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Aliases for GID4 Gene

Aliases for GID4 Gene

  • GID Complex Subunit 4 Homolog 2 3 5
  • Vacuolar Import And Degradation Protein 24 Homolog 3 4
  • Vacuolar Import And Degradation 24 2 3
  • C17orf39 3 4
  • VID24 3 4
  • GID Complex Subunit 4, VID24 Homolog (S. Cerevisiae) 2
  • Glucose-Induced Degradation Protein 4 Homolog 3
  • GID Complex Subunit 4, VID24 Homolog 3
  • Chromosome 17 Open Reading Frame 39 2
  • GID Complex Subunit 4 2

External Ids for GID4 Gene

Previous HGNC Symbols for GID4 Gene

  • C17orf39

Previous GeneCards Identifiers for GID4 Gene

  • GC17P017943

Summaries for GID4 Gene

Entrez Gene Summary for GID4 Gene

  • The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for GID4 Gene

GID4 (GID Complex Subunit 4 Homolog) is a Protein Coding gene. Diseases associated with GID4 include Smith-Magenis Syndrome.

Additional gene information for GID4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GID4 Gene

Genomics for GID4 Gene

Regulatory Elements for GID4 Gene

Enhancers for GID4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H017874 1 FANTOM5 ENCODE dbSUPER 3.6 -164.5 -164517 1 GLIS2 POLR2A SREBF1 MIR33B RAI1 DRC3 GID4 GC17M017867 PIR35691 PIR37368
GH17H018300 1 FANTOM5 Ensembl dbSUPER 2.8 +261.9 261909 1 KLF17 MIEF2 SHMT1 GID4 SMCR8 TOP3A DRC3 RPL7AP65 PIR52104
GH17H018037 1.1 ENCODE 0.7 -0.1 -67 3 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF207 ZNF143 TOM1L2 MPRIP-AS1 MPRIP SREBF1 FAM106A SMCR8 MYO15A GID4 ATPAF2
GH17H018041 0.7 Ensembl ENCODE 0.7 +2.7 2697 1 ZNF10 HMBOX1 TOM1L2 GID4 DRG2
GH17H018070 0.9 Ensembl ENCODE 0.3 +31.8 31756 0 L3MBTL2 ZNF511 NFRKB NR4A1 ZBTB11 MAX MNT ZNF592 POLR2A FOS MYO15A DRG2 GID4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GID4 on UCSC Golden Path with GeneCards custom track

Promoters for GID4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092038 108 2001 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF207 ZNF143

Genomic Location for GID4 Gene

Chromosome:
17
Start:
18,039,292 bp from pter
End:
18,068,405 bp from pter
Size:
29,114 bases
Orientation:
Plus strand

Genomic View for GID4 Gene

Genes around GID4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GID4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GID4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GID4 Gene

Proteins for GID4 Gene

  • Protein details for GID4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVV7-GID4_HUMAN
    Recommended name:
    Glucose-induced degradation protein 4 homolog
    Protein Accession:
    Q8IVV7
    Secondary Accessions:
    • Q8TEB5
    • Q9BW50

    Protein attributes for GID4 Gene

    Size:
    300 amino acids
    Molecular mass:
    33514 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GID4 Gene

Post-translational modifications for GID4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GID4 Gene

No data available for DME Specific Peptides for GID4 Gene

Domains & Families for GID4 Gene

Gene Families for GID4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GID4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVV7

UniProtKB/Swiss-Prot:

GID4_HUMAN :
  • Belongs to the GID4/VID24 family.
Family:
  • Belongs to the GID4/VID24 family.
genes like me logo Genes that share domains with GID4: view

No data available for Suggested Antigen Peptide Sequences for GID4 Gene

Function for GID4 Gene

Phenotypes From GWAS Catalog for GID4 Gene

Gene Ontology (GO) - Molecular Function for GID4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with GID4: view
genes like me logo Genes that share phenotypes with GID4: view

Animal Model Products

CRISPR Products

miRNA for GID4 Gene

miRTarBase miRNAs that target GID4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GID4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GID4 Gene

Localization for GID4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GID4 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GID4 Gene

Pathways & Interactions for GID4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GID4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with GID4: view

No data available for Pathways by source and SIGNOR curated interactions for GID4 Gene

Drugs & Compounds for GID4 Gene

No Compound Related Data Available

Transcripts for GID4 Gene

Unigene Clusters for GID4 Gene

GID complex subunit 4, VID24 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GID4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GID4 Gene

No ASD Table

Relevant External Links for GID4 Gene

GeneLoc Exon Structure for
GID4
ECgene alternative splicing isoforms for
GID4

Expression for GID4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GID4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GID4 Gene

This gene is overexpressed in CD8 Tcells (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GID4 Gene



Protein tissue co-expression partners for GID4 Gene

NURSA nuclear receptor signaling pathways regulating expression of GID4 Gene:

GID4

SOURCE GeneReport for Unigene cluster for GID4 Gene:

Hs.187422

Evidence on tissue expression from TISSUES for GID4 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with GID4: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GID4 Gene

Orthologs for GID4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GID4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C19H17ORF39 34
  • 99 (a)
OneToOne
GID4 33
  • 90.94 (n)
chimpanzee
(Pan troglodytes)
Mammalia GID4 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GID4 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GID4 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GID4 33 34
  • 94.59 (n)
rat
(Rattus norvegicus)
Mammalia Gid4 33
  • 94.16 (n)
mouse
(Mus musculus)
Mammalia Gid4 33 16 34
  • 93.55 (n)
chicken
(Gallus gallus)
Aves C17ORF39 33
  • 82.8 (n)
GID4 34
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GID4 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gid4 33
  • 81.85 (n)
zebrafish
(Danio rerio)
Actinopterygii GID4 34
  • 88 (a)
OneToOne
LOC100333066 33
  • 79.11 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5699 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000312 33
  • 69.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 24 (a)
OneToMany
VID24 34
  • 22 (a)
OneToMany
-- 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37680 33
  • 48.04 (n)
rice
(Oryza sativa)
Liliopsida Os03g0679000 33
  • 47.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04406 33
  • 54.99 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7644 33
Species where no ortholog for GID4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GID4 Gene

ENSEMBL:
Gene Tree for GID4 (if available)
TreeFam:
Gene Tree for GID4 (if available)

Paralogs for GID4 Gene

No data available for Paralogs for GID4 Gene

Variants for GID4 Gene

Sequence variations from dbSNP and Humsavar for GID4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs149036879 Likely benign 18,038,979(+) GGCGT(C/T)CCCCG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs75249497 Likely benign 18,039,160(+) GCCAT(C/T)TTCCG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs143241583 Uncertain significance 18,038,974(+) GAGAC(A/C/G)GCGTC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs371822840 Uncertain significance 18,039,120(+) CTCAA(C/T)GCCTC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs886052665 Uncertain significance 18,039,014(-) GGCGC(G/T)ATGTG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GID4 Gene

Variant ID Type Subtype PubMed ID
esv3325943 CNV insertion 20981092
esv3395120 CNV insertion 20981092
nsv1127540 CNV deletion 24896259
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241
nsv510701 CNV deletion 20534489

Variation tolerance for GID4 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GID4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GID4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GID4 Gene

Disorders for GID4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GID4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
smith-magenis syndrome
  • 17p11.2 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search GID4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GID4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GID4
genes like me logo Genes that share disorders with GID4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GID4 Gene

Publications for GID4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PMID: 11997338) Bi W … Lupski JR (Genome research 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for GID4 Gene

Sources for GID4 Gene

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