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Aliases for GK5 Gene

Aliases for GK5 Gene

  • Glycerol Kinase 5 (Putative) 2 3 5
  • EC 2.7.1.30 4 61
  • ATP:Glycerol 3-Phosphotransferase 5 4
  • Glycerokinase 5 4
  • GK 5 4

External Ids for GK5 Gene

Previous GeneCards Identifiers for GK5 Gene

  • GC03M143359
  • GC03M141876
  • GC03M139249

Summaries for GK5 Gene

GeneCards Summary for GK5 Gene

GK5 (Glycerol Kinase 5 (Putative)) is a Protein Coding gene. Among its related pathways are triacylglycerol biosynthesis and glycerol degradation. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and glycerol kinase activity. An important paralog of this gene is GK.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GK5 Gene

Genomics for GK5 Gene

Regulatory Elements for GK5 Gene

Enhancers for GK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F142019 1.4 Ensembl ENCODE 11.4 +205.5 205507 1.8 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 FOS RNU6-425P GK5 ATP1B3 RPL19P6 PIR46950
GH03F142278 1.2 Ensembl ENCODE 11.4 -53.7 -53729 2.2 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 CBX5 MXD4 MIER2 REST PPARG XRN1 PBX2P1 GK5 RNU6-425P PIR51844
GH03F142021 1.2 Ensembl ENCODE 11.4 +203.3 203289 1.4 PKNOX1 ARNT ELK1 GATA2 REST CREB3 SMARCA4 PBX2 NBN HMBOX1 RNU6-425P GK5 RPL19P6 PIR46950
GH03F142222 1.1 ENCODE 9.8 +1.2 1209 3.6 HDGF PKNOX1 ATF1 CREB3L1 ZFP64 ARID4B SIN3A GLI4 DMAP1 ZNF48 GK5 TFDP2
GH03F142026 0.9 ENCODE 11.4 +197.4 197367 3.9 TBP HDAC1 PKNOX1 TBL1XR1 SIN3A BMI1 FEZF1 ZBTB40 CHAMP1 SCRT2 RNU6-425P GK5 ATP1B3 RPL19P6 PIR46950
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GK5 on UCSC Golden Path with GeneCards custom track

Promoters for GK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001375565 307 2200 HDGF ATF1 CREB3L1 ZFP64 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2

Genomic Location for GK5 Gene

Chromosome:
3
Start:
142,157,527 bp from pter
End:
142,225,607 bp from pter
Size:
68,081 bases
Orientation:
Minus strand

Genomic View for GK5 Gene

Genes around GK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GK5 Gene

Proteins for GK5 Gene

  • Protein details for GK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS86-GLPK5_HUMAN
    Recommended name:
    Putative glycerol kinase 5
    Protein Accession:
    Q6ZS86
    Secondary Accessions:
    • B2R9I2
    • D3DNG2
    • Q8N2A7
    • Q8N5E6

    Protein attributes for GK5 Gene

    Size:
    529 amino acids
    Molecular mass:
    59156 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GK5 Gene

Selected DME Specific Peptides for GK5 Gene

Q6ZS86:
  • AFRNKQL
  • GLAVGFW
  • AVKRSMNW
  • FGTIDTW
  • VPSFSGLQAP
  • IRCHVYD
  • AMFGECCF
  • FHNFISWQDLR
  • IFGVPIP

Post-translational modifications for GK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GK5 Gene

Gene Families for GK5 Gene

Suggested Antigen Peptide Sequences for GK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZS86

UniProtKB/Swiss-Prot:

GLPK5_HUMAN :
  • Belongs to the FGGY kinase family.
Family:
  • Belongs to the FGGY kinase family.
genes like me logo Genes that share domains with GK5: view

Function for GK5 Gene

Molecular function for GK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Enzyme Numbers (IUBMB) for GK5 Gene

Gene Ontology (GO) - Molecular Function for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004370 glycerol kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016773 phosphotransferase activity, alcohol group as acceptor IEA,IBA --
genes like me logo Genes that share ontologies with GK5: view
genes like me logo Genes that share phenotypes with GK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GK5

miRNA for GK5 Gene

miRTarBase miRNAs that target GK5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GK5

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GK5 Gene

Localization for GK5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GK5 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with GK5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GK5 Gene

Pathways & Interactions for GK5 Gene

genes like me logo Genes that share pathways with GK5: view

Pathways by source for GK5 Gene

2 BioSystems pathways for GK5 Gene

UniProtKB/Swiss-Prot Q6ZS86-GLPK5_HUMAN

  • Pathway: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Interacting Proteins for GK5 Gene

