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Aliases for GINS4 Gene

Aliases for GINS4 Gene

  • GINS Complex Subunit 4 2 3 4 5
  • SLD5 3 4
  • DNA Replication Complex GINS Protein SLD5 3
  • GINS Complex Subunit 4 (Sld5 Homolog) 2
  • SLD5 Homolog 3

External Ids for GINS4 Gene

Previous GeneCards Identifiers for GINS4 Gene

  • GC08P041506
  • GC08P041388
  • GC08P039914

Summaries for GINS4 Gene

Entrez Gene Summary for GINS4 Gene

  • The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

GeneCards Summary for GINS4 Gene

GINS4 (GINS Complex Subunit 4) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include 3-5 DNA helicase activity.

UniProtKB/Swiss-Prot for GINS4 Gene

  • The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GINS4 Gene

Genomics for GINS4 Gene

Regulatory Elements for GINS4 Gene

Enhancers for GINS4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G041506 1.4 Ensembl ENCODE dbSUPER 11.8 -21.1 -21121 2.2 HDAC1 TBP PKNOX1 CBX3 SIN3A RFX5 YY1 TCF12 ZNF766 GATA2 GINS4 GOLGA7 KRT18P37 PIR43931
GH08G041609 0.9 ENCODE 12.5 +80.8 80785 1.9 HDAC1 FOXA2 TBL1XR1 ZFP64 THRB RAD21 YY1 RARA SCRT2 SP5 NKX6-3 GPAT4 ENSG00000253174 GINS4 LOC102723729 PIR42833 ENSG00000264578
GH08G041590 1 FANTOM5 Ensembl 11 +61.4 61394 0.8 NFIB FEZF1 ZIC2 ZNF366 SCRT2 ZSCAN5C ZNF263 SCRT1 ZNF680 TSHZ1 GPAT4 ENSG00000254165 GINS4 NKX6-3 KAT6A GOLGA7 LOC102723729 PIR42833
GH08G041507 0.9 ENCODE dbSUPER 11.5 -22.7 -22677 0.1 MTA2 CBFB ZBED1 JUNB TBX21 EP300 CBX5 IKZF1 EED TCF7 GINS4 KRT18P37 PIR43931
GH08G041505 0.9 ENCODE dbSUPER 11.5 -23.4 -23416 1.3 MTA2 CBFB ZBED1 JUNB TBX21 EP300 CBX5 IKZF1 EED TCF7 GINS4 GOLGA7 KRT18P37 PIR43931
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GINS4 on UCSC Golden Path with GeneCards custom track

Promoters for GINS4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223952 -5 1200 HDGF ARID4B SIN3A DMAP1 ZNF143 FOS DEK SP3 SP5 MXD4

Genomic Location for GINS4 Gene

Chromosome:
8
Start:
41,529,206 bp from pter
End:
41,545,046 bp from pter
Size:
15,841 bases
Orientation:
Plus strand

Genomic View for GINS4 Gene

Genes around GINS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GINS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GINS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GINS4 Gene

Proteins for GINS4 Gene

  • Protein details for GINS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRT9-SLD5_HUMAN
    Recommended name:
    DNA replication complex GINS protein SLD5
    Protein Accession:
    Q9BRT9
    Secondary Accessions:
    • B2R8H5
    • D3DSY0
    • Q8N648

    Protein attributes for GINS4 Gene

    Size:
    223 amino acids
    Molecular mass:
    26047 Da
    Quaternary structure:
    • Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS1. GINS complex interacts with DNA primase in vitro.

    Three dimensional structures from OCA and Proteopedia for GINS4 Gene

    Alternative splice isoforms for GINS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GINS4 Gene

Post-translational modifications for GINS4 Gene

  • Ubiquitination at isoforms=164
  • Modification sites at PhosphoSitePlus

Other Protein References for GINS4 Gene

No data available for DME Specific Peptides for GINS4 Gene

Domains & Families for GINS4 Gene

Gene Families for GINS4 Gene

Protein Domains for GINS4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GINS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRT9

UniProtKB/Swiss-Prot:

SLD5_HUMAN :
  • Belongs to the GINS4/SLD5 family.
Family:
  • Belongs to the GINS4/SLD5 family.
genes like me logo Genes that share domains with GINS4: view

Function for GINS4 Gene

Molecular function for GINS4 Gene

UniProtKB/Swiss-Prot Function:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.
UniProtKB/Swiss-Prot Induction:
Significantly up-regulated in aggressive melanomas.

