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Aliases for GID8 Gene

Aliases for GID8 Gene

  • GID Complex Subunit 8 Homolog 2 3 5
  • Two Hybrid Associated Protein No. 1 With RanBPM 2 3
  • Two Hybrid-Associated Protein 1 With RanBPM 3 4
  • C20orf11 3 4
  • TWA1 3 4
  • GID Complex Subunit 8 Homolog (S. Cerevisiae) 2
  • Glucose-Induced Degradation Protein 8 Homolog 3
  • Chromosome 20 Open Reading Frame 11 2
  • GID Complex Subunit 8 2
  • Protein C20orf11 3

External Ids for GID8 Gene

Previous HGNC Symbols for GID8 Gene

  • C20orf11

Previous GeneCards Identifiers for GID8 Gene

  • GC20P061570

Summaries for GID8 Gene

GeneCards Summary for GID8 Gene

GID8 (GID Complex Subunit 8 Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GID8 Gene

Genomics for GID8 Gene

Regulatory Elements for GID8 Gene

Enhancers for GID8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G062935 1.4 ENCODE dbSUPER 17.9 -0.3 -336 4.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC GID8 GMEB2 SLC17A9 DIDO1 LAMA5 ENSG00000226332 ENSG00000273759
GH20G062300 1.8 FANTOM5 ENCODE dbSUPER 13.4 -634.3 -634299 5.7 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ENSG00000226332 GID8 LAMA5 LAMA5-AS1 CABLES2 ADRM1 OSBPL2 GATA5
GH20G062913 1.5 Ensembl ENCODE dbSUPER 12.6 -23.0 -22994 4.0 HDGF FOXA2 ATF1 MLX ARID4B DMAP1 YBX1 ZNF48 ZNF121 SLC30A9 DIDO1 GID8 TCFL5 TNFRSF6B SLC17A9 ENSG00000273759 ARF4P2
GH20G062405 1.4 ENCODE dbSUPER 13.4 -531.1 -531134 3.1 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CABLES2 GID8 ENSG00000226332 LOC105372709
GH20G062898 1.5 Ensembl ENCODE dbSUPER 12 -38.2 -38158 3.5 HDGF FOXA2 AGO1 ZFP64 ARID4B SIN3A YBX1 FEZF1 ZNF143 ZNF207 DIDO1 GID8 TCFL5 SLC17A9 ARF4P2 ENSG00000273759
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GID8 on UCSC Golden Path with GeneCards custom track

Promoters for GID8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139825 -189 2601 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC

Genomic Location for GID8 Gene

Chromosome:
20
Start:
62,938,089 bp from pter
End:
62,948,475 bp from pter
Size:
10,387 bases
Orientation:
Plus strand

Genomic View for GID8 Gene

Genes around GID8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GID8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GID8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GID8 Gene

Proteins for GID8 Gene

  • Protein details for GID8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWU2-GID8_HUMAN
    Recommended name:
    Glucose-induced degradation protein 8 homolog
    Protein Accession:
    Q9NWU2
    Secondary Accessions:
    • E1P5I3
    • Q8N5M5

    Protein attributes for GID8 Gene

    Size:
    228 amino acids
    Molecular mass:
    26749 Da
    Quaternary structure:
    • Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8.

neXtProt entry for GID8 Gene

Post-translational modifications for GID8 Gene

  • Ubiquitination at Lys171 and Lys197
  • Modification sites at PhosphoSitePlus

Other Protein References for GID8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GID8 Gene

Domains & Families for GID8 Gene

Suggested Antigen Peptide Sequences for GID8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWU2

UniProtKB/Swiss-Prot:

GID8_HUMAN :
  • Belongs to the GID8 family.
Family:
  • Belongs to the GID8 family.
genes like me logo Genes that share domains with GID8: view

No data available for Gene Families for GID8 Gene

Function for GID8 Gene

Gene Ontology (GO) - Molecular Function for GID8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27173435
genes like me logo Genes that share ontologies with GID8: view

