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Aliases for GIMAP5 Gene

Aliases for GIMAP5 Gene

  • GTPase, IMAP Family Member 5 2 3 5
  • Immune-Associated Nucleotide-Binding Protein 5 2 3
  • Immunity-Associated Nucleotide 5 Protein 3 4
  • IAN4L1 3 4
  • IAN-5 3 4
  • IMAP3 3 4
  • IAN5 3 4
  • Inhibitor Of Radiation- And OA-Induced Apoptosis, Irod/Ian5 3
  • Immunity-Associated Nucleotide 4-Like 1 Protein 4
  • Immune Associated Nucleotide 4 Like 1 (Mouse) 2
  • Immune Associated Nucleotide 4 Like 1 3
  • Immunity Associated Protein 3 3
  • Immunity-Associated Protein 3 4
  • GTPase IMAP Family Member 5 3
  • HIMAP3 3
  • HIAN5 4
  • IAN4 3
  • IROD 3

External Ids for GIMAP5 Gene

Previous HGNC Symbols for GIMAP5 Gene

  • IAN4L1

Previous GeneCards Identifiers for GIMAP5 Gene

  • GC07P149872
  • GC07P150065
  • GC07P150419
  • GC07P144246

Summaries for GIMAP5 Gene

Entrez Gene Summary for GIMAP5 Gene

  • This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for GIMAP5 Gene

GIMAP5 (GTPase, IMAP Family Member 5) is a Protein Coding gene. Diseases associated with GIMAP5 include Wolfram Syndrome. Among its related pathways are Apoptosis and Autophagy and NF-kappaB Signaling. GO annotations related to this gene include GTP binding. An important paralog of this gene is GIMAP1-GIMAP5.

UniProtKB/Swiss-Prot for GIMAP5 Gene

  • Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity).

Gene Wiki entry for GIMAP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIMAP5 Gene

Genomics for GIMAP5 Gene

Regulatory Elements for GIMAP5 Gene

Enhancers for GIMAP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F150566 1 FANTOM5 ENCODE 28 -153.9 -153919 4.2 POLR2A L3MBTL2 IRF1 ZBTB33 RAD21 MGA SPI1 GIMAP7 GIMAP5 GIMAP1 GIMAP4 GIMAP2 GIMAP8 GIMAP6 TMEM176B GC07P150573
GH07F150647 1.1 Ensembl ENCODE 18.7 -73.7 -73719 2.6 RELA GATA3 CTBP1 ZNF366 GATA2 ZNF512 KDM1A SPI1 GIMAP5 GIMAP1 GIMAP8 GIMAP4 GIMAP2 GIMAP3P GIMAP6 EIF2AP3
GH07F150714 1 FANTOM5 ENCODE 17.5 -4.8 -4821 5.8 PKNOX1 MLX ARID4B DMAP1 ZNF48 SP5 MXD4 MIER2 PPARG KAT8 GIMAP5 GIMAP2 GIMAP1 GIMAP7 GIMAP4 GIMAP6 GIMAP8 GIMAP1-GIMAP5
GH07F150752 1.6 FANTOM5 Ensembl ENCODE 14.1 +32.8 32825 5.0 HDGF PKNOX1 YBX1 BMI1 RAD21 ZNF366 ETV6 CREM EGR2 JUNB GIMAP5 GIMAP3P RARRES2 GIMAP2 GIMAP8 TMEM176B TMEM176A GIMAP1 GIMAP7 GIMAP6
GH07F150448 1.2 FANTOM5 ENCODE 13.4 -271.9 -271938 4.4 HDGF PKNOX1 CBX3 TBL1XR1 BMI1 RAD21 ZNF143 ZMIZ1 CREM MIXL1 GIMAP8 GIMAP7 GIMAP1 GIMAP6 GIMAP5 STRADBP1 GIMAP2 GIMAP4 WDR86-AS1 TMEM176B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GIMAP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GIMAP5 Gene

Chromosome:
7
Start:
150,722,253 bp from pter
End:
150,750,033 bp from pter
Size:
27,781 bases
Orientation:
Plus strand

Genomic View for GIMAP5 Gene

Genes around GIMAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIMAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIMAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIMAP5 Gene

Proteins for GIMAP5 Gene

  • Protein details for GIMAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F15-GIMA5_HUMAN
    Recommended name:
    GTPase IMAP family member 5
    Protein Accession:
    Q96F15
    Secondary Accessions:
    • D3DWZ5
    • Q6IA75
    • Q96NE4
    • Q9NUK9

    Protein attributes for GIMAP5 Gene

    Size:
    307 amino acids
    Molecular mass:
    34846 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GIMAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GIMAP5 Gene

Post-translational modifications for GIMAP5 Gene

  • Ubiquitination at Lys 8, Lys 56, and Lys 77
  • Modification sites at PhosphoSitePlus

Other Protein References for GIMAP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GIMAP5 (GIMAP5)
  • Abcam antibodies for GIMAP5
  • Santa Cruz Biotechnology (SCBT) Antibodies for GIMAP5

No data available for DME Specific Peptides for GIMAP5 Gene

Domains & Families for GIMAP5 Gene

Gene Families for GIMAP5 Gene

Protein Domains for GIMAP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GIMAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F15

UniProtKB/Swiss-Prot:

GIMA5_HUMAN :
  • Contains 1 AIG1-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Domain:
  • Contains 1 AIG1-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
genes like me logo Genes that share domains with GIMAP5: view

Function for GIMAP5 Gene

Molecular function for GIMAP5 Gene

UniProtKB/Swiss-Prot Function:
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity).

