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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GJB5 Gene

protein-coding   GIFtS: 58
GCID: GC01P035220

Gap Junction Protein, Beta 5, 31.1kDa

(Previous names: gap junction protein, beta 5 (connexin 31.1), gap junction...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Gap Junction Protein, Beta 5, 31.1kDa1 2     Gap Junction Beta-5 Protein2
Gap Junction Protein, Beta 5 (Connexin 31.1)1 2     Gap Junctional Protein Cx31.12
CX31.12 5     Connexin-31.13
Connexin 31.11     Cx31.13
Gap Junction Protein, Beta 51     

External Ids:    HGNC: 42871   Entrez Gene: 27092   Ensembl: ENSG000001892807   OMIM: 6044935   UniProtKB: O953773   

Export aliases for GJB5 gene to outside databases

Previous GC identifers: GC01P035042 GC01P034276 GC01P034647 GC06M087990 GC00M9U0074 GC01P034889 GC01P034993 GC01P033338


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GJB5 Gene:
This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction
protein involved in intercellular communication related to epidermal differentiation and environmental sensing.
This gene has been linked to non-small cell lung cancer. (provided by RefSeq, Nov 2012)

GeneCards Summary for GJB5 Gene: 
GJB5 (gap junction protein, beta 5, 31.1kDa) is a protein-coding gene. Diseases associated with GJB5 include erythrokeratodermia variabilis, and peripheral neuropathy, and among its related super-pathways are Gap junction assembly and Myometrial Relaxation and Contraction Pathways. An important paralog of this gene is GJB3.

UniProtKB/Swiss-Prot: CXB5_HUMAN, O95377
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons,
through which materials of low MW diffuse from one cell to a neighboring cell

summary for GJB5 Gene:
Gap channels (also known as gap junctions) are specalized cell-cell contacts between almost all eukaryotic
cells that provide direct intracellular communication. Generally, gap channels allow the passive diffusion
of molecules up to 1 kDa which includes nutrients, small metabolites (e.g. glucose), ions (K+, Ca2+) and
second messengers (IP3, cAMP and cGMP). Gap channels allow electrical and biochemical coupling between cells
and in excitable tissues, such as neurons and the heart, enables the generation of synchronized and rapid
responses. Structurally, gap channels are composed of two hemichannels called 'connexons', which themselves
are formed from six connexin molecules. Homo- and heteromeric combinations are seen, which exhibit distinct
permeability, selectivity and functional properties. Pannexins are related to connexins and can also form
gap junctions. However, their expression is limited to the brain. Furthermore, in nonchordate animals a
family of proteins called innexins form these channels. Gap channels are regulated through
post-translational modifications of the C'-terminal cytoplasmic tail and phosphorylation modulates assembly
and their physiological properties. They are continuously synthesized and degraded, allowing tissues to
rapidly adapt to changing environmental conditions. Connexins play a key role in many physiological
processes including cardiac and smooth muscle contraction, regulation of neuronal excitability, epithelial
electrolyte transport and keratinocyte differentiation. Mutations in connexin genes are associated with
human diseases including sensorineural deafness, a variety of skin disorders, peripheral neuropathy and
cardiovascular disease.

Gene Wiki entry for GJB5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GJB5 gene promoter:
         Max1   NF-1/L   NF-1   Sox5   RFX1   C/EBPalpha   S8   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGJB5 promoter sequence
   Search SABiosciences Chromatin IP Primers for GJB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GJB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

GJB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GJB5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P035220:  view genomic region     (about GC identifiers)

Start:
35,220,648 bp from pter      End:
35,224,113 bp from pter
Size:
3,466 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXB5_HUMAN, O95377 (See protein sequence)
Recommended Name: Gap junction beta-5 protein  
Size: 273 amino acids; 31088 Da
Subunit: A connexon is composed of a hexamer of connexins
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction
Secondary accessions: Q9UPA3

Explore the universe of human proteins at neXtProt for GJB5: NX_O95377

Explore proteomics data for GJB5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95377

  • GJB5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GJB5 Protein Expression
    REFSEQ proteins: NP_005259.1  
    ENSEMBL proteins: 
     ENSP00000340811  
    Reactome Protein details: O95377
    Human Recombinant Protein Products for GJB5: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005922connexon complex IEA--
    GO:0016021integral to membrane IEA--

    GJB5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GJ: Ion channels / Gap junction proteins (connexins)

