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Aliases for GHRH Gene

Aliases for GHRH Gene

  • Growth Hormone Releasing Hormone 2 3
  • Somatocrinin 2 3 4
  • Sermorelin 2 3 4
  • Growth Hormone-Releasing Hormone 3 4
  • Growth Hormone-Releasing Factor 3 4
  • Somatorelin 3 4
  • GHRF 3 4
  • GRF 3 4
  • Somatoliberin 2
  • INN 3

External Ids for GHRH Gene

Previous HGNC Symbols for GHRH Gene

  • GHRF

Previous GeneCards Identifiers for GHRH Gene

  • GC20M035608
  • GC20M036517
  • GC20M036564
  • GC20M035312
  • GC20M035880
  • GC20M032616

Summaries for GHRH Gene

Entrez Gene Summary for GHRH Gene

  • The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008]

GeneCards Summary for GHRH Gene

GHRH (Growth Hormone Releasing Hormone) is a Protein Coding gene. Diseases associated with GHRH include isolated growth hormone deficiency, ghrh-related and mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. GO annotations related to this gene include hormone activity and growth hormone-releasing hormone receptor binding.

UniProtKB/Swiss-Prot for GHRH Gene

  • GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GHRH Gene

Genomics for GHRH Gene

Regulatory Elements for GHRH Gene

Genomic Location for GHRH Gene

Chromosome:
20
Start:
37,251,065 bp from pter
End:
37,261,878 bp from pter
Size:
10,814 bases
Orientation:
Minus strand

Genomic View for GHRH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GHRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GHRH Gene

Proteins for GHRH Gene

  • Protein details for GHRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01286-SLIB_HUMAN
    Recommended name:
    Somatoliberin
    Protein Accession:
    P01286
    Secondary Accessions:
    • Q4KN10
    • Q5JYR1

    Protein attributes for GHRH Gene

    Size:
    108 amino acids
    Molecular mass:
    12447 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GHRH Gene

    Alternative splice isoforms for GHRH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GHRH Gene

Proteomics data for GHRH Gene at MOPED

Post-translational modifications for GHRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GHRH Gene

Antibody Products

No data available for DME Specific Peptides for GHRH Gene

Domains & Families for GHRH Gene

Gene Families for GHRH Gene

Protein Domains for GHRH Gene

Suggested Antigen Peptide Sequences for GHRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01286

UniProtKB/Swiss-Prot:

SLIB_HUMAN :
  • Belongs to the glucagon family.
Family:
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with GHRH: view

Function for GHRH Gene

Molecular function for GHRH Gene

GENATLAS Biochemistry:
growth hormone releasing factor
UniProtKB/Swiss-Prot Function:
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone

Gene Ontology (GO) - Molecular Function for GHRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity --
GO:0005515 protein binding --
GO:0016608 growth hormone-releasing hormone activity IDA 8421089
GO:0031770 growth hormone-releasing hormone receptor binding IPI 1333056
genes like me logo Genes that share ontologies with GHRH: view
genes like me logo Genes that share phenotypes with GHRH: view

Animal Models for GHRH Gene

MGI Knock Outs for GHRH:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GHRH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for GHRH Gene

Localization for GHRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for GHRH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GHRH Gene COMPARTMENTS Subcellular localization image for GHRH gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GHRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0005622 intracellular IDA 7680413
GO:0043195 terminal bouton ISS --
genes like me logo Genes that share ontologies with GHRH: view

Pathways & Interactions for GHRH Gene

genes like me logo Genes that share pathways with GHRH: view

Gene Ontology (GO) - Biological Process for GHRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS --
GO:0007267 cell-cell signaling TAS 6192430
GO:0008284 positive regulation of cell proliferation IDA 12867592
GO:0019933 cAMP-mediated signaling IDA 7680413
GO:0021984 adenohypophysis development ISS --
genes like me logo Genes that share ontologies with GHRH: view

No data available for SIGNOR curated interactions for GHRH Gene

Drugs & Compounds for GHRH Gene

(44) Drugs for GHRH Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Bromocriptine Approved, Investigational Pharma Partial agonist, Agonist 27
Clonidine Approved Pharma Partial agonist, Agonist 177
Dexamethasone Approved, Investigational Pharma Agonist 1806
Dopamine Approved Pharma Full agonist, Agonist 2814

(22) Additional Compounds for GHRH Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
adenylate
amide
aspartate
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
chloride
genes like me logo Genes that share compounds with GHRH: view

Transcripts for GHRH Gene

mRNA/cDNA for GHRH Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GHRH Gene

Growth hormone releasing hormone:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GHRH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GHRH Gene

No ASD Table

Relevant External Links for GHRH Gene

GeneLoc Exon Structure for
GHRH
ECgene alternative splicing isoforms for
GHRH

Expression for GHRH Gene

mRNA expression in normal human tissues for GHRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GHRH Gene

This gene is overexpressed in Brain - Hypothalamus (x31.8) and Heart - Atrial Appendage (x17.8).

