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Aliases for GJA9 Gene

Aliases for GJA9 Gene

  • Gap Junction Protein, Alpha 9, 59kDa 2 3
  • CX59 3 4 6
  • Connexin 59 2 3
  • Connexin-58 3 4
  • GJA10 3 4
  • CX58 3 4
  • Gap Junction Protein, Alpha 10, 59kDa 2
  • Gap Junction Alpha-10 Protein 4
  • Gap Junction Alpha-9 Protein 3
  • Gap Junction Alpha 10 3
  • Connexin-59 4

External Ids for GJA9 Gene

Previous Symbols for GJA9 Gene

  • GJA10

Summaries for GJA9 Gene

Entrez Gene Summary for GJA9 Gene

  • Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GJA9 Gene

GJA9 (Gap Junction Protein, Alpha 9, 59kDa) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Myometrial Relaxation and Contraction Pathways. An important paralog of this gene is GJB3.

UniProtKB/Swiss-Prot for GJA9 Gene

  • One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Tocris Summary for GJA9 Gene

  • Gap channels (also known as gap junctions) are specalized cell-cell contacts between almost all eukaryotic cells that provide direct intracellular communication. Generally, gap channels allow the passive diffusion of molecules up to 1 kDa which includes nutrients, small metabolites (e.g. glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP and cGMP). Gap channels allow electrical and biochemical coupling between cells and in excitable tissues, such as neurons and the heart, enables the generation of synchronized and rapid responses. Structurally, gap channels are composed of two hemichannels called connexons, which themselves are formed from six connexin molecules. Homo- and heteromeric combinations are seen, which exhibit distinct permeability, selectivity and functional properties. Pannexins are related to connexins and can also form gap junctions. However, their expression is limited to the brain. Furthermore, in nonchordate animals a family of proteins called innexins form these channels. Gap channels are regulated through post-translational modifications of the C-terminal cytoplasmic tail and phosphorylation modulates assembly and their physiological properties. They are continuously synthesized and degraded, allowing tissues to rapidly adapt to changing environmental conditions. Connexins play a key role in many physiological processes including cardiac and smooth muscle contraction, regulation of neuronal excitability, epithelial electrolyte transport and keratinocyte differentiation. Mutations in connexin genes are associated with human diseases including sensorineural deafness, a variety of skin disorders, peripheral neuropathy and cardiovascular disease.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GJA9 Gene

Genomics for GJA9 Gene

Genomic Location for GJA9 Gene

Start:
38,874,067 bp from pter
End:
38,881,626 bp from pter
Size:
7,560 bases
Orientation:
Minus strand

Genomic View for GJA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GJA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GJA9 Gene

Regulatory Elements for GJA9 Gene

Proteins for GJA9 Gene

  • Protein details for GJA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57773-CXA9_HUMAN
    Recommended name:
    Gap junction alpha-9 protein
    Protein Accession:
    P57773
    Secondary Accessions:
    • B2R722
    • B3KVQ2
    • Q5TA63
    • Q96KG0

    Protein attributes for GJA9 Gene

    Size:
    515 amino acids
    Molecular mass:
    58842 Da
    Quaternary structure:
    • A connexon is composed of a hexamer of connexins.

    Alternative splice isoforms for GJA9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GJA9 Gene

Proteomics data for GJA9 Gene at MOPED

Post-translational modifications for GJA9 Gene

No Post-translational modifications

Other Protein References for GJA9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GJA9 Gene

Domains for GJA9 Gene

Gene Families for GJA9 Gene

HGNC:
  • GJ :Ion channels / Gap junction proteins (connexins)
IUPHAR :

Protein Domains for GJA9 Gene

UniProtKB/Swiss-Prot:

CXA9_HUMAN
Family:
  • Belongs to the connexin family. Alpha-type (group II) subfamily.:
    • P57773
genes like me logo Genes that share domains with GJA9: view

Function for GJA9 Gene

Molecular function for GJA9 Gene

GENATLAS Biochemistry: gap junction protein alpha 9,31kDa,(connexin 31),expressed in epidermis,mouse Cx 31 homolog,monomer of the connexon (six subunits)
UniProtKB/Swiss-Prot Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GJA9 Gene

