Aliases for GJD3 Gene
External Ids for GJD3 Gene
Previous HGNC Symbols for GJD3 Gene
Previous GeneCards Identifiers for GJD3 Gene
This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for GJD3 Gene
GJD3 (Gap Junction Protein Delta 3) is a Protein Coding gene. Among its related pathways are Gap junction trafficking and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include ion channel activity and gap junction channel activity. An important paralog of this gene is GJD4.
UniProtKB/Swiss-Prot for GJD3 Gene
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).