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Aliases for GIGYF1 Gene

Aliases for GIGYF1 Gene

  • GRB10 Interacting GYF Protein 1 2 3 5
  • PERQ Amino Acid Rich, With GYF Domain 1 2 3
  • GYF Domain Containing 1 2 3
  • PERQ1 3 4
  • PERQ Amino Acid-Rich With GYF Domain-Containing Protein 1 3
  • Postmeiotic Segregation Increased 2-Like 12 3
  • GRB10-Interacting GYF Protein 1 4
  • GYF1 3
  • CDS2 4

External Ids for GIGYF1 Gene

Previous HGNC Symbols for GIGYF1 Gene

  • PERQ1

Previous GeneCards Identifiers for GIGYF1 Gene

  • GC07M100116
  • GC07M100277
  • GC07M094907

Summaries for GIGYF1 Gene

GeneCards Summary for GIGYF1 Gene

GIGYF1 (GRB10 Interacting GYF Protein 1) is a Protein Coding gene. An important paralog of this gene is GIGYF2.

UniProtKB/Swiss-Prot for GIGYF1 Gene

  • May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIGYF1 Gene

Genomics for GIGYF1 Gene

Regulatory Elements for GIGYF1 Gene

Enhancers for GIGYF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100356 1.2 Ensembl ENCODE 80.3 +336.3 336330 2.7 ZFP64 RAD21 ZNF354C FOS EGR2 ZNF202 ZNF680 ZNF654 ZBTB11 ZEB2 ZSCAN25 GIGYF1 PILRA LOC100131859 ZNF655 STAG3L5P AP4M1 ENSG00000242798 PPP1R35 PCOLCE-AS1
GH07F101110 0.6 Ensembl ENCODE 80.3 -419.0 -419042 4.9 ZNF493 ZFP64 ZNF121 ZNF354C ZNF138 ZNF366 SCRT2 KLF7 FOS ZNF202 GIGYF1 STAG3L5P ENSG00000242798 PPP1R35 PCOLCE-AS1 PCOLCE ACTL6B MEPCE VGF NAT16
GH07F101116 1 FANTOM5 ENCODE 76.8 -429.5 -429476 15.1 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF416 ZNF207 ENSG00000242798 GIGYF1 STAG3L5P PPP1R35 PCOLCE-AS1 MBLAC1 MEPCE PCOLCE ACTL6B SERPINE1
GH07F100913 0.6 ENCODE 62.5 -219.8 -219826 1.1 HDGF ATF1 PKNOX1 ARNT ZFP64 YY1 ZNF766 GATA2 ZNF202 NCOA1 GIGYF1 STAG3L5P AP4M1 ENSG00000242798 PPP1R35 PCOLCE-AS1 MUC3A PCOLCE ACTL6B SLC12A9
GH07F100514 1 Ensembl ENCODE 55.5 +178.4 178440 2.3 TBL1XR1 SIN3A ZEB1 ZNF121 CBX5 SCRT2 FOS ZNF202 ZNF263 ZNF680 ZSCAN25 GIGYF1 STAG3L5P AP4M1 ENSG00000242798 ZNF655 PPP1R35 PCOLCE-AS1 FBXO24 PCOLCE
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GIGYF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GIGYF1 Gene

Chromosome:
7
Start:
100,679,507 bp from pter
End:
100,694,268 bp from pter
Size:
14,762 bases
Orientation:
Minus strand

Genomic View for GIGYF1 Gene

Genes around GIGYF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIGYF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIGYF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIGYF1 Gene

Proteins for GIGYF1 Gene

  • Protein details for GIGYF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75420-PERQ1_HUMAN
    Recommended name:
    PERQ amino acid-rich with GYF domain-containing protein 1
    Protein Accession:
    O75420
    Secondary Accessions:
    • Q6Y7W7
    • Q8WZ38

    Protein attributes for GIGYF1 Gene

    Size:
    1035 amino acids
    Molecular mass:
    114601 Da
    Quaternary structure:
    • Interacts with GRB10. This transient binding is increased under IGF1 stimulation and leads to recruitment of GIGYF1/GRB10 complex to IGF1 receptor (By similarity).
    SequenceCaution:
    • Sequence=AAC78792.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAL55738.1; Type=Frameshift; Positions=784, 856; Evidence={ECO:0000305};

neXtProt entry for GIGYF1 Gene

Post-translational modifications for GIGYF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GIGYF1 Gene

Domains & Families for GIGYF1 Gene

Protein Domains for GIGYF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GIGYF1 Gene

