Aliases for GHRH Gene
External Ids for GHRH Gene
Previous Symbols for GHRH Gene
The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008]
GeneCards Summary for GHRH Gene
GHRH (Growth Hormone Releasing Hormone) is a Protein Coding gene. Diseases associated with GHRH include gigantism and carcinoid syndrome. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. GO annotations related to this gene include growth hormone-releasing hormone activity and growth hormone-releasing hormone receptor binding.
UniProtKB/Swiss-Prot for GHRH Gene
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone