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Aliases for GIGYF1 Gene

Aliases for GIGYF1 Gene

  • GRB10 Interacting GYF Protein 1 2 3 5
  • PERQ Amino Acid Rich, With GYF Domain 1 2 3
  • GRB10-Interacting GYF Protein 1 3 4
  • GYF Domain Containing 1 2 3
  • PERQ1 3 4
  • Postmeiotic Segregation Increased 2-Like 12 3
  • GYF1 3
  • CDS2 4

External Ids for GIGYF1 Gene

Previous HGNC Symbols for GIGYF1 Gene

  • PERQ1

Previous GeneCards Identifiers for GIGYF1 Gene

  • GC07M100116
  • GC07M100277
  • GC07M094907

Summaries for GIGYF1 Gene

GeneCards Summary for GIGYF1 Gene

GIGYF1 (GRB10 Interacting GYF Protein 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. An important paralog of this gene is GIGYF2.

UniProtKB/Swiss-Prot for GIGYF1 Gene

  • May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIGYF1 Gene

Genomics for GIGYF1 Gene

Regulatory Elements for GIGYF1 Gene

Genomic Location for GIGYF1 Gene

Chromosome:
7
Start:
100,679,507 bp from pter
End:
100,694,268 bp from pter
Size:
14,762 bases
Orientation:
Minus strand

Genomic View for GIGYF1 Gene

Genes around GIGYF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIGYF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIGYF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIGYF1 Gene

Proteins for GIGYF1 Gene

  • Protein details for GIGYF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75420-PERQ1_HUMAN
    Recommended name:
    PERQ amino acid-rich with GYF domain-containing protein 1
    Protein Accession:
    O75420
    Secondary Accessions:
    • Q6Y7W7
    • Q8WZ38

    Protein attributes for GIGYF1 Gene

    Size:
    1035 amino acids
    Molecular mass:
    114601 Da
    Quaternary structure:
    • Interacts with GRB10. This transient binding is increased under IGF1 stimulation and leads to recruitment of GIGYF1/GRB10 complex to IGF1 receptor (By similarity).
    SequenceCaution:
    • Sequence=AAC78792.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAL55738.1; Type=Frameshift; Positions=784, 856; Evidence={ECO:0000305};

neXtProt entry for GIGYF1 Gene

Proteomics data for GIGYF1 Gene at MOPED

Post-translational modifications for GIGYF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GIGYF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GIGYF1 Gene

Domains & Families for GIGYF1 Gene

Protein Domains for GIGYF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GIGYF1 Gene

Graphical View of Domain Structure for InterPro Entry

O75420

UniProtKB/Swiss-Prot:

PERQ1_HUMAN :
  • The GYF domain interacts with GRB10.
  • Belongs to the PERQ family.
Domain:
  • The GYF domain interacts with GRB10.
  • Contains 1 GYF domain.
Family:
  • Belongs to the PERQ family.
genes like me logo Genes that share domains with GIGYF1: view

No data available for Gene Families for GIGYF1 Gene

Function for GIGYF1 Gene

Molecular function for GIGYF1 Gene

UniProtKB/Swiss-Prot Function:
May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).
genes like me logo Genes that share phenotypes with GIGYF1: view

Animal Model Products

CRISPR Products

miRNA for GIGYF1 Gene

miRTarBase miRNAs that target GIGYF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GIGYF1 Gene

Localization for GIGYF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIGYF1 Gene COMPARTMENTS Subcellular localization image for GIGYF1 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GIGYF1 Gene

Pathways & Interactions for GIGYF1 Gene

genes like me logo Genes that share pathways with GIGYF1: view

Interacting Proteins for GIGYF1 Gene

Gene Ontology (GO) - Biological Process for GIGYF1 Gene

None

No data available for SIGNOR curated interactions for GIGYF1 Gene

Drugs & Compounds for GIGYF1 Gene

No Compound Related Data Available

Transcripts for GIGYF1 Gene

Unigene Clusters for GIGYF1 Gene

GRB10 interacting GYF protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GIGYF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GIGYF1 Gene

GeneLoc Exon Structure for
GIGYF1
ECgene alternative splicing isoforms for
GIGYF1

Expression for GIGYF1 Gene

mRNA expression in normal human tissues for GIGYF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GIGYF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.7) and Adrenal (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GIGYF1 Gene



SOURCE GeneReport for Unigene cluster for GIGYF1 Gene Hs.414396

genes like me logo Genes that share expression patterns with GIGYF1: view

Protein tissue co-expression partners for GIGYF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GIGYF1 Gene

Orthologs for GIGYF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GIGYF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GIGYF1 35
  • 90 (n)
  • 92.79 (a)
GIGYF1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GIGYF1 35
  • 89.17 (n)
  • 93.09 (a)
GIGYF1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gigyf1 35
  • 86.93 (n)
  • 90.44 (a)
Gigyf1 16
Gigyf1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GIGYF1 35
  • 99.26 (n)
  • 99.42 (a)
GIGYF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gigyf1 35
  • 86.98 (n)
  • 90.72 (a)
oppossum
(Monodelphis domestica)
Mammalia GIGYF1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GIGYF1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GIGYF1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gigyf1 35
  • 64.58 (n)
  • 63.52 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC568584 35
  • 65.15 (n)
  • 63.49 (a)
GIGYF1 (1 of 3) 36
  • 58 (a)
OneToMany
GIGYF1 (2 of 3) 36
  • 56 (a)
OneToMany
GIGYF1 (3 of 3) 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11148 36
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for GIGYF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIGYF1 Gene

ENSEMBL:
Gene Tree for GIGYF1 (if available)
TreeFam:
Gene Tree for GIGYF1 (if available)

Paralogs for GIGYF1 Gene

Paralogs for GIGYF1 Gene

(2) SIMAP similar genes for GIGYF1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GIGYF1: view

Variants for GIGYF1 Gene

Sequence variations from dbSNP and Humsavar for GIGYF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs221783 -- 100,695,291(-) ttgag(A/G)ccagg upstream-variant-2KB
rs221784 -- 100,695,207(-) ctggg(C/T)gtgat upstream-variant-2KB
rs221790 -- 100,680,659(+) CTACT(C/G)CAACC utr-variant-3-prime
rs221791 -- 100,680,931(+) CCAGA(A/G)CCAGA utr-variant-3-prime
rs221792 -- 100,681,034(+) GGGCC(A/C/G/T)CTCGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GIGYF1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv888791 CNV Loss 21882294
nsv470381 CNV Loss 18288195
nsv8184 CNV Loss 18304495
nsv888792 CNV Loss 21882294
dgv7401n71 CNV Loss 21882294
nsv888795 CNV Loss 21882294
nsv819414 CNV Loss 19587683

Variation tolerance for GIGYF1 Gene

Residual Variation Intolerance Score: 0.952% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.74; 83.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIGYF1 Gene

HapMap Linkage Disequilibrium report
GIGYF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIGYF1 Gene

Disorders for GIGYF1 Gene

Relevant External Links for GIGYF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIGYF1

No disorders were found for GIGYF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GIGYF1 Gene

Publications for GIGYF1 Gene

  1. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. (PMID: 12771153) Giovannone B. … Smith R.J. (J. Biol. Chem. 2003) 2 3 4 67
  2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3
  3. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  4. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PMID: 23444366) Ichimura T. … Hachiya N. (J. Cell. Sci. 2013) 3
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3

Products for GIGYF1 Gene

Sources for GIGYF1 Gene

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