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Aliases for GIMAP7 Gene

Aliases for GIMAP7 Gene

  • GTPase, IMAP Family Member 7 2 3 5
  • Immune-Associated Nucleotide-Binding Protein 7 2 3
  • Immunity-Associated Nucleotide 7 Protein 3 4
  • IAN-7 3 4
  • IAN7 3 4
  • Immune Associated Nucleotide 3
  • GTPase IMAP Family Member 7 3
  • HIAN7 3

External Ids for GIMAP7 Gene

Previous GeneCards Identifiers for GIMAP7 Gene

  • GC07P149649
  • GC07P149842
  • GC07P150211
  • GC07P144027

Summaries for GIMAP7 Gene

Entrez Gene Summary for GIMAP7 Gene

  • This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

GeneCards Summary for GIMAP7 Gene

GIMAP7 (GTPase, IMAP Family Member 7) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and GTPase activity. An important paralog of this gene is GIMAP4.

UniProtKB/Swiss-Prot for GIMAP7 Gene

  • The dimer has GTPase activity; the active site contains residues from both subunits.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIMAP7 Gene

Genomics for GIMAP7 Gene

Regulatory Elements for GIMAP7 Gene

Enhancers for GIMAP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F150566 0.9 FANTOM5 ENCODE 29 +53.5 53505 4.2 POLR2A L3MBTL2 IRF1 ZBTB33 RAD21 MGA SPI1 GIMAP7 GIMAP5 GIMAP1 GIMAP4 GIMAP2 GIMAP8 GIMAP6 TMEM176B GC07P150573
GH07F150448 1.3 FANTOM5 ENCODE 19.3 -64.5 -64515 4.4 HDGF PKNOX1 CBX3 TBL1XR1 BMI1 RAD21 ZNF143 ZMIZ1 CREM MIXL1 GIMAP8 GIMAP7 GIMAP1 GIMAP6 GIMAP5 STRADBP1 GIMAP2 GIMAP4 WDR86-AS1 TMEM176B
GH07F150674 1.2 FANTOM5 Ensembl ENCODE 18.2 +162.0 161963 3.8 HDGF BCOR PKNOX1 SMAD5 MAFG ZIC2 ARID1B ZNF316 POLR2A STAT2 GIMAP1 GIMAP7 GIMAP4 GIMAP8 STRADBP1 GIMAP2 GIMAP5 GIMAP3P GIMAP6 EIF2AP3
GH07F150555 1.1 FANTOM5 Ensembl ENCODE 19.8 +41.4 41440 1.8 ZNF316 ZNF146 ATF3 NFE2 GIMAP1 GIMAP7 GIMAP4 GIMAP6 STRADBP1 GIMAP5 GIMAP2 GIMAP8 ALDH7A1P3
GH07F150662 1.8 FANTOM5 Ensembl ENCODE 10.9 +152.3 152338 8.5 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000244151 ZNF862 GIMAP1 GIMAP4 GIMAP6 GIMAP2 GIMAP8 ENSG00000243433 GIMAP5 ATP6V0E2-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GIMAP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for GIMAP7 Gene

Chromosome:
7
Start:
150,514,830 bp from pter
End:
150,521,073 bp from pter
Size:
6,244 bases
Orientation:
Plus strand

Genomic View for GIMAP7 Gene

Genes around GIMAP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIMAP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIMAP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIMAP7 Gene

Proteins for GIMAP7 Gene

  • Protein details for GIMAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHV1-GIMA7_HUMAN
    Recommended name:
    GTPase IMAP family member 7
    Protein Accession:
    Q8NHV1

    Protein attributes for GIMAP7 Gene

    Size:
    300 amino acids
    Molecular mass:
    34509 Da
    Quaternary structure:
    • Monomer in the presence of bound GDP and in the absence of bound nucleotide. Homodimer in the presence of bound GTP. Heterodimer with GIMAP2.

    Three dimensional structures from OCA and Proteopedia for GIMAP7 Gene

neXtProt entry for GIMAP7 Gene

Post-translational modifications for GIMAP7 Gene

  • Ubiquitination at Lys 16, Lys 21, Lys 45, Lys 71, and Lys 178
  • Modification sites at PhosphoSitePlus

Other Protein References for GIMAP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GIMAP7 Gene

Domains & Families for GIMAP7 Gene

Gene Families for GIMAP7 Gene

Protein Domains for GIMAP7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GIMAP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHV1

UniProtKB/Swiss-Prot:

GIMA7_HUMAN :
  • Contains 1 AIG1-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Domain:
  • Contains 1 AIG1-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
genes like me logo Genes that share domains with GIMAP7: view

Function for GIMAP7 Gene

Molecular function for GIMAP7 Gene

UniProtKB/Swiss-Prot Function:
The dimer has GTPase activity; the active site contains residues from both subunits.

