Aliases for GJB5 Gene
External Ids for GJB5 Gene
Previous GeneCards Identifiers for GJB5 Gene
This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]
GeneCards Summary for GJB5 Gene
GJB5 (Gap Junction Protein, Beta 5, 31.1kDa) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Myometrial Relaxation and Contraction Pathways. An important paralog of this gene is GJB3.
UniProtKB/Swiss-Prot for GJB5 Gene
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).