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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GIF Gene

protein-coding   GIFtS: 62
GCID: GC11M059596

Gastric Intrinsic Factor (Vitamin B Synthesis)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Gastric Intrinsic Factor (Vitamin B Synthesis)1 2     INF2 3
IF2 3 5     TCN32
Intrinsic Factor2 3     Gastric Intrinsic Factor2
IFMH2 3     

External Ids:    HGNC: 42681   Entrez Gene: 26942   Ensembl: ENSG000001348127   OMIM: 6093425   UniProtKB: P273523   

Export aliases for GIF gene to outside databases

Previous GC identifers: GC11M061990 GC11M061110 GC11M059847 GC11M059372 GC11M059353 GC11M055944


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GIF Gene:
This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal
cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for
erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. (provided by RefSeq,
Jul 2008)

GeneCards Summary for GIF Gene: 
GIF (gastric intrinsic factor (vitamin B synthesis)) is a protein-coding gene. Diseases associated with GIF include pernicious anemia, and intrinsic factor deficiency, and among its related super-pathways are Metabolism of water-soluble vitamins and cofactors and Metabolic pathways. GO annotations related to this gene include cobalamin binding. An important paralog of this gene is TCN1.

UniProtKB/Swiss-Prot: IF_HUMAN, P27352
Function: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN,
the GIF-cobalamin complex is internalized via receptor-mediated endocytosis

Gene Wiki entry for GIF (Intrinsic factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GIF gene promoter:
         Pbx1a   Brachyury   RREB-1   FOXD3   CUTL1   Pax-2b   FOXJ2 (long isoform)   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGIF promoter sequence
   Search SABiosciences Chromatin IP Primers for GIF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GIF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

GIF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GIF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M059596:  view genomic region     (about GC identifiers)

Start:
59,596,741 bp from pter      End:
59,612,974 bp from pter
Size:
16,234 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IF_HUMAN, P27352 (See protein sequence)
Recommended Name: Gastric intrinsic factor precursor  
Size: 417 amino acids; 45416 Da
Subunit: Interacts with CUBN (via CUB domains)
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for GIF:
2CKT (3D)        2PMV (3D)        3KQ4 (3D)    
Secondary accessions: B2RAN8 B4DVZ1
Alternative splicing: 2 isoforms:  P27352-1   P27352-2   

Explore the universe of human proteins at neXtProt for GIF: NX_P27352

Explore proteomics data for GIF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27352

  • GIF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GIF Protein Expression
    REFSEQ proteins: NP_005133.2  
    ENSEMBL proteins: 
     ENSP00000257248   ENSP00000433196   ENSP00000440427  
    Reactome Protein details: P27352
    Human Recombinant Protein Products for GIF: 
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    Novus Biologicals GIF Lysates
    Sino Biological Recombinant Protein for GIF
    Sino Biological Cell Lysate for GIF 
    ProSpec Recombinant Protein for GIF
    Cloud-Clone Corp. Proteins for GIF 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA14695536
    GO:0005768endosome TAS--
    GO:0005902microvillus IDA8886952
    GO:0016324apical plasma membrane IDA8886952

    GIF for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002157 Cbl-bd_transpt_euk

    Graphical View of Domain Structure for InterPro Entry P27352

    ProtoNet protein and cluster: P27352

    1 Blocks protein domain: IPB002157 Eukaryotic cobalamin-binding protein

    UniProtKB/Swiss-Prot: IF_HUMAN, P27352
    Similarity: Belongs to the eukaryotic cobalamin transport proteins family


    GIF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF_HUMAN, P27352
    Function: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN,
    the GIF-cobalamin complex is internalized via receptor-mediated endocytosis

         Genatlas biochemistry entry for GIF:
    gastric intrinsic factor

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031419cobalamin binding IDA14695536
         
    GIF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GIF:
     Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gif):
     behavior/neurological  immune system  reproductive system 

    GIF for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GIF 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate GIF:
    hsa-miR-3672
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GIF About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00
    2Metabolism
    Metabolism0.40
    3Vitamin digestion and absorption
    Vitamin digestion and absorption
    4Cobalamin (Cbl, vitamin B12) transport and metabolism
    Cobalamin (Cbl, vitamin B12) transport and metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for GIF
        Metabolism
    Cobalamin (Cbl, vitamin B12) transport and metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors


