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GINS3 Gene

protein-coding   GIFtS: 50
GCID: GC16P058328

GINS Complex Subunit 3 (Psf3 Homolog)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
GINS Complex Subunit 3 (Psf3 Homolog)1 2
PSF32 3 5
DNA Replication Complex GINS Protein PSF32
GINS Complex Subunit 33

External Ids:    HGNC: 258511   Entrez Gene: 647852   Ensembl: ENSG000001819387   OMIM: 6106105   UniProtKB: Q9BRX53   
ORGUL members:         

Export aliases for GINS3 gene to outside databases

Previous GC identifers: GC16P056985 GC16P058426 GC16P044295


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GINS3 Gene:
This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of
DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding
distinct isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for GINS3 Gene:
GINS3 (GINS complex subunit 3 (Psf3 homolog)) is a protein-coding gene. Diseases associated with GINS3 include long qt syndrome, and lung adenocarcinoma.

UniProtKB/Swiss-Prot: PSF3_HUMAN, Q9BRX5
Function: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA
replication forks. GINS complex seems to bind preferentially to single-stranded DNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GINS3 gene promoter:
         Nkx3-1 v2   Nkx3-1 v4   POU2F1   Pax-5   HSF2   POU2F1a   HFH-1   Nkx3-1 v3   CUTL1   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGINS3 promoter sequence
   Search Chromatin IP Primers for GINS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GINS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21

GINS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GINS3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P058328:  view genomic region     (about GC identifiers)

Start:
58,328,984 bp from pter      End:
58,440,048 bp from pter
Size:
111,065 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PSF3_HUMAN, Q9BRX5 (See protein sequence)
Recommended Name: DNA replication complex GINS protein PSF3  
Size: 216 amino acids; 24535 Da
Subunit: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable
subcomplex with GINS2. GINS complex interacts with DNA primase in vitro
Mass spectrometry: Mass=98373; Mass_error=13; Method=Electrospray; Range=1-216; Note=This is the measured mass for
the GINS complex; Source=PubMed:17557111;
3 PDB 3D structures from and Proteopedia for GINS3:
2E9X (3D)        2EHO (3D)        2Q9Q (3D)    
Secondary accessions: B2RDP3 E9PB21 Q9H870
Alternative splicing: 3 isoforms:  Q9BRX5-1   Q9BRX5-2   Q9BRX5-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for GINS3: NX_Q9BRX5

Explore proteomics data for GINS3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys74, Lys90, Lys181
  • Modification sites at PhosphoSitePlus

  • See GINS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001119601.1  NP_001119602.1  NP_073607.2  

    ENSEMBL proteins: 
     ENSP00000401018   ENSP00000327449   ENSP00000318196  

    GINS3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010492 GINS_Psf3
     IPR021151 GINS_complex

    Graphical View of Domain Structure for InterPro Entry Q9BRX5

    ProtoNet protein and cluster: Q9BRX5

    UniProtKB/Swiss-Prot: PSF3_HUMAN, Q9BRX5
    Similarity: Belongs to the GINS3/PSF3 family


    GINS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSF3_HUMAN, Q9BRX5
    Function: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA
    replication forks. GINS complex seems to bind preferentially to single-stranded DNA

    Phenotypes:
         1 GenomeRNAi human phenotype for GINS3:

     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GINS3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GINS3
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    miRNA
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    miRTarBase miRNAs that target GINS3:
    hsa-mir-193b-3p (MIRT016571)

    Block miRNA regulation of human, mouse, rat GINS3 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate GINS3:
    hsa-miR-3660 hsa-miR-106a* hsa-miR-7 hsa-miR-20b*
    SwitchGear 3'UTR luciferase reporter plasmidGINS3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GINS3

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GINS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSF3_HUMAN, Q9BRX5: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    GINS3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GINS3
    Interactions:

        Search GeneGlobe Interaction Network for GINS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GINS3 (ENSP000004010184) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCM4ENSP000002621054STRING: ENSP00000262105
    MCM5ENSP000002161224STRING: ENSP00000216122
    GINS1ENSP000002624604STRING: ENSP00000262460
    GINS2ENSP000002534624STRING: ENSP00000253462
    GINS4ENSP000002765334STRING: ENSP00000276533
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--

    GINS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GINS3 (PSF3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GINS3 gene (3 alternative transcripts): 
    NM_001126129.1  NM_001126130.1  NM_022770.3  

    Unigene Cluster for GINS3:

    GINS complex subunit 3 (Psf3 homolog)
    Hs.47125  [show with all ESTs]
    Unigene Representative Sequence: AK127454
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000567400 ENST00000561952 ENST00000568468 ENST00000564814 ENST00000567432
    ENST00000426538 ENST00000328514 ENST00000318129(uc010cdj.3 uc002enh.4 uc002enj.4)
    ENST00000567909 ENST00000567143
    miRNA
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    Block miRNA regulation of human, mouse, rat GINS3 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate GINS3:
    hsa-miR-3660 hsa-miR-106a* hsa-miR-7 hsa-miR-20b*
    SwitchGear 3'UTR luciferase reporter plasmidGINS3 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GINS3
      QuantiTect SYBR Green Assays in human, mouse, rat GINS3
      QuantiFast Probe-based Assays in human, mouse, rat GINS3

