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Aliases for GIT2 Gene

Aliases for GIT2 Gene

  • GIT ArfGAP 2 2 3
  • G Protein-Coupled Receptor Kinase Interacting ArfGAP 2 2 3 5
  • Cool-Interacting Tyrosine-Phosphorylated Protein 2 3 4
  • G Protein-Coupled Receptor Kinase-Interactor 2 3 4
  • GRK-Interacting Protein 2 3 4
  • Paxillin Kinase Linker 2 3
  • ARF GAP GIT2 3 4
  • CAT-2 3 4
  • CAT2 3 4
  • Cool-Associated, Tyrosine Phosphorylated Protein 2 3
  • G Protein-Coupled Receptor Kinase Interactor 2 2
  • KIAA0148 4
  • PKL 3

External Ids for GIT2 Gene

Previous GeneCards Identifiers for GIT2 Gene

  • GC12M109433
  • GC12M110206
  • GC12M108830
  • GC12M110367
  • GC12M107383

Summaries for GIT2 Gene

Entrez Gene Summary for GIT2 Gene

  • This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

GeneCards Summary for GIT2 Gene

GIT2 (GIT ArfGAP 2) is a Protein Coding gene. Diseases associated with GIT2 include Systemic Scleroderma. Among its related pathways are Signaling events mediated by focal adhesion kinase and Adhesion. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is GIT1.

UniProtKB/Swiss-Prot for GIT2 Gene

  • GTPase-activating protein for the ADP ribosylation factor family.

Gene Wiki entry for GIT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIT2 Gene

Genomics for GIT2 Gene

Regulatory Elements for GIT2 Gene

Enhancers for GIT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GIT2 on UCSC Golden Path with GeneCards custom track

Promoters for GIT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GIT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GIT2 Gene

Chromosome:
12
Start:
109,929,792 bp from pter
End:
109,996,389 bp from pter
Size:
66,598 bases
Orientation:
Minus strand

Genomic View for GIT2 Gene

Genes around GIT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIT2 Gene

Proteins for GIT2 Gene

  • Protein details for GIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14161-GIT2_HUMAN
    Recommended name:
    ARF GTPase-activating protein GIT2
    Protein Accession:
    Q14161
    Secondary Accessions:
    • Q86U59
    • Q96CI2
    • Q9BV91
    • Q9Y5V2

    Protein attributes for GIT2 Gene

    Size:
    759 amino acids
    Molecular mass:
    84543 Da
    Quaternary structure:
    • Interacts with TGFB1I1 (By similarity). Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Identified in a complex with ARHGEF6 and BIN2.
    SequenceCaution:
    • Sequence=BAA09769.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GIT2 Gene

neXtProt entry for GIT2 Gene

Proteomics data for GIT2 Gene at MOPED

Post-translational modifications for GIT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GIT2 (GIT2)

No data available for DME Specific Peptides for GIT2 Gene

Domains & Families for GIT2 Gene

Gene Families for GIT2 Gene

Suggested Antigen Peptide Sequences for GIT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14161

UniProtKB/Swiss-Prot:

GIT2_HUMAN :
  • Contains 1 Arf-GAP domain.
  • Contains 3 ANK repeats.
Domain:
  • Contains 1 Arf-GAP domain.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with GIT2: view

Function for GIT2 Gene

Molecular function for GIT2 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for the ADP ribosylation factor family.

Gene Ontology (GO) - Molecular Function for GIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA,IPI 16628223
genes like me logo Genes that share ontologies with GIT2: view
genes like me logo Genes that share phenotypes with GIT2: view

Animal Models for GIT2 Gene

MGI Knock Outs for GIT2:

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GIT2 Gene

Localization for GIT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIT2 Gene COMPARTMENTS Subcellular localization image for GIT2 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GIT2 Gene

Pathways & Interactions for GIT2 Gene

genes like me logo Genes that share pathways with GIT2: view

Pathways by source for GIT2 Gene

2 Cell Signaling Technology pathways for GIT2 Gene
1 KEGG pathway for GIT2 Gene

SIGNOR curated interactions for GIT2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for GIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048266 behavioral response to pain IEA --
genes like me logo Genes that share ontologies with GIT2: view

Drugs & Compounds for GIT2 Gene

(1) Drugs for GIT2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GIT2: view

