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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GK5 Gene

protein-coding   GIFtS: 51
GCID: GC03M141876

Glycerol Kinase 5 (Putative)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Glycerol Kinase 5 (Putative)1 2
Glycerokinase 52 3
ATP:Glycerol 3-Phosphotransferase 52 3
GK 52 3
EC 2.7.1.303 8
Putative Glycerol Kinase 52

External Ids:    HGNC: 286351   Entrez Gene: 2563562   Ensembl: ENSG000001750667   UniProtKB: Q6ZS863   
ORGUL members:         
NONCODE14:n409152      

Export aliases for GK5 gene to outside databases

Previous GC identifers: GC03M143359 GC03M139249


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GK5 Gene: 
GK5 (glycerol kinase 5 (putative)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with GK5 include alcoholism, and pneumonia. GO annotations related to this gene include glycerol kinase activity and ATP binding. An important paralog of this gene is GK.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GK5 gene promoter:
         HOXA9   HOXA9B   COUP   MyoD   Egr-4   Meis-1b   COUP-TF   Pax-4a   Meis-1   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GK5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

GK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GK5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M141876:  view genomic region     (about GC identifiers)

Start:
141,876,369 bp from pter      End:
141,944,449 bp from pter
Size:
68,081 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLPK5_HUMAN, Q6ZS86 (See protein sequence)
Recommended Name: Putative glycerol kinase 5  
Size: 529 amino acids; 59156 Da
Secondary accessions: B2R9I2 D3DNG2 Q8N2A7 Q8N5E6
Alternative splicing: 3 isoforms:  Q6ZS86-1   Q6ZS86-2   Q6ZS86-3   

Explore the universe of human proteins at neXtProt for GK5: NX_Q6ZS86

Explore proteomics data for GK5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZS86

  • 4/9 DME Specific Peptides for GK5 (Q6ZS86) (see all 9)
     GLAVGFW  AFRNKQL  IFGVPIP  IRCHVYD 

    GK5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GK5 Protein Expression
    REFSEQ proteins: NP_001034636.1  
    ENSEMBL proteins: 
     ENSP00000420312   ENSP00000419031   ENSP00000418001   ENSP00000417153   ENSP00000420593  
     ENSP00000418239   ENSP00000440860  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GK: Glycerol kinases

    3 InterPro protein domains:
     IPR018485 Carb_kinase_FGGY_C
     IPR018483 Carb_kinase_FGGY_CS
     IPR018484 Carb_kinase_FGGY_N

    Graphical View of Domain Structure for InterPro Entry Q6ZS86

    ProtoNet protein and cluster: Q6ZS86

    1 Blocks protein domain: IPB000577 Carbohydrate kinase

    UniProtKB/Swiss-Prot: GLPK5_HUMAN, Q6ZS86
    Similarity: Belongs to the FGGY kinase family


    GK5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLPK5_HUMAN, Q6ZS86
    Catalytic activity: ATP + glycerol = ADP + sn-glycerol 3-phosphate

         Enzyme Number (IUBMB): EC 2.7.1.301 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004370glycerol kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016773phosphotransferase activity, alcohol group as acceptor ----
         
    GK5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GK5:
     Decreased POU5F1-GFP protein e  Increased Salmonella enterica  

         1 MGI phenotypic allele for Gk5 (no phenotypes)

    GK5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GK5 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GK5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1glycerol degradation I
    glycerol degradation I


    1 BioSystems Pathway for GK5
        glycerol degradation I



    UniProtKB/Swiss-Prot: GLPK5_HUMAN, Q6ZS86
    Pathway: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from
    glycerol: step 1/1

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GK5

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for GK5 (ENSP000004180014) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0019563glycerol catabolic process IEA--

    GK5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GK5 (GLPK5)

    2 HMDB Compounds for GK5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glycerol1,2,3-Trihydroxypropane (see all 22)56-81-5--
    Glycerol 3-phosphate1-(dihydrogen phosphate) Glycerol (see all 37)57-03-4--

    Search CenterWatch for drugs/clinical trials and news about GK5 / GLPK5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GK5 gene (2 alternative transcripts): 
    NM_152776.1  NM_001039547.2  

    Unigene Clusters for GK5:

    Glycerol kinase 5 (putative)
    Hs.135904  [show with all ESTs], Hs.745523
    Unigene Representative Sequences: NR_033289, AK130469
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492097(uc010hus.2) ENST00000480757 ENST00000460515(uc003eup.1)
    ENST00000392993(uc003euq.2) ENST00000463349 ENST00000486459 ENST00000460630
    ENST00000460544 ENST00000487672(uc010hut.2) ENST00000466685 ENST00000472759
    ENST00000489085 ENST00000544571
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate GK5 (see all 76):
    hsa-miR-607 hsa-miR-1304 hsa-miR-29a* hsa-miR-3148 hsa-miR-3622a-5p hsa-miR-34c-5p hsa-miR-186* hsa-miR-3065-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: AK130469.1 

