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Aliases for GID4 Gene

Aliases for GID4 Gene

  • GID Complex Subunit 4 Homolog 2 3
  • Vacuolar Import And Degradation Protein 24 Homolog 3 4
  • Vacuolar Import And Degradation 24 2 3
  • C17orf39 3 4
  • VID24 3 4
  • GID Complex Subunit 4, VID24 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 4, VID24 Homolog 3
  • Chromosome 17 Open Reading Frame 39 2
  • GID Complex Subunit 4 2

External Ids for GID4 Gene

Previous HGNC Symbols for GID4 Gene

  • C17orf39

Previous GeneCards Identifiers for GID4 Gene

  • GC17P017943

Summaries for GID4 Gene

Entrez Gene Summary for GID4 Gene

  • The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for GID4 Gene

GID4 (GID Complex Subunit 4 Homolog) is a Protein Coding gene. Diseases associated with GID4 include smith-magenis syndrome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GID4 Gene

Genomics for GID4 Gene

Genomic Location for GID4 Gene

Chromosome:
17
Start:
18,039,292 bp from pter
End:
18,068,405 bp from pter
Size:
29,114 bases
Orientation:
Plus strand

Genomic View for GID4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GID4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GID4 Gene

No data available for Regulatory Elements for GID4 Gene

Proteins for GID4 Gene

  • Protein details for GID4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVV7-GID4_HUMAN
    Recommended name:
    Glucose-induced degradation protein 4 homolog
    Protein Accession:
    Q8IVV7
    Secondary Accessions:
    • Q8TEB5
    • Q9BW50

    Protein attributes for GID4 Gene

    Size:
    300 amino acids
    Molecular mass:
    33514 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GID4 Gene

Proteomics data for GID4 Gene at MOPED

Post-translational modifications for GID4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GID4 Gene

No data available for DME Specific Peptides for GID4 Gene

Domains & Families for GID4 Gene

Protein Domains for GID4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IVV7

UniProtKB/Swiss-Prot:

GID4_HUMAN :
  • Belongs to the GID4/VID24 family.
Family:
  • Belongs to the GID4/VID24 family.
genes like me logo Genes that share domains with GID4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for GID4 Gene

Function for GID4 Gene

Phenotypes for GID4 Gene

GenomeRNAi human phenotypes for GID4:
genes like me logo Genes that share phenotypes with GID4: view

Animal Model Products

miRNA for GID4 Gene

miRTarBase miRNAs that target GID4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GID4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for GID4 Gene

Localization for GID4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GID4 Gene COMPARTMENTS Subcellular localization image for GID4 gene
Compartment Confidence
cytosol 2
vacuole 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GID4 Gene

Pathways & Interactions for GID4 Gene

SuperPathways for GID4 Gene

No Data Available

Interacting Proteins for GID4 Gene

Gene Ontology (GO) - Biological Process for GID4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GID4 Gene

Drugs & Compounds for GID4 Gene

No Compound Related Data Available

Transcripts for GID4 Gene

Unigene Clusters for GID4 Gene

GID complex subunit 4, VID24 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GID4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GID4 Gene

No ASD Table

Relevant External Links for GID4 Gene

GeneLoc Exon Structure for
GID4
ECgene alternative splicing isoforms for
GID4

Expression for GID4 Gene

mRNA expression in normal human tissues for GID4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GID4 Gene

This gene is overexpressed in CD8 Tcells (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GID4 Gene



SOURCE GeneReport for Unigene cluster for GID4 Gene Hs.187422

genes like me logo Genes that share expression patterns with GID4: view

Protein tissue co-expression partners for GID4 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GID4 Gene

Orthologs for GID4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GID4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GID4 35
  • 90.94 (n)
  • 99.08 (a)
C19H17ORF39 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GID4 35
  • 94.59 (n)
  • 100 (a)
GID4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gid4 35
  • 93.55 (n)
  • 99.08 (a)
Gid4 16
Gid4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gid4 35
  • 94.16 (n)
  • 99.54 (a)
oppossum
(Monodelphis domestica)
Mammalia GID4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GID4 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GID4 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17ORF39 35
  • 82.8 (n)
  • 89.4 (a)
GID4 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GID4 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gid4 35
  • 81.85 (n)
  • 91.55 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333066 35
  • 79.11 (n)
  • 88.94 (a)
GID4 36
  • 88 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5699 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000312 35
  • 69.46 (n)
  • 77.34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 24 (a)
OneToMany
VID24 36
  • 22 (a)
OneToMany
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37680 35
  • 48.04 (n)
  • 39.41 (a)
rice
(Oryza sativa)
Liliopsida Os03g0679000 35
  • 47.94 (n)
  • 37.64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7644 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04406 35
  • 54.99 (n)
  • 51.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for GID4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GID4 Gene

ENSEMBL:
Gene Tree for GID4 (if available)
TreeFam:
Gene Tree for GID4 (if available)

Paralogs for GID4 Gene

No data available for Paralogs for GID4 Gene

Variants for GID4 Gene

Sequence variations from dbSNP and Humsavar for GID4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1133710 -- 18,068,068(+) TTTGC(C/T)TTCAG utr-variant-3-prime
rs2955350 -- 18,050,234(+) TGGGT(A/G)TATAC intron-variant
rs2955352 -- 18,058,075(+) TGATC(C/T)GCCTG intron-variant
rs2955353 -- 18,045,665(-) TGCAC(A/G)CCTCA intron-variant
rs2955354 -- 18,045,402(-) TAAAA(C/G)ATTTG intron-variant

Variation tolerance for GID4 Gene

Residual Variation Intolerance Score: 42.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GID4 Gene

HapMap Linkage Disequilibrium report
GID4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GID4 Gene

Disorders for GID4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GID4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
smith-magenis syndrome
  • smith magenis syndrome
- elite association
Search GID4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GID4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GID4
genes like me logo Genes that share disorders with GID4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GID4 Gene

Publications for GID4 Gene

  1. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PMID: 11997338) Bi W. … Lupski J.R. (Genome Res. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 67
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 67

Products for GID4 Gene

Sources for GID4 Gene

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