Aliases for GIT2 Gene
External Ids for GIT2 Gene
Previous GeneCards Identifiers for GIT2 Gene
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
GeneCards Summary for GIT2 Gene
GIT2 (GIT ArfGAP 2) is a Protein Coding gene. Diseases associated with GIT2 include Systemic Scleroderma. Among its related pathways are Cytoskeletal Signaling and Signaling events mediated by focal adhesion kinase. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is GIT1.
UniProtKB/Swiss-Prot for GIT2 Gene
GTPase-activating protein for the ADP ribosylation factor family.