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Aliases for GINS1 Gene

Aliases for GINS1 Gene

  • GINS Complex Subunit 1 (Psf1 Homolog) 2 3
  • PSF1 3 4
  • GINS Complex Subunit 1 4
  • Partner Of Sld Five-1 3
  • KIAA0186 4

External Ids for GINS1 Gene

Previous GeneCards Identifiers for GINS1 Gene

  • GC20P025329

Summaries for GINS1 Gene

Entrez Gene Summary for GINS1 Gene

  • The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GINS1 Gene

GINS1 (GINS Complex Subunit 1 (Psf1 Homolog)) is a Protein Coding gene. Diseases associated with GINS1 include bare lymphocyte syndrome, type i. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6.

UniProtKB/Swiss-Prot for GINS1 Gene

  • The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function.

Gene Wiki entry for GINS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GINS1 Gene

Genomics for GINS1 Gene

Regulatory Elements for GINS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GINS1 Gene

Chromosome:
20
Start:
25,407,444 bp from pter
End:
25,452,628 bp from pter
Size:
45,185 bases
Orientation:
Plus strand

Genomic View for GINS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GINS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GINS1 Gene

Proteins for GINS1 Gene

  • Protein details for GINS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14691-PSF1_HUMAN
    Recommended name:
    DNA replication complex GINS protein PSF1
    Protein Accession:
    Q14691
    Secondary Accessions:
    • Q9NQE2
    • Q9NQI7

    Protein attributes for GINS1 Gene

    Size:
    196 amino acids
    Molecular mass:
    22988 Da
    Quaternary structure:
    • Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro.
    SequenceCaution:
    • Sequence=BAA11503.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GINS1 Gene

neXtProt entry for GINS1 Gene

Proteomics data for GINS1 Gene at MOPED

Post-translational modifications for GINS1 Gene

  • Ubiquitination at Lys 51 and Lys 63
  • Modification sites at PhosphoSitePlus

Other Protein References for GINS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GINS1 Gene

Domains & Families for GINS1 Gene

Gene Families for GINS1 Gene

Protein Domains for GINS1 Gene

Suggested Antigen Peptide Sequences for GINS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14691

UniProtKB/Swiss-Prot:

PSF1_HUMAN :
  • Belongs to the GINS1/PSF1 family.
Family:
  • Belongs to the GINS1/PSF1 family.
genes like me logo Genes that share domains with GINS1: view

Function for GINS1 Gene

Molecular function for GINS1 Gene

UniProtKB/Swiss-Prot Function:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function.
UniProtKB/Swiss-Prot Induction:
Significantly up-regulated in aggressive melanomas.

Gene Ontology (GO) - Molecular Function for GINS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GINS1: view
genes like me logo Genes that share phenotypes with GINS1: view

Animal Models for GINS1 Gene

MGI Knock Outs for GINS1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GINS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GINS1 Gene

Localization for GINS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GINS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GINS1 Gene COMPARTMENTS Subcellular localization image for GINS1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for GINS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10942595
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 10942595
genes like me logo Genes that share ontologies with GINS1: view

Pathways & Interactions for GINS1 Gene

genes like me logo Genes that share pathways with GINS1: view

Pathways by source for GINS1 Gene

Gene Ontology (GO) - Biological Process for GINS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0001833 inner cell mass cell proliferation IEA --
GO:0006260 DNA replication --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with GINS1: view

No data available for SIGNOR curated interactions for GINS1 Gene

Drugs & Compounds for GINS1 Gene

No Compound Related Data Available

Transcripts for GINS1 Gene

Unigene Clusters for GINS1 Gene

GINS complex subunit 1 (Psf1 homolog):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GINS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GINS1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - -
SP7:
SP8:

Relevant External Links for GINS1 Gene

GeneLoc Exon Structure for
GINS1
ECgene alternative splicing isoforms for
GINS1

Expression for GINS1 Gene

mRNA expression in normal human tissues for GINS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GINS1 Gene

This gene is overexpressed in Testis (x7.9).

