Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GIPR Gene

protein-coding   GIFtS: 65
GCID: GC19P046171

Gastric Inhibitory Polypeptide Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Gastric Inhibitory Polypeptide Receptor1 2
Glucose-Dependent Insulinotropic Polypeptide Receptor2 3
GIP-R2 3
PGQTL22 5

External Ids:    HGNC: 42711   Entrez Gene: 26962   Ensembl: ENSG000000103107   OMIM: 1372415   UniProtKB: P485463   

Export aliases for GIPR gene to outside databases

Previous GC identifers: GC19P046815 GC19P046562 GC19P050847 GC19P050863 GC19P042600


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GIPR Gene:
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally
identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but
subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this
gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect
in this gene thus may contribute to the pathogenesis of diabetes. (provided by RefSeq, Oct 2011)

GeneCards Summary for GIPR Gene: 
GIPR (gastric inhibitory polypeptide receptor) is a protein-coding gene. Diseases associated with GIPR include cushing's syndrome, and adrenal adenoma, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include transmembrane signaling receptor activity and gastric inhibitory peptide receptor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: GIPR_HUMAN, P48546
Function: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate
adenylyl cyclase

Gene Wiki entry for GIPR (Gastric inhibitory polypeptide receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GIPR gene promoter:
         Max1   Meis-1b   CREB   AREB6   deltaCREB   Meis-1a   Pax-4a   c-Myc   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGIPR promoter sequence
   Search SABiosciences Chromatin IP Primers for GIPR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GIPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2-q13.3

GIPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GIPR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046171:  view genomic region     (about GC identifiers)

Start:
46,171,502 bp from pter      End:
46,186,982 bp from pter
Size:
15,481 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GIPR_HUMAN, P48546 (See protein sequence)
Recommended Name: Gastric inhibitory polypeptide receptor precursor  
Size: 466 amino acids; 53157 Da
Subunit: May form homodimers and heterodimers with GLP1R
Subcellular location: Cell membrane; Multi-pass membrane protein
2 PDB 3D structures from and Proteopedia for GIPR:
2QKH (3D)        4HJ0 (3D)    
Secondary accessions: Q14401 Q16400 Q52M04 Q9UPI1
Alternative splicing: 2 isoforms:  P48546-1   P48546-2   

Explore the universe of human proteins at neXtProt for GIPR: NX_P48546

Explore proteomics data for GIPR at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation
    in the ER
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48546

  • GIPR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GIPR Protein Expression
    REFSEQ proteins: NP_000155.1  
    ENSEMBL proteins: 
     ENSP00000467494   ENSP00000263281   ENSP00000305321   ENSP00000467342   ENSP00000465385  
    Reactome Protein details: P48546
    Human Recombinant Protein Products for GIPR: 
    EMD Millipore Purified and/or Recombinant GIPR Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GIPR
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GIPR
    GenScript Custom Purified and Recombinant Proteins Services for GIPR
    Novus Biologicals GIPR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GIPR 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    GIPR for ontologies           About GeneDecksing



    GIPR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GIPR
    OriGene Custom Antibody Services for GIPR
    GenScript Custom Superior Antibodies Services for GIPR
    Novus Biologicals GIPR Antibodies
    Abcam antibodies for GIPR
    Cloud-Clone Corp. Antibodies for GIPR 
    ThermoFisher Antibodies for GIPR
    LSBio Antibodies in human, mouse, rat for GIPR 

    Assay Products for GIPR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GIPR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GIPR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GIPR 
    Cloud-Clone Corp. CLIAs for GIPR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GCGR: GPCR / Class B : Glucagon receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GIP receptor 
    Glucagon receptor family

    5 InterPro protein domains:
     IPR001879 GPCR_2_extracellular_dom
     IPR001749 GPCR_2_GIP_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry P48546

    ProtoNet protein and cluster: P48546

    2 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001749 Gastric inhibitory polypeptide receptor precursor signature


    UniProtKB/Swiss-Prot: GIPR_HUMAN, P48546
    Similarity: Belongs to the G-protein coupled receptor 2 family


    GIPR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GIPR_HUMAN, P48546
    Function: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate
    adenylyl cyclase

