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Aliases for GIPC2 Gene

Aliases for GIPC2 Gene

  • GIPC PDZ Domain Containing Family Member 2 2 3 5
  • Semaphorin Cytoplasmic Domain Associated Protein 2 2 3
  • SemaF Cytoplasmic Domain Associated Protein 2 3
  • GIPC PDZ Domain Containing Family, Member 2 2
  • PDZ Domain-Containing Protein GIPC2 3
  • PDZ Domain Protein GIPC2 3
  • SEMCAP-2 3
  • SEMCAP2 3

External Ids for GIPC2 Gene

Previous GeneCards Identifiers for GIPC2 Gene

  • GC01P078664
  • GC01M077458
  • GC01P077902
  • GC01P078223
  • GC01P078284
  • GC01P078445
  • GC01P076643

Summaries for GIPC2 Gene

GeneCards Summary for GIPC2 Gene

GIPC2 (GIPC PDZ Domain Containing Family Member 2) is a Protein Coding gene. An important paralog of this gene is GIPC1.

Gene Wiki entry for GIPC2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIPC2 Gene

Genomics for GIPC2 Gene

Regulatory Elements for GIPC2 Gene

Enhancers for GIPC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F078038 0.6 ENCODE 12 +59.1 59070 0.2 STAT1 JUN CEBPB EP300 JUND POLR2A STAT3 FOS FOXJ2 TCF7L2 GIPC2 LOC100131495 ENSG00000273338
GH01F078055 0.7 ENCODE 11.6 +76.2 76216 1.2 IRF2 ESRRA ZNF740 DDX20 ELF1 MEF2D CREB3 ID3 IRF1 TAF7 RNU6-1102P LOC100422537 GIPC2 NEXN LOC100131495
GH01F078082 0.6 ENCODE 11.2 +102.9 102898 0.6 MEF2D IKZF1 GIPC2 RNU6-1102P LOC100131495
GH01F078070 0.7 Ensembl ENCODE 11.2 +91.8 91807 2.1 PKNOX1 JUN CEBPB JUNB FEZF1 YY1 JUND ATF3 ZNF512 FOS GIPC2 ACTG1P21 MIGA1 RNA5SP21 IFI44 RNU6-1102P LOC100131495
GH01F078091 1.2 FANTOM5 11 +112.3 112303 0.4 RNF2 POLR2A L3MBTL2 SMARCA4 NFRKB IKZF1 GIPC2 GC01M078095 LOC100422537 RNA5SP22
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GIPC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GIPC2 Gene

Chromosome:
1
Start:
77,979,542 bp from pter
End:
78,138,449 bp from pter
Size:
158,908 bases
Orientation:
Plus strand

Genomic View for GIPC2 Gene

Genes around GIPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIPC2 Gene

Proteins for GIPC2 Gene

  • Protein details for GIPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF65-GIPC2_HUMAN
    Recommended name:
    PDZ domain-containing protein GIPC2
    Protein Accession:
    Q8TF65
    Secondary Accessions:
    • Q8IYD3
    • Q9NXS7

    Protein attributes for GIPC2 Gene

    Size:
    315 amino acids
    Molecular mass:
    34354 Da
    Quaternary structure:
    • Probably interacts with SEMA5A.
    SequenceCaution:
    • Sequence=BAA90933.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GIPC2 Gene

neXtProt entry for GIPC2 Gene

Post-translational modifications for GIPC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GIPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GIPC2 Gene

Domains & Families for GIPC2 Gene

Gene Families for GIPC2 Gene

Protein Domains for GIPC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GIPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF65

UniProtKB/Swiss-Prot:

GIPC2_HUMAN :
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the GIPC family.
Domain:
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the GIPC family.
genes like me logo Genes that share domains with GIPC2: view

Function for GIPC2 Gene

Gene Ontology (GO) - Molecular Function for GIPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GIPC2: view
genes like me logo Genes that share phenotypes with GIPC2: view

Animal Model Products

miRNA for GIPC2 Gene

miRTarBase miRNAs that target GIPC2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GIPC2

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GIPC2 Gene

Localization for GIPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIPC2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIPC2 Gene COMPARTMENTS Subcellular localization image for GIPC2 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GIPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GIPC2: view

