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Aliases for GIN1 Gene

Aliases for GIN1 Gene

  • Gypsy Retrotransposon Integrase 1 2 3
  • Ty3/Gypsy Integrase 1 2 3 4
  • Zinc Finger H2C2 Domain-Containing Protein 3 4
  • Zinc Finger, H2C2 Domain Containing 2 3
  • Gypsy Integrase 1 2 3
  • ZH2C2 3 4
  • GIN-1 3 4
  • TGIN1 3 4

External Ids for GIN1 Gene

Previous HGNC Symbols for GIN1 Gene

  • ZH2C2

Previous GeneCards Identifiers for GIN1 Gene

  • GC05M102453
  • GC05M097602
  • GC05M102421

Summaries for GIN1 Gene

GeneCards Summary for GIN1 Gene

GIN1 (Gypsy Retrotransposon Integrase 1) is a Protein Coding gene. Diseases associated with GIN1 include parametritis. GO annotations related to this gene include nucleic acid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIN1 Gene

Genomics for GIN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GIN1 Gene

103,086,000 bp from pter
103,120,169 bp from pter
34,170 bases
Minus strand

Genomic View for GIN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIN1 Gene

Proteins for GIN1 Gene

  • Protein details for GIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gypsy retrotransposon integrase-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RXF7
    • B4DIV4
    • Q6AI03
    • Q96BR2

    Protein attributes for GIN1 Gene

    522 amino acids
    Molecular mass:
    59842 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA90963.1; Type=Frameshift; Positions=375; Evidence={ECO:0000305}; Sequence=CAH10511.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for GIN1 Gene


neXtProt entry for GIN1 Gene

Proteomics data for GIN1 Gene at MOPED

Post-translational modifications for GIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GIN1 Gene

No data available for DME Specific Peptides for GIN1 Gene

Domains & Families for GIN1 Gene

Protein Domains for GIN1 Gene

Suggested Antigen Peptide Sequences for GIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 integrase catalytic domain.
  • Contains 1 integrase catalytic domain.
genes like me logo Genes that share domains with GIN1: view

No data available for Gene Families for GIN1 Gene

Function for GIN1 Gene

Gene Ontology (GO) - Molecular Function for GIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IBA --
genes like me logo Genes that share ontologies with GIN1: view
genes like me logo Genes that share phenotypes with GIN1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GIN1 Gene

Localization for GIN1 Gene

Subcellular locations from

Jensen Localization Image for GIN1 Gene COMPARTMENTS Subcellular localization image for GIN1 gene
Compartment Confidence
cytosol 1

Gene Ontology (GO) - Cellular Components for GIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with GIN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GIN1 Gene

Pathways & Interactions for GIN1 Gene

SuperPathways for GIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015074 DNA integration IEA --
GO:0032197 transposition, RNA-mediated IBA --
genes like me logo Genes that share ontologies with GIN1: view

No data available for Pathways by source and SIGNOR curated interactions for GIN1 Gene

Drugs & Compounds for GIN1 Gene

(7) Drugs for GIN1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atazanavir Approved, Investigational Pharma HIV protease inhibitor,highly potent 217
BMS-707035 Pharma HIV-I integrase inhibitor,potent and specific 0
Elvitegravir (GS-9137) Pharma HIV-1 integrase inhibitor,potent 0
Fluorouracil (Adrucil) Pharma Antitumor agent;inhibitor of thymidylate synthase 0
GSK744 (S/GSK1265744) Pharma HIV integrase inhibitor, oral active and long-acting 0
genes like me logo Genes that share compounds with GIN1: view

Transcripts for GIN1 Gene

Unigene Clusters for GIN1 Gene

Gypsy retrotransposon integrase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GIN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP3: - - - -

Relevant External Links for GIN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GIN1 Gene

mRNA expression in normal human tissues for GIN1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GIN1 Gene

SOURCE GeneReport for Unigene cluster for GIN1 Gene Hs.24088

mRNA Expression by UniProt/SwissProt for GIN1 Gene

Tissue specificity: Widely expressed. Also found in tumors originating from parathyroid gland, colon, stomach, bladder, uterus and prostate.
genes like me logo Genes that share expression patterns with GIN1: view

Protein tissue co-expression partners for GIN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for GIN1 Gene

Orthologs for GIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GIN1 35
  • 89.04 (n)
  • 87.98 (a)
GIN1 36
  • 89 (a)
(Canis familiaris)
Mammalia GIN1 35
  • 92.66 (n)
  • 92.53 (a)
GIN1 36
  • 89 (a)
(Mus musculus)
Mammalia Gin1 35
  • 85.01 (n)
  • 86.1 (a)
Gin1 16
Gin1 36
  • 86 (a)
(Pan troglodytes)
Mammalia GIN1 35
  • 99.81 (n)
  • 99.43 (a)
GIN1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Gin1 35
  • 82.24 (n)
  • 83.59 (a)
(Monodelphis domestica)
Mammalia GIN1 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia GIN1 36
  • 67 (a)
(Gallus gallus)
Aves GIN1 35
  • 71.3 (n)
  • 68.7 (a)
GIN1 36
  • 61 (a)
(Anolis carolinensis)
Reptilia GIN1 36
  • 57 (a)
(Danio rerio)
Actinopterygii GIN1 36
  • 21 (a)
Species with no ortholog for GIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIN1 Gene

Gene Tree for GIN1 (if available)
Gene Tree for GIN1 (if available)

Paralogs for GIN1 Gene

No data available for Paralogs for GIN1 Gene

Variants for GIN1 Gene

Sequence variations from dbSNP and Humsavar for GIN1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_043041 -
VAR_043042 -

Structural Variations from Database of Genomic Variants (DGV) for GIN1 Gene

Variant ID Type Subtype PubMed ID
nsv882519 CNV Loss 21882294
nsv830430 CNV Gain 17160897

Variation tolerance for GIN1 Gene

Residual Variation Intolerance Score: 34.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIN1 Gene

Disorders for GIN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GIN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • pelvic cellulitis unspecified
- elite association
Search GIN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GIN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIN1 Gene

Publications for GIN1 Gene

  1. A mammalian gene evolved from the integrase domain of an LTR retrotransposon. (PMID: 11470852) Llorens C. … Marin I. (Mol. Biol. Evol. 2001) 2 67
  2. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S. … Ghosh M.K. (Cell Oncol (Dordr) 2015) 67
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  4. Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans. (PMID: 21120996) Hughes L.B. … Bridges S.L. (Arthritis Rheum. 2010) 67
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67

Products for GIN1 Gene

Sources for GIN1 Gene

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