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Aliases for GIPR Gene

Aliases for GIPR Gene

  • Gastric Inhibitory Polypeptide Receptor 2 3 5
  • Glucose-Dependent Insulinotropic Polypeptide Receptor 3 4
  • GIP-R 3 4
  • PGQTL2 3

External Ids for GIPR Gene

Previous GeneCards Identifiers for GIPR Gene

  • GC19P046815
  • GC19P046562
  • GC19P050847
  • GC19P050863
  • GC19P046171
  • GC19P042600

Summaries for GIPR Gene

Entrez Gene Summary for GIPR Gene

  • This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

GeneCards Summary for GIPR Gene

GIPR (Gastric Inhibitory Polypeptide Receptor) is a Protein Coding gene. Diseases associated with GIPR include Adrenal Cortical Adenoma and Adrenal Adenoma. Among its related pathways are G alpha (s) signalling events and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is GCGR.

UniProtKB/Swiss-Prot for GIPR Gene

  • This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene Wiki entry for GIPR Gene

Additional gene information for GIPR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIPR Gene

Genomics for GIPR Gene

Regulatory Elements for GIPR Gene

Enhancers for GIPR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H045446 2 FANTOM5 Ensembl ENCODE dbSUPER 6.6 -218.7 -218676 6 HDGF FOXA2 MLX ARNT ARID4B SIN3A ZNF2 ZBTB7B ZNF143 ZNF207 CD3EAP ZNF180 ENSG00000268810 ERCC1 GIPR RTN2 RELB FOSB CLASRP PPM1N
GH19H045645 1.1 ENCODE 5.5 -22.3 -22296 1 PKNOX1 ATF1 ARNT SIN3A ZNF2 ZNF143 ZNF207 KLF7 FOS ATF7 GIPR EML2-AS1 EML2 RN7SL836P
GH19H045667 1.1 ENCODE 5.5 +0.4 376 2 HDGF PKNOX1 FOXA2 ARNT SIN3A YBX1 ZNF2 ZNF766 ZNF143 FOS SNRPD2 CCDC61 DM1-AS ENSG00000259605 ENSG00000268810 CLASRP FBXO46 PPP1R13L ENSG00000269148 IRF2BP1
GH19H045439 2 FANTOM5 Ensembl ENCODE dbSUPER 2.9 -227.9 -227893 2 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 CBX5 ZNF143 ZNF207 RELB DMPK FOSB CD3EAP VASP GIPR CLASRP BLOC1S3 MIR6088
GH19H045677 0.8 ENCODE 7.1 +9.3 9333 1 ELF3 HDGF CTCF PKNOX1 BACH1 ZBTB7B TEAD3 ZFHX2 GATA3 POLR2A SNRPD2 CCDC61 GIPR PNMA8A MIR642B GC19M045670
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GIPR on UCSC Golden Path with GeneCards custom track

Promoters for GIPR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110247 -93 201 HDAC1 HDGF PKNOX1 ATF1 FOXA2 RB1 ZNF76 ZNF766 EGR1 FOS

Genomic Location for GIPR Gene

Chromosome:
19
Start:
45,668,193 bp from pter
End:
45,683,724 bp from pter
Size:
15,532 bases
Orientation:
Plus strand

Genomic View for GIPR Gene

Genes around GIPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIPR Gene

Proteins for GIPR Gene

  • Protein details for GIPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48546-GIPR_HUMAN
    Recommended name:
    Gastric inhibitory polypeptide receptor
    Protein Accession:
    P48546
    Secondary Accessions:
    • B7WP14
    • B7ZKQ0
    • Q14401
    • Q16400
    • Q52M04
    • Q9UPI1

    Protein attributes for GIPR Gene

    Size:
    466 amino acids
    Molecular mass:
    53157 Da
    Quaternary structure:
    • May form homodimers and heterodimers with GLP1R.
    SequenceCaution:
    • Sequence=CAA57426.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GIPR Gene

    Alternative splice isoforms for GIPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GIPR Gene

Post-translational modifications for GIPR Gene

  • N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
  • Glycosylation at isoforms=262 and posLast=7777
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GIPR Gene

Domains & Families for GIPR Gene

Gene Families for GIPR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for GIPR Gene

Graphical View of Domain Structure for InterPro Entry

P48546

UniProtKB/Swiss-Prot:

GIPR_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GIPR: view

Function for GIPR Gene

Molecular function for GIPR Gene

GENATLAS Biochemistry:
gastric inhibitory polypeptide receptor,G protein coupled receptor superfamily,expressed in pancreatic beta cell,not involved in NIDDM,at least in a Japanese population
UniProtKB/Swiss-Prot Function:
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Phenotypes From GWAS Catalog for GIPR Gene

Gene Ontology (GO) - Molecular Function for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity TAS,IEA 7556958
GO:0004930 G-protein coupled receptor activity IEA --
GO:0016519 gastric inhibitory peptide receptor activity IEA --
GO:0017046 peptide hormone binding IEA --
genes like me logo Genes that share ontologies with GIPR: view
genes like me logo Genes that share phenotypes with GIPR: view

Animal Models for GIPR Gene

MGI Knock Outs for GIPR:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GIPR
  • Applied Biological Materials Clones for GIPR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GIPR Gene

Localization for GIPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GIPR gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GIPR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GIPR Gene

