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Aliases for GIP Gene

Aliases for GIP Gene

  • Gastric Inhibitory Polypeptide 2 3 5
  • Glucose-Dependent Insulinotropic Polypeptide 2 4
  • Incretin Hormone 4

External Ids for GIP Gene

Previous GeneCards Identifiers for GIP Gene

  • GC17M046748
  • GC17M049516
  • GC17M047377
  • GC17M047510
  • GC17M044390
  • GC17M047037
  • GC17M042403

Summaries for GIP Gene

Entrez Gene Summary for GIP Gene

  • This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]

GeneCards Summary for GIP Gene

GIP (Gastric Inhibitory Polypeptide) is a Protein Coding gene. Diseases associated with GIP include ventricular tachycardia, idiopathic and dumping syndrome. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for GIP Gene

  • Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIP Gene

Genomics for GIP Gene

Regulatory Elements for GIP Gene

Genomic Location for GIP Gene

Chromosome:
17
Start:
48,958,554 bp from pter
End:
48,968,596 bp from pter
Size:
10,043 bases
Orientation:
Minus strand

Genomic View for GIP Gene

Genes around GIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIP Gene

Proteins for GIP Gene

  • Protein details for GIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09681-GIP_HUMAN
    Recommended name:
    Gastric inhibitory polypeptide
    Protein Accession:
    P09681
    Secondary Accessions:
    • Q4VB42
    • Q6NTD3

    Protein attributes for GIP Gene

    Size:
    153 amino acids
    Molecular mass:
    17108 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GIP Gene

neXtProt entry for GIP Gene

Proteomics data for GIP Gene at MOPED

Post-translational modifications for GIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GIP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GIP Gene

Domains & Families for GIP Gene

Gene Families for GIP Gene

Protein Domains for GIP Gene

Suggested Antigen Peptide Sequences for GIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09681

UniProtKB/Swiss-Prot:

GIP_HUMAN :
  • Belongs to the glucagon family.
Family:
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with GIP: view

Function for GIP Gene

Molecular function for GIP Gene

GENATLAS Biochemistry:
glucose-dependent insulinotropic polypeptide
UniProtKB/Swiss-Prot Function:
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
genes like me logo Genes that share phenotypes with GIP: view

Animal Models for GIP Gene

MGI Knock Outs for GIP:

Animal Model Products

miRNA for GIP Gene

miRTarBase miRNAs that target GIP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GIP Gene

Localization for GIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIP Gene COMPARTMENTS Subcellular localization image for GIP gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
cytosol 3
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with GIP: view

Pathways & Interactions for GIP Gene

genes like me logo Genes that share pathways with GIP: view

Pathways by source for GIP Gene

Gene Ontology (GO) - Biological Process for GIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 2890159
GO:0007613 memory IEA --
GO:0009743 response to carbohydrate IEA --
GO:0009749 response to glucose IEA --
GO:0010269 response to selenium ion IEA --
genes like me logo Genes that share ontologies with GIP: view

No data available for SIGNOR curated interactions for GIP Gene

Drugs & Compounds for GIP Gene

(80) Drugs for GIP Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma 864
Atropine Approved Pharma Antagonist MAChRs antagonist 115
Bethanechol Approved Pharma Full agonist, Agonist 3
Dexamethasone Approved, Investigational Pharma Agonist 1909
Hydrocortisone Approved Pharma Agonist 583

(11) Additional Compounds for GIP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GIP: view

Transcripts for GIP Gene

mRNA/cDNA for GIP Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GIP Gene

Gastric inhibitory polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GIP Gene

No ASD Table

Relevant External Links for GIP Gene

GeneLoc Exon Structure for
GIP
ECgene alternative splicing isoforms for
GIP

Expression for GIP Gene

mRNA expression in normal human tissues for GIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIP Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x50.6).