    IUPHAR Guide to PHARMACOLOGY protein family classification: Cx31.1 
    Connexins and Pannexins

    5 InterPro protein domains:
     IPR000500 Connexin
     IPR019570 Connexin_CCC
     IPR013092 Connexin_N
     IPR017990 Connexin_CS
     IPR002270 Connexin311

    Graphical View of Domain Structure for InterPro Entry O95377

    ProtoNet protein and cluster: O95377

    1 Blocks protein domain: IPB013092 Connexin

    UniProtKB/Swiss-Prot: CXB5_HUMAN, O95377
    Similarity: Belongs to the connexin family. Beta-type (group I) subfamily


    GJB5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXB5_HUMAN, O95377
    Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons,
    through which materials of low MW diffuse from one cell to a neighboring cell

         Genatlas biochemistry entry for GJB5:
    gap junction protein beta 5,connexin 31.1,monomer of the connexon (six subunits), expressed in epidermis

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gjb5):
     embryogenesis  growth/size  mortality/aging 

    GJB5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GJB5 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GJB5 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GJB5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gap junction trafficking
    Gap junction trafficking0.74
    Gap junction trafficking and regulation0.70
    Gap junction assembly0.74
    2Calcium Regulation in the Cardiac Cell
    Calcium Regulation in the Cardiac Cell0.43
    3Membrane Trafficking
    Membrane Trafficking0.32
    4Signaling in Gap Junctions
    Signaling in Gap Junctions0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GJB5
        Signaling in Gap Junctions

    1 BioSystems Pathway for GJB5
        Calcium Regulation in the Cardiac Cell

    4        Reactome Pathways for GJB5
        Gap junction assembly
    Gap junction trafficking
    Membrane Trafficking
    Gap junction trafficking and regulation



    GJB5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GJB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/24 Interacting proteins for GJB5 (O953772, 3 ENSP000003408114) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8257295 I2D: score=2 
    GJA1ENSP000002825614STRING: ENSP00000282561
    GJA10ENSP000003583584STRING: ENSP00000358358
    GJA3ENSP000002411254STRING: ENSP00000241125
    GJA4ENSP000003436764STRING: ENSP00000343676
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007154cell communication IEA--
    GO:0008544epidermis development TAS9843209
    GO:0060708spongiotrophoblast differentiation IEA--
    GO:0060713labyrinthine layer morphogenesis IEA--

    GJB5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GJB5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Gap 27Selective gap junction blocker[198284-64-9]
    Scrambled 10Panx Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide [1315378-72-3]
    Carbenoxolone disodiumGap junction blocker. Also inhibitor of 11 beta-hydroxysteroid dehydrogenase[7421-40-1]
    10PanxPanx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions[955091-53-9]

    4 IUPHAR Ligands for GJB5 (Cx31.1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    flufenamic acid
    InhibitorNone--
    octanol
    InhibitorNone--
    Ca2+
    InhibitorNone--
    carbenoxolone
    InhibitorNone--

    Search CenterWatch for drugs/clinical trials and news about GJB5 / CXB5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GJB5 gene: 
    NM_005268.3  

    Unigene Cluster for GJB5:

    Gap junction protein, beta 5, 31.1kDa
    Hs.198249  [show with all ESTs]
    Unigene Representative Sequence: NM_005268
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000338513(uc001bxu.3)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GJB5

    Additional mRNA sequence: 

    AF052693.1 AK129509.1 BC004379.1 

    3 DOTS entries:

    DT.111890  DT.99976441  DT.100033566 

    24/45 AceView cDNA sequences (see all 45):

    BM680488 BC004379 BM980646 BX097620 NM_005268 AA482378 BG680772 AK129509 
    AA235826 BM718035 AI686234 BE712515 AA479344 AW176548 BP353329 AA877961 
    BM847427 CA454693 CA495268 BV207900 AA253214 BF509618 AI288883 AA861992 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GJB5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for GJB5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GJB5 expression in normal human tissues (normalized intensities)      GJB5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGCACCTT
    GJB5 Expression
    About this image


    GJB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Esophagus (Gastrointestinal Tract)
             esophageal epithelium   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Uterus (Reproductive System)
             cervix   
     
     Epithelium (Uncategorized)
             esophageal epithelium   
     
     Placenta (Extraembryonic Tissues)

