Aliases for GJA4 Gene
External Ids for GJA4 Gene
Previous GeneCards Identifiers for GJA4 Gene
This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. [provided by RefSeq, Jul 2008]
GeneCards Summary for GJA4 Gene
GJA4 (Gap Junction Protein, Alpha 4, 37kDa) is a Protein Coding gene. Diseases associated with GJA4 include erythrokeratodermia variabilis et progressiva and oculodentodigital dysplasia. Among its related pathways are Vesicle-mediated transport and Myometrial Relaxation and Contraction Pathways. An important paralog of this gene is GJB3.
UniProtKB/Swiss-Prot for GJA4 Gene
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).