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Aliases for GK2 Gene

Aliases for GK2 Gene

  • Glycerol Kinase 2 2 3 5
  • ATP:Glycerol 3-Phosphotransferase 2 3 4
  • Glycerol Kinase, Testis Specific 2 3 4
  • Glycerol Kinase Pseudogene 2 2 3
  • Glycerokinase 2 3 4
  • EC 4 63
  • GKP2 3 4
  • GKTA 3 4
  • Testis Tissue Sperm-Binding Protein Li 77m 3
  • Glycerol Kinase Testis Specific 2 3
  • GK 2 4

External Ids for GK2 Gene

Previous HGNC Symbols for GK2 Gene

  • GKP2

Previous GeneCards Identifiers for GK2 Gene

  • GC04M080255
  • GC04M080601
  • GC04M080720
  • GC04M080785
  • GC04M080684
  • GC04M076074

Summaries for GK2 Gene

GeneCards Summary for GK2 Gene

GK2 (Glycerol Kinase 2) is a Protein Coding gene. Diseases associated with GK2 include Glycerol Kinase Deficiency and X-Linked Adrenal Hypoplasia Congenita. Among its related pathways are glycerol degradation and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and glycerol kinase activity. An important paralog of this gene is GK.

UniProtKB/Swiss-Prot for GK2 Gene

  • Key enzyme in the regulation of glycerol uptake and metabolism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GK2 Gene

Genomics for GK2 Gene

Regulatory Elements for GK2 Gene

Enhancers for GK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GK2 Gene

79,406,352 bp from pter
79,408,293 bp from pter
1,942 bases
Minus strand

Genomic View for GK2 Gene

Genes around GK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GK2 Gene

Proteins for GK2 Gene

  • Protein details for GK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycerol kinase 2
    Protein Accession:
    Secondary Accessions:
    • A8K876
    • Q6PD73
    • Q86XV8

    Protein attributes for GK2 Gene

    553 amino acids
    Molecular mass:
    60594 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GK2 Gene

Proteomics data for GK2 Gene at MOPED

Post-translational modifications for GK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GK2 Gene

Gene Families for GK2 Gene

Suggested Antigen Peptide Sequences for GK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FGGY kinase family.
  • Belongs to the FGGY kinase family.
genes like me logo Genes that share domains with GK2: view

Function for GK2 Gene

Molecular function for GK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + glycerol = ADP + sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Key enzyme in the regulation of glycerol uptake and metabolism.

Enzyme Numbers (IUBMB) for GK2 Gene

genes like me logo Genes that share phenotypes with GK2: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GK2 Gene

Localization for GK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GK2 Gene

Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm the majority of the enzyme is bound to mitochondria. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for GK2 Gene COMPARTMENTS Subcellular localization image for GK2 gene
Compartment Confidence
extracellular 5
mitochondrion 4
peroxisome 2
cytosol 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for GK2 Gene

Pathways & Interactions for GK2 Gene

genes like me logo Genes that share pathways with GK2: view

UniProtKB/Swiss-Prot Q14410-GLPK2_HUMAN

  • Pathway: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Interacting Proteins for GK2 Gene

Gene Ontology (GO) - Biological Process for GK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IBA --
GO:0006072 glycerol-3-phosphate metabolic process IEA --
GO:0046167 glycerol-3-phosphate biosynthetic process IBA --
genes like me logo Genes that share ontologies with GK2: view

No data available for SIGNOR curated interactions for GK2 Gene

Drugs & Compounds for GK2 Gene

(2) Drugs for GK2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Glycerol Experimental Pharma 205

(2) Additional Compounds for GK2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glycerol 3-phosphate
  • 1-(Dihydrogen phosphate) Glycerol
  • 1-Glycerophosphate
  • 1-Glycerophosphorate
  • 1-Glycerophosphoric acid
  • 3-Glycerophosphate
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with GK2: view

Transcripts for GK2 Gene

mRNA/cDNA for GK2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GK2 Gene

Glycerol kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GK2 Gene

No ASD Table

Relevant External Links for GK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GK2 Gene

mRNA expression in normal human tissues for GK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GK2 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for GK2 Gene

This gene is overexpressed in Testis (33.7), Ovary (10.7), and Kidney (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GK2 Gene

SOURCE GeneReport for Unigene cluster for GK2 Gene Hs.98008

genes like me logo Genes that share expression patterns with GK2: view

Protein tissue co-expression partners for GK2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GK2 Gene

Orthologs for GK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GK2 35
  • 87.56 (n)
  • 84.96 (a)
GK2 36
  • 85 (a)
(Canis familiaris)
Mammalia GK2 35
  • 87.98 (n)
  • 85.14 (a)
GK2 36
  • 85 (a)
(Mus musculus)
Mammalia Gk2 35
  • 83.7 (n)
  • 85.09 (a)
Gk2 16
Gk2 36
  • 84 (a)
(Pan troglodytes)
Mammalia GK2 35
  • 99.28 (n)
  • 99.64 (a)
GK2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gk2 35
  • 81.82 (n)
  • 83.45 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
-- 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
(Gallus gallus)
Aves -- 36
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
African clawed frog
(Xenopus laevis)
Amphibia gk2-prov 35
(Danio rerio)
Actinopterygii GK2 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8298 36
  • 36 (a)
Gk 36
  • 45 (a)
Gyk 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea R11F4.1 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUT1 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4742 36
  • 61 (a)
Species with no ortholog for GK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GK2 Gene

Gene Tree for GK2 (if available)
Gene Tree for GK2 (if available)

Paralogs for GK2 Gene

Paralogs for GK2 Gene

(3) SIMAP similar genes for GK2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GK2: view

Variants for GK2 Gene

Sequence variations from dbSNP and Humsavar for GK2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11747 -- 79,406,472(+) CTGCC(A/C/G/T)CTTAA utr-variant-3-prime
rs1052314 -- 79,406,512(-) AAGAT(G/T)TAAAC utr-variant-3-prime
rs1922285 -- 79,410,086(+) TAACT(A/G)TAGAG upstream-variant-2KB
rs4975086 -- 79,408,410(+) ttttt(A/T)aaatc upstream-variant-2KB
rs6837906 -- 79,408,189(+) GTCTT(C/T)GGGGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GK2 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV Deletion 23290073
nsv879506 CNV Loss 21882294

Variation tolerance for GK2 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GK2 Gene

Disorders for GK2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GK2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
glycerol kinase deficiency
  • glycerol kinase
x-linked adrenal hypoplasia congenita
  • ahc
- elite association - COSMIC cancer census association via MalaCards
Search GK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GK2 Gene

Publications for GK2 Gene

  1. The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons. (PMID: 7987308) Sargent C.A. … Affara N.A. (Hum. Mol. Genet. 1994) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L. … Green M.R. (PLoS Genet. 2012) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for GK2 Gene

Sources for GK2 Gene