Aliases for GJA4 Gene
External Ids for GJA4 Gene
Previous GeneCards Identifiers for GJA4 Gene
This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. [provided by RefSeq, Jul 2008]
GeneCards Summary for GJA4 Gene
GJA4 (Gap Junction Protein Alpha 4) is a Protein Coding gene. Diseases associated with GJA4 include erythrokeratodermia variabilis et progressiva and atherosclerosis. Among its related pathways are Signaling in Gap Junctions and Gap junction trafficking. An important paralog of this gene is GJC2.
UniProtKB/Swiss-Prot for GJA4 Gene
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).