Gene Ontology (GO) - Biological Process for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006071 glycerol metabolic process IEA --
GO:0016310 phosphorylation IEA,IBA --
GO:0019563 glycerol catabolic process IEA --
genes like me logo Genes that share ontologies with GK5: view

No data available for SIGNOR curated interactions for GK5 Gene

Drugs & Compounds for GK5 Gene

(2) Drugs for GK5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Approved, Experimental Pharma 223
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for GK5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
glycerol 3-phosphate
  • 1-(Dihydrogen phosphate) Glycerol
  • 1-Glycerophosphate
  • 1-Glycerophosphorate
  • 1-Glycerophosphoric acid
  • 3-Glycerophosphate
57-03-4
genes like me logo Genes that share compounds with GK5: view

Transcripts for GK5 Gene

Unigene Clusters for GK5 Gene

Glycerol kinase 5 (putative):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GK5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GK5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - - - - - -
SP3:

Relevant External Links for GK5 Gene

GeneLoc Exon Structure for
GK5
ECgene alternative splicing isoforms for
GK5

Expression for GK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GK5 Gene

This gene is overexpressed in Fetal gut (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GK5 Gene



Protein tissue co-expression partners for GK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of GK5 Gene:

GK5

SOURCE GeneReport for Unigene cluster for GK5 Gene:

Hs.135904
genes like me logo Genes that share expression patterns with GK5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GK5 Gene

Orthologs for GK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GK5 34 35
  • 98.06 (n)
dog
(Canis familiaris)
Mammalia GK5 34 35
  • 89.27 (n)
cow
(Bos Taurus)
Mammalia GK5 34 35
  • 89.23 (n)
mouse
(Mus musculus)
Mammalia Gk5 34 16 35
  • 83.61 (n)
rat
(Rattus norvegicus)
Mammalia Gk5 34
  • 83.43 (n)
oppossum
(Monodelphis domestica)
Mammalia GK5 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GK5 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GK5 34 35
  • 69.78 (n)
lizard
(Anolis carolinensis)
Reptilia GK5 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gk5 34
  • 66.27 (n)
zebrafish
(Danio rerio)
Actinopterygii gk5 34 35
  • 63.78 (n)
wufc06f04 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007581 34
  • 48.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1271 34 35
  • 47.78 (n)
worm
(Caenorhabditis elegans)
Secernentea C55B6.1 34 35
  • 49.64 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUT1 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.533 34
Species where no ortholog for GK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GK5 Gene

ENSEMBL:
Gene Tree for GK5 (if available)
TreeFam:
Gene Tree for GK5 (if available)

Paralogs for GK5 Gene

Paralogs for GK5 Gene

(3) SIMAP similar genes for GK5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GK5: view

Variants for GK5 Gene

Sequence variations from dbSNP and Humsavar for GK5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10701583 -- 142,168,044(+) CAAAA(-/CAAAA)ACCCT intron-variant
rs10935455 -- 142,219,650(+) AACTA(C/T)ACACC intron-variant
rs111228966 -- 142,215,630(+) ACAAA(C/T)TGAAT nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs111308224 -- 142,189,724(+) CTACC(C/T)TAAGA intron-variant
rs111461663 -- 142,210,504(+) GCTCC(A/G)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GK5 Gene

Variant ID Type Subtype PubMed ID
nsv523945 CNV gain 19592680
nsv1011175 CNV gain 25217958
nsv1008873 CNV gain 25217958
nsv1002953 CNV loss 25217958
esv3598001 CNV gain 21293372
esv3597996 CNV gain 21293372
esv3597995 CNV gain 21293372
esv34483 CNV gain 17911159
esv2763767 CNV gain 21179565
esv2759182 CNV gain 17122850
esv2751979 CNV gain 17911159
dgv8626n54 CNV gain 21841781
dgv8625n54 CNV gain 21841781
dgv619n27 CNV gain 19166990
dgv4912n100 CNV gain 25217958
dgv299n21 CNV gain 19592680
dgv1412e212 CNV gain 25503493

Variation tolerance for GK5 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GK5 Gene

Disorders for GK5 Gene

Relevant External Links for GK5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GK5

No disorders were found for GK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GK5 Gene

Publications for GK5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression. (PMID: 25936394) Yu Y. … Zhang B.Z. (Mol Med Rep 2015) 3 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64

Products for GK5 Gene

Sources for GK5 Gene

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