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Aliases for GK2 Gene

Aliases for GK2 Gene

  • Glycerol Kinase 2 2 3 5
  • ATP:Glycerol 3-Phosphotransferase 2 3 4
  • Glycerol Kinase Pseudogene 2 2 3
  • Glycerokinase 2 3 4
  • EC 2.7.1.30 4 58
  • GKP2 3 4
  • GKTA 3 4
  • Testis Tissue Sperm-Binding Protein Li 77m 3
  • Glycerol Kinase, Testis Specific 2 4
  • Glycerol Kinase Testis Specific 2 3
  • GK 2 4

External Ids for GK2 Gene

Previous HGNC Symbols for GK2 Gene

  • GKP2

Previous GeneCards Identifiers for GK2 Gene

  • GC04M080255
  • GC04M080601
  • GC04M080720
  • GC04M080785
  • GC04M080684
  • GC04M076074

Summaries for GK2 Gene

GeneCards Summary for GK2 Gene

GK2 (Glycerol Kinase 2) is a Protein Coding gene. Diseases associated with GK2 include Glycerol Kinase Deficiency. Among its related pathways are Metabolism and triacylglycerol biosynthesis. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and glycerol kinase activity. An important paralog of this gene is GK.

UniProtKB/Swiss-Prot for GK2 Gene

  • Key enzyme in the regulation of glycerol uptake and metabolism.

Additional gene information for GK2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GK2 Gene

Genomics for GK2 Gene

Regulatory Elements for GK2 Gene

Enhancers for GK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H079378 0.4 dbSUPER 12.6 +27.7 27747 3 ATF2 GK2 NAA11 ANXA3 LOC105377300
GH04H079412 1.4 dbSUPER 0.4 -6.0 -5954 4 POLR2A GK2 GC04P079476
GH04H079382 1.2 dbSUPER 0.3 +20.8 20793 9 PCAT4 ANXA3 NAA11 LOC105377300 GK2
GH04H079394 0.5 dbSUPER 0.4 +12.7 12685 2 SOX6 IKZF1 CEBPB CEBPG GK2 LOC105377300
GH04H079411 0.2 dbSUPER 0.7 -3.2 -3203 0 GK2 GC04P079476
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GK2 Gene

Chromosome:
4
Start:
79,406,352 bp from pter
End:
79,408,293 bp from pter
Size:
1,942 bases
Orientation:
Minus strand

Genomic View for GK2 Gene

Genes around GK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GK2 Gene

Proteins for GK2 Gene

  • Protein details for GK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14410-GLPK2_HUMAN
    Recommended name:
    Glycerol kinase 2
    Protein Accession:
    Q14410
    Secondary Accessions:
    • A8K876
    • Q6PD73
    • Q86XV8

    Protein attributes for GK2 Gene

    Size:
    553 amino acids
    Molecular mass:
    60594 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GK2 Gene

Selected DME Specific Peptides for GK2 Gene

Q14410:
  • TGGVNGG
  • AMNRDCGIPL
  • KNTYGTG
  • YFVPAFS
  • LMQLQAD
  • VPAFSGL
  • HGLLTTVA
  • TGEPLYNA
  • GTIDSWL
  • LFNIHSL
  • TDVTNASRT
  • YALEGSVAIAGA
  • MERFEPQI
  • EGWVEQDPKEIL
  • YYALEGS
  • CGLTQFTNKCHIAFAALEAVCFQTREIL
  • NASRTML
  • ETTALGA
  • NIDISNIKA
  • STRFLVF
  • GALEGVPISGCLGDQ
  • SEHGLLTT
  • TYGTGCF
  • NQRETTV
  • TGLPLSTYF
  • AVMKSMGWVT

Post-translational modifications for GK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GK2 Gene

Gene Families for GK2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for GK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14410

UniProtKB/Swiss-Prot:

GLPK2_HUMAN :
  • Belongs to the FGGY kinase family.
Family:
  • Belongs to the FGGY kinase family.
genes like me logo Genes that share domains with GK2: view

Function for GK2 Gene

Molecular function for GK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + glycerol = ADP + sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Key enzyme in the regulation of glycerol uptake and metabolism.