    Additional mRNA sequence: 

    AK023974.1 AK127454.1 AK315622.1 AL137379.1 BC005879.1 BC014437.1 CR457283.1 

    10 DOTS entries:

    DT.212408  DT.95374156  DT.97843657  DT.100752335  DT.101963956  DT.120687748  DT.120687741  DT.95374155 
    DT.100728261  DT.120687742 

    Selected AceView cDNA sequences (see all 124):

    CR614103 BM542908 AI361922 AL524624 AI499429 BQ231741 BQ645203 BM904357 
    BM722252 BF797402 BP374281 BP372562 CR604342 AW674611 AL137379 BQ422835 
    BF791592 BG744402 AA593197 AI302832 CR611482 BI489800 CD676320 BG257517 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GINS3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                    -                                 
    SP2:                          -                           
    SP3:                    -     -                           
    SP4:                    -     -     -     -               


    ECgene alternative splicing isoforms for GINS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GINS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAGCAAA
    GINS3 Expression
    About this image

    GINS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GINS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.47125
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GINS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GINS3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gins31 , 5 GINS complex subunit 3 (Psf3 homolog)1, 5 86.88(n)1
    89.35(a)1
      8 (47.12 cM)5
    788331  NM_030198.31  NP_084474.11 
     956335595 
    chicken
    (Gallus gallus)
    Aves GINS31 GINS complex subunit 3 (Psf3 homolog) 74.8(n)
    76.53(a)
      415625  XM_413991.4  XP_413991.2 
    lizard
    (Anolis carolinensis)
    Reptilia GINS36
    GINS complex subunit 3 (Psf3 homolog)
    77(a)
    1 ↔ 1
    AAWZ02038008(1545-3581)
    African clawed frog
    (Xenopus laevis)
    Amphibia flj13912-prov2 hypothetical protein MGC53660 76.31(n)    BC043845.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.139622 Transcribed sequence with moderate similarity to protein more 74.16(n)    BM140836.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Psf31 Psf3 46.52(n)
    34.76(a)
      31967  NM_132396.2  NP_572624.1 


    ENSEMBL Gene Tree for GINS3 (if available)
    TreeFam Gene Tree for GINS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GINS3 (see all 373)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383212931,2
    C--58424748(+) AATCTC/TTCTCT 3 -- us2k10--------
    rs1428247771,2
    --58424783(+) TTCCTA/GAAGCC 3 -- us2k10--------
    rs1840731511,2
    --58424960(+) TGACAA/GTCAAT 3 -- us2k10--------
    rs80480371,2
    C,F,A,H--58424968(+) AATGAG/ATTAGT 3 -- us2k1 tfbs328Minor allele frequency- A:0.09NS EA NA WA 2544
    rs1872403581,2
    --58425073(+) GAGAGC/GGAGGA 3 -- us2k10--------
    rs1905140181,2
    --58425106(+) CGTGGC/GAAGGA 3 -- us2k10--------
    rs1146160451,2
    F--58425138(+) AGTCTG/CAACAA 3 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1460739851,2
    --58425311(+) GGTTGA/GTTGGT 3 -- us2k10--------
    rs773983931,2
    C,F--58425567(+) AATATG/CCCGCC 3 -- us2k12Minor allele frequency- C:0.06CSA WA 120
    rs1824335231,2
    --58425597(+) GAGAGA/CCACCA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GINS3 (58328984 - 58440048 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GINS3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GINS3
    DNA2.0 Custom Variant and Variant Library Synthesis for GINS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610610    OMIM disorders: --

    4 diseases for GINS3:    About MalaCards
    long qt syndrome    lung adenocarcinoma    malaria    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for GINS3:
    Long QT syndrome

    GINS3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GINS3
    Human Genome Epidemiology (HuGE) Navigator: GINS3 (1 document)

    Export disorders for GINS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GINS3 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with GINS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 4 Newton-Cheh C.... Stricker B.H. (Nat. Genet. 2009)
    2. Crystal structure of the human GINS complex. (PubMed id 17545466)1, 2 Choi J.M.... Cho Y. (Genes Dev. 2007)
    3. Molecular architecture of the human GINS complex. (PubMed id 17557111)1, 2 Boskovic J.... Montoya G. (EMBO Rep. 2007)
    4. The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase. (PubMed id 17170760)1, 2 De Falco M....Pisani F.M. (EMBO Rep. 2007)
    5. Crystal structure of the GINS complex and functional insights into its role in DNA replication. (PubMed id 17652513)1, 2 Chang Y.P.... Chen X.S. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    6. Structure of the human GINS complex and its assembly and functional interface in replication initiation. (PubMed id 17417653)1, 2 Kamada K.... Hanaoka F. (Nat. Struct. Mol. Biol. 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Psf3 is a prognostic biomarker in lung adenocarcinoma. (PubMed id 23127337)1 Hokka D....Hayashi Y. (Lung Cancer 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64785 HGNC: 25851 AceView: FLJ13912 Ensembl:ENSG00000181938 euGenes: HUgn64785
    ECgene: GINS3 H-InvDB: GINS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GINS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GINS3 gene:
    Search GeneIP for patents involving GINS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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