         Genatlas biochemistry entry for GIPR:
    gastric inhibitory polypeptide receptor,G protein coupled receptor superfamily,expressed in pancreatic beta
    cell,not involved in NIDDM,at least in a Japanese population

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS7556958
    GO:0004930G-protein coupled receptor activity ----
    GO:0016519gastric inhibitory peptide receptor activity IEA--
    GO:0017046peptide hormone binding IEA--
         
    GIPR for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gipr):
     endocrine/exocrine gland  homeostasis/metabolism 

    GIPR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GIPR: Giprtm1Thor Giprtm1Yse

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GIPR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GIPR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GIPR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GIPR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GIPR
    1 QIAGEN miScript miRNA Assays for microRNA that regulate GIPR:
    hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidGIPR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GIPR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GIPR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GIPR
    Sirion Biotech Customized adenovirus for overexpression of GIPR

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of GIPR
    OriGene clones in human, mouse for GIPR (see all 6)
    OriGene ORF clones in mouse, rat for GIPR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GIPR (NM_000164)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GIPR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GIPR
    Sirion Biotech Customized lentivirus for stable overexpression of GIPR 
                         Customized lentivirus expression plasmids for stable overexpression of GIPR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GIPR
    Search LifeMap BioReagents cell lines for GIPR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GIPR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GIPR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Prostacyclin signalling through prostacyclin receptor
    Glucagon-type ligand receptors0.58
    G alpha (s) signalling events0.31
    Class B/2 (Secretin family receptors)0.36
    4GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GIPR
        GPCRs, Class B Secretin-like

    5/7        Reactome Pathways for GIPR (see all 7)
        GPCR downstream signaling
    Glucagon-type ligand receptors
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding


    1         Kegg Pathway  (Kegg details for GIPR):
        Neuroactive ligand-receptor interaction


    GIPR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GIPR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for GIPR (P485463 ENSP000002632814) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPP096813, ENSP000003500054I2D: score=2 STRING: ENSP00000350005
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY8ENSP000002863554STRING: ENSP00000286355
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002029desensitization of G-protein coupled receptor protein signaling pathway IEA--
    GO:0006091generation of precursor metabolites and energy TAS7556958
    GO:0007166cell surface receptor signaling pathway TAS7556958
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007190activation of adenylate cyclase activity TAS7589426

    GIPR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GIPR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GIPR

    2 IUPHAR Ligands for GIPR (GIP receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    gastric inhibitory polypeptide
    AgonistFull agonist8.77589426
    [Pro3]GIP
    AntagonistAntagonist8.7--

    2 Novoseek inferred chemical compound relationships for GIPR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 60.8 5 15705925 (2), 16402925 (1)
    ribonucleic acid 51.1 2 9709947 (1)

    Search CenterWatch for drugs/clinical trials and news about GIPR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GIPR gene: 
    NM_000164.2  

    Unigene Cluster for GIPR:

    Gastric inhibitory polypeptide receptor
    Hs.658534  [show with all ESTs]
    Unigene Representative Sequence: U39231
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590918 ENST00000263281(uc002pct.1 uc002pcu.1 uc010xxp.1 uc010xxq.1)
    ENST00000304207 ENST00000585889 ENST00000591322 ENST00000588816 ENST00000591224
    ENST00000593127
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GIPR
    1 QIAGEN miScript miRNA Assays for microRNA that regulate GIPR:
    hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidGIPR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GIPR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GIPR
    Clone
    Products:
         
    OriGene clones in human, mouse for GIPR (see all 6)
    OriGene ORF clones in mouse, rat for GIPR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GIPR (NM_000164)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GIPR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GIPR
    Sirion Biotech Customized lentivirus for stable overexpression of GIPR 
                         Customized lentivirus expression plasmids for stable overexpression of GIPR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GIPR
    OriGene qSTAR qPCR primer pairs in human, mouse for GIPR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GIPR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GIPR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GIPR

    Additional mRNA sequence: 

    BC093723.1 BC095494.1 BC101673.1 BC143300.1 BC143302.1 S79852.1 U39231.1 

    4 DOTS entries:

    DT.97804527  DT.97792738  DT.91715737  DT.99942283 

    24/35 AceView cDNA sequences (see all 35):