Gene Ontology (GO) - Molecular Function for GIMAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GIMAP5: view
genes like me logo Genes that share phenotypes with GIMAP5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GIMAP5 Gene

Localization for GIMAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIMAP5 Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein. Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIMAP5 Gene COMPARTMENTS Subcellular localization image for GIMAP5 gene
Compartment Confidence
mitochondrion 4
lysosome 3
vacuole 3
cytosol 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GIMAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005764 lysosome IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GIMAP5: view

Pathways & Interactions for GIMAP5 Gene

genes like me logo Genes that share pathways with GIMAP5: view

Pathways by source for GIMAP5 Gene

2 Cell Signaling Technology pathways for GIMAP5 Gene

Gene Ontology (GO) - Biological Process for GIMAP5 Gene

None

No data available for SIGNOR curated interactions for GIMAP5 Gene

Drugs & Compounds for GIMAP5 Gene

(1) Drugs for GIMAP5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GIMAP5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
genes like me logo Genes that share compounds with GIMAP5: view

Transcripts for GIMAP5 Gene

Unigene Clusters for GIMAP5 Gene

GTPase, IMAP family member 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIMAP5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2: - - -
SP3:
SP4:

Relevant External Links for GIMAP5 Gene

GeneLoc Exon Structure for
GIMAP5
ECgene alternative splicing isoforms for
GIMAP5

Expression for GIMAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GIMAP5 Gene

mRNA differential expression in normal tissues according to GTEx for GIMAP5 Gene

This gene is overexpressed in Whole Blood (x6.0) and Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for GIMAP5 Gene

This gene is overexpressed in Tlymphocyte (20.2), Peripheral blood mononuclear cells (17.5), and Lymph node (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GIMAP5 Gene



Protein tissue co-expression partners for GIMAP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GIMAP5 Gene:

GIMAP5

SOURCE GeneReport for Unigene cluster for GIMAP5 Gene:

Hs.647079

mRNA Expression by UniProt/SwissProt for GIMAP5 Gene:

Q96F15-GIMA5_HUMAN
Tissue specificity: Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.
genes like me logo Genes that share expression patterns with GIMAP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GIMAP5 Gene

Orthologs for GIMAP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GIMAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GIMAP5 35
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 62 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gimap3 35
  • 57 (a)
OneToMany
Gimap5 35
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GIMAP5 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:136870 35
  • 25 (a)
ManyToMany
CR626941.1 35
  • 24 (a)
ManyToMany
CR753886.1 35
  • 22 (a)
ManyToMany
si:dkeyp-69e1.8 35
  • 22 (a)
ManyToMany
zgc:113442 35
  • 20 (a)
ManyToMany
zgc:158417 35
  • 18 (a)
ManyToMany
CABZ01081656.1 35
  • 9 (a)
ManyToMany
si:dkey-23k10.5 35
  • 9 (a)
ManyToMany
si:ch211-214j24.15 35
  • 8 (a)
ManyToMany
CABZ01041769.1 35
  • 7 (a)
ManyToMany
Species where no ortholog for GIMAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIMAP5 Gene

ENSEMBL:
Gene Tree for GIMAP5 (if available)
TreeFam:
Gene Tree for GIMAP5 (if available)

Paralogs for GIMAP5 Gene

Paralogs for GIMAP5 Gene

(6) SIMAP similar genes for GIMAP5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GIMAP5 Gene

genes like me logo Genes that share paralogs with GIMAP5: view

Variants for GIMAP5 Gene

Sequence variations from dbSNP and Humsavar for GIMAP5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10239015 -- 150,741,002(+) CCCAT(C/T)TAAAA intron-variant
rs10239400 -- 150,741,309(+) GAAAA(A/C)GAAGA intron-variant
rs10361 -- 150,743,155(+) TCTAT(C/G)GAGCA utr-variant-3-prime
rs1046355 -- 150,742,955(+) GCGCT(C/T)CTCAG reference, synonymous-codon
rs1046367 -- 150,743,247(+) TGCCT(A/G)CTGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GIMAP5 Gene

Variant ID Type Subtype PubMed ID
dgv1146n67 CNV loss 20364138
dgv3695n106 OTHER inversion 24896259
esv2759573 CNV loss 17122850
esv3891235 CNV loss 25118596
nsv1030109 CNV gain 25217958
nsv1034409 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv608990 CNV gain 21841781
nsv824391 CNV gain 20364138
nsv831187 CNV loss 17160897

Variation tolerance for GIMAP5 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIMAP5 Gene

Human Gene Mutation Database (HGMD)
GIMAP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIMAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIMAP5 Gene

Disorders for GIMAP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GIMAP5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
wolfram syndrome
  • wolfram syndrome 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GIMAP5

Genetic Association Database (GAD)
GIMAP5
Human Genome Epidemiology (HuGE) Navigator
GIMAP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIMAP5
genes like me logo Genes that share disorders with GIMAP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIMAP5 Gene

Publications for GIMAP5 Gene

  1. IAN5 polymorphisms are associated with systemic lupus erythematosus. (PMID: 19762377) Lim M.K. … Shim S.C. (Lupus 2009) 3 22 46 64
  2. hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies. (PMID: 14724691) Zenz T. … Daheron L. (Genes Immun. 2004) 3 4 22 64
  3. The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus. (PMID: 17220214) Hellquist A. … Lindgren C.M. (J. Med. Genet. 2007) 3 46 64
  4. Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells. (PMID: 17369194) Dalberg U. … Hornum L. (Int. Immunol. 2007) 3 22 64
  5. IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5. (PMID: 17641683) Shin J.H. … Aman J. (Genes Immun. 2007) 3 46 64

Products for GIMAP5 Gene

Sources for GIMAP5 Gene

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