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GIPR Gene

protein-coding   GIFtS: 64
GCID: GC19P046171

Gastric Inhibitory Polypeptide Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Gastric Inhibitory Polypeptide Receptor1 2
Glucose-Dependent Insulinotropic Polypeptide Receptor2 3
GIP-R2 3
PGQTL22 5

External Ids:    HGNC: 42711   Entrez Gene: 26962   Ensembl: ENSG000000103107   OMIM: 1372415   UniProtKB: P485463   

Export aliases for GIPR gene to outside databases

Previous GC identifers: GC19P046815 GC19P046562 GC19P050847 GC19P050863 GC19P042600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GIPR Gene:
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally
identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but
subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this
gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect
in this gene thus may contribute to the pathogenesis of diabetes. (provided by RefSeq, Oct 2011)

GeneCards Summary for GIPR Gene:
GIPR (gastric inhibitory polypeptide receptor) is a protein-coding gene. Diseases associated with GIPR include adrenal adenoma, and cushing's syndrome. GO annotations related to this gene include transmembrane signaling receptor activity and gastric inhibitory peptide receptor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: GIPR_HUMAN, P48546
Function: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate
adenylyl cyclase

Gene Wiki entry for GIPR (Gastric inhibitory polypeptide receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GIPR gene promoter:
         Max1   Meis-1b   CREB   AREB6   deltaCREB   Meis-1a   Pax-4a   c-Myc   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGIPR promoter sequence
   Search Chromatin IP Primers for GIPR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GIPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2-q13.3

GIPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GIPR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046171:  view genomic region     (about GC identifiers)

Start:
46,171,502 bp from pter      End:
46,186,982 bp from pter
Size:
15,481 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GIPR_HUMAN, P48546 (See protein sequence)
Recommended Name: Gastric inhibitory polypeptide receptor precursor  
Size: 466 amino acids; 53157 Da
Subunit: May form homodimers and heterodimers with GLP1R
Sequence caution: Sequence=CAA57426.1; Type=Frameshift; Positions=Several;
2 PDB 3D structures from and Proteopedia for GIPR:
2QKH (3D)        4HJ0 (3D)    
Secondary accessions: B7WP14 B7ZKQ0 Q14401 Q16400 Q52M04 Q9UPI1
Alternative splicing: 3 isoforms:  P48546-1   P48546-2   P48546-3   

Explore the universe of human proteins at neXtProt for GIPR: NX_P48546

Explore proteomics data for GIPR at MOPED

Post-translational modifications: 

  • N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation
    in the ER1
  • Glycosylation2 at Asn62, Asn77

  • See GIPR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000155.1  
    ENSEMBL proteins: 
     ENSP00000467494   ENSP00000263281   ENSP00000305321   ENSP00000467342   ENSP00000465385  
    Reactome Protein details: P48546

    GIPR Human Recombinant Protein Products:

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    Novus Biologicals GIPR Lysate
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    GIPR Assay Products:

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    Cloud-Clone Corp. CLIAs for GIPR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GCGR: GPCR / Class B : Glucagon receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GIP receptor
    Glucagon receptor family

    5 InterPro protein domains:
     IPR001879 GPCR_2_extracellular_dom
     IPR001749 GPCR_2_GIP_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry P48546

    ProtoNet protein and cluster: P48546

    2 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001749 Gastric inhibitory polypeptide receptor precursor signature


    UniProtKB/Swiss-Prot: GIPR_HUMAN, P48546
    Similarity: Belongs to the G-protein coupled receptor 2 family


    GIPR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GIPR_HUMAN, P48546
    Function: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate
    adenylyl cyclase

         Genatlas biochemistry entry for GIPR:
    gastric inhibitory polypeptide receptor,G protein coupled receptor superfamily,expressed in pancreatic beta
    cell,not involved in NIDDM,at least in a Japanese population

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS7556958
    GO:0004930G-protein coupled receptor activity ----
    GO:0016519gastric inhibitory peptide receptor activity IEA--
    GO:0017046peptide hormone binding IEA--
         
    GIPR for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gipr):
     endocrine/exocrine gland  homeostasis/metabolism 

    GIPR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GIPR: Giprtm1Thor Giprtm1Yse

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GIPR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GIPR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GIPR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GIPR

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GIPR using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GIPR:
    hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidGIPR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GIPR
    Predesigned siRNA for gene silencing in human, mouse, rat GIPR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GIPR

    Clone
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    OriGene clones in human, mouse for GIPR (see all 5)
    OriGene ORF clones in mouse, rat for GIPR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GIPR (NM_000164)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GIPR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GIPR