    BE045616 AI805809 NM_000164 BM991965 CA432623 BU784011 BE673877 BQ286360 
    U39231 CD742748 AI694139 BQ269710 AW770558 BQ185901 BM129730 CA437464 
    CN839764 CA942479 AA987372 BE504400 S79852 AA483616 CN839937 AA345686 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GIPR    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:              -                       -                 -                       -                                       
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for GIPR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GIPR expression in normal human tissues (normalized intensities)      GIPR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTATTGA
    GIPR Expression
    About this image


    GIPR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             breast ; myoepithelial cells   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   

    See GIPR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GIPR

    SOURCE GeneReport for Unigene cluster: Hs.658534
        SABiosciences Expression via Pathway-Focused PCR Arrays including GIPR: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GIPR
    OriGene qSTAR qPCR primer pairs in human, mouse for GIPR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GIPR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GIPR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GIPR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GIPR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GIPR gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gipr1 , 5 gastric inhibitory polypeptide receptor1, 5 82.24(n)1
    81.36(a)1
      7 (9.46 cM)5
    3818531  NM_001080815.11  NP_001074284.11 
     191571255 
    chicken
    (Gallus gallus)
    Aves --
    glucagon receptor-like precursor
    45(a)
    possible ortholog
    14(12826395-12829326)
    lizard
    (Anolis carolinensis)
    Reptilia GIPR6
    --
    --
    53(a)
    50(a)
    1 ↔ 1
    possible ortholog
    GL344349.1(11997-36127)
    GL343518.1(278393-296377)
    zebrafish
    (Danio rerio)
    Actinopterygii GIPR6
    gastric inhibitory polypeptide receptor
    44(a)
    1 ↔ 1
    15(28304201-28322308)


    ENSEMBL Gene Tree for GIPR (if available)
    TreeFam Gene Tree for GIPR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GIPR gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  
    PTH2R2  CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  
    14 SIMAP similar genes for GIPR using alignment to 5 protein entries:     GIPR_HUMAN (see all proteins):
    CRHR1    GLP2R    GCGR    SCTR    VIPR2    GLP1R
    VIPR1    GHRHR    PTH1R    CRHR2    CALCRL    PTH2R
    PTHR2    CALCR

    GIPR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/300 SNPs in GIPR are shown (see all 300)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0118084
    ----see VAR_0118082 A V mis40--------
    VAR_0293334
    ----see VAR_0293332 R W mis40--------
    rs1816398721,2
    --46169596(+) GTGCAA/GTACAC 1 -- us2k10--------
    rs561234641,2
    C--46169794(+) CCAGGC/GGTGGT 1 -- us2k14Minor allele frequency- G:0.16NA WA 126
    rs43757721,2
    C,F--46169826(+) CTACTC/GTGGTG 1 -- us2k15Minor allele frequency- G:0.30WA NA EA 246
    rs561824031,2
    C,F--46169848(+) AGAATC/TGCCTG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs616634261,2
    C--46170056(+) TGAGGC/TCAAGA 1 -- us2k10--------
    rs1871850821,2
    --46170163(+) TACTCA/GGGAGG 1 -- us2k10--------
    rs1924926691,2
    --46170226(+) GATGGC/TGCCAC 1 -- us2k10--------
    rs1818367881,2
    --46170403(+) AGCTAC/TAATTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GIPR (46171502 - 46186982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GIPR:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3954n71CNV Loss21882294
    nsv912159CNV Loss21882294


    Human Gene Mutation Database (HGMD): GIPR
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GIPR
    DNA2.0 Custom Variant and Variant Library Synthesis for GIPR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 137241    OMIM disorders: --

    13 diseases for GIPR:    About MalaCards
    cushing's syndrome    adrenal adenoma    insulinoma    adenoma
    hyperparathyroidism    neuroendocrine tumor    multiple sclerosis    obesity
    insulin resistance    diabetes mellitus    lung cancer    endotheliitis
    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for GIPR:
    Cushing's syndrome     Diabetes mellitus