Enzyme Numbers (IUBMB) for GK2 Gene

Gene Ontology (GO) - Molecular Function for GK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004370 glycerol kinase activity NAS,IBA 7987308
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016773 phosphotransferase activity, alcohol group as acceptor IEA --
genes like me logo Genes that share ontologies with GK2: view
genes like me logo Genes that share phenotypes with GK2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GK2
  • Applied Biological Materials Clones for GK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GK2 Gene

Localization for GK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GK2 Gene

Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm the majority of the enzyme is bound to mitochondria. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GK2 gene
Compartment Confidence
extracellular 5
mitochondrion 4
peroxisome 2
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IBA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GK2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GK2 Gene

Pathways & Interactions for GK2 Gene

genes like me logo Genes that share pathways with GK2: view

UniProtKB/Swiss-Prot Q14410-GLPK2_HUMAN

  • Pathway: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Gene Ontology (GO) - Biological Process for GK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006071 glycerol metabolic process IBA --
GO:0006072 glycerol-3-phosphate metabolic process IEA --
GO:0006641 triglyceride metabolic process IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with GK2: view

No data available for SIGNOR curated interactions for GK2 Gene

Drugs & Compounds for GK2 Gene

(2) Drugs for GK2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Approved, Investigational Pharma 253
ATP Nutra Agonist 0

(2) Additional Compounds for GK2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glycerol 3-phosphate
  • 1-(Dihydrogen phosphate) Glycerol
  • 1-Glycerophosphate
  • 1-Glycerophosphorate
  • 1-Glycerophosphoric acid
  • 3-Glycerophosphate
57-03-4
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with GK2: view

Transcripts for GK2 Gene

mRNA/cDNA for GK2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GK2 Gene

Glycerol kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GK2
  • Applied Biological Materials Clones for GK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GK2 Gene

No ASD Table

Relevant External Links for GK2 Gene

GeneLoc Exon Structure for
GK2
ECgene alternative splicing isoforms for
GK2

Expression for GK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GK2 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for GK2 Gene

This gene is overexpressed in Testis (33.7), Ovary (10.7), and Kidney (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GK2 Gene



Protein tissue co-expression partners for GK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GK2 Gene:

GK2

SOURCE GeneReport for Unigene cluster for GK2 Gene:

Hs.98008

Evidence on tissue expression from TISSUES for GK2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GK2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GK2 Gene

Orthologs for GK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GK2 33 34
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia GK2 33 34
  • 87.98 (n)
cow
(Bos Taurus)
Mammalia GK2 33 34
  • 87.56 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
ManyToMany
-- 34
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gk2 33 16 34
  • 83.7 (n)
rat
(Rattus norvegicus)
Mammalia Gk2 33
  • 81.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia gk2-prov 33
zebrafish
(Danio rerio)
Actinopterygii GK2 34
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Gyk 34
  • 51 (a)
ManyToMany
Gk 34
  • 45 (a)
ManyToMany
CG8298 34
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R11F4.1 34
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUT1 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4742 34
  • 61 (a)
OneToMany
Species where no ortholog for GK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GK2 Gene

ENSEMBL:
Gene Tree for GK2 (if available)
TreeFam:
Gene Tree for GK2 (if available)

Paralogs for GK2 Gene

Paralogs for GK2 Gene

(3) SIMAP similar genes for GK2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GK2: view

Variants for GK2 Gene

Sequence variations from dbSNP and Humsavar for GK2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000185205 -- 79,408,207(+) ACACC(A/C)GTAGG utr-variant-5-prime
rs1000217797 -- 79,408,362(+) CCAGG(C/G)TTCAC upstream-variant-2KB
rs1001851314 -- 79,406,653(+) GACTG(A/T)CTGGT reference, missense
rs1002632383 -- 79,409,798(+) CAATT(A/G)GGTTC upstream-variant-2KB
rs1002663442 -- 79,410,107(+) AAGAC(C/T)TATTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GK2 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV deletion 23290073
nsv1006026 CNV loss 25217958
nsv999174 CNV loss 25217958

Variation tolerance for GK2 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GK2 Gene

Disorders for GK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GK2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
glycerol kinase deficiency
  • hyperglycerolemia
- elite association - COSMIC cancer census association via MalaCards
Search GK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GK2

Genetic Association Database (GAD)
GK2
Human Genome Epidemiology (HuGE) Navigator
GK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GK2
genes like me logo Genes that share disorders with GK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GK2 Gene

Publications for GK2 Gene

  1. The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons. (PMID: 7987308) Sargent CA … Affara NA (Human molecular genetics 1994) 2 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Identification of a panel of complex autoantigens (LGALS3, PHB2, MUC1, and GK2) in combination with CA15-3 for the diagnosis of early-stage breast cancer. (PMID: 26289852) Zuo X … Qin T (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for GK2 Gene

  • Addgene plasmids for GK2

Sources for GK2 Gene

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