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Aliases for GHRH Gene

Aliases for GHRH Gene

  • Growth Hormone Releasing Hormone 2 3
  • Somatocrinin 2 3 4
  • Sermorelin 2 3 4
  • GHRF 3 4 6
  • Growth Hormone-Releasing Hormone 3 4
  • Growth Hormone-Releasing Factor 3 4
  • Somatoliberin 2 3
  • Somatorelin 3 4
  • GRF 3 4
  • INN 3

External Ids for GHRH Gene

Previous Symbols for GHRH Gene

  • GHRF

Summaries for GHRH Gene

Entrez Gene Summary for GHRH Gene

  • The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008]

GeneCards Summary for GHRH Gene

GHRH (Growth Hormone Releasing Hormone) is a Protein Coding gene. Diseases associated with GHRH include gigantism and carcinoid syndrome. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. GO annotations related to this gene include growth hormone-releasing hormone activity and growth hormone-releasing hormone receptor binding.

UniProtKB/Swiss-Prot for GHRH Gene

  • GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GHRH Gene

Genomics for GHRH Gene

Genomic Location for GHRH Gene

Start:
37,251,082 bp from pter
End:
37,261,835 bp from pter
Size:
10,754 bases
Orientation:
Minus strand

Genomic View for GHRH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GHRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GHRH Gene

Regulatory Elements for GHRH Gene

Proteins for GHRH Gene

  • Protein details for GHRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01286-SLIB_HUMAN
    Recommended name:
    Somatoliberin
    Protein Accession:
    P01286
    Secondary Accessions:
    • Q4KN10
    • Q5JYR1

    Protein attributes for GHRH Gene

    Size:
    108 amino acids
    Molecular mass:
    12447 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GHRH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GHRH Gene

Proteomics data for GHRH Gene at MOPED

Post-translational modifications for GHRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GHRH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GHRH Gene

Domains for GHRH Gene

Gene Families for GHRH Gene

HGNC:

Protein Domains for GHRH Gene

UniProtKB/Swiss-Prot:

SLIB_HUMAN
Family:
  • Belongs to the glucagon family.:
    • P01286
genes like me logo Genes that share domains with GHRH: view

Function for GHRH Gene

Molecular function for GHRH Gene

GENATLAS Biochemistry: growth hormone releasing factor
UniProtKB/Swiss-Prot Function: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone

Gene Ontology (GO) - Molecular Function for GHRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity --
GO:0005515 protein binding --
GO:0016608 growth hormone-releasing hormone activity IDA 18329818
GO:0031770 growth hormone-releasing hormone receptor binding IPI 1333056
genes like me logo Genes that share ontologies with GHRH: view
genes like me logo Genes that share phenotypes with GHRH: view

Animal Models for GHRH Gene

MGI Knock Outs for GHRH:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GHRH Gene

Localization for GHRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for GHRH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GHRH Gene COMPARTMENTS Subcellular localization image for GHRH gene
Compartment Confidence
extracellular 5
nucleus 3
endoplasmic reticulum 2
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GHRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0043195 terminal bouton ISS --
genes like me logo Genes that share ontologies with GHRH: view

Pathways for GHRH Gene

genes like me logo Genes that share pathways with GHRH: view

Gene Ontology (GO) - Biological Process for GHRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS --
GO:0007267 cell-cell signaling TAS 6192430
GO:0008284 positive regulation of cell proliferation IDA 12867592
GO:0019933 cAMP-mediated signaling IDA 7680413
GO:0021984 adenohypophysis development ISS --
genes like me logo Genes that share ontologies with GHRH: view

Compounds for GHRH Gene

UniProtKB/Swiss-Prot:

P01286-SLIB_HUMAN
Pharmaceutical: Available under the names Groliberin (Pharmacia) or Somatrel (Ferring). Also available under the name Geref (Serono). Geref is a synthetic acetylated form of residues 1 to 29 of GHRH. Used for the treatment of growth hormone deficiency

(66) Novoseek inferred chemical compound relationships for GHRH Gene

Compound -log(P) Hits PubMed IDs
ghrp 86.4 48
hexarelin 83.3 58
pyridostigmine 79.1 47
leucinamide 70.7 1
acipimox 61 4
genes like me logo Genes that share compounds with GHRH: view

Transcripts for GHRH Gene

mRNA/cDNA for GHRH Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GHRH Gene

Growth hormone releasing hormone:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GHRH Gene

No ASD Table

Relevant External Links for GHRH Gene

GeneLoc Exon Structure for
GHRH
ECgene alternative splicing isoforms for
GHRH

Expression for GHRH Gene

mRNA expression in normal human tissues for GHRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GHRH Gene

This gene is overexpressed in Brain - Hypothalamus (31.8) and Heart - Atrial Appendage (17.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GHRH Gene

SOURCE GeneReport for Unigene cluster for GHRH Gene Hs.37023

genes like me logo Genes that share expressions with GHRH: view

Orthologs for GHRH Gene

This gene was present in the common ancestor of mammals.

Orthologs for GHRH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GHRH 36
  • 99.38 (n)
  • 98.13 (a)
GHRH 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GHRH 36
  • 84.91 (n)
  • 74.53 (a)
GHRH 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GHRH 36
  • 83.96 (n)
  • 78.3 (a)
GHRH 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ghrh 36
  • 76.56 (n)
  • 65.93 (a)
Ghrh 16
Ghrh 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ghrh 36
  • 76.81 (n)
  • 68.48 (a)
Species with no ortholog for GHRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GHRH Gene

ENSEMBL:
Gene Tree for GHRH (if available)
TreeFam:
Gene Tree for GHRH (if available)

Paralogs for GHRH Gene

No data available for Paralogs for GHRH Gene

Variants for GHRH Gene

Sequence variations from dbSNP and Humsavar for GHRH Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs4812952 -- 37,255,064(+) agtac(C/T)taagg intron-variant
rs4988491 -- 37,251,001(+) AGCTT(C/T)AAAAA downstream-variant-500B
rs4988492 - 37,254,295(+) ACCAA(A/G)CCGTG reference, missense
rs6017640 -- 37,250,950(+) ATCCT(A/C/G)TGCAT downstream-variant-500B
rs6017655 -- 37,258,137(+) TCCGC(C/T)GGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GHRH Gene

Variant ID Type Subtype PubMed ID
nsv524059 CNV Loss 19592680

Relevant External Links for GHRH Gene

HapMap Linkage Disequilibrium report
GHRH
Human Gene Mutation Database (HGMD)
GHRH

Disorders for GHRH Gene

(63) Novoseek inferred disease relationships for GHRH Gene

Disease -log(P) Hits PubMed IDs
acromegaly 71.3 19
growth hormone deficiency 65.2 9
pituitary adenoma 60.1 11
hypopituitarism 57.5 1
dwarfism 55.1 4

Relevant External Links for GHRH

Genetic Association Database (GAD)
GHRH
Human Genome Epidemiology (HuGE) Navigator
GHRH
genes like me logo Genes that share disorders with GHRH: view

No data available for UniProtKB/Swiss-Prot for GHRH Gene

Publications for GHRH Gene

  1. Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment. (PMID: 3918305) Mayo K.E. … Evans R.M. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4
  2. Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin. (PMID: 6192430) Gubler U. … Gage L.P. (Proc. Natl. Acad. Sci. U.S.A. 1983) 3 4
  3. Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor. (PMID: 6415488) Mayo K.E. … Evans R.M. (Nature 1983) 3 4
  4. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. (PMID: 6812220) Guillemin R. … Wehrenberg W.B. (Science 1982) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for GHRH Gene

Sources for GHRH Gene

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