17911159
dgv8626n54 CNV gain 21841781
dgv8625n54 CNV gain 21841781
dgv619n27 CNV gain 19166990
dgv4912n100 CNV gain 25217958
dgv299n21 CNV gain 19592680
dgv1412e212 CNV gain 25503493

Variation tolerance for GK5 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GK5 Gene

Disorders for GK5 Gene

Relevant External Links for GK5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GK5 Gene

Publications for GK5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression. (PMID: 25936394) Yu Y … Zhang BZ (Molecular medicine reports 2015) 3 60
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 60
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 60

Products for GK5 Gene

  • Addgene plasmids for GK5

Sources for GK5 Gene

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