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Aliases for GINS3 Gene

Aliases for GINS3 Gene

  • GINS Complex Subunit 3 2 3 4
  • GINS Complex Subunit 3 (Psf3 Homolog) 2 3 5
  • PSF3 3 4

External Ids for GINS3 Gene

Previous GeneCards Identifiers for GINS3 Gene

  • GC16P056985
  • GC16P058426
  • GC16P044295

Summaries for GINS3 Gene

Entrez Gene Summary for GINS3 Gene

  • This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for GINS3 Gene

GINS3 (GINS Complex Subunit 3) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6.

UniProtKB/Swiss-Prot for GINS3 Gene

  • The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GINS3 Gene

Genomics for GINS3 Gene

Regulatory Elements for GINS3 Gene

Genomic Location for GINS3 Gene

Chromosome:
16
Start:
58,295,080 bp from pter
End:
58,406,144 bp from pter
Size:
111,065 bases
Orientation:
Plus strand

Genomic View for GINS3 Gene

Genes around GINS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GINS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GINS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GINS3 Gene

Proteins for GINS3 Gene

  • Protein details for GINS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRX5-PSF3_HUMAN
    Recommended name:
    DNA replication complex GINS protein PSF3
    Protein Accession:
    Q9BRX5
    Secondary Accessions:
    • B2RDP3
    • E9PB21
    • Q9H870

    Protein attributes for GINS3 Gene

    Size:
    216 amino acids
    Molecular mass:
    24535 Da
    Quaternary structure:
    • Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2. GINS complex interacts with DNA primase in vitro.

    Three dimensional structures from OCA and Proteopedia for GINS3 Gene

    Alternative splice isoforms for GINS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GINS3 Gene

Proteomics data for GINS3 Gene at MOPED

Post-translational modifications for GINS3 Gene

  • Ubiquitination at Lys 74, Lys 90, and Lys 181
  • Modification sites at PhosphoSitePlus

Other Protein References for GINS3 Gene

Antibody Products

No data available for DME Specific Peptides for GINS3 Gene

Domains & Families for GINS3 Gene

Gene Families for GINS3 Gene

Protein Domains for GINS3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GINS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRX5

UniProtKB/Swiss-Prot:

PSF3_HUMAN :
  • Belongs to the GINS3/PSF3 family.
Family:
  • Belongs to the GINS3/PSF3 family.
genes like me logo Genes that share domains with GINS3: view

Function for GINS3 Gene

Molecular function for GINS3 Gene

UniProtKB/Swiss-Prot Function:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
genes like me logo Genes that share phenotypes with GINS3: view

Animal Model Products

CRISPR Products

miRNA for GINS3 Gene

miRTarBase miRNAs that target GINS3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GINS3 Gene

Localization for GINS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GINS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GINS3 Gene COMPARTMENTS Subcellular localization image for GINS3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for GINS3 Gene

Pathways & Interactions for GINS3 Gene

genes like me logo Genes that share pathways with GINS3: view

Pathways by source for GINS3 Gene

Interacting Proteins for GINS3 Gene

Gene Ontology (GO) - Biological Process for GINS3 Gene

None

No data available for SIGNOR curated interactions for GINS3 Gene

Drugs & Compounds for GINS3 Gene

No Compound Related Data Available

Transcripts for GINS3 Gene

Unigene Clusters for GINS3 Gene

GINS complex subunit 3 (Psf3 homolog):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GINS3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: - - - -

Relevant External Links for GINS3 Gene

GeneLoc Exon Structure for
GINS3
ECgene alternative splicing isoforms for
GINS3

Expression for GINS3 Gene

mRNA expression in normal human tissues for GINS3 Gene

Protein differential expression in normal tissues from HIPED for GINS3 Gene

This gene is overexpressed in Monocytes (33.9) and Lung (33.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GINS3 Gene



SOURCE GeneReport for Unigene cluster for GINS3 Gene Hs.47125

genes like me logo Genes that share expression patterns with GINS3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GINS3 Gene

Orthologs for GINS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GINS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GINS3 35
  • 89.04 (n)
  • 93.98 (a)
GINS3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GINS3 35
  • 91.01 (n)
  • 94.88 (a)
GINS3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gins3 35
  • 86.88 (n)
  • 89.35 (a)
Gins3 16
Gins3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GINS3 35
  • 99.69 (n)
  • 99.54 (a)
GINS3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gins3 35
  • 86.88 (n)
  • 90.28 (a)
oppossum
(Monodelphis domestica)
Mammalia GINS3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GINS3 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GINS3 35
  • 74.8 (n)
  • 76.53 (a)
GINS3 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GINS3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gins3 35
  • 70.49 (n)
  • 75.12 (a)
Str.15218 35
African clawed frog
(Xenopus laevis)
Amphibia flj13912-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13962 35
gins3 35
  • 65.54 (n)
  • 68.27 (a)
gins3 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.421 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011132 35
  • 42.75 (n)
  • 29.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Psf3 35
  • 46.52 (n)
  • 34.76 (a)
Psf3 36
  • 30 (a)
OneToOne
Species with no ortholog for GINS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GINS3 Gene

ENSEMBL:
Gene Tree for GINS3 (if available)
TreeFam:
Gene Tree for GINS3 (if available)

Paralogs for GINS3 Gene

No data available for Paralogs for GINS3 Gene

Variants for GINS3 Gene

Sequence variations from dbSNP and Humsavar for GINS3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1862801 -- 58,406,481(+) ATTAC(A/C/G)TGTAG downstream-variant-500B
rs2914192 -- 58,401,513(-) ctgta(A/G)aatgg intron-variant
rs3214480 -- 58,392,368(+) CCCAG(-/C)CCGTG upstream-variant-2KB
rs3743565 -- 58,392,278(-) CTCGT(C/T)GAAGC upstream-variant-2KB
rs3833043 -- 58,406,127(-) GATTT(-/ATTT)GTGTA utr-variant-3-prime

Variation tolerance for GINS3 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GINS3 Gene

HapMap Linkage Disequilibrium report
GINS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GINS3 Gene

Disorders for GINS3 Gene

Relevant External Links for GINS3

Genetic Association Database (GAD)
GINS3
Human Genome Epidemiology (HuGE) Navigator
GINS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GINS3

No disorders were found for GINS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GINS3 Gene

Publications for GINS3 Gene

  1. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C. … Stricker B.H. (Nat. Genet. 2009) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Psf3 is a prognostic biomarker in lung adenocarcinoma. (PMID: 23127337) Hokka D. … Hayashi Y. (Lung Cancer 2013) 3

Products for GINS3 Gene

Sources for GINS3 Gene

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