Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GIT2 Gene

Aliases for GIT2 Gene

  • GIT ArfGAP 2 2 3 5
  • G Protein-Coupled Receptor Kinase Interacting ArfGAP 2 2 3
  • Cool-Interacting Tyrosine-Phosphorylated Protein 2 3 4
  • G Protein-Coupled Receptor Kinase-Interactor 2 3 4
  • GRK-Interacting Protein 2 3 4
  • Paxillin Kinase Linker 2 3
  • ARF GAP GIT2 3 4
  • CAT-2 3 4
  • CAT2 3 4
  • Cool-Associated, Tyrosine Phosphorylated Protein 2 3
  • G Protein-Coupled Receptor Kinase Interactor 2 2
  • ARF GTPase-Activating Protein GIT2 3
  • KIAA0148 4
  • PKL 3

External Ids for GIT2 Gene

Previous GeneCards Identifiers for GIT2 Gene

  • GC12M109433
  • GC12M110206
  • GC12M108830
  • GC12M110367
  • GC12M107383

Summaries for GIT2 Gene

Entrez Gene Summary for GIT2 Gene

  • This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

GeneCards Summary for GIT2 Gene

GIT2 (GIT ArfGAP 2) is a Protein Coding gene. Diseases associated with GIT2 include Systemic Scleroderma. Among its related pathways are Cytoskeletal Signaling and Signaling events mediated by focal adhesion kinase. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is GIT1.

UniProtKB/Swiss-Prot for GIT2 Gene

  • GTPase-activating protein for the ADP ribosylation factor family.

Gene Wiki entry for GIT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIT2 Gene

Genomics for GIT2 Gene

Regulatory Elements for GIT2 Gene

Enhancers for GIT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GIT2 on UCSC Golden Path with GeneCards custom track

Promoters for GIT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GIT2 Gene

109,929,792 bp from pter
109,996,389 bp from pter
66,598 bases
Minus strand

Genomic View for GIT2 Gene

Genes around GIT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIT2 Gene

Proteins for GIT2 Gene

  • Protein details for GIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ARF GTPase-activating protein GIT2
    Protein Accession:
    Secondary Accessions:
    • Q86U59
    • Q96CI2
    • Q9BV91
    • Q9Y5V2

    Protein attributes for GIT2 Gene

    759 amino acids
    Molecular mass:
    84543 Da
    Quaternary structure:
    • Interacts with TGFB1I1 (By similarity). Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Identified in a complex with ARHGEF6 and BIN2.
    • Sequence=BAA09769.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GIT2 Gene

neXtProt entry for GIT2 Gene

Post-translational modifications for GIT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GIT2 Gene

Domains & Families for GIT2 Gene

Gene Families for GIT2 Gene

Suggested Antigen Peptide Sequences for GIT2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Arf-GAP domain.
  • Contains 3 ANK repeats.
  • Contains 1 Arf-GAP domain.
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with GIT2: view

Function for GIT2 Gene

Molecular function for GIT2 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for the ADP ribosylation factor family.

Gene Ontology (GO) - Molecular Function for GIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 16628223
GO:0032403 protein complex binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GIT2: view
genes like me logo Genes that share phenotypes with GIT2: view

Animal Models for GIT2 Gene

MGI Knock Outs for GIT2:

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GIT2 Gene

Localization for GIT2 Gene

Subcellular locations from

Jensen Localization Image for GIT2 Gene COMPARTMENTS Subcellular localization image for GIT2 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 10942595
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with GIT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GIT2 Gene

Pathways & Interactions for GIT2 Gene

genes like me logo Genes that share pathways with GIT2: view

Pathways by source for GIT2 Gene

2 Cell Signaling Technology pathways for GIT2 Gene
1 KEGG pathway for GIT2 Gene

SIGNOR curated interactions for GIT2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for GIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10896954
GO:0043547 positive regulation of GTPase activity IEA --
GO:0048266 behavioral response to pain IEA --
genes like me logo Genes that share ontologies with GIT2: view

Drugs & Compounds for GIT2 Gene

(1) Drugs for GIT2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GIT2: view

Transcripts for GIT2 Gene

Unigene Clusters for GIT2 Gene

G protein-coupled receptor kinase interacting ArfGAP 2:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - -
SP2: - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: - - - - - - - - - - - - - - - - - - - -
SP7: - - - -