    1         Kegg Pathway  (Kegg details for GIF):
        Vitamin digestion and absorption


    GIF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GIF

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for GIF (P273523 ENSP000002572484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUBNO604943, ENSP000003670644I2D: score=2 STRING: ENSP00000367064
    CBLENSP000002640334STRING: ENSP00000264033
    GORASP2ENSP000002341604STRING: ENSP00000234160
    FIBPENSP000003445724STRING: ENSP00000344572
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006824cobalt ion transport IEA--
    GO:0009235cobalamin metabolic process TAS--
    GO:0015889cobalamin transport IMP15738392

    GIF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GIF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GIF (IF)

    2 HMDB Compounds for GIF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cobalamin5,6-dimethyl-1-a-D-ribofuranosylbenzimidazole (see all 15)13408-78-1--
    CobaltCo (see all 6)7440-48-4--

    2 Novoseek inferred chemical compound relationships for GIF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cobalamin 85.8 8 14576042 (1), 15738392 (1), 12436132 (1), 18620679 (1) (see all 6)
    vitamin b12 78.8 13 10554842 (2), 16704961 (2), 1463480 (1), 14633882 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about GIF / IF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GIF gene: 
    NM_005142.2  

    Unigene Cluster for GIF:

    Gastric intrinsic factor (vitamin B synthesis)
    Hs.110014  [show with all ESTs]
    Unigene Representative Sequence: AK301295
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257248(uc001noi.3) ENST00000525058 ENST00000533067 ENST00000533847
    ENST00000532070(uc010rkz.1) ENST00000541311
    miRNA
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    hsa-miR-3672
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK301290.1 AK301295.1 AK314275.1 BC037958.1 X76562.1 

    3 DOTS entries:

    DT.103657  DT.100748079  DT.120718870 

    24/33 AceView cDNA sequences (see all 33):

    BX095985 BP340940 NM_005142 BP342967 BP341210 BC037958 BP340846 X76562 
    BP341304 BP342359 BI517628 BM923811 BI762524 BM830734 BI760081 BM826770 
    BQ082954 BM821607 BI762182 BP343508 BM856169 CD619933 M63154 BP342491 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GIF    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:                    -                 -                             -         
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for GIF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GIF expression in normal human tissues (normalized intensities)      GIF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GIF Expression
    About this image


    GIF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 3 entries
             stomach, upper ; glandular cells   
             stomach cardiac   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Lung (Respiratory System)

    See GIF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GIF

    SOURCE GeneReport for Unigene cluster: Hs.110014

    UniProtKB/Swiss-Prot: IF_HUMAN, P27352
    Tissue specificity: Gastric mucosa

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GIF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GIF gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gif1 , 5 gastric intrinsic factor1, 5 83.29(n)1
    81.77(a)1
      19 (8.51 cM)5
    146031  NM_008118.31  NP_032144.21 
     117475545 
    chicken
    (Gallus gallus)
    Aves GIF1 gastric intrinsic factor (vitamin B synthesis) 48.19(n)
    38.73(a)
      770547  XM_001233884.2  XP_001233885.2 
    lizard
    (Anolis carolinensis)
    Reptilia GIF6
    gastric intrinsic factor (vitamin B synthesis)
    38(a)
    1 ↔ 1
    1(90861309-90873330)


    ENSEMBL Gene Tree for GIF (if available)
    TreeFam Gene Tree for GIF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GIF gene
    TCN12  TCN22  
    1 SIMAP similar gene for GIF using alignment to 2 protein entries:     IF_HUMAN (see all proteins):
    TCN1

    GIF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/457 SNPs in GIF are shown (see all 457)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0227434
    Hereditary intrinsic factor deficiency (IFD)4--see VAR_0227432 S L mis40--------
    rs352116341,2,4
    C,F,Hother159533533(+) AACTCT/CGGGTC 2 /Q /R mis125Minor allele frequency- C:0.10NS EA NA CSA WA EU 8496
    rs3677487381,2
    C--55949266(+) TTTTT-/TTTTTT 1 -- int10--------
    rs1442043691,2
    --59516956(+) ATTATA/GTATAA 1 -- ds50010--------
    rs2018957311,2
    --59516971(+) ATAAC-/ATAT  
            