    4 DOTS entries:

    DT.75116731  DT.40233186  DT.75189915  DT.75165086 

    24/64 AceView cDNA sequences (see all 64):

    AI250691 CR598125 CA412196 AK090901 AA648374 AL567263 AW299704 AW769016 
    AK127641 AX746669 AA347327 BM685050 BG697446 BU170345 BE875664 NM_152776 
    CA430820 AW275257 BM782446 BG681650 BM932018 BM808050 BX648681 BG740603 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GK5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                -                                   -     -                                             
    SP2:                                      -     -     -     -     -     -                                                   
    SP3:                                                                                                                        


    ECgene alternative splicing isoforms for GK5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GK5 expression in normal human tissues (normalized intensities)      GK5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCACTTT
    GK5 Expression
    About this image


    GK5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   

    See GK5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GK5

    SOURCE GeneReport for Unigene clusters: Hs.135904 Hs.745523
        SABiosciences Custom PCR Arrays for GK5
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GK5 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gk51 , 5 glycerol kinase 5 (putative)1, 5 83.61(n)1
    83.27(a)1
      9 (50.31 cM)5
    2355331  NM_177352.41  NP_796326.11 
     961193625 
    chicken
    (Gallus gallus)
    Aves GK51 glycerol kinase 5 (putative) 69.78(n)
    64.02(a)
      424779  NM_001031306.1  NP_001026477.1 
    lizard
    (Anolis carolinensis)
    Reptilia GK56
    Uncharacterized protein
    67(a)
    1 ↔ 1
    3(21955380-21978549)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc06f042 Transcribed sequence with weak similarity to protein more 74.11(n)    CK126414.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG12711 CG1271 47.71(n)
    41.18(a)
      38364  NM_139506.2  NP_647763.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C55B6.11 Protein C55B6.1 49.64(n)
    37.82(a)
      180984  NM_001029332.2  NP_001024503.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GUT16
    Glycerol kinase, converts glycerol to glycerol-3-p...
    20(a)
    1 → many
    VIII(36379-38508)


    ENSEMBL Gene Tree for GK5 (if available)
    TreeFam Gene Tree for GK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GK5 gene
    GK2  GK22  
    3 SIMAP similar genes for GK5 using alignment to 4 protein entries:     GLPK5_HUMAN (see all proteins):
    GK    GK3P    GK2

    GK5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1305 SNPs in GK5 are shown (see all 1305)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830960361,2
    --141875954(+) AAAAAA/GTACAC 2 -- int10--------
    rs1115829221,2
    F--141875955(+) AAAAAT/CACACG 2 -- int12Minor allele frequency- C:0.03CSA WA 120
    rs1883757311,2
    --141875957(+) AAATAA/CACGAA 2 -- int10--------
    rs1917472061,2
    --141875965(+) GAATAC/TTCAAT 2 -- int10--------
    rs1147371481,2
    F--141876015(+) AAAACC/TCATTC 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1387587371,2
    C--141876063(+) AGCAAC/TGTCAG 2 -- int10--------
    rs1847109961,2
    --141876172(+) CCTCTC/TCCTTT 2 -- int10--------
    rs762448221,2
    C,F--141876357(+) AGCAAA/GTAACA 2 -- int11Minor allele frequency- G:0.05WA 118
    rs1873537361,2
    --141876755(+) ACAAGA/TGCTAT 2 -- ut31 nc-transcript-variant0--------
    rs1513134861,2
    --141876787(+) TTGTT-/GT    
       TGTTG
    TTTTT
    2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for GK5 (141876369 - 141944449 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GK5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv877556CNV Loss21882294
    dgv299n21CNV Gain19592680
    esv34483CNV Gain17911159
    nsv523945CNV Gain19592680
    esv2751979CNV Gain17911159
    dgv619n27CNV Gain19166990
    essv24219CNV CNV17122850
    dgv1514e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GK5
    DNA2.0 Custom Variant and Variant Library Synthesis for GK5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for GK5:    About MalaCards
    alcoholism    pneumonia


    GK5 for disorders           About GeneDecksing


    Export disorders for GK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GK5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with GK5)
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    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 256356 HGNC: 28635 AceView: MGC40579 Ensembl:ENSG00000175066 euGenes: HUgn256356
    ECgene: GK5 H-InvDB: GK5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GK5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GK5 gene:
    Search GeneIP for patents involving GK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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