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Aliases for GINS2 Gene

Aliases for GINS2 Gene

  • GINS Complex Subunit 2 2 3 4
  • GINS Complex Subunit 2 (Psf2 Homolog) 2 3 5
  • PSF2 3 4
  • HSPC037 3
  • Pfs2 3

External Ids for GINS2 Gene

Previous GeneCards Identifiers for GINS2 Gene

  • GC16M084269
  • GC16M085709
  • GC16M071453

Summaries for GINS2 Gene

Entrez Gene Summary for GINS2 Gene

  • The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

GeneCards Summary for GINS2 Gene

GINS2 (GINS Complex Subunit 2) is a Protein Coding gene. Diseases associated with GINS2 include Bare Lymphocyte Syndrome, Type I. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and DNA strand elongation. GO annotations related to this gene include 3-5 DNA helicase activity.

UniProtKB/Swiss-Prot for GINS2 Gene

  • The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

Gene Wiki entry for GINS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GINS2 Gene

Genomics for GINS2 Gene

Regulatory Elements for GINS2 Gene

Enhancers for GINS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GINS2 on UCSC Golden Path with GeneCards custom track

Promoters for GINS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GINS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GINS2 Gene

Chromosome:
16
Start:
85,676,198 bp from pter
End:
85,690,073 bp from pter
Size:
13,876 bases
Orientation:
Minus strand

Genomic View for GINS2 Gene

Genes around GINS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GINS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GINS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GINS2 Gene

Proteins for GINS2 Gene

  • Protein details for GINS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y248-PSF2_HUMAN
    Recommended name:
    DNA replication complex GINS protein PSF2
    Protein Accession:
    Q9Y248
    Secondary Accessions:
    • D3DUM5
    • Q6IAG9

    Protein attributes for GINS2 Gene

    Size:
    185 amino acids
    Molecular mass:
    21428 Da
    Quaternary structure:
    • Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro.

    Three dimensional structures from OCA and Proteopedia for GINS2 Gene

neXtProt entry for GINS2 Gene

Proteomics data for GINS2 Gene at MOPED

Post-translational modifications for GINS2 Gene

  • Ubiquitination at Lys 73, Lys 80, and Lys 118
  • Modification sites at PhosphoSitePlus

Other Protein References for GINS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GINS2 Gene

Domains & Families for GINS2 Gene

Gene Families for GINS2 Gene

Protein Domains for GINS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GINS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y248

UniProtKB/Swiss-Prot:

PSF2_HUMAN :
  • Belongs to the GINS2/PSF2 family.
Family:
  • Belongs to the GINS2/PSF2 family.
genes like me logo Genes that share domains with GINS2: view

Function for GINS2 Gene

Molecular function for GINS2 Gene

UniProtKB/Swiss-Prot Function:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
genes like me logo Genes that share phenotypes with GINS2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GINS2 Gene

Localization for GINS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GINS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GINS2 Gene COMPARTMENTS Subcellular localization image for GINS2 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for GINS2 Gene

Pathways & Interactions for GINS2 Gene

genes like me logo Genes that share pathways with GINS2: view

Pathways by source for GINS2 Gene

Gene Ontology (GO) - Biological Process for GINS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006271 DNA strand elongation involved in DNA replication TAS --
GO:1902975 mitotic DNA replication initiation IBA --
genes like me logo Genes that share ontologies with GINS2: view

No data available for SIGNOR curated interactions for GINS2 Gene

Drugs & Compounds for GINS2 Gene

No Compound Related Data Available

Transcripts for GINS2 Gene

mRNA/cDNA for GINS2 Gene

Unigene Clusters for GINS2 Gene

GINS complex subunit 2 (Psf2 homolog):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GINS2 Gene

No ASD Table

Relevant External Links for GINS2 Gene

GeneLoc Exon Structure for
GINS2
ECgene alternative splicing isoforms for
GINS2

Expression for GINS2 Gene

mRNA expression in normal human tissues for GINS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GINS2 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for GINS2 Gene

This gene is overexpressed in Fetal heart (25.7), Lymph node (22.7), and Fetal Brain (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GINS2 Gene



SOURCE GeneReport for Unigene cluster for GINS2 Gene Hs.433180

genes like me logo Genes that share expression patterns with GINS2: view

Protein tissue co-expression partners for GINS2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GINS2 Gene

Orthologs for GINS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GINS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GINS2 35
  • 87.75 (n)
  • 94.59 (a)
GINS2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GINS2 35
  • 89.19 (n)
  • 94.59 (a)
GINS2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gins2 35
  • 83.96 (n)
  • 92.43 (a)
Gins2 16
Gins2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GINS2 35
  • 98.92 (n)
  • 99.46 (a)
GINS2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gins2 35
  • 85.77 (n)
  • 92.97 (a)
oppossum
(Monodelphis domestica)
Mammalia GINS2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GINS2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves GINS2 35
  • 78.74 (n)
  • 85.95 (a)
GINS2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GINS2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gins2 35
  • 75.68 (n)
  • 84.32 (a)
Str.7608 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3786 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15045 35
gins2 35
  • 68.5 (n)
  • 80.22 (a)
gins2 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1858 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012743 35
  • 52.25 (n)
  • 43.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Psf2 35
  • 56.02 (n)
  • 44.97 (a)
Psf2 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F31C3.5 35
  • 48.93 (n)
  • 38.01 (a)
psf-2 36
  • 36 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR121W 35
  • 49.69 (n)
  • 35.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06501g 35
  • 48.45 (n)
  • 36.02 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSF2 35
  • 44.79 (n)
  • 30.06 (a)
PSF2 36
  • 24 (a)
OneToOne
PSF2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PSF2 35
  • 50.82 (n)
  • 43.83 (a)
rice
(Oryza sativa)
Liliopsida Os01g0248600 35
  • 52.03 (n)
  • 41.46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06322 35
  • 50.1 (n)
  • 36.84 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes psf2 35
  • 48.15 (n)
  • 36.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for GINS2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GINS2 Gene

ENSEMBL:
Gene Tree for GINS2 (if available)
TreeFam:
Gene Tree for GINS2 (if available)

Paralogs for GINS2 Gene

Pseudogenes.org Pseudogenes for GINS2 Gene

genes like me logo Genes that share paralogs with GINS2: view

No data available for Paralogs for GINS2 Gene

Variants for GINS2 Gene

Sequence variations from dbSNP and Humsavar for GINS2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4565 -- 85,677,805(-) ATCCT(C/G)ATTTC utr-variant-3-prime
rs9534 -- 85,677,896(-) AAGCC(A/G)TCACA utr-variant-3-prime
rs13584 -- 85,678,323(-) TTGAC(C/T)TTGAT reference, synonymous-codon
rs4143865 -- 85,683,006(+) CCCCA(A/T)CCCCC intron-variant
rs4143866 -- 85,682,760(+) CCTCT(A/G)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GINS2 Gene

Variant ID Type Subtype PubMed ID
nsv907090 CNV Loss 21882294
esv4262 CNV Complex 18987735

Variation tolerance for GINS2 Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GINS2 Gene

Disorders for GINS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GINS2 Gene - From: OMIM

Disorder Aliases PubMed IDs
bare lymphocyte syndrome, type i
  • bare lymphocyte syndrome, type i, due to tap2 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search GINS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GINS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GINS2
genes like me logo Genes that share disorders with GINS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GINS2 Gene

Publications for GINS2 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7. (PMID: 24299456) Kusunoki S. … Ishimi Y. (FEBS J. 2014) 3

Products for GINS2 Gene

Sources for GINS2 Gene

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