    See GJB5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GJB5

    SOURCE GeneReport for Unigene cluster: Hs.198249
        SABiosciences Expression via Pathway-Focused PCR Arrays including GJB5: 
              Cell Junction PathwayFinder in human mouse rat
              Gap Junctions in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GJB5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GJB5 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gjb51 , 5 gap junction protein, beta 51, 5 78.97(n)1
    77.49(a)1
      4 (61.51 cM)5
    146221  NM_010291.31  NP_034421.11 
     1273548095 
    chicken
    (Gallus gallus)
    Aves GJB51 gap junction protein, beta 5, 31.1kDa 72.93(n)
    69.43(a)
      428225  XM_425784.3  XP_425784.3 
    lizard
    (Anolis carolinensis)
    Reptilia GJB56
    Gap junction protein
    62(a)
    1 ↔ 1
    GL343594.1(126863-127916)
    zebrafish
    (Danio rerio)
    Actinopterygii cx28.66
    cx34.46
    (see all 3)
    connexin 34.4
    (see all 3)
    51(a)
    48(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    17(14553004-14553838)
    17(24671558-24672593)


    ENSEMBL Gene Tree for GJB5 (if available)
    TreeFam Gene Tree for GJB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GJB5 gene
    GJB32  GJA102  GJB62  GJB42  GJB22  GJB72  GJA42  GJA12  
    GJC12  GJC22  GJA52  GJD22  GJA32  GJA92  GJA82  GJB12  
    17 SIMAP similar genes for GJB5 using alignment to 1 protein entry:     CXB5_HUMAN:
    GJB4    GJB1    GJB3    GJB2    GJB7    GJB6
    GJA8    GJA3    GJA5    GJA10    GJA9    GJA4
    GJA1    GJC3    GJD4    GJD3    GJC1

    GJB5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/114 SNPs in GJB5 are shown (see all 114)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs284727551,2
    C--35218694(+) ATTCTG/TCCTTC 1 -- us2k14Minor allele frequency- T:0.14NA WA EA 360
    rs1152916901,2
    C,F--35219004(+) TTCTGT/CATTGA 1 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1143523841,2
    F--35219078(+) AGAATG/CCTTCA 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs757112771,2
    C,F--35219198(+) CAATAC/TAAAAT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1403052661,2
    --35219235(+) CCCTCA/TTGCCT 1 -- us2k10--------
    rs1503606071,2
    --35219334(+) CCTTGC/GCATGT 1 -- us2k10--------
    rs286340351,2
    C,F,H--35219373(+) TCCAAT/CGCTCT 1 -- us2k121Minor allele frequency- C:0.30NS EA NA WA CSA 2347
    rs562301421,2
    C,F--35219470(+) TATACA/GTCCTT 1 -- us2k17Minor allele frequency- G:0.35WA NA CSA EA 365
    rs285042121,2
    C,F--35219511(+) GCTCTC/TCCTCT 1 -- us2k1 trp37Minor allele frequency- T:0.33WA NA CSA EA 365
    rs799445241,2
    F--35219585(+) TGATCT/GCTTTA 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for GJB5 (35220648 - 35224113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GJB5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv870700CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604493    OMIM disorders: --

    5 diseases for GJB5:    About MalaCards
    erythrokeratodermia variabilis    peripheral neuropathy    neuropathy    lung cancer
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for GJB5:
    Erythrokeratodermia variabilis

    GJB5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GJB5
    Human Genome Epidemiology (HuGE) Navigator: GJB5 (2 documents)

    Export disorders for GJB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GJB5 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with GJB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis. (PubMed id 9843209)1, 2, 3, 9 Richard G.... Bale S.J. (1998)
    2. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Connexin mutations in Brazilian patients with skin disorders with or without hearing loss. (PubMed id 19283857)1, 9 Alexandrino F....Sartorato E.L. (2009)
    6. Cx31.1 acts as a tumour suppressor in non-small cell l ung cancer (NSCLC) cell lines through inhibition of cell proliferation and metas tasis. (PubMed id 21777377)1 Zhang D....Huang Y. (2012)
    7. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Low incidence of GJB2, GJB6 and mitochondrial DNA mut ations in North Indian patients with non-syndromic hearing impairment. (PubMed id 19465004)4 Bhalla S....Khullar M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2709 HGNC: 4287 AceView: GJB5 Ensembl:ENSG00000189280 euGenes: HUgn2709
    ECgene: GJB5 H-InvDB: GJB5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GJB5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GJB5 gene:
    Search GeneIP for patents involving GJB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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