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Aliases for GIPR Gene

Aliases for GIPR Gene

  • Gastric Inhibitory Polypeptide Receptor 2 3
  • Glucose-Dependent Insulinotropic Polypeptide Receptor 3 4
  • PGQTL2 3 6
  • GIP-R 3 4

External Ids for GIPR Gene

Previous GeneCards Identifiers for GIPR Gene

  • GC19P046815
  • GC19P046562
  • GC19P050847
  • GC19P050863
  • GC19P046171
  • GC19P042600

Summaries for GIPR Gene

Entrez Gene Summary for GIPR Gene

  • This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

GeneCards Summary for GIPR Gene

GIPR (Gastric Inhibitory Polypeptide Receptor) is a Protein Coding gene. Diseases associated with GIPR include adrenal cortical adenoma and adrenal adenoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include transmembrane signaling receptor activity and gastric inhibitory peptide receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for GIPR Gene

  • This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Wiki entry for GIPR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIPR Gene

Genomics for GIPR Gene

Regulatory Elements for GIPR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GIPR Gene

Start:
45,668,244 bp from pter
End:
45,683,724 bp from pter
Size:
15,481 bases
Orientation:
Plus strand

Genomic View for GIPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GIPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIPR Gene

Proteins for GIPR Gene

  • Protein details for GIPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48546-GIPR_HUMAN
    Recommended name:
    Gastric inhibitory polypeptide receptor
    Protein Accession:
    P48546
    Secondary Accessions:
    • B7WP14
    • B7ZKQ0
    • Q14401
    • Q16400
    • Q52M04
    • Q9UPI1

    Protein attributes for GIPR Gene

    Size:
    466 amino acids
    Molecular mass:
    53157 Da
    Quaternary structure:
    • May form homodimers and heterodimers with GLP1R.
    SequenceCaution:
    • Sequence=CAA57426.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GIPR Gene

    Alternative splice isoforms for GIPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GIPR Gene

Proteomics data for GIPR Gene at MOPED

Post-translational modifications for GIPR Gene

  • N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
  • Glycosylation at Asn62 and Asn77
  • Modification sites at PhosphoSitePlus

Other Protein References for GIPR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GIPR Gene

Domains for GIPR Gene

Gene Families for GIPR Gene

HGNC:
  • GCGR :GPCR / Class B : Glucagon receptors
IUPHAR :

Suggested Antigen Peptide Sequences for GIPR Gene

Graphical View of Domain Structure for InterPro Entry

P48546

UniProtKB/Swiss-Prot:

GIPR_HUMAN :
  • P48546
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GIPR: view

Function for GIPR Gene

Molecular function for GIPR Gene

GENATLAS Biochemistry: gastric inhibitory polypeptide receptor,G protein coupled receptor superfamily,expressed in pancreatic beta cell,not involved in NIDDM,at least in a Japanese population
UniProtKB/Swiss-Prot Function: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO) - Molecular Function for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 7556958
GO:0004930 G-protein coupled receptor activity --
GO:0016519 gastric inhibitory peptide receptor activity IEA --
GO:0017046 peptide hormone binding IEA --
genes like me logo Genes that share ontologies with GIPR: view

Phenotypes for GIPR Gene

genes like me logo Genes that share phenotypes with GIPR: view

Animal Models for GIPR Gene

MGI Knock Outs for GIPR:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GIPR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GIPR Gene

Localization for GIPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIPR Gene COMPARTMENTS Subcellular localization image for GIPR gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GIPR: view

Pathways for GIPR Gene

genes like me logo Genes that share pathways with GIPR: view

Pathways by source for GIPR Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
    • cAMP / Ca2+ Signaling PathwayFinder in human,mouse,rat

Gene Ontology (GO) - Biological Process for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA --
GO:0006091 generation of precursor metabolites and energy TAS 7556958
GO:0007166 cell surface receptor signaling pathway TAS 7556958
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007190 activation of adenylate cyclase activity TAS 7589426
genes like me logo Genes that share ontologies with GIPR: view

Compounds for GIPR Gene

(2) Tocris Compounds for GIPR Gene

Compound Action Cas Number
GIP (1-39) Highly potent insulinotropic peptide [725474-97-5]
GIP (human) Potent insulinotropic gut hormone [100040-31-1]

