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Aliases for GIT1 Gene

Aliases for GIT1 Gene

  • G Protein-Coupled Receptor Kinase Interacting ArfGAP 1 2 3
  • Cool-Associated And Tyrosine-Phosphorylated Protein 1 3 4
  • G Protein-Coupled Receptor Kinase Interactor 1 2 3
  • G Protein-Coupled Receptor Kinase-Interactor 1 3 4
  • GRK-Interacting Protein 1 3 4
  • ARF GAP GIT1 3 4
  • CAT-1 3 4
  • CAT1 3 4
  • ARF GTPase-Activating Protein GIT1 3

External Ids for GIT1 Gene

Previous GeneCards Identifiers for GIT1 Gene

  • GC17M027560
  • GC17M029800
  • GC17M027752
  • GC17M028046
  • GC17M024924
  • GC17M027900
  • GC17M024109

Summaries for GIT1 Gene

GeneCards Summary for GIT1 Gene

GIT1 (G Protein-Coupled Receptor Kinase Interacting ArfGAP 1) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. An important paralog of this gene is GIT2.

UniProtKB/Swiss-Prot for GIT1 Gene

  • GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity).

Gene Wiki entry for GIT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIT1 Gene

Genomics for GIT1 Gene

Regulatory Elements for GIT1 Gene

Genomic Location for GIT1 Gene

Start:
29,573,469 bp from pter
End:
29,594,054 bp from pter
Size:
20,586 bases
Orientation:
Minus strand

Genomic View for GIT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIT1 Gene

Proteins for GIT1 Gene

  • Protein details for GIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2X7-GIT1_HUMAN
    Recommended name:
    ARF GTPase-activating protein GIT1
    Protein Accession:
    Q9Y2X7
    Secondary Accessions:
    • B4DGU9
    • B4DSV3
    • Q86SS0
    • Q9BRJ4

    Protein attributes for GIT1 Gene

    Size:
    761 amino acids
    Molecular mass:
    84341 Da
    Quaternary structure:
    • Interacts with G protein-coupled receptor kinases: ADRBK1/GRK2, PPFIA1 and PPFIA4. Interacts with ARHGEF6/alpha-PIX, with ARHGEF7/beta-PIX, with PXN/paxillin and with PTK2/FAK1 (By similarity). Component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and PAK1. Interacts with TGFB1I1. Interacts with SCRIB. Interacts with SDCCAG3 (PubMed:23108400).
    SequenceCaution:
    • Sequence=AAH48196.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GIT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GIT1 Gene

Proteomics data for GIT1 Gene at MOPED

Post-translational modifications for GIT1 Gene

  • Phosphorylated on tyrosine residues by PTK2/FAK1 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase (By similarity).
  • Ubiquitination at Lys49
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GIT1 (GIT1)

No data available for DME Specific Peptides for GIT1 Gene

Domains for GIT1 Gene

Gene Families for GIT1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • ArfGAP :ADP-ribosylation factor GTPase activating proteins

Suggested Antigen Peptide Sequences for GIT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2X7

UniProtKB/Swiss-Prot:

GIT1_HUMAN :
  • Q9Y2X7
Domain:
  • The paxillin-binding domain is masked in the full-length protein and is regulated by ARHGEF6.
  • Contains 1 Arf-GAP domain.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with GIT1: view

Function for GIT1 Gene

Molecular function for GIT1 Gene

UniProtKB/Swiss-Prot Function: GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity).

Gene Ontology (GO) - Molecular Function for GIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 15182672
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with GIT1: view
genes like me logo Genes that share phenotypes with GIT1: view

Animal Models for GIT1 Gene

MGI Knock Outs for GIT1:

Animal Model Products

CRISPR Products

miRNA for GIT1 Gene

miRTarBase miRNAs that target GIT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GIT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GIT1 Gene

Localization for GIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIT1 Gene

Cytoplasm. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIT1 Gene COMPARTMENTS Subcellular localization image for GIT1 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA --
GO:0016020 membrane IDA 19946888
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with GIT1: view

Pathways for GIT1 Gene

genes like me logo Genes that share pathways with GIT1: view

Gene Ontology (GO) - Biological Process for GIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 9826657
GO:0032465 regulation of cytokinesis IDA 23108400
GO:0043547 positive regulation of GTPase activity IEA --
GO:0048013 ephrin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GIT1: view