SOURCE GeneReport for Unigene cluster for GIP Gene Hs.1454

genes like me logo Genes that share expression patterns with GIP: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GIP Gene

Orthologs for GIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for GIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GIP 35
  • 99.56 (n)
  • 99.35 (a)
GIP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GIP 36
  • 72 (a)
OneToOne
GIP 35
  • 80.79 (n)
  • 73.61 (a)
dog
(Canis familiaris)
Mammalia GIP 35
  • 78.67 (n)
  • 70.67 (a)
GIP 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gip 16
Gip 36
  • 73 (a)
OneToOne
Gip 35
  • 76.85 (n)
  • 73.61 (a)
oppossum
(Monodelphis domestica)
Mammalia GIP 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gip 35
  • 77.08 (n)
  • 75.69 (a)
Species with no ortholog for GIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GIP Gene

ENSEMBL:
Gene Tree for GIP (if available)
TreeFam:
Gene Tree for GIP (if available)

Paralogs for GIP Gene

No data available for Paralogs for GIP Gene

Variants for GIP Gene

Sequence variations from dbSNP and Humsavar for GIP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2291725 - 48,961,770(+) TTGAC(C/T)GGCCA reference, missense
rs35703924 - 48,960,901(-) GACAA(A/G)CCTCT reference, missense
rs937301 -- 48,968,914(-) AAGTA(C/T)CCCTT upstream-variant-2KB
rs1965983 -- 48,962,971(+) gcatg(A/G)tggcg intron-variant
rs1973405 -- 48,963,099(+) AAAAA(A/G)AATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIP Gene

Variant ID Type Subtype PubMed ID
nsv482969 CNV Loss 15286789
nsv833472 CNV Gain 17160897
nsv2073 CNV Insertion 18451855
nsv482204 CNV Loss 20164927
esv2651898 CNV Deletion 19546169
dgv14e194 CNV Deletion 18987734
esv2237705 CNV Deletion 18987734
esv21954 CNV Gain+Loss 19812545
nsv820855 CNV Deletion 20802225
esv3754 CNV Deletion 18987735
esv2716019 CNV Deletion 23290073
esv1008009 CNV Deletion 20482838
dgv51n6 CNV Loss 16902084
esv1331947 CNV Deletion 17803354
esv1297877 CNV Deletion 17803354

Variation tolerance for GIP Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIP Gene

HapMap Linkage Disequilibrium report
GIP
Human Gene Mutation Database (HGMD)
GIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIP Gene

Disorders for GIP Gene

MalaCards: The human disease database

(13) MalaCards diseases for GIP Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ventricular tachycardia, idiopathic
  • familial ventricular tachycardia
dumping syndrome
  • dumping syndrome
postgastrectomy syndrome
  • postgastric surgery syndrome
somatostatinoma
  • pancreatic somatostatinoma
endocrine pancreas disease
  • disorder of endocrine pancreas
- elite association - COSMIC cancer census association via MalaCards
Search GIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for GIP

Genetic Association Database (GAD)
GIP
Human Genome Epidemiology (HuGE) Navigator
GIP
Tumor Gene Database (TGDB):
GIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIP
genes like me logo Genes that share disorders with GIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIP Gene

Publications for GIP Gene

  1. Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene. (PMID: 2739653) Inagaki N. … Imura H. (Mol. Endocrinol. 1989) 2 3 4 67
  2. Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion. (PMID: 20138041) Fujita Y. … Kieffer T.J. (Gastroenterology 2010) 3 23
  3. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. (PMID: 19351807) Kelly K.R. … Kirwan J.P. (Am. J. Physiol. Endocrinol. Metab. 2009) 3 23
  4. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. (PMID: 17624916) Nitz I. … DAPring F. (Mol Nutr Food Res 2007) 3 23
  5. Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase I^ in rodent and human I^-cells. (PMID: 25288806) Kolic J. … MacDonald P.E. (J. Biol. Chem. 2014) 3

Products for GIP Gene

Sources for GIP Gene

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