    ATTAA
    1 -- ds50010--------
    rs1498684851,2
    C--59516972(+) TAACA-/TATAT 
            
    TAAGT
    1 -- ds50010--------
    rs1812960371,2
    --59517009(+) ATGATA/GTATTA 1 -- ds50010--------
    rs1172409291,2
    F--59517121(+) GAAGGA/GGAGAG 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs764317681,2
    --59517217(+) TGTACA/GTACGT 1 -- ds50011Minor allele frequency- G:0.01EA 120
    rs1138591251,2
    F--59517220(+) ACATAC/TGTGGG 1 -- ds50011Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for GIF (59596741 - 59612974 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GIF: --

    Human Gene Mutation Database (HGMD): GIF
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GIF
    DNA2.0 Custom Variant and Variant Library Synthesis for GIF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609342   
    OMIM disorders: 261000  
    UniProtKB/Swiss-Prot: IF_HUMAN, P27352
  • Hereditary intrinsic factor deficiency (IFD) [MIM:261000]: Autosomal recessive disorder characterized by
    megaloblastic anemia. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/25 diseases for GIF (see all 25):    About MalaCards
    pernicious anemia    intrinsic factor deficiency    congenital intrinsic factor deficiency    diphyllobothriasis
    blind loop syndrome    tropical sprue    hypersensitivity reaction type ii disease    vitamin b12 deficiency
    glossitis    exocrine pancreatic insufficiency    homocystinuria    megaloblastic anemia
    steatorrhea    galactosemia    anemia    blindness
    gastritis    asthma    schizophrenia    acute lymphoblastic leukemia

    6 diseases from the University of Copenhagen DISEASES database for GIF:
    Pernicious anemia     Vitamin B12 deficiency     Gastritis     Anemia
    Diphyllobothriasis     Blind loop syndrome

    GIF for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for GIF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anemia megaloblastic 83.3 3 19900336 (1), 14695536 (1)
    asthma 0 1 16000205 (1)

    Genatlas disease: GIF
    pernicious anemia,congenital

    Genetic Association Database (GAD): GIF
    Human Genome Epidemiology (HuGE) Navigator: GIF (93 documents)

    Export disorders for GIF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GIF gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with GIF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency. (PubMed id 14695536)1, 2, 4, 9 Gordon M.M.... Alpers D.H. (2004)
    2. Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11. (PubMed id 2071148)1, 2, 3 Hewitt J.E.... Alpers D.H. (1991)
    3. Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution. (PubMed id 17954916)1, 2, 9 Mathews F.S....Sukumar N. (2007)
    4. Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene. (PubMed id 15738392)1, 2, 9 Tanner S.M....de la Chapelle A. (2005)
    5. Structural basis for receptor recognition of vitamin- B(12)-intrinsic factor complexes. (PubMed id 20237569)1, 2, 9 Andersen C.B....Andersen G.R. (2010)
    6. A candidate gene study of folate-associated one carbo n metabolism genes and colorectal cancer risk. (PubMed id 20615890)1, 4 Levine A.J....Haile R.W. (2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Human gastric intrinsic factor expression is not restricted to parietal cells. (PubMed id 8886952)1, 9 Howard T.A....Alpers D.H. (1996)
    9. Identification of a 4-base deletion in the gene in inherited intrinsic factor deficiency. (PubMed id 14576042)1, 9 Yassin F....Quadros E.V. (2004)
    10. Acute lymphoblastic leukemia and vitamin B12 deficienc y secondary to a gastric intrinsic factor gene mutation. (PubMed id 22556038)1 Zia A....Savasan S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2694 HGNC: 4268 AceView: GIF Ensembl:ENSG00000134812 euGenes: HUgn2694
    ECgene: GIF Kegg: 2694 H-InvDB: GIF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GIF Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GIF
    Wikipedia http://en.wikipedia.org/wiki/Intrinsic_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GIF gene:
    Search GeneIP for patents involving GIF

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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