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Aliases for GIMAP2 Gene

Aliases for GIMAP2 Gene

  • GTPase, IMAP Family Member 2 2 3 5
  • Immune-Associated Nucleotide-Binding Protein 12 2 3
  • HIMAP2 3 4
  • IMAP2 3 4
  • Immunity Associated Protein 2 3
  • Immunity-Associated Protein 2 4
  • GTPase IMAP Family Member 2 3
  • IAN12 3

External Ids for GIMAP2 Gene

Previous GeneCards Identifiers for GIMAP2 Gene

  • GC07P149820
  • GC07P150014
  • GC07P150015
  • GC07P150382
  • GC07P144195

Summaries for GIMAP2 Gene

Entrez Gene Summary for GIMAP2 Gene

  • This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

GeneCards Summary for GIMAP2 Gene

GIMAP2 (GTPase, IMAP Family Member 2) is a Protein Coding gene. Diseases associated with GIMAP2 include Behcet Syndrome. GO annotations related to this gene include GTP binding. An important paralog of this gene is GIMAP1-GIMAP5.

UniProtKB/Swiss-Prot for GIMAP2 Gene

  • The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIMAP2 Gene

Genomics for GIMAP2 Gene

Regulatory Elements for GIMAP2 Gene

Enhancers for GIMAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G150662 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.4 -18.5 -18530 8.5 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 TBX21 MEF2D GLIS1 NBN ENSG00000244151 ATP6V0E2-AS1 GIMAP1 ENSG00000273419 GIMAP4 GIMAP6 GIMAP2 ZNF862 ASIC3 GIMAP8
GH07G150566 1.2 FANTOM5 ENCODE dbSUPER 21.1 -117.4 -117363 4.2 CTCF IRF2 L3MBTL2 RAD21 POLR2A IRF1 ZBTB33 SPI1 MGA GIMAP7 GIMAP5 GIMAP1 GIMAP4 GIMAP2 GIMAP8 GIMAP6 TMEM176B GC07P150573
GH07G150683 1.6 FANTOM5 ENCODE dbSUPER 15.4 +0.5 502 5.9 HDGF FOXA2 SIN3A ARID4B DMAP1 ZNF48 YY1 TCF12 CBX5 SP5 GIMAP2 GIMAP5 GIMAP4 GIMAP1 GIMAP7 GIMAP3P TMEM176B GIMAP8 GIMAP6 GIMAP1-GIMAP5
GH07G150714 1.3 FANTOM5 ENCODE 13.7 +31.7 31736 5.8 FOXA2 PKNOX1 MLX ARID4B DMAP1 ZNF48 TCF12 SP5 MXD4 MIER2 GIMAP5 GIMAP2 GIMAP1 GIMAP7 GIMAP4 GIMAP6 GIMAP8 GIMAP1-GIMAP5
GH07G150674 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -8.9 -8905 3.8 HDGF BCOR PKNOX1 NFIB AGO1 MAX ZIC2 ZNF316 GATA2 POLR2A GIMAP1 GIMAP7 GIMAP4 GIMAP8 STRADBP1 GIMAP2 ENSG00000244151 GIMAP5 GIMAP3P GIMAP6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GIMAP2 on UCSC Golden Path with GeneCards custom track

Promoters for GIMAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219729 203 1401 HDGF ELF3 TBP FOXA2 TBL1XR1 SIN3A ZSCAN9 ZNF48 RAD21 YY1

Genomic Location for GIMAP2 Gene

Chromosome:
7
Start:
150,685,697 bp from pter
End:
150,693,641 bp from pter
Size:
7,945 bases
Orientation:
Plus strand

Genomic View for GIMAP2 Gene

Genes around GIMAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIMAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIMAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIMAP2 Gene

Proteins for GIMAP2 Gene

  • Protein details for GIMAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UG22-GIMA2_HUMAN
    Recommended name:
    GTPase IMAP family member 2
    Protein Accession:
    Q9UG22
    Secondary Accessions:
    • Q96L25

    Protein attributes for GIMAP2 Gene

    Size:
    337 amino acids
    Molecular mass:
    38017 Da
    Quaternary structure:
    • Monomer in the presence of bound GDP and in the absence of bound nucleotide. Homodimer in the presence of bound GTP. Can form linear oligomers. Heterodimer with GIMAP7.

    Three dimensional structures from OCA and Proteopedia for GIMAP2 Gene

neXtProt entry for GIMAP2 Gene

Post-translational modifications for GIMAP2 Gene

  • Ubiquitination at isoforms=1170
  • Modification sites at PhosphoSitePlus

Other Protein References for GIMAP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GIMAP2 Gene

Domains & Families for GIMAP2 Gene

Gene Families for GIMAP2 Gene

Protein Domains for GIMAP2 Gene

Suggested Antigen Peptide Sequences for GIMAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UG22

UniProtKB/Swiss-Prot:

GIMA2_HUMAN :
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
genes like me logo Genes that share domains with GIMAP2: view

Function for GIMAP2 Gene

Molecular function for GIMAP2 Gene

UniProtKB/Swiss-Prot Function:
The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself.

