Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GJA10 Gene

Aliases for GJA10 Gene

  • Gap Junction Protein, Alpha 10, 62kDa 2 3
  • CX62 3 4 6
  • Connexin 62 2 3
  • Connexin-62 3 4
  • Gap Junction Alpha-10 Protein 3

External Ids for GJA10 Gene

Previous GeneCards Identifiers for GJA10 Gene

  • GC01M039264
  • GC01M038347
  • GC01M038803
  • GC01M038742
  • GC01M038743
  • GC01M038998
  • GC01M039009
  • GC01M039102
  • GC06P090661
  • GC06P090604
  • GC06P087823

Summaries for GJA10 Gene

Entrez Gene Summary for GJA10 Gene

  • Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GJA10 Gene

GJA10 (Gap Junction Protein, Alpha 10, 62kDa) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Transmission across Chemical Synapses. GO annotations related to this gene include gap junction channel activity. An important paralog of this gene is GJB3.

UniProtKB/Swiss-Prot for GJA10 Gene

  • One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity).

Tocris Summary for GJA10 Gene

  • Gap channels (also known as gap junctions) are specalized cell-cell contacts between almost all eukaryotic cells that provide direct intracellular communication. Generally, gap channels allow the passive diffusion of molecules up to 1 kDa which includes nutrients, small metabolites (e.g. glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP and cGMP). Gap channels allow electrical and biochemical coupling between cells and in excitable tissues, such as neurons and the heart, enables the generation of synchronized and rapid responses. Structurally, gap channels are composed of two hemichannels called 'connexons', which themselves are formed from six connexin molecules. Homo- and heteromeric combinations are seen, which exhibit distinct permeability, selectivity and functional properties. Pannexins are related to connexins and can also form gap junctions. However, their expression is limited to the brain. Furthermore, in nonchordate animals a family of proteins called innexins form these channels. Gap channels are regulated through post-translational modifications of the C'-terminal cytoplasmic tail and phosphorylation modulates assembly and their physiological properties. They are continuously synthesized and degraded, allowing tissues to rapidly adapt to changing environmental conditions. Connexins play a key role in many physiological processes including cardiac and smooth muscle contraction, regulation of neuronal excitability, epithelial electrolyte transport and keratinocyte differentiation. Mutations in connexin genes are associated with human diseases including sensorineural deafness, a variety of skin disorders, peripheral neuropathy and cardiovascular disease.

Gene Wiki entry for GJA10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GJA10 Gene

Genomics for GJA10 Gene

Regulatory Elements for GJA10 Gene

Genomic Location for GJA10 Gene

Start:
89,894,469 bp from pter
End:
89,896,120 bp from pter
Size:
1,652 bases
Orientation:
Plus strand

Genomic View for GJA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GJA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GJA10 Gene

Proteins for GJA10 Gene

  • Protein details for GJA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M2-CXA10_HUMAN
    Recommended name:
    Gap junction alpha-10 protein
    Protein Accession:
    Q969M2
    Secondary Accessions:

    Protein attributes for GJA10 Gene

    Size:
    543 amino acids
    Molecular mass:
    61872 Da
    Quaternary structure:
    • A connexon is composed of a hexamer of connexins.

neXtProt entry for GJA10 Gene

Proteomics data for GJA10 Gene at MOPED

Post-translational modifications for GJA10 Gene

No Post-translational modifications

Other Protein References for GJA10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GJA10 Gene

Domains for GJA10 Gene

Gene Families for GJA10 Gene

HGNC:
  • GJ :Ion channels / Gap junction proteins (connexins)
IUPHAR :

Protein Domains for GJA10 Gene

Suggested Antigen Peptide Sequences for GJA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969M2

UniProtKB/Swiss-Prot:

CXA10_HUMAN :
  • Q969M2
Family:
  • Belongs to the connexin family. Alpha-type (group II) subfamily.
genes like me logo Genes that share domains with GJA10: view

Function for GJA10 Gene

Molecular function for GJA10 Gene

GENATLAS Biochemistry: gap junction protein alpha 10,31.1kB,(connexin 31.1),expressed in epidermis,mouse Cx 31.1 homolog,monomer of the connexon (six subunits)
UniProtKB/Swiss-Prot Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity).

