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GIPC1 Gene

protein-coding   GIFtS: 60
GCID: GC19M014600

GIPC PDZ Domain Containing Family, Member 1

(Previous names: chromosome 19 open reading frame 3, regulator of G-protein...)
(Previous symbols: C19orf3, RGS19IP1)
  Search for GIPC1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GIPC PDZ Domain Containing Family, Member 11 2     GLUT1CBP2
C19orf31 2 3 5     IIP-12
RGS19IP11 2 3 5     NIP2
GIPC2 3 5     SEMCAP2
Regulator Of G-Protein Signalling 19 Interacting Protein 11 2     SYNECTIIN2
Tax Interaction Protein 22 3     SYNECTIN2
TIP-22 3     GLUT1 C-Terminal Binding Protein2
GAIP C-Terminus-Interacting Protein2 3     IGF-1 Receptor Interacting Protein 12
RGS-GAIP-Interacting Protein2 3     PDZ Domain-Containing Protein GIPC12
RGS19-Interacting Protein 12 3     Synectin3
Chromosome 19 Open Reading Frame 31     

External Ids:    HGNC: 12261   Entrez Gene: 107552   Ensembl: ENSG000001231597   OMIM: 6050725   UniProtKB: O149083   

Export aliases for GIPC1 gene to outside databases

Previous GC identifers: GC19M014450 GC19M014592 GC19M014158 GC19M014593 GC19M014596


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GIPC1 Gene:
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008
(PubMed 18775991)).(supplied by OMIM, Apr 2009)

GeneCards Summary for GIPC1 Gene:
GIPC1 (GIPC PDZ domain containing family, member 1) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is GIPC2.

UniProtKB/Swiss-Prot: GIPC1_HUMAN, O14908
Function: May be involved in G protein-linked signaling

Gene Wiki entry for GIPC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the GIPC1 gene promoter:
         HOXA9   HOXA9B   Elk-1   MEF-2   C/EBPalpha   YY1   Meis-1b   MEF-2A   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGIPC1 promoter sequence
   Search Chromatin IP Primers for GIPC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GIPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

GIPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GIPC1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014600:  view genomic region     (about GC identifiers)

Start:
14,588,571 bp from pter      End:
14,606,944 bp from pter
Size:
18,374 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GIPC1_HUMAN, O14908 (See protein sequence)
Recommended Name: PDZ domain-containing protein GIPC1  
Size: 333 amino acids; 36049 Da
Subunit: Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C
(By similarity). Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain
Secondary accessions: A8K4I3 A8MZG3 Q9BTC9
Alternative splicing: 2 isoforms:  O14908-1   O14908-2   

Explore the universe of human proteins at neXtProt for GIPC1: NX_O14908

Explore proteomics data for GIPC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys80, Lys210
  • Modification sites at PhosphoSitePlus

  • See GIPC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_005707.1  NP_974197.1  NP_974198.1  NP_974199.1  NP_974223.1  

    ENSEMBL proteins: 
     ENSP00000376753   ENSP00000340698   ENSP00000466312   ENSP00000466747   ENSP00000467077  
     ENSP00000465003   ENSP00000468787   ENSP00000464879   ENSP00000466624   ENSP00000466105  
     ENSP00000376749   ENSP00000376748  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017379 UCP038083_PDZ
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry O14908

    ProtoNet protein and cluster: O14908

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: GIPC1_HUMAN, O14908
    Similarity: Belongs to the GIPC family
    Similarity: Contains 1 PDZ (DHR) domain


    Find genes that share domains with GIPC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GIPC1_HUMAN, O14908
    Function: May be involved in G protein-linked signaling

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0005102receptor binding IPI15459234
    GO:0005515protein binding IPI11441007
    GO:0017022myosin binding ISS--
    GO:0030165PDZ domain binding IEA--
         
    Find genes that share ontologies with GIPC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GIPC1:
     Decreased G3BP1 protein expres  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gipc1):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  muscle 
     renal/urinary system 

    Find genes that share phenotypes with GIPC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gipc1tm1Mvc for GIPC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GIPC1
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    miRNA
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    hsa-mir-18a-3p (MIRT040897)

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    hsa-let-7d hsa-miR-513a-5p hsa-miR-202 hsa-miR-25 hsa-miR-1271 hsa-let-7c hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidGIPC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GIPC1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GIPC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GIPC1_HUMAN, O14908: Cytoplasm. Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    plasma membrane2
    cytoskeleton1
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol ISS--
    GO:0005903brush border IEA--
    GO:0005938cell cortex IDA12857860
    GO:0008021synaptic vesicle ISS--

