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Aliases for GIPR Gene

Aliases for GIPR Gene

  • Gastric Inhibitory Polypeptide Receptor 2 3 5
  • Glucose-Dependent Insulinotropic Polypeptide Receptor 3 4
  • GIP-R 3 4
  • PGQTL2 3

External Ids for GIPR Gene

Previous GeneCards Identifiers for GIPR Gene

  • GC19P046815
  • GC19P046562
  • GC19P050847
  • GC19P050863
  • GC19P046171
  • GC19P042600

Summaries for GIPR Gene

Entrez Gene Summary for GIPR Gene

  • This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

GeneCards Summary for GIPR Gene

GIPR (Gastric Inhibitory Polypeptide Receptor) is a Protein Coding gene. Diseases associated with GIPR include adrenal cortical adenoma and adrenal adenoma. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is MGC57346-CRHR1.

UniProtKB/Swiss-Prot for GIPR Gene

  • This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene Wiki entry for GIPR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIPR Gene

Genomics for GIPR Gene

Regulatory Elements for GIPR Gene

Promoters for GIPR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GIPR on UCSC Golden Path with GeneCards custom track

Genomic Location for GIPR Gene

Chromosome:
19
Start:
45,668,193 bp from pter
End:
45,683,724 bp from pter
Size:
15,532 bases
Orientation:
Plus strand

Genomic View for GIPR Gene

Genes around GIPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIPR Gene

Proteins for GIPR Gene

  • Protein details for GIPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48546-GIPR_HUMAN
    Recommended name:
    Gastric inhibitory polypeptide receptor
    Protein Accession:
    P48546
    Secondary Accessions:
    • B7WP14
    • B7ZKQ0
    • Q14401
    • Q16400
    • Q52M04
    • Q9UPI1

    Protein attributes for GIPR Gene

    Size:
    466 amino acids
    Molecular mass:
    53157 Da
    Quaternary structure:
    • May form homodimers and heterodimers with GLP1R.
    SequenceCaution:
    • Sequence=CAA57426.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GIPR Gene

    Alternative splice isoforms for GIPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GIPR Gene

Proteomics data for GIPR Gene at MOPED

Post-translational modifications for GIPR Gene

  • N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
  • Glycosylation at Asn 62 and Asn 77
  • Modification sites at PhosphoSitePlus

Other Protein References for GIPR Gene

Antibody Products

No data available for DME Specific Peptides for GIPR Gene

Domains & Families for GIPR Gene

Gene Families for GIPR Gene

Suggested Antigen Peptide Sequences for GIPR Gene

Graphical View of Domain Structure for InterPro Entry

P48546

UniProtKB/Swiss-Prot:

GIPR_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GIPR: view

Function for GIPR Gene

Molecular function for GIPR Gene

GENATLAS Biochemistry:
gastric inhibitory polypeptide receptor,G protein coupled receptor superfamily,expressed in pancreatic beta cell,not involved in NIDDM,at least in a Japanese population
UniProtKB/Swiss-Prot Function:
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GIPR: view
genes like me logo Genes that share phenotypes with GIPR: view

Animal Models for GIPR Gene

MGI Knock Outs for GIPR:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GIPR Gene

Localization for GIPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIPR Gene COMPARTMENTS Subcellular localization image for GIPR gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with GIPR: view

Pathways & Interactions for GIPR Gene

genes like me logo Genes that share pathways with GIPR: view

Pathways by source for GIPR Gene

Gene Ontology (GO) - Biological Process for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA --
GO:0006091 generation of precursor metabolites and energy TAS 7556958
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007584 response to nutrient TAS 7556958
genes like me logo Genes that share ontologies with GIPR: view

No data available for SIGNOR curated interactions for GIPR Gene

Drugs & Compounds for GIPR Gene

(5) Drugs for GIPR Gene - From: Novoseek, PharmGKB, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olanzapine Approved, Investigational Pharma Antagonist 379
[Pro<sup>3</sup>]GIP Pharma Antagonist 0
gastric inhibitory polypeptide Pharma Full agonist, Agonist 79
MAR701 Pharma 0

(3) Additional Compounds for GIPR Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GIP (1-39)
725474-97-5
GIP (human)
100040-31-1