    GIPR for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for GIPR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adrenal hyperplasia 88.3 4 16087722 (1), 19578593 (1), 11994328 (1)
    adrenal adenoma 82.8 3 8784063 (1), 16087722 (1), 11994328 (1)
    cushing syndrome 81.6 18 9709947 (5), 8784063 (1), 9851802 (1), 10333644 (1) (see all 11)
    adenoma adrenocortical 66.8 2 10333644 (1), 11158012 (1)
    adenoma 55.9 4 18971217 (1), 9709947 (1)
    hypercortisolism 47.2 1 12638519 (1)
    insulinoma 38.4 1 16403775 (1)
    hyperplasia 37.6 8 19578593 (4), 9709947 (1), 11994328 (1), 10443649 (1)
    tumors 0 7 18971217 (3), 11994328 (1)

    Genetic Association Database (GAD): GIPR
    Human Genome Epidemiology (HuGE) Navigator: GIPR (11 documents)

    Export disorders for GIPR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GIPR gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with GIPR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. (PubMed id 17624916)1, 4, 9 Nitz I....Doring F. (2007)
    2. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PubMed id 20081857)1, 4, 9 Saxena R....Zhao J.H. (2010)
    3. Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups. (PubMed id 19254363)1, 4, 9 Vogel C.I....Hinney A. (2009)
    4. Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA. (PubMed id 8575774)1, 2, 9 Yamada Y.... Seino Y. (1995)
    5. Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization. (PubMed id 7490109)1, 3, 9 Stoffel M....Bell G.I. (1995)
    6. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PubMed id 19195718)1, 4, 9 Bonetti A....Tienari P.J. (2009)
    7. Regulation of GIP and GLP1 receptor cell surface expression by N- glycosylation and receptor heteromerization. (PubMed id 22412906)1, 2 Whitaker G.M.... Accili E.A. (2012)
    8. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (PubMed id 22344221)1, 4 Okada Y....Tanaka T. (2012)
    9. Meta-analysis identifies common variants associated wi th body mass index in east Asians. (PubMed id 22344219)1, 4 Wen W....Shu X.O. (2012)
    10. Association of variants in gastric inhibitory polypep tide receptor gene with impaired glucose homeostasis in obese children and adol escents from Berlin. (PubMed id 20516203)1, 4 Sauber J....Biebermann H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2696 HGNC: 4271 AceView: GIPR Ensembl:ENSG00000010310 euGenes: HUgn2696
    ECgene: GIPR Kegg: 2696 H-InvDB: GIPR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GIPR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GIPR gene:
    Search GeneIP for patents involving GIPR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Purified and/or Recombinant GIPR Protein
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Clones for the Expression of GIPR
     Browse Small Molecules at EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for GIPR (GIPR)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GIPR   OriGene RNAi products in human, mouse, rat for GIPR  
     OriGene qPCR primer pairs and template standards for GIPR   OriGene Protein Over-expression Lysate for GIPR  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GIPR  
     OriGene qSTAR qPCR primer pairs in human, mouse for GIPR   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GIPR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GIPR   OriGene Custom Protein Services for GIPR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GIPR
     QIAGEN SeqTarget long-range PCR primers for resequencing GIPR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GIPR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GIPR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GIPR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GIPR
     GenScript Custom Purified and Recombinant Proteins Services for GIPR GenScript cDNA clones with any tag delivered in your preferred vector for GIPR
     GenScript Custom Assay Services for GIPR GenScript Custom Superior Antibodies Services for GIPR
     GenScript Custom overexpressing Cell Line Services for GIPR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GIPR promoter
     Search Chromatin IP Primers for GIPR
     RT2 qPCR Primer Assay in human, mouse, rat GIPR
     GNC Network for GIPR
     SABiosciences PCR Arrays including human, mouse, rat GIPR
     Search Tocris compounds for GIPR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GIPR antibodies
     GIPR lysates
     Antibodies for GIPR
     See all of Abcam's Antibodies, Kits and Proteins for GIPR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GIPR
     Antibodies for GIPR
     ELISAs for GIPR
     CLIAs for GIPR
     Search LifeMap BioReagents cell lines for GIPR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GIPR
     SwitchGear 3'UTR luciferase reporter plasmids for GIPR
     SwitchGear Promoter luciferase reporter plasmids for GIPR
     ThermoFisher Antibodies for GIPR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GIPR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GIPR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GIPR
    Customized:
     lentivirus for stable overexpression of GIPR
     lentivirus expression plasmids for stable overexpression of GIPR
     adenovirus for overexpression of GIPR
     LSBio Antibodies in human, mouse, rat for GIPR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GIPR gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4