Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GINS3 Gene

Aliases for GINS3 Gene

  • GINS Complex Subunit 3 2 3 4 5
  • GINS Complex Subunit 3 (Psf3 Homolog) 2 3
  • PSF3 3 4
  • DNA Replication Complex GINS Protein PSF3 3

External Ids for GINS3 Gene

Previous GeneCards Identifiers for GINS3 Gene

  • GC16P056985
  • GC16P058426
  • GC16P044295

Summaries for GINS3 Gene

Entrez Gene Summary for GINS3 Gene

  • This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for GINS3 Gene

GINS3 (GINS Complex Subunit 3) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Telomere C-strand (Lagging Strand) Synthesis.

UniProtKB/Swiss-Prot for GINS3 Gene

  • The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GINS3 Gene

Genomics for GINS3 Gene

Regulatory Elements for GINS3 Gene

Enhancers for GINS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G058366 1.5 FANTOM5 Ensembl ENCODE 11.4 +71.4 71350 0.5 HDAC1 PKNOX1 ATF1 INSM2 ZNF366 FOS ZEB2 ZNF843 MAFF PRDM6 GINS3 PRSS54 SLC38A7 PIR48676 GC16M058378 RNU6-269P
GH16G058418 1.4 Ensembl ENCODE dbSUPER 11.7 +124.2 124238 2.0 ELF3 FOXA2 PKNOX1 KLF17 RAD21 TCF12 ZNF766 GATA2 FOS CREM LINC02137 GINS3 CSNK2A2 GC16P058413
GH16G058451 1.4 Ensembl ENCODE dbSUPER 10.2 +157.0 156992 0.8 ELF3 PKNOX1 FOXA2 ATF1 RAD21 TCF12 ZNF766 GATA2 RCOR1 FOS GINS3 GC16M058446 NDRG4
GH16G058336 1.2 Ensembl ENCODE 11.2 +41.9 41912 0.8 ELF3 ATF1 FOXA2 CBX3 RB1 ARNT ARID4B ZBTB40 DNMT3B THRB GINS3 PRSS54 GC16P058353
GH16G058455 1.1 ENCODE dbSUPER 10.7 +161.4 161395 1.9 FOXA2 RARA TCF12 GATA4 GATA2 FOS CREM THAP11 HMG20B USF2 GINS3 PRSS54 GC16M058446 NDRG4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GINS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GINS3 Gene

Chromosome:
16
Start:
58,295,080 bp from pter
End:
58,406,144 bp from pter
Size:
111,065 bases
Orientation:
Plus strand

Genomic View for GINS3 Gene

Genes around GINS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GINS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GINS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GINS3 Gene

Proteins for GINS3 Gene

  • Protein details for GINS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRX5-PSF3_HUMAN
    Recommended name:
    DNA replication complex GINS protein PSF3
    Protein Accession:
    Q9BRX5
    Secondary Accessions:
    • B2RDP3
    • E9PB21
    • Q9H870

    Protein attributes for GINS3 Gene

    Size:
    216 amino acids
    Molecular mass:
    24535 Da
    Quaternary structure:
    • Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2. GINS complex interacts with DNA primase in vitro.

    Three dimensional structures from OCA and Proteopedia for GINS3 Gene

    Alternative splice isoforms for GINS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GINS3 Gene

Post-translational modifications for GINS3 Gene

  • Ubiquitination at Lys74, isoforms=390, and Lys181
  • Modification sites at PhosphoSitePlus

Other Protein References for GINS3 Gene

No data available for DME Specific Peptides for GINS3 Gene

Domains & Families for GINS3 Gene

Gene Families for GINS3 Gene

Protein Domains for GINS3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GINS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRX5

UniProtKB/Swiss-Prot:

PSF3_HUMAN :
  • Belongs to the GINS3/PSF3 family.
Family:
  • Belongs to the GINS3/PSF3 family.
genes like me logo Genes that share domains with GINS3: view

Function for GINS3 Gene

Molecular function for GINS3 Gene

UniProtKB/Swiss-Prot Function:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
genes like me logo Genes that share phenotypes with GINS3: view

Animal Model Products

CRISPR Products

miRNA for GINS3 Gene

miRTarBase miRNAs that target GINS3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GINS3 Gene

Localization for GINS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GINS3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GINS3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GINS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GINS3: view