Pathways & Interactions for GIPR Gene

genes like me logo Genes that share pathways with GIPR: view

Gene Ontology (GO) - Biological Process for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA --
GO:0006091 generation of precursor metabolites and energy TAS 7556958
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GIPR: view

No data available for SIGNOR curated interactions for GIPR Gene

Drugs & Compounds for GIPR Gene

(7) Drugs for GIPR Gene - From: PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olanzapine Approved, Investigational Pharma Antagonist 406
GIP (1-39) Pharma Highly potent insulinotropic peptide 0
GIP (human) Pharma Potent insulinotropic gut hormone 0
[Pro<sup>3</sup>]GIP Pharma Antagonist 0
gastric inhibitory polypeptide Pharma Full agonist, Agonist 82

(3) Additional Compounds for GIPR Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Pro3]-GIP (Mouse)
[Pro3]-GIP (Rat)

(4) Tocris Compounds for GIPR Gene

Compound Action Cas Number
[Pro3]-GIP (Mouse) GIP receptor antagonist
[Pro3]-GIP (Rat) High affinity rat GIP receptor partial agonist
GIP (1-39) Highly potent insulinotropic peptide 725474-97-5
GIP (human) Potent insulinotropic gut hormone 100040-31-1

(2) ApexBio Compounds for GIPR Gene

Compound Action Cas Number
GIP (1-39) 725474-97-5
GIP (human) 100040-31-1
genes like me logo Genes that share compounds with GIPR: view

Drug Products

Transcripts for GIPR Gene

Unigene Clusters for GIPR Gene

Gastric inhibitory polypeptide receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GIPR
  • Applied Biological Materials Clones for GIPR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GIPR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for GIPR Gene

GeneLoc Exon Structure for
GIPR
ECgene alternative splicing isoforms for
GIPR

Expression for GIPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GIPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIPR Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.2).

Protein differential expression in normal tissues from HIPED for GIPR Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GIPR Gene



Protein tissue co-expression partners for GIPR Gene

NURSA nuclear receptor signaling pathways regulating expression of GIPR Gene:

GIPR

SOURCE GeneReport for Unigene cluster for GIPR Gene:

Hs.658534

Evidence on tissue expression from TISSUES for GIPR Gene

  • Pancreas(4.5)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with GIPR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GIPR Gene

Orthologs for GIPR Gene

This gene was present in the common ancestor of animals.

Orthologs for GIPR Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GIPR 33 34
  • 89.59 (n)
cow
(Bos Taurus)
Mammalia GIPR 33 34
  • 88.51 (n)
rat
(Rattus norvegicus)
Mammalia Gipr 33
  • 83.68 (n)
mouse
(Mus musculus)
Mammalia Gipr 33 16 34
  • 82.81 (n)
oppossum
(Monodelphis domestica)
Mammalia GIPR 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia GIPR 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gipr 33
  • 54.91 (n)
zebrafish
(Danio rerio)
Actinopterygii GIPR 34
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 35
  • 28 (a)
Species where no ortholog for GIPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIPR Gene

ENSEMBL:
Gene Tree for GIPR (if available)
TreeFam:
Gene Tree for GIPR (if available)

Paralogs for GIPR Gene

Paralogs for GIPR Gene

(14) SIMAP similar genes for GIPR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GIPR: view

Variants for GIPR Gene

Sequence variations from dbSNP and Humsavar for GIPR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000136002 -- 45,668,231(+) CGAGA(A/C)AAGGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000223438 -- 45,669,678(+) CTGTC(C/G)CTCAC intron-variant
rs1000497732 -- 45,679,336(+) AATTA(C/G)CTGGA intron-variant
rs1000635403 -- 45,679,695(+) TTGGA(A/C)TCCTG intron-variant
rs1000695076 -- 45,668,545(+) CCTAG(C/T)CCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIPR Gene

Variant ID Type Subtype PubMed ID
esv3556465 CNV deletion 23714750
esv3644509 CNV gain 21293372

Variation tolerance for GIPR Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.77; 83.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIPR Gene

Human Gene Mutation Database (HGMD)
GIPR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIPR Gene

Disorders for GIPR Gene

MalaCards: The human disease database

(4) MalaCards diseases for GIPR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adrenal cortical adenoma
  • adrenocortical adenoma
adrenal adenoma
  • adenoma of the adrenal gland
cushing's syndrome
  • adrenal cortical adenoma
adrenal gland hyperfunction
  • adrenocortical hyperfunction
- elite association - COSMIC cancer census association via MalaCards
Search GIPR in MalaCards View complete list of genes associated with diseases

Relevant External Links for GIPR

Genetic Association Database (GAD)
GIPR
Human Genome Epidemiology (HuGE) Navigator
GIPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIPR
genes like me logo Genes that share disorders with GIPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIPR Gene

Publications for GIPR Gene

  1. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PMID: 20081857) Saxena R … Watanabe RM (Nature genetics 2010) 3 22 45 60
  2. Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups. (PMID: 19254363) Vogel CI … Hinney A (BMC medical genetics 2009) 3 22 45 60
  3. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PMID: 19195718) Bonetti A … Tienari PJ (Journal of neuroimmunology 2009) 3 22 45 60
  4. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. (PMID: 17624916) Nitz I … Döring F (Molecular nutrition & food research 2007) 3 22 45 60
  5. Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA. (PMID: 8575774) Yamada Y … Seino Y (Genomics 1995) 3 4 22 60

Products for GIPR Gene

  • Addgene plasmids for GIPR

Sources for GIPR Gene

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