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Aliases for GID8 Gene

Aliases for GID8 Gene

  • GID Complex Subunit 8 Homolog 2 3 5
  • Two Hybrid Associated Protein No. 1 With RanBPM 2 3
  • Two Hybrid-Associated Protein 1 With RanBPM 3 4
  • C20orf11 3 4
  • TWA1 3 4
  • GID Complex Subunit 8 Homolog (S. Cerevisiae) 2
  • Glucose-Induced Degradation Protein 8 Homolog 3
  • Chromosome 20 Open Reading Frame 11 2
  • GID Complex Subunit 8 2
  • Protein C20orf11 3

External Ids for GID8 Gene

Previous HGNC Symbols for GID8 Gene

  • C20orf11

Previous GeneCards Identifiers for GID8 Gene

  • GC20P061570

Summaries for GID8 Gene

GeneCards Summary for GID8 Gene

GID8 (GID Complex Subunit 8 Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GID8 Gene

Genomics for GID8 Gene

Regulatory Elements for GID8 Gene

Enhancers for GID8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F062935 1.1 ENCODE 26.6 -0.3 -336 4.7 PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 LINC00029 GMEB2 GID8 LOC105372725 LINC01056 SLC17A9 DIDO1 MIR4758 CABLES2 ENSG00000226332
GH20F062405 0.2 ENCODE 13.4 -531.1 -531134 3.1 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CABLES2 GID8 ENSG00000226332 LOC105372709
GH20F062913 1.4 Ensembl ENCODE 12.6 -23.0 -22994 4.0 ATF1 MLX ARID4B SIN3A DMAP1 YBX1 ZNF48 ZNF121 SLC30A9 FOS DIDO1 GID8 TCFL5 TNFRSF6B SLC17A9 ENSG00000273759 ARF4P2
GH20F062903 0.2 ENCODE 12 -34.5 -34514 0.8 PAF1 GLIS2 POLR2A SCRT2 GLIS1 INSM2 ZIC2 DIDO1 GID8 TCFL5 SLC17A9 ENSG00000273759 ARF4P2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GID8 on UCSC Golden Path with GeneCards custom track

Promoters for GID8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001450375 -389 3001 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for GID8 Gene

62,938,089 bp from pter
62,948,475 bp from pter
10,387 bases
Plus strand

Genomic View for GID8 Gene

Genes around GID8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GID8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GID8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GID8 Gene

Proteins for GID8 Gene

  • Protein details for GID8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucose-induced degradation protein 8 homolog
    Protein Accession:
    Secondary Accessions:
    • E1P5I3
    • Q8N5M5

    Protein attributes for GID8 Gene

    228 amino acids
    Molecular mass:
    26749 Da
    Quaternary structure:
    • Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8.

neXtProt entry for GID8 Gene

Post-translational modifications for GID8 Gene

  • Ubiquitination at Lys 171 and Lys 197
  • Modification sites at PhosphoSitePlus

Other Protein References for GID8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GID8 Gene

Domains & Families for GID8 Gene

Suggested Antigen Peptide Sequences for GID8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CTLH domain.
  • Belongs to the GID8 family.
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
  • Belongs to the GID8 family.
genes like me logo Genes that share domains with GID8: view

No data available for Gene Families for GID8 Gene

Function for GID8 Gene

Phenotypes for GID8 Gene

genes like me logo Genes that share phenotypes with GID8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GID8 Gene

Localization for GID8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GID8 Gene

Subcellular locations from

Jensen Localization Image for GID8 Gene COMPARTMENTS Subcellular localization image for GID8 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for GID8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with GID8: view

Pathways & Interactions for GID8 Gene

SuperPathways for GID8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GID8 Gene


No data available for Pathways by source and SIGNOR curated interactions for GID8 Gene

Transcripts for GID8 Gene

mRNA/cDNA for GID8 Gene

Unigene Clusters for GID8 Gene

GID complex subunit 8 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GID8 Gene

No ASD Table

Relevant External Links for GID8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GID8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GID8 Gene

Protein differential expression in normal tissues from HIPED for GID8 Gene

This gene is overexpressed in Cervix (21.5), Urine (7.5), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GID8 Gene

Protein tissue co-expression partners for GID8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GID8 Gene:


SOURCE GeneReport for Unigene cluster for GID8 Gene:

genes like me logo Genes that share expression patterns with GID8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GID8 Gene

Orthologs for GID8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GID8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GID8 34 35
  • 99.71 (n)
(Monodelphis domestica)
Mammalia GID8 35
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia GID8 35
  • 98 (a)
(Canis familiaris)
Mammalia GID8 34 35
  • 90.2 (n)
(Bos Taurus)
Mammalia GID8 34 35
  • 89.62 (n)
(Mus musculus)
Mammalia Gid8 34 16 35
  • 89.47 (n)
(Rattus norvegicus)
Mammalia Gid8 34
  • 88.89 (n)
(Gallus gallus)
Aves GID8 35
  • 97 (a)
C20H20ORF11 34
  • 84.21 (n)
(Anolis carolinensis)
Reptilia GID8 35
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gid8 34
  • 80.7 (n)
Str.9059 34
(Danio rerio)
Actinopterygii gid8a 35
  • 83 (a)
gid8b 34 35
  • 79.82 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1136 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000951 34
  • 62.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6617 34 35
  • 62.05 (n)
CG18467 35
  • 37 (a)
(Caenorhabditis elegans)
Secernentea tag-304 35
  • 13 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G61150 34
  • 55.61 (n)
(Oryza sativa)
Liliopsida Os03g0235100 34
  • 56 (n)
(Triticum aestivum)
Liliopsida Ta.28704 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5728 35
  • 61 (a)
Species where no ortholog for GID8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GID8 Gene

Gene Tree for GID8 (if available)
Gene Tree for GID8 (if available)

Paralogs for GID8 Gene

No data available for Paralogs for GID8 Gene

Variants for GID8 Gene

Sequence variations from dbSNP and Humsavar for GID8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1044628 -- 62,948,437(+) CTGTT(C/T)TTAAT utr-variant-3-prime
rs1052826 -- 62,945,425(+) GGCTC(A/G)TGTGT utr-variant-3-prime
rs1052849 -- 62,945,554(+) GGTAA(A/G)AGACT utr-variant-3-prime
rs1054866 -- 62,939,856(+) TACTT(A/C)GTATA intron-variant, upstream-variant-2KB
rs10623609 -- 62,940,985(+) ATAAT(-/TGTA)CGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GID8 Gene

Variant ID Type Subtype PubMed ID
nsv459069 CNV gain 19166990
nsv470559 CNV loss 18288195
nsv586532 CNV gain 21841781
nsv9825 CNV gain 18304495

Variation tolerance for GID8 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GID8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GID8 Gene

Disorders for GID8 Gene

Relevant External Links for GID8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GID8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GID8 Gene

Publications for GID8 Gene

  1. A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. (PMID: 12559565) Umeda M. … Nishimoto T. (Gene 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GID8 Gene

Sources for GID8 Gene

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