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Aliases for GINS4 Gene

Aliases for GINS4 Gene

  • GINS Complex Subunit 4 2 3 4
  • GINS Complex Subunit 4 (Sld5 Homolog) 2 3 5
  • SLD5 3 4
  • SLD5 Homolog 3

External Ids for GINS4 Gene

Previous GeneCards Identifiers for GINS4 Gene

  • GC08P041506
  • GC08P041388
  • GC08P039914

Summaries for GINS4 Gene

Entrez Gene Summary for GINS4 Gene

  • The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

GeneCards Summary for GINS4 Gene

GINS4 (GINS Complex Subunit 4) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include 3-5 DNA helicase activity.

UniProtKB/Swiss-Prot for GINS4 Gene

  • The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GINS4 Gene

Genomics for GINS4 Gene

Regulatory Elements for GINS4 Gene

Enhancers for GINS4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GINS4 on UCSC Golden Path with GeneCards custom track

Promoters for GINS4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GINS4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GINS4 Gene

Chromosome:
8
Start:
41,529,206 bp from pter
End:
41,545,046 bp from pter
Size:
15,841 bases
Orientation:
Plus strand

Genomic View for GINS4 Gene

Genes around GINS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GINS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GINS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GINS4 Gene

Proteins for GINS4 Gene

  • Protein details for GINS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRT9-SLD5_HUMAN
    Recommended name:
    DNA replication complex GINS protein SLD5
    Protein Accession:
    Q9BRT9
    Secondary Accessions:
    • B2R8H5
    • D3DSY0
    • Q8N648

    Protein attributes for GINS4 Gene

    Size:
    223 amino acids
    Molecular mass:
    26047 Da
    Quaternary structure:
    • Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS1. GINS complex interacts with DNA primase in vitro.

    Three dimensional structures from OCA and Proteopedia for GINS4 Gene

    Alternative splice isoforms for GINS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GINS4 Gene

Proteomics data for GINS4 Gene at MOPED

Post-translational modifications for GINS4 Gene

  • Ubiquitination at Lys 164
  • Modification sites at PhosphoSitePlus

Other Protein References for GINS4 Gene

Antibody Products

No data available for DME Specific Peptides for GINS4 Gene

Domains & Families for GINS4 Gene

Gene Families for GINS4 Gene

Protein Domains for GINS4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GINS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRT9

UniProtKB/Swiss-Prot:

SLD5_HUMAN :
  • Belongs to the GINS4/SLD5 family.
Family:
  • Belongs to the GINS4/SLD5 family.
genes like me logo Genes that share domains with GINS4: view

Function for GINS4 Gene

Molecular function for GINS4 Gene

UniProtKB/Swiss-Prot Function:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.
UniProtKB/Swiss-Prot Induction:
Significantly up-regulated in aggressive melanomas.
genes like me logo Genes that share phenotypes with GINS4: view

Animal Models for GINS4 Gene

MGI Knock Outs for GINS4:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GINS4 Gene

Localization for GINS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GINS4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GINS4 Gene COMPARTMENTS Subcellular localization image for GINS4 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GINS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GINS4: view

Pathways & Interactions for GINS4 Gene

genes like me logo Genes that share pathways with GINS4: view

Pathways by source for GINS4 Gene

Gene Ontology (GO) - Biological Process for GINS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001833 inner cell mass cell proliferation IEA --
GO:0006270 DNA replication initiation IBA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with GINS4: view

No data available for SIGNOR curated interactions for GINS4 Gene

Drugs & Compounds for GINS4 Gene

No Compound Related Data Available

Transcripts for GINS4 Gene

Unigene Clusters for GINS4 Gene

GINS complex subunit 4 (Sld5 homolog):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GINS4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1:
SP2: -
SP3:

Relevant External Links for GINS4 Gene

GeneLoc Exon Structure for
GINS4
ECgene alternative splicing isoforms for
GINS4

Expression for GINS4 Gene

mRNA expression in normal human tissues for GINS4 Gene

Protein differential expression in normal tissues from HIPED for GINS4 Gene

This gene is overexpressed in Fetal testis (49.2) and Fetal heart (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GINS4 Gene



SOURCE GeneReport for Unigene cluster for GINS4 Gene Hs.656996

genes like me logo Genes that share expression patterns with GINS4: view

Protein tissue co-expression partners for GINS4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GINS4 Gene

Orthologs for GINS4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GINS4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GINS4 35
  • 84.45 (n)
  • 84.75 (a)
GINS4 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GINS4 35
  • 86.55 (n)
  • 88.79 (a)
GINS4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gins4 35
  • 87.14 (n)
  • 87.89 (a)
Gins4 16
Gins4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GINS4 35
  • 99.55 (n)
  • 99.55 (a)
GINS4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gins4 35
  • 86.7 (n)
  • 88.79 (a)
oppossum
(Monodelphis domestica)
Mammalia GINS4 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GINS4 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves GINS4 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GINS4 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gins4 35
  • 70.44 (n)
  • 73.3 (a)
Str.6917 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1783 35
zebrafish
(Danio rerio)
Actinopterygii gins4 35
  • 71.43 (n)
  • 73.81 (a)
gins4 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3995 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001166 35
  • 50.83 (n)
  • 42.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sld5 35
  • 50.68 (n)
  • 41.33 (a)
Sld5 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y113G7B.24 35
  • 45.71 (n)
  • 34.76 (a)
sld-5 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLD5 36
  • 18 (a)
OneToOne
SLD5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SLD5 35
  • 46.93 (n)
  • 35.82 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7958 36
  • 45 (a)
OneToOne
Species with no ortholog for GINS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GINS4 Gene

ENSEMBL:
Gene Tree for GINS4 (if available)
TreeFam:
Gene Tree for GINS4 (if available)

Paralogs for GINS4 Gene

No data available for Paralogs for GINS4 Gene

Variants for GINS4 Gene

Sequence variations from dbSNP and Humsavar for GINS4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2081499 -- 41,532,696(-) caaca(A/C)gcctg intron-variant
rs3808636 -- 41,528,946(+) CCGCC(G/T)CTCCC upstream-variant-2KB
rs3808637 -- 41,529,012(+) CCGCA(C/G)AGCGG upstream-variant-2KB
rs3808638 -- 41,529,101(+) AGGCC(G/T)CCGCG upstream-variant-2KB
rs3808639 -- 41,529,155(+) CCCCG(C/T)TCTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GINS4 Gene

Variant ID Type Subtype PubMed ID
nsv831299 CNV Loss 17160897

Variation tolerance for GINS4 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GINS4 Gene

HapMap Linkage Disequilibrium report
GINS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GINS4 Gene

Disorders for GINS4 Gene

Relevant External Links for GINS4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GINS4

No disorders were found for GINS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GINS4 Gene

Publications for GINS4 Gene

  1. Structure and function of the GINS complex, a key component of the eukaryotic replisome. (PMID: 20070258) MacNeill S.A. (Biochem. J. 2010) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7. (PMID: 24299456) Kusunoki S. … Ishimi Y. (FEBS J. 2014) 3

Products for GINS4 Gene

Sources for GINS4 Gene

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