    Find genes that share ontologies with GIPC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GIPC1 About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    2Syndecan-4-mediated signaling events
    Syndecan-4-mediated signaling events
    3Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling
    4G protein signaling H RAS regulation pathway
    G protein signaling H RAS regulation pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GIPC1
        G-protein signaling H-RAS regulation pathway

    3 BioSystems Pathways for GIPC1
        TGF-beta Receptor Signaling Pathway
    Neurotrophic factor-mediated Trk receptor signaling
    Syndecan-4-mediated signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GIPC1
    Interactions:

        GeneGlobe Interaction Network for GIPC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GIPC1 (O149081, 2, 3 ENSP000003406984) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TYRP1P176431, 2, 3, ENSP000003735704EBI-373132,EBI-7900408 MINT-1784737 MINT-1784850 MINT-1784818 I2D: score=3 STRING: ENSP00000373570
    TGFBR3Q031671, 2, 3, ENSP000002123554EBI-373132,EBI-2852679 MINT-1785662 MINT-1785690 MINT-1785632 I2D: score=2 STRING: ENSP00000212355
    TPBGQ136412, 3, ENSP000003587654MINT-62472 MINT-62471 MINT-62470 I2D: score=3 STRING: ENSP00000358765
    SDC4P314312, 3, ENSP000003618184MINT-72943 I2D: score=4 STRING: ENSP00000361818
    BCRP112742, 3, ENSP000003035074MINT-69539 I2D: score=1 STRING: ENSP00000303507
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting ISS--
    GO:0007186G-protein coupled receptor signaling pathway NAS9770488
    GO:0007268synaptic transmission ISS--
    GO:0014047glutamate secretion ISS--
    GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway ISS--

    Find genes that share ontologies with GIPC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GIPC1

    1 Novoseek inferred chemical compound relationship for GIPC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 20.9 3 11251075 (1), 11956658 (1), 18314626 (1)



    Find genes that share compounds with GIPC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GIPC1 gene (6 alternative transcripts): 
    NM_202467.1  NM_005716.3  NM_202468.2  NM_202469.2  NM_202470.2  NM_202494.2  

    Unigene Cluster for GIPC1:

    GIPC PDZ domain containing family, member 1
    Hs.655012  [show with all ESTs]
    Unigene Representative Sequence: NM_005716
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393033(uc002myt.3 uc002myu.3) ENST00000345425(uc002myx.3)
    ENST00000585606 ENST00000589631 ENST00000586027 ENST00000591349 ENST00000589497
    ENST00000587210 ENST00000587969 ENST00000587811 ENST00000587934 ENST00000591245
    ENST00000393029(uc002myv.3 uc002myw.3) ENST00000393028(uc002myy.3)

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    Selected qRT-PCR Assays for microRNAs that regulate GIPC1 (see all 27):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-202 hsa-miR-25 hsa-miR-1271 hsa-let-7c hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidGIPC1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat GIPC1

    Additional mRNA sequence: 

    AF028824.1 AF089816.1 AK022585.1 AK290252.1 AK290948.1 BC000410.2 BC004226.2 BC012810.2 
    BC016169.1 

    18 DOTS entries:

    DT.86841734  DT.117283  DT.97797376  DT.100840336  DT.100708602  DT.100646640  DT.100646636  DT.95271713 
    DT.121419597  DT.91766542  DT.100677679  DT.121419577  DT.121419578  DT.91766535  DT.95271715  DT.95271721 
    DT.95271734  DT.97855162 

    Selected AceView cDNA sequences (see all 454):

    CR621243 AA160211 CD515797 BQ936616 CB242277 AA160212 AL526196 NM_202468 
    AA404606 AW001284 AW079213 CR614936 BQ231484 NM_202470 AW262654 BQ641411 
    CA426453 AI241188 BM817546 BM849178 BG035370 NM_202469 BE276976 BQ889774 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GIPC1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:                                            -     -     -                       -                                             
    SP2:                                                        -                       -                                             
    SP3:                          -     -     -     -     -     -                       -                                             
    SP4:                                            -     -     -                 -     -                                             
    SP5:                                            -     -     -                       -                                             


    ECgene alternative splicing isoforms for GIPC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GIPC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTTCCTAG
    GIPC1 Expression
    About this image

    GIPC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GIPC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655012

    UniProtKB/Swiss-Prot: GIPC1_HUMAN, O14908
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GIPC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GIPC1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gipc11 , 5 GIPC PDZ domain containing family, member 11, 5 87.99(n)1
    96.4(a)1
      8 (40.22 cM)5
    679031  NM_018771.31  NP_061241.11 
     836526785 
    lizard
    (Anolis carolinensis)
    Reptilia GIPC16
    GIPC PDZ domain containing family, member 1
    87(a)
    1 ↔ 1
    2(102629233-102649145)
    African clawed frog
    (Xenopus laevis)
    Amphibia Kermit2 developmental regulator 75.49(n)    AF215838.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561572 similar to regulator of G-protein signaling 19 interacting more 77.57(n)   393904  BC045953.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kermit6
    kermit
    47(a)
    1 → many
    2R(4034423-4044126)
    worm
    (Caenorhabditis elegans)
    Secernentea gipc-21 gipc-2 46.95(n)
    41.22(a)
      177865  NM_069409.5  NP_501810.2 


