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Aliases for GINM1 Gene

Aliases for GINM1 Gene

  • Glycoprotein Integral Membrane 1 2 3 5
  • C6orf72 3 4
  • Glycoprotein Integral Membrane Protein 1 3
  • Chromosome 6 Open Reading Frame 72 2

External Ids for GINM1 Gene

Previous HGNC Symbols for GINM1 Gene

  • C6orf72

Previous GeneCards Identifiers for GINM1 Gene

  • GC06P149888

Summaries for GINM1 Gene

GeneCards Summary for GINM1 Gene

GINM1 (Glycoprotein Integral Membrane 1) is a Protein Coding gene.

Additional gene information for GINM1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GINM1 Gene

Genomics for GINM1 Gene

GeneHancer (GH) Regulatory Elements for GINM1 Gene

Promoters and enhancers for GINM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I149565 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 557.9 +0.2 249 3.1 PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 GINM1 ENSG00000231760 RAET1E PCMT1 GC06M149575 GC06P149237
GH06I149748 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.3 +183.6 183592 3.3 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF766 E2F8 NUP43 PCMT1 ENSG00000231760 LATS1 GINM1 PPIL4 RPS18P9 BTBD10P2 GC06P149237
GH06I149842 Enhancer 1.4 Ensembl ENCODE dbSUPER 20.3 +278.9 278922 6.4 CLOCK SMAD1 FOXA2 SIN3A NCOA2 ATF7 FOS ZNF214 MCM3 JUNB ENSG00000231760 LATS1 GINM1 RPS18P9 RAET1E NUP43 ENSG00000268592 LRP11 ENSG00000216906 KATNA1
GH06I149543 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 -20.7 -20732 3.9 MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC ZNF610 PPIL4 NUP43 LATS1 ENSG00000231760 KATNA1 GINM1 ENSG00000268592 RNU7-3P ENSG00000216906 GC06P149517
GH06I149479 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -83.3 -83341 7 HDGF PKNOX1 ARID4B DMAP1 IRF4 ZNF48 ETS1 GATA2 ZNF207 ZNF143 ZC3H12D GINM1 RPS18P9 ENSG00000231760 PPIL4 TAB2 LATS1 KATNA1 SUMO4 GC06P149237
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GINM1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GINM1 Gene

Genomic Locations for GINM1 Gene
chr6:149,566,294-149,591,748
(GRCh38/hg38)
Size:
25,455 bases
Orientation:
Plus strand
chr6:149,887,430-149,912,884
(GRCh37/hg19)

Genomic View for GINM1 Gene

Genes around GINM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GINM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GINM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GINM1 Gene

Proteins for GINM1 Gene

  • Protein details for GINM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NU53-GINM1_HUMAN
    Recommended name:
    Glycoprotein integral membrane protein 1
    Protein Accession:
    Q9NU53
    Secondary Accessions:
    • B2RDY7
    • E1P5A2

    Protein attributes for GINM1 Gene

    Size:
    330 amino acids
    Molecular mass:
    36840 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GINM1 Gene

Post-translational modifications for GINM1 Gene

  • Ubiquitination at isoforms=294, isoforms=301, posLast=319319, and isoforms=327

Other Protein References for GINM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GINM1 Gene

Domains & Families for GINM1 Gene

Gene Families for GINM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GINM1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for GINM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GINM1: view

No data available for UniProtKB/Swiss-Prot for GINM1 Gene

Function for GINM1 Gene

Phenotypes From GWAS Catalog for GINM1 Gene

genes like me logo Genes that share phenotypes with GINM1: view

miRNA for GINM1 Gene

miRTarBase miRNAs that target GINM1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GINM1 Gene

Localization for GINM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GINM1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GINM1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GINM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with GINM1: view

Pathways & Interactions for GINM1 Gene

SuperPathways for GINM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GINM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GINM1 Gene

Drugs & Compounds for GINM1 Gene

No Compound Related Data Available

Transcripts for GINM1 Gene

mRNA/cDNA for GINM1 Gene

Unigene Clusters for GINM1 Gene

Glycoprotein integral membrane 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GINM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: -

Relevant External Links for GINM1 Gene

GeneLoc Exon Structure for
GINM1
ECgene alternative splicing isoforms for
GINM1

Expression for GINM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GINM1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GINM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of GINM1 Gene:

GINM1

SOURCE GeneReport for Unigene cluster for GINM1 Gene:

Hs.438872

Evidence on tissue expression from TISSUES for GINM1 Gene

  • Bone marrow(4.2)
  • Kidney(2.2)
  • Heart(2)
  • Liver(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with GINM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GINM1 Gene

Orthologs for GINM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GINM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GINM1 33 34
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia GINM1 33
  • 88.82 (n)
MGC133692 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GINM1 33 34
  • 88.07 (n)
rat
(Rattus norvegicus)
Mammalia Ginm1 33
  • 81.81 (n)
mouse
(Mus musculus)
Mammalia Ginm1 33 16 34
  • 80.94 (n)
oppossum
(Monodelphis domestica)
Mammalia GINM1 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GINM1 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H6ORF72 34 33
  • 68.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 57 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-15j16.2 33
  • 49.75 (n)
ginm1 34
  • 28 (a)
OneToOne
Species where no ortholog for GINM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GINM1 Gene

ENSEMBL:
Gene Tree for GINM1 (if available)
TreeFam:
Gene Tree for GINM1 (if available)

Paralogs for GINM1 Gene

No data available for Paralogs for GINM1 Gene

Variants for GINM1 Gene

Sequence variations from dbSNP and Humsavar for GINM1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000040656 -- 149,585,839(+) G/A intron_variant
rs1000130949 -- 149,573,149(+) C/G intron_variant
rs1000178859 -- 149,567,779(+) C/T intron_variant
rs1000417578 -- 149,579,955(+) A/T coding_sequence_variant, missense_variant
rs1000466032 -- 149,574,211(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GINM1 Gene

Variant ID Type Subtype PubMed ID
esv2566421 CNV deletion 19546169
esv3611209 CNV loss 21293372
nsv7976 CNV gain 18304495
nsv7977 CNV gain 18304495

Variation tolerance for GINM1 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GINM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GINM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GINM1 Gene

Disorders for GINM1 Gene

Additional Disease Information for GINM1

No disorders were found for GINM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GINM1 Gene

Publications for GINM1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for GINM1 Gene

Sources for GINM1 Gene

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