Graphical View of Domain Structure for InterPro Entry

O75420

UniProtKB/Swiss-Prot:

PERQ1_HUMAN :
  • The GYF domain interacts with GRB10.
  • Belongs to the PERQ family.
Domain:
  • The GYF domain interacts with GRB10.
  • Contains 1 GYF domain.
Family:
  • Belongs to the PERQ family.
genes like me logo Genes that share domains with GIGYF1: view

No data available for Gene Families for GIGYF1 Gene

Function for GIGYF1 Gene

Molecular function for GIGYF1 Gene

UniProtKB/Swiss-Prot Function:
May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).
genes like me logo Genes that share phenotypes with GIGYF1: view

Animal Model Products

miRNA for GIGYF1 Gene

miRTarBase miRNAs that target GIGYF1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GIGYF1 Gene

Localization for GIGYF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GIGYF1 Gene COMPARTMENTS Subcellular localization image for GIGYF1 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GIGYF1 Gene

Pathways & Interactions for GIGYF1 Gene

SuperPathways for GIGYF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GIGYF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048009 insulin-like growth factor receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GIGYF1: view

No data available for Pathways by source and SIGNOR curated interactions for GIGYF1 Gene

Transcripts for GIGYF1 Gene

Unigene Clusters for GIGYF1 Gene

GRB10 interacting GYF protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIGYF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GIGYF1 Gene

GeneLoc Exon Structure for
GIGYF1
ECgene alternative splicing isoforms for
GIGYF1

Expression for GIGYF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GIGYF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GIGYF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.7) and Adrenal (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GIGYF1 Gene



Protein tissue co-expression partners for GIGYF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GIGYF1 Gene:

GIGYF1

SOURCE GeneReport for Unigene cluster for GIGYF1 Gene:

Hs.414396
genes like me logo Genes that share expression patterns with GIGYF1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GIGYF1 Gene

Orthologs for GIGYF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GIGYF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GIGYF1 34 35
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia GIGYF1 34 35
  • 90 (n)
dog
(Canis familiaris)
Mammalia GIGYF1 34 35
  • 89.17 (n)
rat
(Rattus norvegicus)
Mammalia Gigyf1 34
  • 86.98 (n)
mouse
(Mus musculus)
Mammalia Gigyf1 34 16 35
  • 86.93 (n)
oppossum
(Monodelphis domestica)
Mammalia GIGYF1 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GIGYF1 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GIGYF1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gigyf1 34
  • 64.58 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC568584 34
  • 65.15 (n)
GIGYF1 (1 of 3) 35
  • 58 (a)
OneToMany
GIGYF1 (2 of 3) 35
  • 56 (a)
OneToMany
GIGYF1 (3 of 3) 35
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11148 35
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY2 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for GIGYF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIGYF1 Gene

ENSEMBL:
Gene Tree for GIGYF1 (if available)
TreeFam:
Gene Tree for GIGYF1 (if available)

Paralogs for GIGYF1 Gene

Paralogs for GIGYF1 Gene

(2) SIMAP similar genes for GIGYF1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GIGYF1: view

Variants for GIGYF1 Gene

Sequence variations from dbSNP and Humsavar for GIGYF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10233533 -- 100,689,046(+) CTTTC(C/T)CTCAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1052713 -- 100,679,022(+) TCCTT(C/T)TGCTG downstream-variant-500B, utr-variant-3-prime
rs10713381 -- 100,681,505(+) AAATT(-/A)AAAAA utr-variant-3-prime
rs111254792 -- 100,683,598(+) GAAGA(A/G)TTAAT reference, synonymous-codon
rs111314461 -- 100,680,902(+) AAAAT(A/G)GCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GIGYF1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv470381 CNV loss 18288195
nsv607933 CNV gain 21841781
nsv8184 CNV loss 18304495
nsv819414 CNV loss 19587683
nsv831072 CNV loss 17160897
nsv951386 CNV deletion 24416366
nsv951387 CNV deletion 24416366

Variation tolerance for GIGYF1 Gene

Residual Variation Intolerance Score: 0.952% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.74; 83.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GIGYF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIGYF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIGYF1 Gene

Disorders for GIGYF1 Gene

Relevant External Links for GIGYF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GIGYF1

No disorders were found for GIGYF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GIGYF1 Gene

Publications for GIGYF1 Gene

  1. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. (PMID: 12771153) Giovannone B. … Smith R.J. (J. Biol. Chem. 2003) 2 3 4 64
  2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 4 64
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for GIGYF1 Gene

Sources for GIGYF1 Gene

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