    ENSEMBL Gene Tree for GIPC1 (if available)
    TreeFam Gene Tree for GIPC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GIPC1 gene
    GIPC22  GIPC32  
    2 SIMAP similar genes for GIPC1 using alignment to 6 protein entries:     GIPC1_HUMAN (see all proteins):
    GIPC3    GIPC2

    Find genes that share paralogs with GIPC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GIPC1 (see all 517)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37607021,2
    C,F--14588237(-) AACCTC/TAGGCC 5 -- int17Minor allele frequency- T:0.19NA WA EA 366
    rs22413581,2
    C,F,H--14588476(-) AATTAG/CGAGCT 5 -- int114Minor allele frequency- C:0.23EA NS NA WA 2156
    rs1925582401,2
    --14588555(+) CCCACC/TCCGAA 5 -- int10--------
    rs1851694551,2
    --14588599(+) TGTTCA/CAGACA 5 -- ut310--------
    rs1419320991,2
    C--14588605(+) AGACAG/TCAAAT 5 -- ut310--------
    rs1150971231,2
    F--14588763(+) GAGGGG/AGCTCC 5 -- ut311Minor allele frequency- A:0.03WA 118
    rs1883859901,2
    --14588876(+) CAGAAC/TCCAAG 5 -- ut310--------
    rs1448578021,2
    --14588947(+) GTGGCC/TGCCCA 5 -- ut310--------
    rs1928308201,2
    --14588985(+) CCTGAC/TCCAGC 5 -- ut310--------
    rs1485833781,2
    C--14589018(+) ACAGGA/GGGGCC 5 -- ut310--------

    HapMap Linkage Disequilibrium report for GIPC1 (14588571 - 14606944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GIPC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665387CNV Deletion23128226
    esv2663771CNV Deletion23128226
    nsv833764CNV Loss17160897
    nsv527867CNV Loss19592680
    nsv911121CNV Loss21882294
    nsv470127CNV Loss18288195
    nsv817814CNV Loss17921354
    nsv911126CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GIPC1
    DNA2.0 Custom Variant and Variant Library Synthesis for GIPC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605072    OMIM disorders: --


    Find genes that share disorders with GIPC1           About GenesLikeMe

    6 Novoseek inferred disease relationships for GIPC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kidney tumor 51.4 1 11956658 (1)
    colorectal tumors 45.8 1 11956658 (1)
    pancreatic cancer 33.5 8 18314626 (2), 11956658 (1), 17079444 (1)
    primary tumor 13.5 2 11836570 (1), 11956658 (1)
    gastric cancer 12.7 4 11956658 (2), 12011974 (1)
    tumors 0 2 11956658 (1)

    Genetic Association Database (GAD): GIPC1
    Human Genome Epidemiology (HuGE) Navigator: GIPC1 (4 documents)

    Export disorders for GIPC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GIPC1 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with GIPC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP. (PubMed id 9770488)1, 2, 3 De Vries L.... Farquhar M.G. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. (PubMed id 9482110)1, 2, 3 Rousset R.... Jalinot P. (Oncogene 1998)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. [Analysis of polymorphic variants of gene GIPC1 CGG repeats in healthy individuals and in patients with breast cancer and non-small cell lung cancer]. (PubMed id 16240642)1, 4 MikhaA-lenko D.S....Zaletaev D.V. (Genetika 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. (PubMed id 11251075)1, 9 Lou X....Farquhar M.G. (Mol. Biol. Cell 2001)
    8. Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors. (PubMed id 11956658)1, 9 Kirikoshi H. and Katoh M. (Int. J. Mol. Med. 2002)
    9. [GIPC: a new target for therapy in pancreatic adenocarcinoma?]. (PubMed id 18314626)1, 9 Muders M.H....Mukhopadhyay D. (Verh Dtsch Ges Pathol 2007)
    10. TRP1 interacting PDZ-domain protein GIPC forms oligomers and is localized to intracellular vesicles in human melanocytes. (PubMed id 16962991)1, 9 Kedlaya R.H....Setaluri V. (Arch. Biochem. Biophys. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10755 HGNC: 1226 AceView: RGS19IP1 Ensembl:ENSG00000123159 euGenes: HUgn10755
    ECgene: GIPC1 H-InvDB: GIPC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GIPC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GIPC1 gene:
    Search GeneIP for patents involving GIPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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