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Aliases for GID8 Gene

Aliases for GID8 Gene

  • GID Complex Subunit 8 Homolog 2 3
  • Two Hybrid Associated Protein No. 1 With RanBPM 2 3
  • Two Hybrid-Associated Protein 1 With RanBPM 3 4
  • GID Complex Subunit 8 2 5
  • C20orf11 3 4
  • TWA1 3 4
  • GID Complex Subunit 8 Homolog (S. Cerevisiae) 2
  • Chromosome 20 Open Reading Frame 11 2
  • Protein C20orf11 3

External Ids for GID8 Gene

Previous HGNC Symbols for GID8 Gene

  • C20orf11

Previous GeneCards Identifiers for GID8 Gene

  • GC20P061570

Summaries for GID8 Gene

GeneCards Summary for GID8 Gene

GID8 (GID Complex Subunit 8 Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GID8 Gene

Genomics for GID8 Gene

Regulatory Elements for GID8 Gene

Promoters for GID8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GID8 on UCSC Golden Path with GeneCards custom track

Genomic Location for GID8 Gene

Chromosome:
20
Start:
62,938,089 bp from pter
End:
62,948,475 bp from pter
Size:
10,387 bases
Orientation:
Plus strand

Genomic View for GID8 Gene

Genes around GID8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GID8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GID8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GID8 Gene

Proteins for GID8 Gene

  • Protein details for GID8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWU2-GID8_HUMAN
    Recommended name:
    Glucose-induced degradation protein 8 homolog
    Protein Accession:
    Q9NWU2
    Secondary Accessions:
    • E1P5I3
    • Q8N5M5

    Protein attributes for GID8 Gene

    Size:
    228 amino acids
    Molecular mass:
    26749 Da
    Quaternary structure:
    • Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8.

neXtProt entry for GID8 Gene

Proteomics data for GID8 Gene at MOPED

Post-translational modifications for GID8 Gene

  • Ubiquitination at Lys 171 and Lys 197
  • Modification sites at PhosphoSitePlus

Other Protein References for GID8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GID8 Gene

Domains & Families for GID8 Gene

Suggested Antigen Peptide Sequences for GID8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWU2

UniProtKB/Swiss-Prot:

GID8_HUMAN :
  • Contains 1 CTLH domain.
  • Belongs to the GID8 family.
Domain:
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
Family:
  • Belongs to the GID8 family.
genes like me logo Genes that share domains with GID8: view

No data available for Gene Families for GID8 Gene

Function for GID8 Gene

Phenotypes for GID8 Gene

genes like me logo Genes that share phenotypes with GID8: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GID8 Gene

Localization for GID8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GID8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GID8 Gene COMPARTMENTS Subcellular localization image for GID8 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for GID8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with GID8: view

Pathways & Interactions for GID8 Gene

SuperPathways for GID8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GID8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GID8 Gene

Drugs & Compounds for GID8 Gene

No Compound Related Data Available

Transcripts for GID8 Gene

mRNA/cDNA for GID8 Gene

Unigene Clusters for GID8 Gene

GID complex subunit 8 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GID8 Gene

No ASD Table

Relevant External Links for GID8 Gene

GeneLoc Exon Structure for
GID8
ECgene alternative splicing isoforms for
GID8

Expression for GID8 Gene

mRNA expression in normal human tissues for GID8 Gene

Protein differential expression in normal tissues from HIPED for GID8 Gene

This gene is overexpressed in Cervix (21.5), Urine (7.5), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GID8 Gene



SOURCE GeneReport for Unigene cluster for GID8 Gene Hs.353013

genes like me logo Genes that share expression patterns with GID8: view

Protein tissue co-expression partners for GID8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GID8 Gene

Orthologs for GID8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GID8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GID8 35
  • 89.62 (n)
  • 97.81 (a)
GID8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GID8 35
  • 90.2 (n)
  • 99.12 (a)
GID8 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gid8 35
  • 89.47 (n)
  • 99.56 (a)
Gid8 16
Gid8 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GID8 35
  • 99.71 (n)
  • 100 (a)
GID8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gid8 35
  • 88.89 (n)
  • 99.56 (a)
oppossum
(Monodelphis domestica)
Mammalia GID8 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GID8 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20H20ORF11 35
  • 84.21 (n)
  • 97.37 (a)
GID8 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GID8 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gid8 35
  • 80.7 (n)
  • 94.74 (a)
Str.9059 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
gid8b 35
  • 79.82 (n)
  • 93.86 (a)
gid8a 36
  • 83 (a)
OneToMany
gid8b 36
  • 88 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1136 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000951 35
  • 62.7 (n)
  • 61.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6617 35
  • 62.05 (n)
  • 59.37 (a)
CG18467 36
  • 37 (a)
OneToMany
CG6617 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-304 36
  • 13 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G61150 35
  • 55.61 (n)
  • 52.07 (a)
rice
(Oryza sativa)
Liliopsida Os03g0235100 35
  • 56 (n)
  • 49.78 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28704 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5728 36
  • 61 (a)
OneToOne
Species with no ortholog for GID8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GID8 Gene

ENSEMBL:
Gene Tree for GID8 (if available)
TreeFam:
Gene Tree for GID8 (if available)

Paralogs for GID8 Gene

No data available for Paralogs for GID8 Gene

Variants for GID8 Gene

Sequence variations from dbSNP and Humsavar for GID8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2039 -- 62,946,970(+) GCACA(A/C/G)CAATA utr-variant-3-prime
rs9503 -- 62,948,206(+) TACTA(C/T)GCGTG utr-variant-3-prime
rs2038405 -- 62,941,745(+) ACACA(A/C)TGCTA intron-variant
rs1044628 -- 62,948,437(+) CTGTT(C/T)TTAAT utr-variant-3-prime
rs1052826 -- 62,945,425(+) GGCTC(A/G)TGTGT utr-variant-3-prime

Variation tolerance for GID8 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GID8 Gene

HapMap Linkage Disequilibrium report
GID8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GID8 Gene

Disorders for GID8 Gene

Relevant External Links for GID8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GID8

No disorders were found for GID8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GID8 Gene

Publications for GID8 Gene

  1. A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. (PMID: 12559565) Umeda M. … Nishimoto T. (Gene 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for GID8 Gene

Sources for GID8 Gene

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