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GIPR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GIPR_HUMAN, P48546: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    GIPR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GIPR About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3ADP signalling through P2Y purinoceptor 12
    Glucagon-type ligand receptors0.61
    Class B/2 (Secretin family receptors)0.36
    4GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like
    5G alpha (s) signalling events
    G alpha (s) signalling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GIPR
        GPCRs, Class B Secretin-like

    2 Reactome Pathways for GIPR
        Glucagon-type ligand receptors
    G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for GIPR):
        Neuroactive ligand-receptor interaction


    GIPR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GIPR: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GIPR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GIPR (P485463 ENSP000002632814) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPP096813, ENSP000003500054I2D: score=2 STRING: ENSP00000350005
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY8ENSP000002863554STRING: ENSP00000286355
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002029desensitization of G-protein coupled receptor protein signaling pathway IEA--
    GO:0006091generation of precursor metabolites and energy TAS7556958
    GO:0007166cell surface receptor signaling pathway TAS7556958
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007190activation of adenylate cyclase activity TAS7589426

    GIPR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GIPR

    2 IUPHAR Ligands for GIPR (GIP receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    gastric inhibitory polypeptide
    AgonistFull agonist8.77589426
    [Pro3]GIP
    AntagonistAntagonist8.7--

    2 Novoseek inferred chemical compound relationships for GIPR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 60.8 5 15705925 (2), 16402925 (1)
    ribonucleic acid 51.1 2 9709947 (1)



    GIPR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GIPR gene: 
    NM_000164.2  

    Unigene Cluster for GIPR:

    Gastric inhibitory polypeptide receptor
    Hs.658534  [show with all ESTs]
    Unigene Representative Sequence: U39231
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590918 ENST00000263281(uc002pct.1 uc002pcu.1 uc010xxp.1 uc010xxq.1)
    ENST00000304207 ENST00000585889 ENST00000591322 ENST00000588816 ENST00000591224
    ENST00000593127
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GIPR using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GIPR:
    hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidGIPR 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: GIPR (NM_000164)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GIPR
      QuantiTect SYBR Green Assays in human, mouse, rat GIPR
      QuantiFast Probe-based Assays in human, mouse, rat GIPR

    Additional mRNA sequence: 

    BC093723.1 BC095494.1 BC101673.1 BC143300.1 BC143302.1 S79852.1 U39231.1 

    4 DOTS entries:

    DT.97804527  DT.97792738  DT.91715737  DT.99942283 

    Selected AceView cDNA sequences (see all 35):

    BM991965 CA432623 NM_000164 AI805809 AI694139 BU784011 BQ286360 CD742748 
    U39231 BE045616 BE673877 CA942479 S79852 AW770558 AA483616 AA987372 
    BM129730 BQ269710 BQ185901 BE504400 CA437464 CN839764 CN839937 CA867184 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GIPR    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:              -                       -                 -                       -                                       
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for GIPR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GIPR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTATTGA
    GIPR Expression
    About this image


    GIPR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Brain (Nervous System)
             Cerebral Cortex
    GIPR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GIPR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658534
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GIPR: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GIPR
    OriGene qSTAR qPCR primer pairs in human, mouse for GIPR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GIPR
    QuantiTect SYBR Green Assays in human, mouse, rat GIPR
    QuantiFast Probe-based Assays in human, mouse, rat GIPR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GIPR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GIPR gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gipr1 , 5 gastric inhibitory polypeptide receptor1, 5 82.81(n)1
    82.13(a)1
      7 (9.46 cM)5
    3818531  NM_001080815.11  NP_001074284.11 
     191571255 
    chicken
    (Gallus gallus)
    Aves --
    Gallus gallus glucagon receptor-like (LOC772096), ...
    46(a)
    many ↔ many
    14(12826395-12829326)
    lizard
    (Anolis carolinensis)
    Reptilia GIPR6
    gastric inhibitory polypeptide receptor
    56(a)
    1 ↔ 1
    GL344349.1(11997-36127)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gipr1 gastric inhibitory polypeptide receptor 54.91(n)
    54.11(a)
      100490534  XM_002932633.2  XP_002932679.2 
    zebrafish
    (Danio rerio)
    Actinopterygii GIPR6
    gastric inhibitory polypeptide receptor
    47(a)
    1 ↔ 1
    15(28289446-28323214) ENSDARG00000025478


    ENSEMBL Gene Tree for GIPR (if available)
    TreeFam Gene Tree for GIPR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GIPR gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  
    PTH2R2  CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  
    14 SIMAP similar genes for GIPR using alignment to 4 protein entries:     GIPR_HUMAN (see all proteins):
    CRHR1    GLP2R    GLP1R    GCGR    VIPR2    SCTR
    GHRHR    VIPR1    CRHR2    PTH1R    CALCRL    PTH2R
    PTHR2    CALCR

