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Aliases for GIPC2 Gene

Aliases for GIPC2 Gene

  • GIPC PDZ Domain Containing Family Member 2 2 3 5
  • Semaphorin Cytoplasmic Domain Associated Protein 2 2 3
  • GIPC PDZ Domain Containing Family, Member 2 2 3
  • SemaF Cytoplasmic Domain Associated Protein 2 3
  • PDZ Domain Protein GIPC2 3
  • SEMCAP-2 3
  • SEMCAP2 3

External Ids for GIPC2 Gene

Previous GeneCards Identifiers for GIPC2 Gene

  • GC01P078664
  • GC01M077458
  • GC01P077902
  • GC01P078223
  • GC01P078284
  • GC01P078445
  • GC01P076643

Summaries for GIPC2 Gene

GeneCards Summary for GIPC2 Gene

GIPC2 (GIPC PDZ Domain Containing Family Member 2) is a Protein Coding gene. An important paralog of this gene is GIPC3.

Gene Wiki entry for GIPC2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIPC2 Gene

Genomics for GIPC2 Gene

Regulatory Elements for GIPC2 Gene

Enhancers for GIPC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GIPC2 on UCSC Golden Path with GeneCards custom track

Promoters for GIPC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GIPC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GIPC2 Gene

77,979,542 bp from pter
78,138,449 bp from pter
158,908 bases
Plus strand

Genomic View for GIPC2 Gene

Genes around GIPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIPC2 Gene

Proteins for GIPC2 Gene

  • Protein details for GIPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PDZ domain-containing protein GIPC2
    Protein Accession:
    Secondary Accessions:
    • Q8IYD3
    • Q9NXS7

    Protein attributes for GIPC2 Gene

    315 amino acids
    Molecular mass:
    34354 Da
    Quaternary structure:
    • Probably interacts with SEMA5A.
    • Sequence=BAA90933.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GIPC2 Gene

neXtProt entry for GIPC2 Gene

Proteomics data for GIPC2 Gene at MOPED

Post-translational modifications for GIPC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GIPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GIPC2 Gene

Domains & Families for GIPC2 Gene

Gene Families for GIPC2 Gene

Protein Domains for GIPC2 Gene


Suggested Antigen Peptide Sequences for GIPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PDZ (DHR) domain.
  • Belongs to the GIPC family.
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the GIPC family.
genes like me logo Genes that share domains with GIPC2: view

Function for GIPC2 Gene

Gene Ontology (GO) - Molecular Function for GIPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GIPC2: view
genes like me logo Genes that share phenotypes with GIPC2: view

Animal Model Products

miRNA for GIPC2 Gene

miRTarBase miRNAs that target GIPC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GIPC2 Gene

Localization for GIPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIPC2 Gene


Subcellular locations from

Jensen Localization Image for GIPC2 Gene COMPARTMENTS Subcellular localization image for GIPC2 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GIPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GIPC2: view

Pathways & Interactions for GIPC2 Gene

SuperPathways for GIPC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GIPC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for GIPC2 Gene

Drugs & Compounds for GIPC2 Gene

No Compound Related Data Available

Transcripts for GIPC2 Gene

mRNA/cDNA for GIPC2 Gene

Unigene Clusters for GIPC2 Gene

GIPC PDZ domain containing family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GIPC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP2: -

Relevant External Links for GIPC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GIPC2 Gene

mRNA expression in normal human tissues for GIPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIPC2 Gene

This gene is overexpressed in Adrenal Gland (x6.8), Pancreas (x5.8), Spleen (x4.8), and Kidney - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for GIPC2 Gene

This gene is overexpressed in Spleen (16.2) and Fetal gut (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GIPC2 Gene

SOURCE GeneReport for Unigene cluster for GIPC2 Gene Hs.659356

mRNA Expression by UniProt/SwissProt for GIPC2 Gene

Tissue specificity: Expressed at highest levels in ascending colon and at moderate levels in adult kidney. Expressed at low levels in adult pancreas and at very low levels in adult liver. Expression is down-regulated in several primary tumors, such as kidney, colon and rectal tumors.
genes like me logo Genes that share expression patterns with GIPC2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for GIPC2 Gene

Orthologs for GIPC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GIPC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GIPC2 35
  • 87.29 (n)
  • 83.33 (a)
GIPC2 36
  • 83 (a)
(Mus musculus)
Mammalia Gipc2 35
  • 81.03 (n)
  • 83.92 (a)
Gipc2 16
Gipc2 36
  • 82 (a)
(Pan troglodytes)
Mammalia GIPC2 35
  • 99.7 (n)
  • 99.1 (a)
GIPC2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Gipc2 35
  • 82.42 (n)
  • 85.21 (a)
(Canis familiaris)
Mammalia GIPC2 36
  • 86 (a)
(Monodelphis domestica)
Mammalia GIPC2 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia GIPC2 36
  • 67 (a)
(Gallus gallus)
Aves GIPC2 35
  • 70.3 (n)
  • 66.03 (a)
GIPC2 36
  • 64 (a)
(Anolis carolinensis)
Reptilia GIPC2 36
  • 65 (a)
African clawed frog
(Xenopus laevis)
Amphibia GIPC 35
(Danio rerio)
Actinopterygii gipc2 35
  • 67.31 (n)
  • 71.38 (a)
gipc2 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)02045 37
  • 49 (a)
kermit 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea C35D10.2 37
  • 36 (a)
F44D12.4 37
  • 35 (a)
gipc-1 36
  • 30 (a)
gipc-2 36
  • 29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7918 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for GIPC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GIPC2 Gene

Gene Tree for GIPC2 (if available)
Gene Tree for GIPC2 (if available)

Paralogs for GIPC2 Gene

Paralogs for GIPC2 Gene

(2) SIMAP similar genes for GIPC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GIPC2: view

Variants for GIPC2 Gene

Sequence variations from dbSNP and Humsavar for GIPC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17101180 - 78,046,276(+) CTTCT(C/G/T)CAGCA intron-variant, reference, missense
rs540742 - 78,119,402(+) AGAGC(C/T)GAGGT reference, missense
rs478308 -- 78,128,030(-) CATCT(C/G)TATAT intron-variant
rs481199 -- 78,092,227(-) GCATA(C/T)ACTCT intron-variant
rs483760 -- 78,082,139(-) AAATA(A/G)GGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIPC2 Gene

Variant ID Type Subtype PubMed ID
nsv870608 CNV Gain 21882294
esv1010689 CNV Deletion 20482838
esv2750174 CNV Deletion 23290073
esv1368582 CNV Deletion 17803354
nsv871835 CNV Gain 21882294
esv2673736 CNV Deletion 23128226
nsv159417 CNV Loss 16902084

Variation tolerance for GIPC2 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIPC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIPC2 Gene

Disorders for GIPC2 Gene

Relevant External Links for GIPC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GIPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GIPC2 Gene

Publications for GIPC2 Gene

  1. Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit. (PMID: 11836570) Kirikoshi H. … Katoh M. (Int. J. Oncol. 2002) 2 3 4 23 67
  2. GIPC gene family (Review). (PMID: 12011974) Katoh M. (Int. J. Mol. Med. 2002) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for GIPC2 Gene

Sources for GIPC2 Gene