Aliases for GIMAP4 Gene
External Ids for GIMAP4 Gene
Previous GeneCards Identifiers for GIMAP4 Gene
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
GeneCards Summary for GIMAP4 Gene
GIMAP4 (GTPase, IMAP Family Member 4) is a Protein Coding gene. Diseases associated with GIMAP4 include t-cell acute lymphocytic leukemia-1 and behcet's disease. GO annotations related to this gene include GTP binding. An important paralog of this gene is GIMAP5.
UniProtKB/Swiss-Prot for GIMAP4 Gene
May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.