Gene Ontology (GO) - Molecular Function for GIMAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 23454188
GO:0005515 protein binding IPI 23454188
GO:0005525 GTP binding IDA 23454188
GO:0042803 protein homodimerization activity IPI 23454188
genes like me logo Genes that share ontologies with GIMAP7: view

Phenotypes for GIMAP7 Gene

genes like me logo Genes that share phenotypes with GIMAP7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GIMAP7 Gene

Localization for GIMAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIMAP7 Gene

Lipid droplet. Cytoplasm. Endoplasmic reticulum. Golgi apparatus. Note=Colocalizes with GIMAP2 on the surface of cytoplasmic lipid droplets.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GIMAP7 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
golgi apparatus 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GIMAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005811 lipid particle IEA,IDA 23454188
genes like me logo Genes that share ontologies with GIMAP7: view

Pathways & Interactions for GIMAP7 Gene

SuperPathways for GIMAP7 Gene

No Data Available

Interacting Proteins for GIMAP7 Gene

Gene Ontology (GO) - Biological Process for GIMAP7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GIMAP7 Gene

Drugs & Compounds for GIMAP7 Gene

(1) Drugs for GIMAP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GIMAP7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
genes like me logo Genes that share compounds with GIMAP7: view

Transcripts for GIMAP7 Gene

mRNA/cDNA for GIMAP7 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(83) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GIMAP7 Gene

GTPase, IMAP family member 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIMAP7 Gene

No ASD Table

Relevant External Links for GIMAP7 Gene

GeneLoc Exon Structure for
GIMAP7
ECgene alternative splicing isoforms for
GIMAP7

Expression for GIMAP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GIMAP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIMAP7 Gene

This gene is overexpressed in Spleen (x5.2) and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for GIMAP7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.5) and Lymph node (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GIMAP7 Gene



Protein tissue co-expression partners for GIMAP7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GIMAP7 Gene:

GIMAP7

SOURCE GeneReport for Unigene cluster for GIMAP7 Gene:

Hs.647074

mRNA Expression by UniProt/SwissProt for GIMAP7 Gene:

Q8NHV1-GIMA7_HUMAN
Tissue specificity: Most abundantly expressed in spleen, lymph nodes, and fetal kidney, but also present in the heart and the small intestine. Lower expression levels are found in lung, kidney, liver, and thyroid, salivary, and mammary glands. Also detected in the thymus (PubMed:15474311). Detected in T-cells (PubMed:23454188).
genes like me logo Genes that share expression patterns with GIMAP7: view

Primer Products

Orthologs for GIMAP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GIMAP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GIMAP7 34 35
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia GIMAP7 34 35 35 35
  • 74.23 (n)
-- 35
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GIMAP7 35
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gimap7 34 16 35
  • 70.24 (n)
rat
(Rattus norvegicus)
Mammalia Gimap7 34
  • 69.43 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 36 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU550714.1 35
  • 38 (a)
ManyToMany
si:ch211-254c8.3 35
  • 37 (a)
ManyToMany
CR933791.1 35
  • 35 (a)
ManyToMany
CR450842.1 35
  • 34 (a)
ManyToMany
BX323987.1 35
  • 32 (a)
ManyToMany
CR933791.3 35
  • 31 (a)
ManyToMany
si:dkeyp-67a8.4 35 35
  • 30 (a)
ManyToMany
BX322792.2 35
  • 29 (a)
ManyToMany
CU695221.1 35
  • 29 (a)
ManyToMany
zgc:172131 35
  • 29 (a)
ManyToMany
zgc:152753 35
  • 27 (a)
ManyToMany
BX005442.2 35
  • 26 (a)
ManyToMany
zgc:101806 35
  • 25 (a)
ManyToMany
si:ch211-280c16.1 35
  • 23 (a)
ManyToMany
zgc:165583 35
  • 21 (a)
ManyToMany
BX322792.1 35
  • 18 (a)
ManyToMany
zgc:195075 35
  • 18 (a)
ManyToMany
BX004816.3 35
  • 17 (a)
ManyToMany
BX004857.2 35
  • 17 (a)
ManyToMany
si:ch73-308m11.1 35
  • 17 (a)
ManyToMany
zgc:172090 35
  • 17 (a)
ManyToMany
CABZ01029902.1 35
  • 16 (a)
ManyToMany
si:dkey-30g5.1 35
  • 15 (a)
ManyToMany
si:ch1073-185p12.2 35
  • 13 (a)
ManyToMany
BX321875.5 35 35
  • 12 (a)
ManyToMany
Species where no ortholog for GIMAP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIMAP7 Gene

ENSEMBL:
Gene Tree for GIMAP7 (if available)
TreeFam:
Gene Tree for GIMAP7 (if available)

Paralogs for GIMAP7 Gene

Paralogs for GIMAP7 Gene

(6) SIMAP similar genes for GIMAP7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GIMAP7: view

Variants for GIMAP7 Gene

Sequence variations from dbSNP and Humsavar for GIMAP7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10254829 -- 150,516,063(+) TACCT(A/C)TTAGC intron-variant
rs10270302 -- 150,515,931(+) ATCTC(C/T)GTGCC intron-variant
rs10275200 -- 150,519,459(+) gaaat(A/G)aatca intron-variant
rs10578 -- 150,520,914(-) TCTTT(A/G)CAAAA utr-variant-3-prime
rs112086502 -- 150,513,709(+) GAAAG(G/T)GTTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GIMAP7 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
nsv1015582 CNV gain 25217958
nsv1031309 CNV loss 25217958
nsv1034409 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv608990 CNV gain 21841781

Variation tolerance for GIMAP7 Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIMAP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIMAP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIMAP7 Gene

Disorders for GIMAP7 Gene

Relevant External Links for GIMAP7

Genetic Association Database (GAD)
GIMAP7
Human Genome Epidemiology (HuGE) Navigator
GIMAP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIMAP7

No disorders were found for GIMAP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GIMAP7 Gene

Publications for GIMAP7 Gene

  1. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. (PMID: 15474311) Kruecken J. … Wunderlich F. (Gene 2004) 2 3 4 64
  2. Structural insights into the mechanism of GTPase activation in the GIMAP family. (PMID: 23454188) Schwefel D. … Daumke O. (Structure 2013) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 64

Products for GIMAP7 Gene

Sources for GIMAP7 Gene

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