(2) IUPHAR Ligand for GIPR Gene

Ligand Type Action Affinity Pubmed IDs
gastric inhibitory polypeptide Agonist Full agonist 8.7
[Pro3]GIP Antagonist Antagonist

(2) Novoseek inferred chemical compound relationships for GIPR Gene

Compound -log(P) Hits PubMed IDs
acth 60.8 3
ribonucleic acid 51.1 1

(1) PharmGKB related drug/compound annotations for GIPR Gene

Drug/compound Annotation
olanzapine CA
genes like me logo Genes that share compounds with GIPR: view

Transcripts for GIPR Gene

Unigene Clusters for GIPR Gene

Gastric inhibitory polypeptide receptor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GIPR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIPR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for GIPR Gene

GeneLoc Exon Structure for
GIPR
ECgene alternative splicing isoforms for
GIPR

Expression for GIPR Gene

mRNA expression in normal human tissues for GIPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIPR Gene

This gene is overexpressed in Heart - Atrial Appendage (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GIPR Gene

SOURCE GeneReport for Unigene cluster for GIPR Gene Hs.658534

genes like me logo Genes that share expressions with GIPR: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GIPR Gene

Orthologs for GIPR Gene

This gene was present in the common ancestor of animals.

Orthologs for GIPR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GIPR 35
  • 88.51 (n)
  • 87.39 (a)
GIPR 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GIPR 35
  • 89.59 (n)
  • 88.76 (a)
GIPR 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gipr 35
  • 82.81 (n)
  • 82.13 (a)
Gipr 16
Gipr 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GIPR 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gipr 35
  • 83.68 (n)
  • 82.84 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia GIPR 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gipr 35
  • 54.91 (n)
  • 54.11 (a)
zebrafish
(Danio rerio)
Actinopterygii GIPR 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 37
  • 28 (a)
Species with no ortholog for GIPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIPR Gene

ENSEMBL:
Gene Tree for GIPR (if available)
TreeFam:
Gene Tree for GIPR (if available)

Paralogs for GIPR Gene

Selected SIMAP similar genes for GIPR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GIPR: view

Variants for GIPR Gene

Sequence variations from dbSNP and Humsavar for GIPR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs5390 -- 45,669,519(+) CCTCA(C/G)GATGA utr-variant-5-prime
rs5392 - 45,677,099(+) TGCTC(C/G)TCGGC reference, missense
rs1800437 - 45,678,134(+) TCCAC(C/G)AGGTG missense, reference
rs2302382 -- 45,669,311(+) TCCCC(A/C)CAGAT intron-variant
rs2334255 -- 45,682,892(+) AGGAG(G/T)ACAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GIPR Gene

Variant ID Type Subtype PubMed ID
nsv912159 CNV Loss 21882294
dgv3954n71 CNV Loss 21882294

Relevant External Links for GIPR Gene

HapMap Linkage Disequilibrium report
GIPR
Human Gene Mutation Database (HGMD)
GIPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIPR Gene

Disorders for GIPR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for GIPR Gene including...

Search for GIPR Gene in MalaCards »

(2) University of Copenhagen DISEASES for GIPR Gene

(9) Novoseek inferred disease relationships for GIPR Gene

Disease -log(P) Hits PubMed IDs
adrenal hyperplasia 88.3 3
adrenal adenoma 82.8 3
cushing syndrome 81.6 15
adenoma adrenocortical 66.8 2
adenoma 55.9 2

Relevant External Links for GIPR

Genetic Association Database (GAD)
GIPR
Human Genome Epidemiology (HuGE) Navigator
GIPR
genes like me logo Genes that share disorders with GIPR: view

No data available for UniProtKB/Swiss-Prot for GIPR Gene

Publications for GIPR Gene

  1. Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA. (PMID: 8575774) Yamada Y. … Seino Y. (Genomics 1995) 3 4 23
  2. Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization. (PMID: 7490109) Stoffel M. … Bell G.I. (Genomics 1995) 2 3 23
  3. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. (PMID: 17624916) Nitz I. … DAPring F. (Mol Nutr Food Res 2007) 3 23 48
  4. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PMID: 19195718) Bonetti A. … Tienari P.J. (J. Neuroimmunol. 2009) 3 23 48
  5. Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups. (PMID: 19254363) Vogel C.I. … Hinney A. (BMC Med. Genet. 2009) 3 23 48

Products for GIPR Gene

  • Addgene plasmids for GIPR

Sources for GIPR Gene

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