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Aliases for GIGYF1 Gene

Aliases for GIGYF1 Gene

  • GRB10 Interacting GYF Protein 1 2 3
  • PERQ Amino Acid Rich, With GYF Domain 1 2 3
  • GRB10-Interacting GYF Protein 1 3 4
  • GYF Domain Containing 1 2 3
  • PERQ1 3 4
  • PERQ Amino Acid-Rich With GYF Domain-Containing Protein 1 3
  • Postmeiotic Segregation Increased 2-Like 12 3
  • GYF1 3
  • CDS2 4

External Ids for GIGYF1 Gene

Previous HGNC Symbols for GIGYF1 Gene

  • PERQ1

Previous GeneCards Identifiers for GIGYF1 Gene

  • GC07M100116
  • GC07M100277
  • GC07M094907

Summaries for GIGYF1 Gene

GeneCards Summary for GIGYF1 Gene

GIGYF1 (GRB10 Interacting GYF Protein 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. An important paralog of this gene is GIGYF2.

UniProtKB/Swiss-Prot for GIGYF1 Gene

  • May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIGYF1 Gene

Genomics for GIGYF1 Gene

Regulatory Elements for GIGYF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GIGYF1 Gene

100,679,507 bp from pter
100,694,273 bp from pter
14,767 bases
Minus strand

Genomic View for GIGYF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GIGYF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIGYF1 Gene

Proteins for GIGYF1 Gene

  • Protein details for GIGYF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PERQ amino acid-rich with GYF domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6Y7W7
    • Q8WZ38

    Protein attributes for GIGYF1 Gene

    1035 amino acids
    Molecular mass:
    114601 Da
    Quaternary structure:
    • Interacts with GRB10. This transient binding is increased under IGF1 stimulation and leads to recruitment of GIGYF1/GRB10 complex to IGF1 receptor (By similarity).
    • Sequence=AAC78792.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAL55738.1; Type=Frameshift; Positions=784, 856; Evidence={ECO:0000305};

neXtProt entry for GIGYF1 Gene

Proteomics data for GIGYF1 Gene at MOPED

Post-translational modifications for GIGYF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GIGYF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GIGYF1 Gene

Domains for GIGYF1 Gene

Protein Domains for GIGYF1 Gene


Suggested Antigen Peptide Sequences for GIGYF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75420
  • The GYF domain interacts with GRB10.
  • Contains 1 GYF domain.
  • Belongs to the PERQ family.
genes like me logo Genes that share domains with GIGYF1: view

No data available for Gene Families for GIGYF1 Gene

Function for GIGYF1 Gene

Molecular function for GIGYF1 Gene

UniProtKB/Swiss-Prot Function: May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).

Gene Ontology (GO) - Molecular Function for GIGYF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GIGYF1: view

Phenotypes for GIGYF1 Gene

genes like me logo Genes that share phenotypes with GIGYF1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GIGYF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GIGYF1 Gene

Localization for GIGYF1 Gene

Subcellular locations from

Jensen Localization Image for GIGYF1 Gene COMPARTMENTS Subcellular localization image for GIGYF1 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GIGYF1 Gene

Pathways for GIGYF1 Gene

genes like me logo Genes that share pathways with GIGYF1: view

Interacting Proteins for GIGYF1 Gene

Gene Ontology (GO) - Biological Process for GIGYF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048009 insulin-like growth factor receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GIGYF1: view

Transcripts for GIGYF1 Gene

Unigene Clusters for GIGYF1 Gene

GRB10 interacting GYF protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GIGYF1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GIGYF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIGYF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21

Relevant External Links for GIGYF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GIGYF1 Gene

mRNA expression in normal human tissues for GIGYF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GIGYF1 Gene

SOURCE GeneReport for Unigene cluster for GIGYF1 Gene Hs.414396

genes like me logo Genes that share expressions with GIGYF1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GIGYF1 Gene

Orthologs for GIGYF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GIGYF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GIGYF1 35
  • 99.26 (n)
  • 99.42 (a)
  • 100 (a)
(Bos Taurus)
Mammalia GIGYF1 35
  • 90 (n)
  • 92.79 (a)
  • 93 (a)
(Canis familiaris)
Mammalia GIGYF1 35
  • 89.17 (n)
  • 93.09 (a)
  • 89 (a)
(Mus musculus)
Mammalia Gigyf1 35
  • 86.93 (n)
  • 90.44 (a)
Gigyf1 16
Gigyf1 36
  • 90 (a)
(Monodelphis domestica)
Mammalia GIGYF1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia GIGYF1 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Gigyf1 35
  • 86.98 (n)
  • 90.72 (a)
(Anolis carolinensis)
Reptilia GIGYF1 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gigyf1 35
  • 64.58 (n)
  • 63.52 (a)
(Danio rerio)
Actinopterygii GIGYF1 (1 of 3) 36
  • 58 (a)
GIGYF1 (2 of 3) 36
  • 56 (a)
GIGYF1 (3 of 3) 36
  • 50 (a)
LOC568584 35
  • 65.15 (n)
  • 63.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11148 36
  • 14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for GIGYF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIGYF1 Gene

Gene Tree for GIGYF1 (if available)
Gene Tree for GIGYF1 (if available)

Paralogs for GIGYF1 Gene

Paralogs for GIGYF1 Gene

Selected SIMAP similar genes for GIGYF1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GIGYF1: view

Variants for GIGYF1 Gene

Sequence variations from dbSNP and Humsavar for GIGYF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs221783 -- 100,695,291(-) ttgag(A/G)ccagg upstream-variant-2KB
rs221784 -- 100,695,207(-) ctggg(C/T)gtgat upstream-variant-2KB
rs221790 -- 100,680,659(+) CTACT(C/G)CAACC utr-variant-3-prime
rs221791 -- 100,680,931(+) CCAGA(A/G)CCAGA utr-variant-3-prime
rs221792 -- 100,681,034(+) GGGCC(A/C/G/T)CTCGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GIGYF1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv888791 CNV Loss 21882294
nsv470381 CNV Loss 18288195
nsv8184 CNV Loss 18304495
nsv888792 CNV Loss 21882294
dgv7401n71 CNV Loss 21882294
nsv888795 CNV Loss 21882294
nsv819414 CNV Loss 19587683

Relevant External Links for GIGYF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIGYF1 Gene

Disorders for GIGYF1 Gene

No disorders were found for GIGYF1 Gene.

No data available for UniProtKB/Swiss-Prot for GIGYF1 Gene

Publications for GIGYF1 Gene

  1. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. (PMID: 12771153) Giovannone B. … Smith R.J. (J. Biol. Chem. 2003) 2 3 4
  2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 4
  3. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PMID: 11239002) Wilson M.D. … Koop B.F. (Nucleic Acids Res. 2001) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3

Products for GIGYF1 Gene

Sources for GIGYF1 Gene

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