Aliases for GJB5 Gene
External Ids for GJB5 Gene
Previous GeneCards Identifiers for GJB5 Gene
This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]
GeneCards Summary for GJB5 Gene
GJB5 (Gap Junction Protein Beta 5) is a Protein Coding gene. Diseases associated with GJB5 include Larynx Cancer. Among its related pathways are Gap junction trafficking and Signaling in Gap Junctions. An important paralog of this gene is GJB4.
UniProtKB/Swiss-Prot for GJB5 Gene
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).