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Aliases for GIP Gene

Aliases for GIP Gene

  • Gastric Inhibitory Polypeptide 2 3 5
  • Glucose-Dependent Insulinotropic Polypeptide 2 4
  • Incretin Hormone 4

External Ids for GIP Gene

Previous GeneCards Identifiers for GIP Gene

  • GC17M046748
  • GC17M049516
  • GC17M047377
  • GC17M047510
  • GC17M044390
  • GC17M047037
  • GC17M042403

Summaries for GIP Gene

Entrez Gene Summary for GIP Gene

  • This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]

GeneCards Summary for GIP Gene

GIP (Gastric Inhibitory Polypeptide) is a Protein Coding gene. Diseases associated with GIP include Dumping Syndrome and Postgastrectomy Syndrome. Among its related pathways are Presynaptic function of Kainate receptors and Peptide ligand-binding receptors. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for GIP Gene

  • Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIP Gene

Genomics for GIP Gene

Regulatory Elements for GIP Gene

Enhancers for GIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G048970 1.7 FANTOM5 Ensembl ENCODE 0.7 -3.7 -3717 3.7 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF548 FOS DEK SUMO2P17 UBE2Z ENSG00000262837 ENSG00000230532 TTLL6 PHOSPHO1 IGF2BP1 SNF8 GIP
GH17G048960 1.2 Ensembl ENCODE 0.4 +7.1 7105 1.6 HDAC1 FOXA2 ARID4B KLF17 SIN3A ZNF48 RAD21 RARA ZNF121 GATA2 UBE2Z ATP5G1 NFE2L1 ENSG00000238804 GIP
GH17G048990 0.8 Ensembl 0.3 -22.3 -22305 0.2 HDGF PKNOX1 FOXA2 NFRKB ZBTB40 CHAMP1 ZNF366 U2AF2 SP3 NCOA1 IGF2BP1 GIP
GH17G048992 0.7 dbSUPER 0.3 -24.0 -24017 1.0 SMARCA5 NFRKB CHD1 MAFG BMI1 ZNF335 JUND PRDM6 ZNF316 CREB1 SNF8 IGF2BP1 GIP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GIP on UCSC Golden Path with GeneCards custom track

Genomic Location for GIP Gene

48,958,554 bp from pter
48,968,596 bp from pter
10,043 bases
Minus strand

Genomic View for GIP Gene

Genes around GIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIP Gene

Proteins for GIP Gene

  • Protein details for GIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gastric inhibitory polypeptide
    Protein Accession:
    Secondary Accessions:
    • Q4VB42
    • Q6NTD3

    Protein attributes for GIP Gene

    153 amino acids
    Molecular mass:
    17108 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GIP Gene

neXtProt entry for GIP Gene

Post-translational modifications for GIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GIP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for GIP

Protein Products

  • Abcam proteins for GIP

No data available for DME Specific Peptides for GIP Gene

Domains & Families for GIP Gene

Gene Families for GIP Gene

Protein Domains for GIP Gene

Suggested Antigen Peptide Sequences for GIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glucagon family.
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with GIP: view

Function for GIP Gene

Molecular function for GIP Gene

GENATLAS Biochemistry:
glucose-dependent insulinotropic polypeptide
UniProtKB/Swiss-Prot Function:
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

Gene Ontology (GO) - Molecular Function for GIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS,IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GIP: view
genes like me logo Genes that share phenotypes with GIP: view

Animal Models for GIP Gene

MGI Knock Outs for GIP:

Animal Model Products

  • Taconic Biosciences Mouse Models for GIP

CRISPR Products

miRNA for GIP Gene

miRTarBase miRNAs that target GIP

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GIP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GIP Gene

Localization for GIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GIP gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
cytosol 3
plasma membrane 2
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with GIP: view

Pathways & Interactions for GIP Gene

genes like me logo Genes that share pathways with GIP: view

Gene Ontology (GO) - Biological Process for GIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 2890159
GO:0007565 female pregnancy IEA --
GO:0007613 memory IEA --
GO:0008344 adult locomotory behavior IEA --
GO:0009743 response to carbohydrate IEA --
genes like me logo Genes that share ontologies with GIP: view

