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Aliases for GK5 Gene

Aliases for GK5 Gene

  • Glycerol Kinase 5 (Putative) 2 3 5
  • EC 4 63
  • ATP:Glycerol 3-Phosphotransferase 5 4
  • Glycerokinase 5 4
  • GK 5 4

External Ids for GK5 Gene

Previous GeneCards Identifiers for GK5 Gene

  • GC03M143359
  • GC03M141876
  • GC03M139249

Summaries for GK5 Gene

GeneCards Summary for GK5 Gene

GK5 (Glycerol Kinase 5 (Putative)) is a Protein Coding gene. Among its related pathways are glycerol degradation and triacylglycerol biosynthesis. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and glycerol kinase activity. An important paralog of this gene is GK.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GK5 Gene

Genomics for GK5 Gene

Regulatory Elements for GK5 Gene

Enhancers for GK5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GK5 on UCSC Golden Path with GeneCards custom track

Promoters for GK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GK5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GK5 Gene

142,157,527 bp from pter
142,225,607 bp from pter
68,081 bases
Minus strand

Genomic View for GK5 Gene

Genes around GK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GK5 Gene

Proteins for GK5 Gene

  • Protein details for GK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative glycerol kinase 5
    Protein Accession:
    Secondary Accessions:
    • B2R9I2
    • D3DNG2
    • Q8N2A7
    • Q8N5E6

    Protein attributes for GK5 Gene

    529 amino acids
    Molecular mass:
    59156 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GK5 Gene


neXtProt entry for GK5 Gene

Proteomics data for GK5 Gene at MOPED

Selected DME Specific Peptides for GK5 Gene

Post-translational modifications for GK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GK5 Gene

Domains & Families for GK5 Gene

Gene Families for GK5 Gene

Suggested Antigen Peptide Sequences for GK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FGGY kinase family.
  • Belongs to the FGGY kinase family.
genes like me logo Genes that share domains with GK5: view

Function for GK5 Gene

Molecular function for GK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Enzyme Numbers (IUBMB) for GK5 Gene

genes like me logo Genes that share phenotypes with GK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GK5

miRNA for GK5 Gene

miRTarBase miRNAs that target GK5

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GK5 Gene

Localization for GK5 Gene

Subcellular locations from

Jensen Localization Image for GK5 Gene COMPARTMENTS Subcellular localization image for GK5 gene
Compartment Confidence
cytosol 3
nucleus 3
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GK5 Gene

Pathways & Interactions for GK5 Gene

genes like me logo Genes that share pathways with GK5: view

Pathways by source for GK5 Gene

2 BioSystems pathways for GK5 Gene

UniProtKB/Swiss-Prot Q6ZS86-GLPK5_HUMAN

  • Pathway: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Interacting Proteins for GK5 Gene

Gene Ontology (GO) - Biological Process for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
genes like me logo Genes that share ontologies with GK5: view

No data available for SIGNOR curated interactions for GK5 Gene

Drugs & Compounds for GK5 Gene

(2) Drugs for GK5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Glycerol Experimental Pharma 205

(2) Additional Compounds for GK5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
glycerol 3-phosphate
  • 1-(Dihydrogen phosphate) Glycerol
  • 1-Glycerophosphate
  • 1-Glycerophosphorate
  • 1-Glycerophosphoric acid
  • 3-Glycerophosphate
genes like me logo Genes that share compounds with GK5: view

Transcripts for GK5 Gene

Unigene Clusters for GK5 Gene

Glycerol kinase 5 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GK5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - - - - - -

Relevant External Links for GK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GK5 Gene

mRNA expression in normal human tissues for GK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GK5 Gene

This gene is overexpressed in Fetal gut (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GK5 Gene

SOURCE GeneReport for Unigene cluster for GK5 Gene Hs.135904

genes like me logo Genes that share expression patterns with GK5: view

Protein tissue co-expression partners for GK5 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GK5 Gene

Orthologs for GK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GK5 35
  • 89.23 (n)
  • 87.07 (a)
GK5 36
  • 82 (a)
(Canis familiaris)
Mammalia GK5 35
  • 89.27 (n)
  • 85.23 (a)
GK5 36
  • 83 (a)
(Mus musculus)
Mammalia Gk5 35
  • 83.61 (n)
  • 83.27 (a)
Gk5 16
Gk5 36
  • 79 (a)
(Pan troglodytes)
Mammalia GK5 35
  • 98.06 (n)
  • 97.51 (a)
GK5 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Gk5 35
  • 83.43 (n)
  • 81.66 (a)
(Monodelphis domestica)
Mammalia GK5 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia GK5 36
  • 82 (a)
(Gallus gallus)
Aves GK5 35
  • 69.78 (n)
  • 64.02 (a)
GK5 36
  • 62 (a)
(Anolis carolinensis)
Reptilia GK5 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gk5 35
  • 66.27 (n)
  • 65.1 (a)
(Danio rerio)
Actinopterygii gk5 35
  • 63.78 (n)
  • 62.62 (a)
wufc06f04 35
gk5 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007581 35
  • 48.45 (n)
  • 42.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1271 35
  • 47.78 (n)
  • 41.18 (a)
CG1271 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea C55B6.1 35
  • 49.64 (n)
  • 37.82 (a)
C55B6.1 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUT1 36
  • 20 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.533 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for GK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GK5 Gene

Gene Tree for GK5 (if available)
Gene Tree for GK5 (if available)

Paralogs for GK5 Gene

Paralogs for GK5 Gene

(3) SIMAP similar genes for GK5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GK5: view

Variants for GK5 Gene

Sequence variations from dbSNP and Humsavar for GK5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7609682 -- 142,194,724(+) tatac(C/T)ctccc intron-variant
rs7610565 -- 142,219,784(+) cagcc(C/T)gagca intron-variant
rs9813746 -- 142,192,095(+) tgctc(C/T)gtatc intron-variant
rs4485736 -- 142,206,197(+) tttgg(C/T)tatcg intron-variant
rs9814627 -- 142,201,592(+) tggat(A/G)catga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GK5 Gene

Variant ID Type Subtype PubMed ID
dgv1514e1 CNV Complex 17122850
essv24219 CNV CNV 17122850
dgv299n21 CNV Gain 19592680
dgv619n27 CNV Gain 19166990
esv2751979 CNV Gain 17911159
esv34483 CNV Gain 17911159
nsv877556 CNV Loss 21882294
nsv523945 CNV Gain 19592680

Variation tolerance for GK5 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GK5 Gene

Disorders for GK5 Gene

Relevant External Links for GK5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GK5 Gene

Publications for GK5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression. (PMID: 25936394) Yu Y. … Zhang B.Z. (Mol Med Rep 2015) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for GK5 Gene

Sources for GK5 Gene