Aliases for GJB7 Gene
External Ids for GJB7 Gene
Previous GeneCards Identifiers for GJB7 Gene
Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GJB7 Gene
GJB7 (Gap Junction Protein Beta 7) is a Protein Coding gene. Among its related pathways are Signaling in Gap Junctions and Hypothetical Network for Drug Addiction. An important paralog of this gene is GJC2.
UniProtKB/Swiss-Prot for GJB7 Gene
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).