Compounds for GIT1 Gene

(5) Novoseek inferred chemical compound relationships for GIT1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 43.3 12
gtp 31.3 3
gdp 24.6 1
adp 16.7 3
calcium 3.04 3
genes like me logo Genes that share compounds with GIT1: view

Transcripts for GIT1 Gene

Unigene Clusters for GIT1 Gene

G protein-coupled receptor kinase interacting ArfGAP 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GIT1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GIT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8:
SP9: - -
SP10: -
SP11: - - - - -
SP12:

ExUns: 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for GIT1 Gene

GeneLoc Exon Structure for
GIT1
ECgene alternative splicing isoforms for
GIT1

Expression for GIT1 Gene

mRNA expression in normal human tissues for GIT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GIT1 Gene

SOURCE GeneReport for Unigene cluster for GIT1 Gene Hs.514051

genes like me logo Genes that share expressions with GIT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GIT1 Gene

Orthologs for GIT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GIT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GIT1 35
  • 99.44 (n)
  • 99.87 (a)
GIT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GIT1 35
  • 92.65 (n)
  • 98.41 (a)
GIT1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GIT1 35
  • 92.16 (n)
  • 98.94 (a)
GIT1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Git1 35
  • 90.09 (n)
  • 97.79 (a)
Git1 16
Git1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Git1 35
  • 90.3 (n)
  • 96.88 (a)
chicken
(Gallus gallus)
Aves GIT1 35
  • 80.9 (n)
  • 87.84 (a)
GIT1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GIT1 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii git1 36
  • 76 (a)
OneToOne
LOC568935 35
  • 70.95 (n)
  • 79.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta Git 36
  • 38 (a)
OneToMany
CG16728 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea git-1 36
  • 29 (a)
OneToMany
F14F3.2 37
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for GIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GIT1 Gene

ENSEMBL:
Gene Tree for GIT1 (if available)
TreeFam:
Gene Tree for GIT1 (if available)

Paralogs for GIT1 Gene

Paralogs for GIT1 Gene

genes like me logo Genes that share paralogs with GIT1: view

Variants for GIT1 Gene

Sequence variations from dbSNP and Humsavar for GIT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs546843 -- 29,575,187(+) AGGGA(A/G)GTTCC intron-variant
rs550818 -- 29,574,957(+) AAGCC(A/G)CCAGC intron-variant
rs563976 -- 29,578,655(+) GGCAG(A/G)GGAAG intron-variant
rs601364 -- 29,577,304(+) GCAGG(A/G)CGGCA intron-variant
rs614334 -- 29,577,967(+) ATCCA(A/G)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIT1 Gene

Variant ID Type Subtype PubMed ID
nsv833409 CNV Gain 17160897
nsv908033 CNV Loss 21882294
nsv521557 CNV Loss 19592680
dgv3135n71 CNV Loss 21882294
nsv526524 CNV Loss 19592680
dgv3136n71 CNV Loss 21882294
nsv908038 CNV Loss 21882294
esv25114 CNV Loss 19812545

Relevant External Links for GIT1 Gene

HapMap Linkage Disequilibrium report
GIT1
Human Gene Mutation Database (HGMD)
GIT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIT1 Gene

Disorders for GIT1 Gene

(1) Novoseek inferred disease relationships for GIT1 Gene

Disease -log(P) Hits PubMed IDs
mental retardation 8.43 2

Relevant External Links for GIT1

Genetic Association Database (GAD)
GIT1
Human Genome Epidemiology (HuGE) Navigator
GIT1
genes like me logo Genes that share disorders with GIT1: view

No data available for UniProtKB/Swiss-Prot for GIT1 Gene

Publications for GIT1 Gene

  1. Beta2-adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (PMID: 9826657) Premont R.T. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. (PMID: 10896954) Premont R.T. … Lefkowitz R.J. (J. Biol. Chem. 2000) 2 3 4 23
  3. GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration. (PMID: 11896197) Manabe R. … Horwitz A.R. (J. Cell Sci. 2002) 3 4 23
  4. Mammalian Scribble forms a tight complex with the betaPIX exchange factor. (PMID: 15182672) Audebert S. … Borg J.-P. (Curr. Biol. 2004) 3 4 23
  5. The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. (PMID: 12473661) Kim S. … Kim E. (J. Biol. Chem. 2003) 3 23

Products for GIT1 Gene

Sources for GIT1 Gene

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