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c · 25d · 25e · 25f
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - -

Relevant External Links for GIT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GIT2 Gene

mRNA expression in normal human tissues for GIT2 Gene

mRNA differential expression in normal tissues according to GTEx for GIT2 Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for GIT2 Gene

This gene is overexpressed in Heart (14.7), Lymph node (12.0), and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GIT2 Gene

Protein tissue co-expression partners for GIT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GIT2 Gene:


SOURCE GeneReport for Unigene cluster for GIT2 Gene:

genes like me logo Genes that share expression patterns with GIT2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GIT2 Gene

Orthologs for GIT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GIT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GIT2 34
  • 92.14 (n)
  • 96.02 (a)
GIT2 35
  • 96 (a)
(Canis familiaris)
Mammalia GIT2 34
  • 92.68 (n)
  • 96.3 (a)
GIT2 35
  • 97 (a)
(Mus musculus)
Mammalia Git2 34
  • 86.94 (n)
  • 91.75 (a)
Git2 16
Git2 35
  • 92 (a)
(Pan troglodytes)
Mammalia GIT2 34
  • 99.72 (n)
  • 99.83 (a)
GIT2 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Git2 34
  • 87.15 (n)
  • 91.5 (a)
(Monodelphis domestica)
Mammalia GIT2 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia GIT2 35
  • 81 (a)
(Gallus gallus)
Aves GIT2 34
  • 80.74 (n)
  • 89.41 (a)
GIT2 35
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia git2 34
  • 77.27 (n)
  • 87.24 (a)
Str.9172 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11463 34
(Danio rerio)
Actinopterygii git2a 34
  • 70.38 (n)
  • 75.27 (a)
git2a 35
  • 73 (a)
git2b 35
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16728 36
  • 37 (a)
Git 34
  • 47.65 (n)
  • 41.86 (a)
Git 35
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006888 34
  • 50.03 (n)
  • 46.19 (a)
(Caenorhabditis elegans)
Secernentea F14F3.2 36
  • 35 (a)
git-1 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
Species where no ortholog for GIT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GIT2 Gene

Gene Tree for GIT2 (if available)
Gene Tree for GIT2 (if available)

Paralogs for GIT2 Gene

Paralogs for GIT2 Gene

genes like me logo Genes that share paralogs with GIT2: view

Variants for GIT2 Gene

Sequence variations from dbSNP and Humsavar for GIT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs925368 - 109,953,174(-) AGACA(A/G)CGATC reference, missense
rs9804905 - 109,959,933(+) GGGCG(C/T)TGAAC reference, missense
rs11068997 - 109,945,336(+) CAAGT(A/G)CACTC intron-variant, reference, missense
rs7308379 -- 109,981,559(+) CAAAG(C/G)CTTCA intron-variant
rs7309323 -- 109,977,683(+) cgggc(A/T)tggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIT2 Gene

Variant ID Type Subtype PubMed ID
nsv1138168 CNV deletion 24896259
nsv884 CNV insertion 18451855
nsv952475 CNV duplication 24416366

Variation tolerance for GIT2 Gene

Residual Variation Intolerance Score: 6.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.07; 68.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIT2 Gene

Disorders for GIT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GIT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
systemic scleroderma
  • progressive systemic sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search GIT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GIT2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GIT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIT2 Gene

Publications for GIT2 Gene

  1. An ADP-ribosylation factor GTPase-activating protein Git2- short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization. (PMID: 11251077) Mazaki Y. … Sabe H. (Mol. Biol. Cell 2001) 3 4 22 65
  2. The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. (PMID: 10896954) Premont R.T. … Lefkowitz R.J. (J. Biol. Chem. 2000) 2 3 4 65
  3. A genome-wide association study of the metabolic syndrome in Indian Asian men. (PMID: 20694148) Zabaneh D. … Balding D.J. (PLoS ONE 2010) 3 46 65
  4. The multifunctional GIT family of proteins. (PMID: 16598076) Hoefen R.J. … Berk B.C. (J. Cell. Sci. 2006) 3 22 65
  5. GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. (PMID: 16628223) Frank S.R. … Hansen S.H. (EMBO J. 2006) 3 22 65

Products for GIT2 Gene

Sources for GIT2 Gene

Loading form....