Gene Ontology (GO) - Molecular Function for GIMAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GIMAP2: view
genes like me logo Genes that share phenotypes with GIMAP2: view

Animal Model Products

CRISPR Products

miRNA for GIMAP2 Gene

miRTarBase miRNAs that target GIMAP2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GIMAP2 Gene

Localization for GIMAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIMAP2 Gene

Membrane; Multi-pass membrane protein. Cytoplasm. Lipid droplet. Note=Detected on the surface of cytoplasmic lipid droplets.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GIMAP2 gene
Compartment Confidence
plasma membrane 3
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GIMAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005811 lipid particle IEA,IDA 23454188
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GIMAP2: view

Pathways & Interactions for GIMAP2 Gene

SuperPathways for GIMAP2 Gene

No Data Available

Interacting Proteins for GIMAP2 Gene

Gene Ontology (GO) - Biological Process for GIMAP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GIMAP2 Gene

Drugs & Compounds for GIMAP2 Gene

(1) Drugs for GIMAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GIMAP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
genes like me logo Genes that share compounds with GIMAP2: view

Transcripts for GIMAP2 Gene

mRNA/cDNA for GIMAP2 Gene

Unigene Clusters for GIMAP2 Gene

GTPase, IMAP family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIMAP2 Gene

No ASD Table

Relevant External Links for GIMAP2 Gene

GeneLoc Exon Structure for
GIMAP2
ECgene alternative splicing isoforms for
GIMAP2

Expression for GIMAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GIMAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIMAP2 Gene

This gene is overexpressed in Whole Blood (x12.2) and Spleen (x5.1).

Protein differential expression in normal tissues from HIPED for GIMAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.0), Monocytes (23.0), and Lymph node (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GIMAP2 Gene



Protein tissue co-expression partners for GIMAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GIMAP2 Gene:

GIMAP2

SOURCE GeneReport for Unigene cluster for GIMAP2 Gene:

Hs.647071

mRNA Expression by UniProt/SwissProt for GIMAP2 Gene:

Q9UG22-GIMA2_HUMAN
Tissue specificity: Detected in T-cells.

Evidence on tissue expression from TISSUES for GIMAP2 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with GIMAP2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GIMAP2 Gene

Orthologs for GIMAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GIMAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GIMAP2 34 35
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia GIMAP2 34 35
  • 78.61 (n)
cow
(Bos Taurus)
Mammalia GIMAP2 34
  • 77.64 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 33 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR848784.1 35
  • 24 (a)
ManyToMany
Species where no ortholog for GIMAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIMAP2 Gene

ENSEMBL:
Gene Tree for GIMAP2 (if available)
TreeFam:
Gene Tree for GIMAP2 (if available)

Paralogs for GIMAP2 Gene

Paralogs for GIMAP2 Gene

(6) SIMAP similar genes for GIMAP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GIMAP2: view

Variants for GIMAP2 Gene

Sequence variations from dbSNP and Humsavar for GIMAP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000242562 -- 150,689,255(+) TTCTG(C/T)CATTC intron-variant
rs1000485732 -- 150,689,099(+) CTAGT(C/T)AGCCT intron-variant
rs1000574537 -- 150,688,114(+) TGCAA(C/T)CTTGA intron-variant
rs1000642566 -- 150,689,595(+) TAATG(C/T)AATGC intron-variant
rs1001082075 -- 150,688,837(+) TCGCC(A/C)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GIMAP2 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
esv2759573 CNV loss 17122850
esv3615468 CNV loss 21293372
esv3891235 CNV loss 25118596
nsv1030109 CNV gain 25217958
nsv1034409 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv608990 CNV gain 21841781
nsv831187 CNV loss 17160897

Variation tolerance for GIMAP2 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIMAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIMAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIMAP2 Gene

Disorders for GIMAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GIMAP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
behcet syndrome
  • behcet's disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GIMAP2

Human Genome Epidemiology (HuGE) Navigator
GIMAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIMAP2
genes like me logo Genes that share disorders with GIMAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIMAP2 Gene

Publications for GIMAP2 Gene

  1. Structural insights into the mechanism of GTPase activation in the GIMAP family. (PMID: 23454188) Schwefel D. … Daumke O. (Structure 2013) 3 4 64
  2. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. (PMID: 15474311) Kruecken J. … Wunderlich F. (Gene 2004) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Genome-wide association study of smoking behaviours in patients with COPD. (PMID: 21685187) Siedlinski M. … . (Thorax 2011) 3 64

Products for GIMAP2 Gene

Sources for GIMAP2 Gene

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