Pathways & Interactions for GIPC2 Gene

SuperPathways for GIPC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GIPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GIPC2: view

No data available for Pathways by source and SIGNOR curated interactions for GIPC2 Gene

Transcripts for GIPC2 Gene

mRNA/cDNA for GIPC2 Gene

Unigene Clusters for GIPC2 Gene

GIPC PDZ domain containing family, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GIPC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIPC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for GIPC2 Gene

GeneLoc Exon Structure for
GIPC2
ECgene alternative splicing isoforms for
GIPC2

Expression for GIPC2 Gene

mRNA expression in normal human tissues for GIPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIPC2 Gene

This gene is overexpressed in Adrenal Gland (x6.8), Pancreas (x5.8), Spleen (x4.8), and Kidney - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for GIPC2 Gene

This gene is overexpressed in Spleen (16.2) and Fetal gut (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GIPC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of GIPC2 Gene:

GIPC2

SOURCE GeneReport for Unigene cluster for GIPC2 Gene:

Hs.659356

mRNA Expression by UniProt/SwissProt for GIPC2 Gene:

Q8TF65-GIPC2_HUMAN
Tissue specificity: Expressed at highest levels in ascending colon and at moderate levels in adult kidney. Expressed at low levels in adult pancreas and at very low levels in adult liver. Expression is down-regulated in several primary tumors, such as kidney, colon and rectal tumors.
genes like me logo Genes that share expression patterns with GIPC2: view

Primer Products

No data available for Protein tissue co-expression partners for GIPC2 Gene

Orthologs for GIPC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GIPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GIPC2 34 35
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia GIPC2 34 35
  • 87.29 (n)
dog
(Canis familiaris)
Mammalia GIPC2 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gipc2 34
  • 82.42 (n)
mouse
(Mus musculus)
Mammalia Gipc2 34 16 35
  • 81.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GIPC2 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GIPC2 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GIPC2 34 35
  • 70.3 (n)
lizard
(Anolis carolinensis)
Reptilia GIPC2 35
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia GIPC 34
zebrafish
(Danio rerio)
Actinopterygii gipc2 34 35
  • 67.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)02045 36
  • 49 (a)
kermit 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35D10.2 36
  • 36 (a)
F44D12.4 36
  • 35 (a)
gipc-1 35
  • 30 (a)
ManyToMany
gipc-2 35
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7918 34
Species where no ortholog for GIPC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GIPC2 Gene

ENSEMBL:
Gene Tree for GIPC2 (if available)
TreeFam:
Gene Tree for GIPC2 (if available)

Paralogs for GIPC2 Gene

Paralogs for GIPC2 Gene

(2) SIMAP similar genes for GIPC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GIPC2: view

Variants for GIPC2 Gene

Sequence variations from dbSNP and Humsavar for GIPC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001070 -- 78,052,748(+) AAGCA(A/T)AGTCA intron-variant
rs1001103 -- 78,054,205(-) ATAGC(A/G)GGTAT intron-variant
rs1001104 -- 78,054,191(-) GATTT(C/G)TGGAT intron-variant
rs1022103 -- 78,123,914(+) TGTTA(C/T)TGTTT intron-variant
rs1039865 -- 78,137,595(-) AGCTG(C/T)ACATG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GIPC2 Gene

Variant ID Type Subtype PubMed ID
dgv112n106 CNV deletion 24896259
esv1010689 CNV deletion 20482838
esv1368582 CNV deletion 17803354
esv2673736 CNV deletion 23128226
esv2750174 CNV deletion 23290073
esv3564493 CNV deletion 23714750
esv3586534 CNV loss 21293372
nsv1076554 CNV deletion 25765185
nsv159417 CNV deletion 16902084
nsv954769 CNV deletion 24416366

Variation tolerance for GIPC2 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIPC2 Gene

Disorders for GIPC2 Gene

Relevant External Links for GIPC2

Genetic Association Database (GAD)
GIPC2
Human Genome Epidemiology (HuGE) Navigator
GIPC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIPC2

No disorders were found for GIPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GIPC2 Gene

Publications for GIPC2 Gene

  1. Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit. (PMID: 11836570) Kirikoshi H. … Katoh M. (Int. J. Oncol. 2002) 2 3 4 22 64
  2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
  3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GIPC2 Gene

Sources for GIPC2 Gene

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