Protein differential expression in normal tissues from HIPED for GINS1 Gene

This gene is overexpressed in Lung (60.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GINS1 Gene



SOURCE GeneReport for Unigene cluster for GINS1 Gene Hs.658464

genes like me logo Genes that share expression patterns with GINS1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GINS1 Gene

Orthologs for GINS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GINS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC523427 35
  • 88.78 (n)
  • 92.86 (a)
GINS1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GINS1 35
  • 89.97 (n)
  • 95.41 (a)
-- 36
  • 98 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gins1 35
  • 88.44 (n)
  • 93.37 (a)
Gins1 16
Gins1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GINS1 35
  • 99.83 (n)
  • 100 (a)
GINS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gins1 35
  • 88.44 (n)
  • 94.39 (a)
oppossum
(Monodelphis domestica)
Mammalia GINS1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves GINS1 35
  • 71.97 (n)
  • 77.44 (a)
GINS1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GINS1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gins1 35
  • 78.74 (n)
  • 91.33 (a)
Str.20188 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23934 35
zebrafish
(Danio rerio)
Actinopterygii Dr.8483 35
gins1 35
  • 73.64 (n)
  • 84.18 (a)
gins1 36
  • 85 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.769 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010835 35
  • 53.37 (n)
  • 49.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Psf1 35
  • 52.5 (n)
  • 52.85 (a)
CG32318 36
  • 33 (a)
OneToMany
Psf1 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R53.6 35
  • 50 (n)
  • 40.96 (a)
psf-1 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSF1 36
  • 24 (a)
OneToOne
PSF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PSF1 35
  • 42.86 (n)
  • 32.28 (a)
rice
(Oryza sativa)
Liliopsida Os05g0453800 35
  • 48.24 (n)
  • 44.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10775 36
  • 61 (a)
OneToOne
Species with no ortholog for GINS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GINS1 Gene

ENSEMBL:
Gene Tree for GINS1 (if available)
TreeFam:
Gene Tree for GINS1 (if available)

Paralogs for GINS1 Gene

(9) SIMAP similar genes for GINS1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GINS1: view

No data available for Paralogs for GINS1 Gene

Variants for GINS1 Gene

Sequence variations from dbSNP and Humsavar for GINS1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs761025 -- 25,446,332(-) AGGGG(C/T)CGGGT utr-variant-3-prime, downstream-variant-500B
rs1047171 -- 25,448,150(+) atcaa(C/T)ttgtc utr-variant-3-prime
rs1888995 -- 25,419,851(+) gagac(A/G)gggtt intron-variant
rs1888996 -- 25,424,442(+) tcaac(A/T)ttttt intron-variant
rs2151141 -- 25,415,470(+) ATCAT(C/T)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GINS1 Gene

Variant ID Type Subtype PubMed ID
nsv522873 CNV Gain 19592680
nsv833948 CNV Loss 17160897
esv2676461 CNV Deletion 23128226

Variation tolerance for GINS1 Gene

Residual Variation Intolerance Score: 55.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GINS1 Gene

HapMap Linkage Disequilibrium report
GINS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GINS1 Gene

Disorders for GINS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GINS1 Gene - From: OMIM

Disorder Aliases PubMed IDs
bare lymphocyte syndrome, type i
  • bare lymphocyte syndrome, type i, due to tap2 deficiency
- elite association
Search GINS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GINS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GINS1
genes like me logo Genes that share disorders with GINS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GINS1 Gene

Publications for GINS1 Gene

  1. Structure and function of the GINS complex, a key component of the eukaryotic replisome. (PMID: 20070258) MacNeill S.A. (Biochem. J. 2010) 23 67
  2. GINS, a central nexus in the archaeal DNA replication fork. (PMID: 16485022) Marinsek N. … Bell S.D. (EMBO Rep. 2006) 23 67
  3. A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS. (PMID: 17127213) Hayashi R. … Yoshida K. (Genomics Proteomics Bioinformatics 2006) 23 67
  4. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 67
  5. Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h. (PMID: 8786132) Chiang P.-W. … Kurnit D.M. (Genomics 1996) 2 67

Products for GINS1 Gene

Sources for GINS1 Gene

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