Pathways & Interactions for GINS3 Gene

genes like me logo Genes that share pathways with GINS3: view

Pathways by source for GINS3 Gene

Gene Ontology (GO) - Biological Process for GINS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with GINS3: view

No data available for SIGNOR curated interactions for GINS3 Gene

Drugs & Compounds for GINS3 Gene

No Compound Related Data Available

Transcripts for GINS3 Gene

Unigene Clusters for GINS3 Gene

GINS complex subunit 3 (Psf3 homolog):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GINS3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: - - - -

Relevant External Links for GINS3 Gene

GeneLoc Exon Structure for
GINS3
ECgene alternative splicing isoforms for
GINS3

Expression for GINS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GINS3 Gene

Protein differential expression in normal tissues from HIPED for GINS3 Gene

This gene is overexpressed in Monocytes (33.9) and Lung (33.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GINS3 Gene



NURSA nuclear receptor signaling pathways regulating expression of GINS3 Gene:

GINS3

SOURCE GeneReport for Unigene cluster for GINS3 Gene:

Hs.47125

Evidence on tissue expression from TISSUES for GINS3 Gene

  • Muscle(4.1)
  • Skin(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with GINS3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GINS3 Gene

Orthologs for GINS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GINS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GINS3 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia GINS3 34 35
  • 91.01 (n)
cow
(Bos Taurus)
Mammalia GINS3 34 35
  • 89.04 (n)
mouse
(Mus musculus)
Mammalia Gins3 34 16 35
  • 86.88 (n)
rat
(Rattus norvegicus)
Mammalia Gins3 34
  • 86.88 (n)
oppossum
(Monodelphis domestica)
Mammalia GINS3 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GINS3 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GINS3 34 35
  • 74.8 (n)
lizard
(Anolis carolinensis)
Reptilia GINS3 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gins3 34
  • 70.49 (n)
Str.15218 34
African clawed frog
(Xenopus laevis)
Amphibia flj13912-prov 34
zebrafish
(Danio rerio)
Actinopterygii gins3 34 35
  • 65.54 (n)
Dr.13962 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.421 34
fruit fly
(Drosophila melanogaster)
Insecta Psf3 34 35
  • 46.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011132 34
  • 42.75 (n)
Species where no ortholog for GINS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GINS3 Gene

ENSEMBL:
Gene Tree for GINS3 (if available)
TreeFam:
Gene Tree for GINS3 (if available)

Paralogs for GINS3 Gene

No data available for Paralogs for GINS3 Gene

Variants for GINS3 Gene

Sequence variations from dbSNP and Humsavar for GINS3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000587386 -- 58,400,159(+) ACTCA(A/G)AGGAC intron-variant
rs1000756066 -- 58,392,033(+) CTAGA(C/T)CATAA upstream-variant-2KB
rs1000799545 -- 58,397,012(+) GGGCG(A/G)GGGGC intron-variant
rs1000871482 -- 58,401,764(+) TGTTC(A/C)TTCTT intron-variant
rs1001039962 -- 58,390,780(+) ATACT(C/T)CACTT upstream-variant-2KB

Variation tolerance for GINS3 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GINS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GINS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GINS3 Gene

Disorders for GINS3 Gene

Relevant External Links for GINS3

Genetic Association Database (GAD)
GINS3
Human Genome Epidemiology (HuGE) Navigator
GINS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GINS3

No disorders were found for GINS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GINS3 Gene

Publications for GINS3 Gene

  1. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C. … Stricker B.H. (Nat. Genet. 2009) 3 46 64
  2. Structure of the human GINS complex and its assembly and functional interface in replication initiation. (PMID: 17417653) Kamada K. … Hanaoka F. (Nat. Struct. Mol. Biol. 2007) 3 4 64
  3. Crystal structure of the human GINS complex. (PMID: 17545466) Choi J.M. … Cho Y. (Genes Dev. 2007) 3 4 64
  4. Crystal structure of the GINS complex and functional insights into its role in DNA replication. (PMID: 17652513) Chang Y.P. … Chen X.S. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 64
  5. The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase. (PMID: 17170760) De Falco M. … Pisani F.M. (EMBO Rep. 2007) 3 4 64

Products for GINS3 Gene

Sources for GINS3 Gene

Content
Loading form....