(2) Tocris Compounds for GIPR Gene

Compound Action Cas Number
GIP (1-39) Highly potent insulinotropic peptide 725474-97-5
GIP (human) Potent insulinotropic gut hormone 100040-31-1
genes like me logo Genes that share compounds with GIPR: view

Transcripts for GIPR Gene

Unigene Clusters for GIPR Gene

Gastric inhibitory polypeptide receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GIPR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for GIPR Gene

GeneLoc Exon Structure for
GIPR
ECgene alternative splicing isoforms for
GIPR

Expression for GIPR Gene

mRNA expression in normal human tissues for GIPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIPR Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.2).

Protein differential expression in normal tissues from HIPED for GIPR Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GIPR Gene



SOURCE GeneReport for Unigene cluster for GIPR Gene Hs.658534

genes like me logo Genes that share expression patterns with GIPR: view

Protein tissue co-expression partners for GIPR Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GIPR Gene

Orthologs for GIPR Gene

This gene was present in the common ancestor of animals.

Orthologs for GIPR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GIPR 35
  • 88.51 (n)
  • 87.39 (a)
GIPR 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GIPR 35
  • 89.59 (n)
  • 88.76 (a)
GIPR 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gipr 35
  • 82.81 (n)
  • 82.13 (a)
Gipr 16
Gipr 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gipr 35
  • 83.68 (n)
  • 82.84 (a)
oppossum
(Monodelphis domestica)
Mammalia GIPR 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia GIPR 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gipr 35
  • 54.91 (n)
  • 54.11 (a)
zebrafish
(Danio rerio)
Actinopterygii GIPR 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 37
  • 28 (a)
Species with no ortholog for GIPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIPR Gene

ENSEMBL:
Gene Tree for GIPR (if available)
TreeFam:
Gene Tree for GIPR (if available)

Paralogs for GIPR Gene

(14) SIMAP similar genes for GIPR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GIPR: view

Variants for GIPR Gene

Sequence variations from dbSNP and Humsavar for GIPR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_011808 -
rs5392 - 45,677,099(+) TGCTC(C/G)TCGGC nc-transcript-variant, reference, missense
rs1800437 - 45,678,134(+) TCCAC(C/G)AGGTG nc-transcript-variant, downstream-variant-500B, reference, missense
VAR_029333 -
rs5390 -- 45,669,519(+) CCTCA(C/G)GATGA intron-variant, nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GIPR Gene

Variant ID Type Subtype PubMed ID
nsv912159 CNV Loss 21882294
dgv3954n71 CNV Loss 21882294

Variation tolerance for GIPR Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.77; 83.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIPR Gene

HapMap Linkage Disequilibrium report
GIPR
Human Gene Mutation Database (HGMD)
GIPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIPR Gene

Disorders for GIPR Gene

MalaCards: The human disease database

(2) MalaCards diseases for GIPR Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
adrenal cortical adenoma
  • adrenocortical adenoma
adrenal adenoma
  • adrenal cortical adenoma
- elite association - COSMIC cancer census association via MalaCards
Search GIPR in MalaCards View complete list of genes associated with diseases

Relevant External Links for GIPR

Genetic Association Database (GAD)
GIPR
Human Genome Epidemiology (HuGE) Navigator
GIPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIPR
genes like me logo Genes that share disorders with GIPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIPR Gene

Publications for GIPR Gene

  1. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. (PMID: 17624916) Nitz I. … DAPring F. (Mol Nutr Food Res 2007) 3 23 48 67
  2. Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization. (PMID: 7490109) Stoffel M. … Bell G.I. (Genomics 1995) 2 3 23
  3. Identification of determinants of glucose-dependent insulinotropic polypeptide receptor that interact with N-terminal biologically active region of the natural ligand. (PMID: 20061446) Yaqub T. … Fourmy D. (Mol. Pharmacol. 2010) 3 23
  4. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PMID: 20081857) Saxena R. … Watanabe R.M. (Nat. Genet. 2010) 3 23
  5. Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. (PMID: 20185807) Ingelsson E. … Florez J.C. (Diabetes 2010) 3 23

Products for GIPR Gene

Sources for GIPR Gene

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