Transcripts for GIT2 Gene

Unigene Clusters for GIT2 Gene

G protein-coupled receptor kinase interacting ArfGAP 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GIT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - -
SP2: - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: - - - - - - - - - - - - - - - - - - - -
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c · 25d · 25e · 25f
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4:
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:

Relevant External Links for GIT2 Gene

GeneLoc Exon Structure for
GIT2
ECgene alternative splicing isoforms for
GIT2

Expression for GIT2 Gene

mRNA expression in normal human tissues for GIT2 Gene

mRNA differential expression in normal tissues according to GTEx for GIT2 Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for GIT2 Gene

This gene is overexpressed in Heart (14.7), Lymph node (12.0), and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GIT2 Gene



SOURCE GeneReport for Unigene cluster for GIT2 Gene Hs.434996

genes like me logo Genes that share expression patterns with GIT2: view

Protein tissue co-expression partners for GIT2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GIT2 Gene

Orthologs for GIT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GIT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GIT2 35
  • 92.14 (n)
  • 96.02 (a)
GIT2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GIT2 35
  • 92.68 (n)
  • 96.3 (a)
GIT2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Git2 35
  • 86.94 (n)
  • 91.75 (a)
Git2 16
Git2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GIT2 35
  • 99.72 (n)
  • 99.83 (a)
GIT2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Git2 35
  • 87.15 (n)
  • 91.5 (a)
oppossum
(Monodelphis domestica)
Mammalia GIT2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GIT2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GIT2 35
  • 80.74 (n)
  • 89.41 (a)
GIT2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia git2 35
  • 77.27 (n)
  • 87.24 (a)
Str.9172 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11463 35
zebrafish
(Danio rerio)
Actinopterygii git2a 35
  • 70.38 (n)
  • 75.27 (a)
git2a 36
  • 73 (a)
OneToMany
git2b 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG16728 37
  • 37 (a)
Git 35
  • 47.65 (n)
  • 41.86 (a)
Git 36
  • 37 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006888 35
  • 50.03 (n)
  • 46.19 (a)
worm
(Caenorhabditis elegans)
Secernentea F14F3.2 37
  • 35 (a)
git-1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for GIT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GIT2 Gene

ENSEMBL:
Gene Tree for GIT2 (if available)
TreeFam:
Gene Tree for GIT2 (if available)

Paralogs for GIT2 Gene

Paralogs for GIT2 Gene

genes like me logo Genes that share paralogs with GIT2: view

Variants for GIT2 Gene

Sequence variations from dbSNP and Humsavar for GIT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs925368 - 109,953,174(-) AGACA(A/G)CGATC reference, missense
rs9804905 - 109,959,933(+) GGGCG(C/T)TGAAC reference, missense
rs11068997 - 109,945,336(+) CAAGT(A/G)CACTC intron-variant, reference, missense
rs2063388 -- 109,947,274(-) AGACT(A/C)CAGCC intron-variant, reference, synonymous-codon
rs7133426 -- 109,966,470(+) cacca(C/T)tgcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIT2 Gene

Variant ID Type Subtype PubMed ID
nsv884 CNV Insertion 18451855

Variation tolerance for GIT2 Gene

Residual Variation Intolerance Score: 6.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.07; 68.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GIT2 Gene

Disorders for GIT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GIT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
systemic scleroderma
  • diffuse scleroderma
- elite association - COSMIC cancer census association via MalaCards
Search GIT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GIT2

Genetic Association Database (GAD)
GIT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIT2
genes like me logo Genes that share disorders with GIT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIT2 Gene

Publications for GIT2 Gene

  1. The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. (PMID: 10896954) Premont R.T. … Lefkowitz R.J. (J. Biol. Chem. 2000) 2 3 4 67
  2. The multifunctional GIT family of proteins. (PMID: 16598076) Hoefen R.J. … Berk B.C. (J. Cell. Sci. 2006) 3 23
  3. GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. (PMID: 16628223) Frank S.R. … Hansen S.H. (EMBO J. 2006) 3 23
  4. An ADP-ribosylation factor GTPase-activating protein Git2- short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization. (PMID: 11251077) Mazaki Y. … Sabe H. (Mol. Biol. Cell 2001) 3 23
  5. GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. (PMID: 10788515) Vitale N. … Premont R.T. (J. Biol. Chem. 2000) 3 23

Products for GIT2 Gene

Sources for GIT2 Gene

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