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Aliases for GIMAP4 Gene

Aliases for GIMAP4 Gene

  • GTPase, IMAP Family Member 4 2 3 5
  • Immune-Associated Nucleotide-Binding Protein 1 2 3
  • Immunity-Associated Nucleotide 1 Protein 3 4
  • Immunity-Associated Protein 4 3 4
  • IAN-1 3 4
  • IMAP4 3 4
  • IAN1 3 4
  • Human Immune Associated Nucleotide 1 3
  • Immunity Associated Protein 4 3
  • MSTP062 3
  • HIAN1 4

External Ids for GIMAP4 Gene

Previous GeneCards Identifiers for GIMAP4 Gene

  • GC07P149702
  • GC07P149895
  • GC07P150264
  • GC07P144080

Summaries for GIMAP4 Gene

Entrez Gene Summary for GIMAP4 Gene

  • This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

GeneCards Summary for GIMAP4 Gene

GIMAP4 (GTPase, IMAP Family Member 4) is a Protein Coding gene. Diseases associated with GIMAP4 include T-Cell Acute Lymphocytic Leukemia-1 and Behcet's Disease. GO annotations related to this gene include GTP binding. An important paralog of this gene is GIMAP5.

UniProtKB/Swiss-Prot for GIMAP4 Gene

  • May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.

Gene Wiki entry for GIMAP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIMAP4 Gene

Genomics for GIMAP4 Gene

Regulatory Elements for GIMAP4 Gene

Enhancers for GIMAP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GIMAP4 on UCSC Golden Path with GeneCards custom track

Promoters for GIMAP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GIMAP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GIMAP4 Gene

Chromosome:
7
Start:
150,567,277 bp from pter
End:
150,573,955 bp from pter
Size:
6,679 bases
Orientation:
Plus strand

Genomic View for GIMAP4 Gene

Genes around GIMAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIMAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIMAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIMAP4 Gene

Proteins for GIMAP4 Gene

  • Protein details for GIMAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUV9-GIMA4_HUMAN
    Recommended name:
    GTPase IMAP family member 4
    Protein Accession:
    Q9NUV9

    Protein attributes for GIMAP4 Gene

    Size:
    329 amino acids
    Molecular mass:
    37534 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GIMAP4 Gene

neXtProt entry for GIMAP4 Gene

Proteomics data for GIMAP4 Gene at MOPED

Post-translational modifications for GIMAP4 Gene

  • Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation (By similarity).
  • Ubiquitination at Lys 217 and Lys 282
  • Modification sites at PhosphoSitePlus

Other Protein References for GIMAP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GIMAP4 Gene

Domains & Families for GIMAP4 Gene

Gene Families for GIMAP4 Gene

Protein Domains for GIMAP4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GIMAP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUV9

UniProtKB/Swiss-Prot:

GIMA4_HUMAN :
  • Contains 1 AIG1-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Domain:
  • Contains 1 AIG1-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
genes like me logo Genes that share domains with GIMAP4: view

Function for GIMAP4 Gene

Molecular function for GIMAP4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.
genes like me logo Genes that share phenotypes with GIMAP4: view

Animal Models for GIMAP4 Gene

MGI Knock Outs for GIMAP4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GIMAP4 Gene

Localization for GIMAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIMAP4 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIMAP4 Gene COMPARTMENTS Subcellular localization image for GIMAP4 gene
Compartment Confidence
cytosol 5
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for GIMAP4 Gene

Pathways & Interactions for GIMAP4 Gene

SuperPathways for GIMAP4 Gene

No Data Available

Interacting Proteins for GIMAP4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000255945%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000255945 for GIMAP4 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for GIMAP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GIMAP4 Gene

Drugs & Compounds for GIMAP4 Gene

(2) Drugs for GIMAP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for GIMAP4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
genes like me logo Genes that share compounds with GIMAP4: view

Transcripts for GIMAP4 Gene

Unigene Clusters for GIMAP4 Gene

GTPase, IMAP family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GIMAP4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:
SP4: - - -

Relevant External Links for GIMAP4 Gene

GeneLoc Exon Structure for
GIMAP4
ECgene alternative splicing isoforms for
GIMAP4

Expression for GIMAP4 Gene

mRNA expression in normal human tissues for GIMAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIMAP4 Gene

This gene is overexpressed in Whole Blood (x10.3).

