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Aliases for GINS3 Gene

Aliases for GINS3 Gene

  • GINS Complex Subunit 3 (Psf3 Homolog) 2 3
  • PSF3 3 4 6
  • DNA Replication Complex GINS Protein PSF3 3
  • GINS Complex Subunit 3 4

External Ids for GINS3 Gene

Previous GeneCards Identifiers for GINS3 Gene

  • GC16P056985
  • GC16P058426
  • GC16P044295

Summaries for GINS3 Gene

Entrez Gene Summary for GINS3 Gene

  • This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for GINS3 Gene

GINS3 (GINS Complex Subunit 3 (Psf3 Homolog)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for GINS3 Gene

  • The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GINS3 Gene

Genomics for GINS3 Gene

Regulatory Elements for GINS3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GINS3 Gene

Start:
58,295,080 bp from pter
End:
58,406,144 bp from pter
Size:
111,065 bases
Orientation:
Plus strand

Genomic View for GINS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GINS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GINS3 Gene

Proteins for GINS3 Gene

  • Protein details for GINS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRX5-PSF3_HUMAN
    Recommended name:
    DNA replication complex GINS protein PSF3
    Protein Accession:
    Q9BRX5
    Secondary Accessions:
    • B2RDP3
    • E9PB21
    • Q9H870

    Protein attributes for GINS3 Gene

    Size:
    216 amino acids
    Molecular mass:
    24535 Da
    Quaternary structure:
    • Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2. GINS complex interacts with DNA primase in vitro.

    Three dimensional structures from OCA and Proteopedia for GINS3 Gene

    Alternative splice isoforms for GINS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GINS3 Gene

Proteomics data for GINS3 Gene at MOPED

Post-translational modifications for GINS3 Gene

  • Ubiquitination at Lys74, Lys90, and Lys181
  • Modification sites at PhosphoSitePlus

Other Protein References for GINS3 Gene

No data available for DME Specific Peptides for GINS3 Gene

Domains for GINS3 Gene

Protein Domains for GINS3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GINS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRX5

UniProtKB/Swiss-Prot:

PSF3_HUMAN :
  • Q9BRX5
Family:
  • Belongs to the GINS3/PSF3 family.
genes like me logo Genes that share domains with GINS3: view

No data available for Gene Families for GINS3 Gene

Function for GINS3 Gene

Molecular function for GINS3 Gene

UniProtKB/Swiss-Prot Function: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

Phenotypes for GINS3 Gene

genes like me logo Genes that share phenotypes with GINS3: view

Animal Model Products

CRISPR Products

miRNA for GINS3 Gene

miRTarBase miRNAs that target GINS3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for GINS3 Gene

Localization for GINS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GINS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GINS3 Gene COMPARTMENTS Subcellular localization image for GINS3 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GINS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with GINS3: view

Pathways for GINS3 Gene

SuperPathways for GINS3 Gene

No Data Available

Interacting Proteins for GINS3 Gene

Gene Ontology (GO) - Biological Process for GINS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
genes like me logo Genes that share ontologies with GINS3: view

No data available for Pathways by source for GINS3 Gene

Transcripts for GINS3 Gene

Unigene Clusters for GINS3 Gene

GINS complex subunit 3 (Psf3 homolog):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GINS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GINS3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: - - - -

Relevant External Links for GINS3 Gene

GeneLoc Exon Structure for
GINS3
ECgene alternative splicing isoforms for
GINS3

Expression for GINS3 Gene

mRNA expression in normal human tissues for GINS3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GINS3 Gene

SOURCE GeneReport for Unigene cluster for GINS3 Gene Hs.47125

genes like me logo Genes that share expressions with GINS3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GINS3 Gene

Orthologs for GINS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GINS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GINS3 35
  • 99.69 (n)
  • 99.54 (a)
GINS3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GINS3 35
  • 89.04 (n)
  • 93.98 (a)
GINS3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GINS3 35
  • 91.01 (n)
  • 94.88 (a)
GINS3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gins3 35
  • 86.88 (n)
  • 89.35 (a)
Gins3 16
Gins3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GINS3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GINS3 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gins3 35
  • 86.88 (n)
  • 90.28 (a)
chicken
(Gallus gallus)
Aves GINS3 35
  • 74.8 (n)
  • 76.53 (a)
GINS3 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GINS3 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia flj13912-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gins3 35
  • 70.49 (n)
  • 75.12 (a)
Str.15218 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.421 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13962 35
gins3 35
  • 65.54 (n)
  • 68.27 (a)
gins3 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011132 35
  • 42.75 (n)
  • 29.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Psf3 35
  • 46.52 (n)
  • 34.76 (a)
Psf3 36
  • 30 (a)
OneToOne
Species with no ortholog for GINS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GINS3 Gene

ENSEMBL:
Gene Tree for GINS3 (if available)
TreeFam:
Gene Tree for GINS3 (if available)

Paralogs for GINS3 Gene

No data available for Paralogs for GINS3 Gene

Variants for GINS3 Gene

Sequence variations from dbSNP and Humsavar for GINS3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1862801 -- 58,406,481(+) ATTAC(A/C/G)TGTAG downstream-variant-500B
rs2914192 -- 58,401,513(-) ctgta(A/G)aatgg intron-variant
rs3214480 -- 58,392,368(+) CCCAG(-/C)CCGTG upstream-variant-2KB
rs3743565 -- 58,392,278(-) CTCGT(C/T)GAAGC upstream-variant-2KB
rs3833043 -- 58,406,127(-) GATTT(-/ATTT)GTGTA utr-variant-3-prime

Relevant External Links for GINS3 Gene

HapMap Linkage Disequilibrium report
GINS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GINS3 Gene

Disorders for GINS3 Gene

(1) University of Copenhagen DISEASES for GINS3 Gene

Relevant External Links for GINS3

Genetic Association Database (GAD)
GINS3
Human Genome Epidemiology (HuGE) Navigator
GINS3
genes like me logo Genes that share disorders with GINS3: view

No data available for UniProtKB/Swiss-Prot for GINS3 Gene

Publications for GINS3 Gene

  1. The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase. (PMID: 17170760) De Falco M. … Pisani F.M. (EMBO Rep. 2007) 3 4
  2. Structure of the human GINS complex and its assembly and functional interface in replication initiation. (PMID: 17417653) Kamada K. … Hanaoka F. (Nat. Struct. Mol. Biol. 2007) 3 4
  3. Crystal structure of the human GINS complex. (PMID: 17545466) Choi J.M. … Cho Y. (Genes Dev. 2007) 3 4
  4. Molecular architecture of the human GINS complex. (PMID: 17557111) Boskovic J. … Montoya G. (EMBO Rep. 2007) 3 4
  5. Crystal structure of the GINS complex and functional insights into its role in DNA replication. (PMID: 17652513) Chang Y.P. … Chen X.S. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4

Products for GINS3 Gene

Sources for GINS3 Gene

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