No data available for SIGNOR curated interactions for GIP Gene

Drugs & Compounds for GIP Gene

(81) Drugs for GIP Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma Cyclooxygenase inhibitor; may be selective for COX-3 1026
Atropine Approved, Vet_approved Pharma Antagonist MAChRs antagonist 136
Bethanechol Approved Pharma Full agonist, Agonist 4
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist 2171
Hydrocortisone Approved, Vet_approved Pharma Agonist Adrenal glucocorticoid; immunosuppressant 667

(10) Additional Compounds for GIP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GIP: view

Transcripts for GIP Gene

mRNA/cDNA for GIP Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GIP Gene

Gastric inhibitory polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GIP

Alternative Splicing Database (ASD) splice patterns (SP) for GIP Gene

No ASD Table

Relevant External Links for GIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIP Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x50.6).

NURSA nuclear receptor signaling pathways regulating expression of GIP Gene:


SOURCE GeneReport for Unigene cluster for GIP Gene:


Evidence on tissue expression from TISSUES for GIP Gene

  • Intestine(3.6)
  • Pancreas(3.2)
  • Blood(3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with GIP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GIP Gene

Orthologs for GIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for GIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GIP 34 35
  • 99.56 (n)
(Bos Taurus)
Mammalia GIP 34 35
  • 80.79 (n)
(Canis familiaris)
Mammalia GIP 34 35
  • 78.67 (n)
(Rattus norvegicus)
Mammalia Gip 34
  • 77.08 (n)
(Mus musculus)
Mammalia Gip 34 16 35
  • 76.85 (n)
(Monodelphis domestica)
Mammalia GIP 35
  • 47 (a)
Species where no ortholog for GIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GIP Gene

Gene Tree for GIP (if available)
Gene Tree for GIP (if available)

Paralogs for GIP Gene

No data available for Paralogs for GIP Gene

Variants for GIP Gene

Sequence variations from dbSNP and Humsavar for GIP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000031676 -- 48,962,433(+) GTGCA(A/G)TCTCA intron-variant
rs1000106420 -- 48,962,152(+) GCAAC(C/T)TCTGC intron-variant
rs1001334309 -- 48,966,667(+) CCGAG(C/T)GTGGT intron-variant
rs1001397478 -- 48,958,428(+) TTAAG(A/C/T)GAATC downstream-variant-500B
rs1001468858 -- 48,967,780(+) GGTGC(A/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIP Gene

Variant ID Type Subtype PubMed ID
dgv14e194 CNV deletion 18987734
dgv51n6 CNV deletion 16902084
esv1008009 CNV deletion 20482838
esv1297877 CNV deletion 17803354
esv1331947 CNV deletion 17803354
esv21954 CNV gain+loss 19812545
esv2237705 CNV deletion 18987734
esv2651898 CNV deletion 19546169
esv2716019 CNV deletion 23290073
esv3554512 CNV deletion 23714750
esv3754 CNV loss 18987735
nsv1109086 CNV deletion 24896259
nsv2073 CNV insertion 18451855
nsv482204 CNV loss 20164927
nsv482969 CNV loss 15286789
nsv820855 CNV deletion 20802225
nsv833472 CNV gain 17160897

Variation tolerance for GIP Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIP Gene

Disorders for GIP Gene

MalaCards: The human disease database

(11) MalaCards diseases for GIP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dumping syndrome
  • dumping syndrome
postgastrectomy syndrome
  • postgastric surgery syndrome
pancreatic cholera
  • excessive vasoactive intestinal peptide secretion
endocrine pancreas disease
  • disorder of endocrine pancreas
glucose metabolism disease
  • disorder of glucose metabolism
- elite association - COSMIC cancer census association via MalaCards
Search GIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for GIP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIP Gene

Publications for GIP Gene

  1. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. (PMID: 17624916) Nitz I. … DAPring F. (Mol Nutr Food Res 2007) 3 22 46 64
  2. Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene. (PMID: 2739653) Inagaki N. … Imura H. (Mol. Endocrinol. 1989) 2 3 4 64
  3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 64
  4. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  5. A case-control analysis of common variants in GIP with type 2 diabetes and related biochemical parameters in a South Indian population. (PMID: 20673334) Sugunan D. … Gopalakrishnapillai A. (BMC Med. Genet. 2010) 3 46 64

Products for GIP Gene

Sources for GIP Gene

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