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Aliases for GIMAP2 Gene

Aliases for GIMAP2 Gene

  • GTPase, IMAP Family Member 2 2 3 5
  • Immune-Associated Nucleotide-Binding Protein 12 2 3
  • Immunity-Associated Protein 2 3 4
  • HIMAP2 3 4
  • IMAP2 3 4
  • Immunity Associated Protein 2 3
  • IAN12 3

External Ids for GIMAP2 Gene

Previous GeneCards Identifiers for GIMAP2 Gene

  • GC07P149820
  • GC07P150014
  • GC07P150015
  • GC07P150382
  • GC07P144195

Summaries for GIMAP2 Gene

Entrez Gene Summary for GIMAP2 Gene

  • This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

GeneCards Summary for GIMAP2 Gene

GIMAP2 (GTPase, IMAP Family Member 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is GIMAP4.

UniProtKB/Swiss-Prot for GIMAP2 Gene

  • The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIMAP2 Gene

Genomics for GIMAP2 Gene

Regulatory Elements for GIMAP2 Gene

Promoters for GIMAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GIMAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GIMAP2 Gene

Chromosome:
7
Start:
150,685,697 bp from pter
End:
150,693,641 bp from pter
Size:
7,945 bases
Orientation:
Plus strand

Genomic View for GIMAP2 Gene

Genes around GIMAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIMAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIMAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIMAP2 Gene

Proteins for GIMAP2 Gene

  • Protein details for GIMAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UG22-GIMA2_HUMAN
    Recommended name:
    GTPase IMAP family member 2
    Protein Accession:
    Q9UG22
    Secondary Accessions:
    • Q96L25

    Protein attributes for GIMAP2 Gene

    Size:
    337 amino acids
    Molecular mass:
    38017 Da
    Quaternary structure:
    • Monomer in the presence of bound GDP and in the absence of bound nucleotide. Homodimer in the presence of bound GTP. Can form linear oligomers. Heterodimer with GIMAP7.

    Three dimensional structures from OCA and Proteopedia for GIMAP2 Gene

neXtProt entry for GIMAP2 Gene

Proteomics data for GIMAP2 Gene at MOPED

Post-translational modifications for GIMAP2 Gene

  • Ubiquitination at Lys 170
  • Modification sites at PhosphoSitePlus

Other Protein References for GIMAP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GIMAP2 Gene

Domains & Families for GIMAP2 Gene

Gene Families for GIMAP2 Gene

Protein Domains for GIMAP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GIMAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UG22

UniProtKB/Swiss-Prot:

GIMA2_HUMAN :
  • Contains 1 AIG1-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Domain:
  • Contains 1 AIG1-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
genes like me logo Genes that share domains with GIMAP2: view

Function for GIMAP2 Gene

Molecular function for GIMAP2 Gene

UniProtKB/Swiss-Prot Function:
The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself.
genes like me logo Genes that share phenotypes with GIMAP2: view

Animal Model Products

CRISPR Products

miRNA for GIMAP2 Gene

miRTarBase miRNAs that target GIMAP2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GIMAP2 Gene

Localization for GIMAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIMAP2 Gene

Membrane; Multi-pass membrane protein. Cytoplasm. Lipid droplet. Note=Detected on the surface of cytoplasmic lipid droplets.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIMAP2 Gene COMPARTMENTS Subcellular localization image for GIMAP2 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GIMAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GIMAP2: view

Pathways & Interactions for GIMAP2 Gene

SuperPathways for GIMAP2 Gene

No Data Available

Interacting Proteins for GIMAP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000223293%0d%0a9606.ENSP00000315474%0d%0a
Selected Interacting proteins: ENSP00000223293 for GIMAP2 Gene via STRING

Symbol External ID(s) Details
GIMAP7

Gene Ontology (GO) - Biological Process for GIMAP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GIMAP2 Gene

Drugs & Compounds for GIMAP2 Gene

(1) Drugs for GIMAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GIMAP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
genes like me logo Genes that share compounds with GIMAP2: view

Transcripts for GIMAP2 Gene

mRNA/cDNA for GIMAP2 Gene

Unigene Clusters for GIMAP2 Gene

GTPase, IMAP family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIMAP2 Gene

No ASD Table

Relevant External Links for GIMAP2 Gene

GeneLoc Exon Structure for
GIMAP2
ECgene alternative splicing isoforms for
GIMAP2

Expression for GIMAP2 Gene

mRNA expression in normal human tissues for GIMAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIMAP2 Gene

This gene is overexpressed in Whole Blood (x12.2) and Spleen (x5.1).

Protein differential expression in normal tissues from HIPED for GIMAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.0), Monocytes (23.0), and Lymph node (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GIMAP2 Gene



SOURCE GeneReport for Unigene cluster for GIMAP2 Gene Hs.647071

mRNA Expression by UniProt/SwissProt for GIMAP2 Gene

Q9UG22-GIMA2_HUMAN
Tissue specificity: Detected in T-cells.
genes like me logo Genes that share expression patterns with GIMAP2: view

Protein tissue co-expression partners for GIMAP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GIMAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GIMAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GIMAP2 35
  • 77.64 (n)
  • 62.92 (a)
dog
(Canis familiaris)
Mammalia GIMAP2 35
  • 78.61 (n)
  • 67.16 (a)
GIMAP2 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GIMAP2 35
  • 99.01 (n)
  • 98.81 (a)
GIMAP2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR848784.1 36
  • 24 (a)
ManyToMany
Species with no ortholog for GIMAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIMAP2 Gene

ENSEMBL:
Gene Tree for GIMAP2 (if available)
TreeFam:
Gene Tree for GIMAP2 (if available)

Paralogs for GIMAP2 Gene

Paralogs for GIMAP2 Gene

(6) SIMAP similar genes for GIMAP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GIMAP2: view

Variants for GIMAP2 Gene

Sequence variations from dbSNP and Humsavar for GIMAP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2075078 - 150,692,768(-) AGTCG(C/T)GCATG reference, missense
rs11558054 - 150,692,506(+) AGATT(G/T)TCATT reference, missense
rs17173567 - 150,692,741(+) CCTCA(A/G)TGGTG reference, missense
rs1055240 -- 150,693,416(+) AATCT(G/T)AACAT utr-variant-3-prime
rs1234353 -- 150,688,831(-) GGCGA(C/T)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIMAP2 Gene

Variant ID Type Subtype PubMed ID
dgv2155e1 CNV Complex 17122850
nsv831187 CNV Loss 17160897

Variation tolerance for GIMAP2 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIMAP2 Gene

HapMap Linkage Disequilibrium report
GIMAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIMAP2 Gene

Disorders for GIMAP2 Gene

Relevant External Links for GIMAP2

Human Genome Epidemiology (HuGE) Navigator
GIMAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIMAP2

No disorders were found for GIMAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GIMAP2 Gene

Publications for GIMAP2 Gene

  1. Structural insights into the mechanism of GTPase activation in the GIMAP family. (PMID: 23454188) Schwefel D. … Daumke O. (Structure 2013) 3 4 67
  2. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. (PMID: 15474311) Kruecken J. … Wunderlich F. (Gene 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study of smoking behaviours in patients with COPD. (PMID: 21685187) Siedlinski M. … . (Thorax 2011) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for GIMAP2 Gene

Sources for GIMAP2 Gene

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