Gene Ontology (GO) - Molecular Function for GINS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043138 contributes_to 3-5 DNA helicase activity IBA --
genes like me logo Genes that share ontologies with GINS4: view
genes like me logo Genes that share phenotypes with GINS4: view

Animal Models for GINS4 Gene

MGI Knock Outs for GINS4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GINS4 Gene

Localization for GINS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GINS4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GINS4 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GINS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000811 GINS complex IBA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0031298 replication fork protection complex IBA --
genes like me logo Genes that share ontologies with GINS4: view

Pathways & Interactions for GINS4 Gene

genes like me logo Genes that share pathways with GINS4: view

Pathways by source for GINS4 Gene

Gene Ontology (GO) - Biological Process for GINS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000727 double-strand break repair via break-induced replication IBA --
GO:0001833 inner cell mass cell proliferation IEA --
GO:0006260 DNA replication IEA --
GO:0006270 DNA replication initiation IBA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with GINS4: view

No data available for SIGNOR curated interactions for GINS4 Gene

Drugs & Compounds for GINS4 Gene

No Compound Related Data Available

Transcripts for GINS4 Gene

Unigene Clusters for GINS4 Gene

GINS complex subunit 4 (Sld5 homolog):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GINS4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1:
SP2: -
SP3:

Relevant External Links for GINS4 Gene

GeneLoc Exon Structure for
GINS4
ECgene alternative splicing isoforms for
GINS4

Expression for GINS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GINS4 Gene

Protein differential expression in normal tissues from HIPED for GINS4 Gene

This gene is overexpressed in Fetal testis (49.2) and Fetal heart (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GINS4 Gene



Protein tissue co-expression partners for GINS4 Gene

NURSA nuclear receptor signaling pathways regulating expression of GINS4 Gene:

GINS4

SOURCE GeneReport for Unigene cluster for GINS4 Gene:

Hs.656996

Evidence on tissue expression from TISSUES for GINS4 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with GINS4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GINS4 Gene

Orthologs for GINS4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GINS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GINS4 34 35
  • 99.55 (n)
mouse
(Mus musculus)
Mammalia Gins4 34 16 35
  • 87.14 (n)
rat
(Rattus norvegicus)
Mammalia Gins4 34
  • 86.7 (n)
dog
(Canis familiaris)
Mammalia GINS4 34 35
  • 86.55 (n)
oppossum
(Monodelphis domestica)
Mammalia GINS4 35
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GINS4 34 35
  • 84.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GINS4 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves GINS4 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GINS4 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gins4 34
  • 70.44 (n)
Str.6917 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1783 34
zebrafish
(Danio rerio)
Actinopterygii gins4 34 35
  • 71.43 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3995 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001166 34
  • 50.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sld5 34 35
  • 50.68 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y113G7B.24 34
  • 45.71 (n)
sld-5 35
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLD5 35 37
  • 18 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SLD5 34
  • 46.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7958 35
  • 45 (a)
OneToOne
Species where no ortholog for GINS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GINS4 Gene

ENSEMBL:
Gene Tree for GINS4 (if available)
TreeFam:
Gene Tree for GINS4 (if available)

Paralogs for GINS4 Gene

No data available for Paralogs for GINS4 Gene

Variants for GINS4 Gene

Sequence variations from dbSNP and Humsavar for GINS4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000262073 -- 41,544,986(+) AGACT(G/T)GTTTT intron-variant, utr-variant-3-prime
rs1000419496 -- 41,530,507(+) GTGGG(G/T)TCAGT intron-variant
rs1000702407 -- 41,532,427(+) GGCTC(A/C/G)TGCCT intron-variant
rs1000805511 -- 41,545,255(+) TCATC(C/T)GTCAT intron-variant, downstream-variant-500B
rs1000866372 -- 41,534,597(+) CACTA(A/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GINS4 Gene

Variant ID Type Subtype PubMed ID
dgv2070e212 CNV loss 25503493
esv3576565 CNV gain 25503493
nsv831299 CNV loss 17160897

Variation tolerance for GINS4 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GINS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GINS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GINS4 Gene

Disorders for GINS4 Gene

Relevant External Links for GINS4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GINS4

No disorders were found for GINS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GINS4 Gene

Publications for GINS4 Gene

  1. Structure and function of the GINS complex, a key component of the eukaryotic replisome. (PMID: 20070258) MacNeill S.A. (Biochem. J. 2010) 2 3 64
  2. Structure of the human GINS complex and its assembly and functional interface in replication initiation. (PMID: 17417653) Kamada K. … Hanaoka F. (Nat. Struct. Mol. Biol. 2007) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for GINS4 Gene

Sources for GINS4 Gene

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