Phenotypes for GID8 Gene

genes like me logo Genes that share phenotypes with GID8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GID8 Gene

Localization for GID8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GID8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GID8 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for GID8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with GID8: view

Pathways & Interactions for GID8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GID8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GID8 Gene

Transcripts for GID8 Gene

mRNA/cDNA for GID8 Gene

Unigene Clusters for GID8 Gene

GID complex subunit 8 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GID8 Gene

No ASD Table

Relevant External Links for GID8 Gene

GeneLoc Exon Structure for
GID8
ECgene alternative splicing isoforms for
GID8

Expression for GID8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GID8 Gene

Protein differential expression in normal tissues from HIPED for GID8 Gene

This gene is overexpressed in Cervix (21.5), Urine (7.5), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GID8 Gene



Protein tissue co-expression partners for GID8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GID8 Gene:

GID8

SOURCE GeneReport for Unigene cluster for GID8 Gene:

Hs.353013

Evidence on tissue expression from TISSUES for GID8 Gene

  • Muscle(4.2)
  • Nervous system(3.8)
  • Lung(2)
genes like me logo Genes that share expression patterns with GID8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GID8 Gene

Orthologs for GID8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GID8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GID8 34 35
  • 99.71 (n)
oppossum
(Monodelphis domestica)
Mammalia GID8 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GID8 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GID8 34 35
  • 90.2 (n)
cow
(Bos Taurus)
Mammalia GID8 34 35
  • 89.62 (n)
mouse
(Mus musculus)
Mammalia Gid8 34 16 35
  • 89.47 (n)
rat
(Rattus norvegicus)
Mammalia Gid8 34
  • 88.89 (n)
chicken
(Gallus gallus)
Aves GID8 35
  • 97 (a)
OneToOne
C20H20ORF11 34
  • 84.21 (n)
lizard
(Anolis carolinensis)
Reptilia GID8 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gid8 34
  • 80.7 (n)
Str.9059 34
zebrafish
(Danio rerio)
Actinopterygii gid8a 35
  • 83 (a)
OneToMany
gid8b 34 35
  • 79.82 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1136 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000951 34
  • 62.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6617 34 35
  • 62.05 (n)
CG18467 35
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-304 35
  • 13 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G61150 34
  • 55.61 (n)
rice
(Oryza sativa)
Liliopsida Os03g0235100 34
  • 56 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.28704 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5728 35
  • 61 (a)
OneToOne
Species where no ortholog for GID8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GID8 Gene

ENSEMBL:
Gene Tree for GID8 (if available)
TreeFam:
Gene Tree for GID8 (if available)

Paralogs for GID8 Gene

No data available for Paralogs for GID8 Gene

Variants for GID8 Gene

Sequence variations from dbSNP and Humsavar for GID8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000085881 -- 62,937,224(+) CTTCG(C/G)CTCTA intron-variant, upstream-variant-2KB
rs1000150377 -- 62,938,526(+) GGGGC(A/G)GCGGT intron-variant, upstream-variant-2KB
rs1000222345 -- 62,945,378(+) TTTCC(A/G)TAGGA utr-variant-3-prime
rs1000257014 -- 62,942,751(+) TGGCT(A/G)ATGGG intron-variant
rs1000300119 -- 62,942,087(+) TAGAT(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GID8 Gene

Variant ID Type Subtype PubMed ID
nsv459069 CNV gain 19166990
nsv470559 CNV loss 18288195
nsv586532 CNV gain 21841781
nsv9825 CNV gain 18304495

Variation tolerance for GID8 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GID8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GID8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GID8 Gene

Disorders for GID8 Gene

Relevant External Links for GID8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GID8

No disorders were found for GID8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GID8 Gene

Publications for GID8 Gene

  1. A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. (PMID: 12559565) Umeda M. … Nishimoto T. (Gene 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K. … Roepman R. (Nat Commun 2016) 3 64

Products for GID8 Gene

Sources for GID8 Gene

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