Gene Ontology (GO) - Molecular Function for GJA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005243 gap junction channel activity TAS --
genes like me logo Genes that share ontologies with GJA10: view

Phenotypes for GJA10 Gene

genes like me logo Genes that share phenotypes with GJA10: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GJA10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GJA10 Gene

Localization for GJA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GJA10 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GJA10 Gene COMPARTMENTS Subcellular localization image for GJA10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GJA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005921 gap junction --
GO:0005922 connexon complex IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GJA10: view

Pathways for GJA10 Gene

genes like me logo Genes that share pathways with GJA10: view

Interacting Proteins for GJA10 Gene

Gene Ontology (GO) - Biological Process for GJA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS --
GO:0007276 gamete generation IEA --
GO:0007416 synapse assembly IEA --
GO:0009416 response to light stimulus --
GO:0050908 detection of light stimulus involved in visual perception IEA --
genes like me logo Genes that share ontologies with GJA10: view

Compounds for GJA10 Gene

(5) Tocris Compounds for GJA10 Gene

Compound Action Cas Number
10Panx Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions [955091-53-9]
Carbenoxolone disodium Gap junction blocker. Also inhibitor of 11 beta-hydroxysteroid dehydrogenase [7421-40-1]
Gap 26 Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release [197250-15-0]
Gap 27 Selective gap junction blocker [198284-64-9]
Scrambled 10Panx Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide [1315378-72-3]

(4) IUPHAR Ligand for GJA10 Gene

Ligand Type Action Affinity Pubmed IDs
flufenamic acid Channel blocker None
octanol Inhibitor None
Ca2+ Antagonist Antagonist
carbenoxolone Inhibitor None
genes like me logo Genes that share compounds with GJA10: view

Transcripts for GJA10 Gene

mRNA/cDNA for GJA10 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GJA10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GJA10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GJA10 Gene

No ASD Table

Relevant External Links for GJA10 Gene

GeneLoc Exon Structure for
GJA10
ECgene alternative splicing isoforms for
GJA10

Expression for GJA10 Gene

mRNA expression in normal human tissues for GJA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GJA10 Gene

This gene is overexpressed in Testis (42.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GJA10 Gene

SOURCE GeneReport for Unigene cluster for GJA10 Gene Hs.334499

mRNA Expression by UniProt/SwissProt for GJA10 Gene

Q969M2-CXA10_HUMAN
Tissue specificity: Expressed in skeletal muscle and heart.
genes like me logo Genes that share expressions with GJA10: view

In Situ Assay Products

Orthologs for GJA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GJA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GJA10 35
  • 99.39 (n)
  • 99.26 (a)
GJA10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GJA10 35
  • 84.77 (n)
  • 78.39 (a)
GJA10 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GJA10 35
  • 87.68 (n)
  • 82.67 (a)
GJA10 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gja10 35
  • 83.85 (n)
  • 81.44 (a)
Gja10 16
Gja10 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GJA10 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gja10 35
  • 82.38 (n)
  • 78.61 (a)
chicken
(Gallus gallus)
Aves GJA10 35
  • 62.31 (n)
  • 62.31 (a)
GJA10 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GJA10 36
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cx39.4 36
  • 34 (a)
ManyToMany
cx52.6 36
  • 48 (a)
ManyToMany
cx52.7 36
  • 44 (a)
ManyToMany
Species with no ortholog for GJA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GJA10 Gene

ENSEMBL:
Gene Tree for GJA10 (if available)
TreeFam:
Gene Tree for GJA10 (if available)

Paralogs for GJA10 Gene

Paralogs for GJA10 Gene

Selected SIMAP similar genes for GJA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GJA10: view

Variants for GJA10 Gene

Sequence variations from dbSNP and Humsavar for GJA10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs292241 -- 89,893,786(-) ATCAA(C/T)AGGCA upstream-variant-2KB
rs292242 -- 89,892,912(-) CGGGC(A/G)GATGA upstream-variant-2KB
rs292243 -- 89,892,906(-) gatga(C/T)gaggt upstream-variant-2KB
rs7738845 -- 89,896,117(+) AAAAA(A/T)CTTAT downstream-variant-500B
rs7774604 -- 89,892,837(+) tggct(A/C)atttt upstream-variant-2KB

Relevant External Links for GJA10 Gene

HapMap Linkage Disequilibrium report
GJA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GJA10 Gene

Disorders for GJA10 Gene

Relevant External Links for GJA10

Genetic Association Database (GAD)
GJA10
Human Genome Epidemiology (HuGE) Navigator
GJA10
genes like me logo Genes that share disorders with GJA10: view

No data available for UniProtKB/Swiss-Prot for GJA10 Gene

Publications for GJA10 Gene

  1. Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues. (PMID: 12881038) Soehl G. … Willecke K. (Cell Commun. Adhes. 2003) 3 4
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48
  3. Structural and functional diversity of connexin genes in the mouse and human genome. (PMID: 12108537) Willecke K. … Soehl G. (Biol. Chem. 2002) 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4

Products for GJA10 Gene

Sources for GJA10 Gene

Back to Top

Content