Protein differential expression in normal tissues from HIPED for GHRH Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GHRH Gene



SOURCE GeneReport for Unigene cluster for GHRH Gene Hs.37023

genes like me logo Genes that share expression patterns with GHRH: view

Protein tissue co-expression partners for GHRH Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GHRH Gene

Orthologs for GHRH Gene

This gene was present in the common ancestor of mammals.

Orthologs for GHRH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GHRH 35
  • 84.91 (n)
  • 74.53 (a)
GHRH 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GHRH 35
  • 83.96 (n)
  • 78.3 (a)
GHRH 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ghrh 35
  • 76.56 (n)
  • 65.93 (a)
Ghrh 16
Ghrh 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GHRH 35
  • 99.38 (n)
  • 98.13 (a)
GHRH 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ghrh 35
  • 76.81 (n)
  • 68.48 (a)
Species with no ortholog for GHRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GHRH Gene

ENSEMBL:
Gene Tree for GHRH (if available)
TreeFam:
Gene Tree for GHRH (if available)

Paralogs for GHRH Gene

No data available for Paralogs for GHRH Gene

Variants for GHRH Gene

Sequence variations from dbSNP and Humsavar for GHRH Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs4988490 -- 37,261,669(+) TCAGT(A/G)TTTCT intron-variant, upstream-variant-2KB
rs4988491 -- 37,251,001(+) AGCTT(C/T)AAAAA downstream-variant-500B
rs4988492 - 37,254,295(+) ACCAA(A/G)CCGTG reference, missense
rs6017640 -- 37,250,950(+) ATCCT(A/C/G)TGCAT downstream-variant-500B
rs6017655 -- 37,258,137(+) TCCGC(C/T)GGGGC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GHRH Gene

Variant ID Type Subtype PubMed ID
nsv524059 CNV Loss 19592680

Variation tolerance for GHRH Gene

Residual Variation Intolerance Score: 63.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GHRH Gene

HapMap Linkage Disequilibrium report
GHRH
Human Gene Mutation Database (HGMD)
GHRH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GHRH Gene

Disorders for GHRH Gene

MalaCards: The human disease database

(28) MalaCards diseases for GHRH Gene - From: GeneTests, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
isolated growth hormone deficiency, ghrh-related
  • isolated growth hormone deficiency due to defect in ghrf
mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes
  • melas
gigantism
hyperpituitarism
glucagonoma
  • glucagonoma syndrome
- elite association
Search GHRH in MalaCards View complete list of genes associated with diseases

Relevant External Links for GHRH

Genetic Association Database (GAD)
GHRH
Human Genome Epidemiology (HuGE) Navigator
GHRH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GHRH
genes like me logo Genes that share disorders with GHRH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GHRH Gene

Publications for GHRH Gene

  1. Effects of growth hormone-releasing hormone and its agonistic and antagonistic analogs in cancer and non-cancerous cell lines. (PMID: 20372804) Barabutis N. … Schally A.V. (Int. J. Oncol. 2010) 23 67
  2. Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp. (PMID: 19858315) Hudson S.B. … Veldhuis J.D. (J. Clin. Endocrinol. Metab. 2010) 23 67
  3. Activation of mitogen-activated protein kinases by a splice variant of GHRH receptor. (PMID: 19897610) Barabutis N. … Varga J.L. (J. Mol. Endocrinol. 2010) 23 67
  4. Antagonists of growth hormone-releasing hormone inhibit the proliferation of human benign prostatic hyperplasia cells. (PMID: 20232355) Siejka A. … Barabutis N. (Prostate 2010) 23 67
  5. Effects of somatostatin analogs on a growth hormone-releasing hormone secreting bronchial carcinoid, in vivo and in vitro studies. (PMID: 19017754) van Hoek M. … Feelders R.A. (J. Clin. Endocrinol. Metab. 2009) 23 67

Products for GHRH Gene

Sources for GHRH Gene

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