Aliases for GJD3 Gene
External Ids for GJD3 Gene
Previous HGNC Symbols for GJD3 Gene
Previous GeneCards Identifiers for GJD3 Gene
This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for GJD3 Gene
GJD3 (Gap Junction Protein, Delta 3, 31.9kDa) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include ion channel activity and gap junction channel activity. An important paralog of this gene is GJB3.
UniProtKB/Swiss-Prot for GJD3 Gene
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).