Localization for GJA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GJA9 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GJA9 Gene COMPARTMENTS Subcellular localization image for GJA9 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GJA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005922 connexon complex IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GJA9: view

Pathways for GJA9 Gene

genes like me logo Genes that share pathways with GJA9: view

Pathways by source for GJA9 Gene

Interacting Proteins for GJA9 Gene

Gene Ontology (GO) - Biological Process for GJA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007154 cell communication IEA --
genes like me logo Genes that share ontologies with GJA9: view

Compounds for GJA9 Gene

(4) Tocris Compounds for GJA9 Gene

Compound Action Cas Number
10Panx Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions [955091-53-9]
Carbenoxolone disodium Gap junction blocker. Also inhibitor of 11 beta-hydroxysteroid dehydrogenase [7421-40-1]
Gap 27 Selective gap junction blocker [198284-64-9]
Scrambled 10Panx Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide [1315378-72-3]

(4) IUPHAR Ligand for GJA9 Gene

Ligand Type Action Affinity Pubmed IDs
flufenamic acid Channel blocker None
octanol Inhibitor None
Ca2+ Antagonist Antagonist
carbenoxolone Inhibitor None
genes like me logo Genes that share compounds with GJA9: view

Transcripts for GJA9 Gene

mRNA/cDNA for GJA9 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GJA9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - - -
SP4:
SP5: -

Relevant External Links for GJA9 Gene

GeneLoc Exon Structure for
GJA9
ECgene alternative splicing isoforms for
GJA9

Expression for GJA9 Gene

mRNA expression in normal human tissues for GJA9 Gene

mRNA Expression by UniProt/SwissProt for GJA9 Gene

P57773-CXA9_HUMAN
Tissue specificity: Highly abundant in skeletal muscle. Also detected in testis.
genes like me logo Genes that share expressions with GJA9: view

Orthologs for GJA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GJA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GJA9 36
  • 99.81 (n)
  • 99.61 (a)
GJA9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GJA9 36
  • 86.65 (n)
  • 80.08 (a)
GJA9 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GJA9 36
  • 86.09 (n)
  • 79.53 (a)
GJA9 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gja1 37
  • 32 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GJA9 37
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves GJA9 36
  • 60.5 (n)
  • 56.06 (a)
GJA9 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gja9 36
  • 59.9 (n)
  • 52.54 (a)
zebrafish
(Danio rerio)
Actinopterygii cx52.9 36
  • 58.28 (n)
  • 60.18 (a)
cx52.9 37
  • 48 (a)
OneToMany
CX55.5 37
  • 49 (a)
OneToMany
Species with no ortholog for GJA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GJA9 Gene

ENSEMBL:
Gene Tree for GJA9 (if available)
TreeFam:
Gene Tree for GJA9 (if available)

Paralogs for GJA9 Gene

Paralogs for GJA9 Gene

Selected SIMAP similar genes for GJA9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GJA9: view

Variants for GJA9 Gene

Sequence variations from dbSNP and Humsavar for GJA9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_019392 -

Relevant External Links for GJA9 Gene

HapMap Linkage Disequilibrium report
GJA9

No data available for Structural Variations from Database of Genomic Variants (DGV) for GJA9 Gene

Disorders for GJA9 Gene

Relevant External Links for GJA9

Genetic Association Database (GAD)
GJA9
Human Genome Epidemiology (HuGE) Navigator
GJA9
genes like me logo Genes that share disorders with GJA9: view

No data available for UniProtKB/Swiss-Prot for GJA9 Gene

Publications for GJA9 Gene

  1. Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues. (PMID: 12881038) Soehl G. … Willecke K. (Cell Commun. Adhes. 2003) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Expression of connexin genes in the human retina. (PMID: 20979653) SAPhl G. … Willecke K. (BMC Ophthalmol 2010) 3
  4. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3
  5. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A. … Oetting W.S. (Transplantation 2010) 49

Products for GJA9 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Gap Junctions in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GJA9
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GJA9
    • Block miRNA regulation of GJA9 using miScript Target Protectors

    Sources for GJA9 Gene

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