Protein differential expression in normal tissues from HIPED for GIMAP4 Gene

This gene is overexpressed in Tlymphocyte (13.2), Peripheral blood mononuclear cells (12.1), Lymph node (9.6), Spleen (6.4), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GIMAP4 Gene



SOURCE GeneReport for Unigene cluster for GIMAP4 Gene Hs.647101

mRNA Expression by UniProt/SwissProt for GIMAP4 Gene

Q9NUV9-GIMA4_HUMAN
Tissue specificity: Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.
genes like me logo Genes that share expression patterns with GIMAP4: view

Protein tissue co-expression partners for GIMAP4 Gene

- Elite partner

Primer Products

Orthologs for GIMAP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GIMAP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GIMAP4 35
  • 74.31 (n)
  • 62.74 (a)
-- 36
  • 65 (a)
OneToMany
GIMAP4 36
  • 62 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GIMAP4 35
  • 75.08 (n)
  • 65.96 (a)
GIMAP4 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gimap4 35
  • 71.64 (n)
  • 61.8 (a)
Gimap4 16
Gimap4 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GIMAP4 35
  • 99.9 (n)
  • 99.7 (a)
GIMAP4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gimap4 35
  • 70.79 (n)
  • 60.59 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX004816.3 36
  • 16 (a)
ManyToMany
BX004857.2 36
  • 19 (a)
ManyToMany
BX005442.2 36
  • 25 (a)
ManyToMany
BX321875.5 36
  • 11 (a)
ManyToMany
BX321875.5 36
  • 14 (a)
ManyToMany
BX322792.1 36
  • 19 (a)
ManyToMany
BX322792.2 36
  • 27 (a)
ManyToMany
BX323987.1 36
  • 30 (a)
ManyToMany
CABZ01029902.1 36
  • 14 (a)
ManyToMany
CR450842.1 36
  • 29 (a)
ManyToMany
CR933791.1 36
  • 33 (a)
ManyToMany
CR933791.3 36
  • 25 (a)
ManyToMany
CU550714.1 36
  • 38 (a)
ManyToMany
CU695221.1 36
  • 25 (a)
ManyToMany
si:ch1073-185p12.2 36
  • 15 (a)
ManyToMany
si:ch211-254c8.3 36
  • 33 (a)
ManyToMany
si:ch211-280c16.1 36
  • 21 (a)
ManyToMany
si:ch73-308m11.1 36
  • 14 (a)
ManyToMany
si:dkey-30g5.1 36
  • 17 (a)
ManyToMany
si:dkeyp-67a8.4 36
  • 28 (a)
ManyToMany
si:dkeyp-67a8.4 36
  • 19 (a)
ManyToMany
zgc:101806 36
  • 27 (a)
ManyToMany
zgc:152753 36
  • 26 (a)
ManyToMany
zgc:165583 36
  • 20 (a)
ManyToMany
zgc:172090 36
  • 18 (a)
ManyToMany
zgc:172131 36
  • 26 (a)
ManyToMany
zgc:195075 36
  • 17 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os02g0557100 35
  • 46.16 (n)
  • 34.89 (a)
Species with no ortholog for GIMAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIMAP4 Gene

ENSEMBL:
Gene Tree for GIMAP4 (if available)
TreeFam:
Gene Tree for GIMAP4 (if available)

Paralogs for GIMAP4 Gene

Paralogs for GIMAP4 Gene

(6) SIMAP similar genes for GIMAP4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GIMAP4: view

Variants for GIMAP4 Gene

Sequence variations from dbSNP and Humsavar for GIMAP4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2293172 - 150,572,454(-) TCTTC(A/C/T)TCAGT reference, missense
rs952642 -- 150,573,962(-) ATTCT(G/T)CACAA downstream-variant-500B
rs1046811 -- 150,573,375(+) TTTTC(A/T)TCTAG utr-variant-3-prime
rs1317276 -- 150,571,428(-) GTGGA(G/T)ATTTA intron-variant
rs1317277 -- 150,571,148(-) GGCAT(C/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIMAP4 Gene

Variant ID Type Subtype PubMed ID
esv29812 CNV Gain 19812545
dgv2155e1 CNV Complex 17122850

Variation tolerance for GIMAP4 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIMAP4 Gene

Human Gene Mutation Database (HGMD)
GIMAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIMAP4 Gene

Disorders for GIMAP4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GIMAP4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell acute lymphocytic leukemia-1
behcet's disease
  • adamantiades-behcet disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GIMAP4

Human Genome Epidemiology (HuGE) Navigator
GIMAP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIMAP4
genes like me logo Genes that share disorders with GIMAP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIMAP4 Gene

Publications for GIMAP4 Gene

  1. Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation. (PMID: 18701445) FilAcn J.J. … Lahesmaa R. (Mol. Cell Proteomics 2009) 2 3 23 67
  2. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. (PMID: 15474311) Kruecken J. … Wunderlich F. (Gene 2004) 2 3
  3. Tubulin- and actin-associating GIMAP4 is required for IFN-I^ secretion during Th cell differentiation. (PMID: 25287446) Heinonen M.T. … Henttinen T.A. (Immunol. Cell Biol. 2015) 3
  4. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease. (PMID: 23041938) Lee Y.J. … Lee E.B. (Ann. Rheum. Dis. 2013) 3
  5. Structural insights into the mechanism of GTPase activation in the GIMAP family. (PMID: 23454188) Schwefel D. … Daumke O. (Structure 2013) 3

Products for GIMAP4 Gene

Sources for GIMAP4 Gene

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