    GIPR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GIPR (see all 300)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816398721,2
    --46169596(+) GTGCAA/GTACAC 1 -- us2k10--------
    rs561234641,2
    C--46169794(+) CCAGGC/GGTGGT 1 -- us2k14Minor allele frequency- G:0.16NA WA 126
    rs43757721,2
    C,F--46169826(+) CTACTC/GTGGTG 1 -- us2k15Minor allele frequency- G:0.30WA NA EA 246
    rs561824031,2
    C,F--46169848(+) AGAATC/TGCCTG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs616634261,2
    C--46170056(+) TGAGGC/TCAAGA 1 -- us2k10--------
    rs1871850821,2
    --46170163(+) TACTCA/GGGAGG 1 -- us2k10--------
    rs1924926691,2
    --46170226(+) GATGGC/TGCCAC 1 -- us2k10--------
    rs1818367881,2
    --46170403(+) AGCTAC/TAATTG 1 -- us2k10--------
    rs1851972651,2
    --46170407(+) ATAATC/TGTTCC 1 -- us2k10--------
    rs43801431,2
    C,F--46170465(+) GATTGT/CATGGG 1 -- us2k111Minor allele frequency- C:0.28NA WA CSA EA 373

    HapMap Linkage Disequilibrium report for GIPR (46171502 - 46186982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GIPR:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3954n71CNV Loss21882294
    nsv912159CNV Loss21882294

    Human Gene Mutation Database (HGMD): GIPR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GIPR
    DNA2.0 Custom Variant and Variant Library Synthesis for GIPR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 137241    OMIM disorders: --

    16 diseases for GIPR:    
    About MalaCards
    adrenal adenoma    cushing's syndrome    insulinoma    neuroendocrine tumor
    adenoma    hyperparathyroidism    insulin resistance    multiple sclerosis
    obesity    diabetes mellitus    lung cancer    endotheliitis
    cerebritis    pancreatitis    thyroiditis    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for GIPR:
    Cushing's syndrome     Diabetes mellitus

    GIPR for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for GIPR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adrenal hyperplasia 88.3 4 16087722 (1), 19578593 (1), 11994328 (1)
    adrenal adenoma 82.8 3 8784063 (1), 16087722 (1), 11994328 (1)
    cushing syndrome 81.6 18 9709947 (5), 8784063 (1), 9851802 (1), 10333644 (1) (see all 11)
    adenoma adrenocortical 66.8 2 10333644 (1), 11158012 (1)
    adenoma 55.9 4 18971217 (1), 9709947 (1)
    hypercortisolism 47.2 1 12638519 (1)
    insulinoma 38.4 1 16403775 (1)
    hyperplasia 37.6 8 19578593 (4), 9709947 (1), 11994328 (1), 10443649 (1)
    tumors 0 7 18971217 (3), 11994328 (1)

    Genetic Association Database (GAD): GIPR
    Human Genome Epidemiology (HuGE) Navigator: GIPR (11 documents)

    Export disorders for GIPR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GIPR gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with GIPR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. (PubMed id 17624916)1, 4, 9 Nitz I....DAPring F. (amp 2007)
    2. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PubMed id 20081857)1, 4, 9 Saxena R....Watanabe R.M. (Nat. Genet. 2010)
    3. Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups. (PubMed id 19254363)1, 4, 9 Vogel C.I....Hinney A. (BMC Med. Genet. 2009)
    4. Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA. (PubMed id 8575774)1, 2, 9 Yamada Y.... Seino Y. (Genomics 1995)
    5. Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization. (PubMed id 7490109)1, 3, 9 Stoffel M....Bell G.I. (Genomics 1995)
    6. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PubMed id 19195718)1, 4, 9 Bonetti A....Tienari P.J. (J. Neuroimmunol. 2009)
    7. Regulation of GIP and GLP1 receptor cell surface expression by N- glycosylation and receptor heteromerization. (PubMed id 22412906)1, 2 Whitaker G.M.... Accili E.A. (PLoS ONE 2012)
    8. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (PubMed id 22344221)1, 4 Okada Y....Tanaka T. (Nat. Genet. 2012)
    9. Meta-analysis identifies common variants associated with body mass index in east Asians. (PubMed id 22344219)1, 4 Wen W....Shu X.O. (Nat. Genet. 2012)
    10. Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin. (PubMed id 20516203)1, 4 Sauber J....Biebermann H. (Eur. J. Endocrinol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2696 HGNC: 4271 AceView: GIPR Ensembl:ENSG00000010310 euGenes: HUgn2696
    ECgene: GIPR Kegg: 2696 H-InvDB: GIPR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GIPR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GIPR gene:
    Search GeneIP for patents involving GIPR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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