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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GHRH Gene

protein-coding   GIFtS: 61
GCID: GC20M035880

Growth Hormone Releasing Hormone


(Previous symbol: GHRF)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Growth Hormone Releasing Hormone1 2     GRF2 3
GHRF1 2 3 5     INN2
sermorelin1 2     somatorelin2
somatocrinin1 2     Sermorelin3
somatoliberin1 2     Somatocrinin3
Growth Hormone-Releasing Factor2 3     Somatorelin3
Growth Hormone-Releasing Hormone2 3     

External Ids:    HGNC: 42651   Entrez Gene: 26912   Ensembl: ENSG000001187027   OMIM: 1391905   UniProtKB: P012863   

Export aliases for GHRH gene to outside databases

Previous GC identifers: GC20M035608 GC20M036517 GC20M036564 GC20M035312 GC20M032616


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GHRH Gene:
The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the
hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to
stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in
several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this
gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. (provided by
RefSeq, Jul 2008)

GeneCards Summary for GHRH Gene: 
GHRH (growth hormone releasing hormone) is a protein-coding gene. Diseases associated with GHRH include gigantism, and carcinoid syndrome, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include growth hormone-releasing hormone receptor binding and growth hormone-releasing hormone activity.

UniProtKB/Swiss-Prot: SLIB_HUMAN, P01286
Function: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth
hormone




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GHRH gene promoter:
         c-Fos   AP-1   ATF-2   NF-kappaB   CREB   deltaCREB   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGHRH promoter sequence
   Search SABiosciences Chromatin IP Primers for GHRH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GHRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.2

GHRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GHRH gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M035880:  view genomic region     (about GC identifiers)

Start:
35,879,489 bp from pter      End:
35,890,238 bp from pter
Size:
10,750 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLIB_HUMAN, P01286 (See protein sequence)
Recommended Name: Somatoliberin precursor  
Size: 108 amino acids; 12447 Da
Subcellular location: Secreted
Secondary accessions: Q4KN10 Q5JYR1
Alternative splicing: 2 isoforms:  P01286-1   P01286-2   

Explore the universe of human proteins at neXtProt for GHRH: NX_P01286

Explore proteomics data for GHRH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01286

  • GHRH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GHRH Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171660.1  NP_066567.1  

    ENSEMBL proteins: 
     ENSP00000362716   ENSP00000362713   ENSP00000237527  
    Reactome Protein details: P01286
    Human Recombinant Protein Products for GHRH: 
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    OriGene Custom Protein Services for GHRH
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    Novus Biologicals GHRH Proteins
    Novus Biologicals GHRH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GHRH
    Cloud-Clone Corp. Proteins for GHRH 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--
    GO:0043195terminal bouton ISS--

    GHRH for ontologies           About GeneDecksing



    GHRH Antibody Products: 
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    ThermoFisher Antibodies for GHRH
    LSBio Antibodies in human, mouse, rat for GHRH 

    Assay Products for GHRH: 
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    Cloud-Clone Corp. ELISAs for GHRH 
    Cloud-Clone Corp. CLIAs for GHRH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000532 Glucagon_GIP_secretin_VIP

    Graphical View of Domain Structure for InterPro Entry P01286

    ProtoNet protein and cluster: P01286

    1 Blocks protein domain: IPB000532 Glucagon/GIP/secretin/VIP

    UniProtKB/Swiss-Prot: SLIB_HUMAN, P01286
    Similarity: Belongs to the glucagon family


    GHRH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLIB_HUMAN, P01286
    Function: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth
    hormone

         Genatlas biochemistry entry for GHRH:
    growth hormone releasing factor

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity ----
    GO:0005515protein binding ----
    GO:0016608growth hormone-releasing hormone activity IDA18329818
    GO:0031770growth hormone-releasing hormone receptor binding IPI1333056
         
    GHRH for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ghrh):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  immune system  liver/biliary system 
     nervous system  reproductive system 

    GHRH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ghrhtm1Salv for GHRH

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GHRH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GHRH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GHRH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GHRH 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GHRH
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GHRH:
    hsa-miR-625 hsa-miR-590-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidGHRH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): GHRH (NM_021081)
    Sino Biological Human cDNA Clone for GHRH
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GHRH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GHRH About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GHRH (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    5/7        Reactome Pathways for GHRH (see all 7)
        GPCR downstream signaling
    Glucagon-type ligand receptors
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding



    GHRH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GHRH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for GHRH (P012862, 3 ENSP000002375274) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8090823 I2D: score=1 STRING: ENSP00000353731
    FAPQ128842, 3, ENSP000001887904MINT-8090620 I2D: score=1 STRING: ENSP00000188790
    GHRHRQ026433, ENSP000003201804I2D: score=1 STRING: ENSP00000320180
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS--
    GO:0007267cell-cell signaling TAS6192430
    GO:0008284positive regulation of cell proliferation IDA12867592
    GO:0019933cAMP-mediated signaling IDA7680413
    GO:0021984adenohypophysis development ISS--

    GHRH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GHRH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GHRH (SLIB)

    UniProtKB/Swiss-Prot: SLIB_HUMAN, P01286
    Pharmaceutical: Available under the names Groliberin (Pharmacia) or Somatrel (Ferring). Also available under the
    name Geref (Serono). Geref is a synthetic acetylated form of residues 1 to 29 of GHRH. Used for the treatment of
    growth hormone deficiency

    10/66 Novoseek inferred chemical compound relationships for GHRH gene (see all 66)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ghrp 86.4 100 9768668 (7), 11322505 (6), 9053785 (6), 15634714 (5) (see all 15)
    hexarelin 83.3 82 8977750 (11), 9186817 (7), 11238504 (6), 8799695 (6) (see all 14)
    pyridostigmine 79.1 68 8370132 (5), 11106919 (5), 2220258 (5), 10754475 (4) (see all 18)
    leucinamide 70.7 1 1478784 (1)
    acipimox 61 5 10848875 (3), 11085190 (1)
    arginine 54.7 113 12864804 (5), 8736266 (5), 10754475 (4), 1617799 (4) (see all 36)
    adenylate 54.5 36 7962343 (2), 19215372 (2), 8721987 (1), 10698193 (1) (see all 23)
    acth 54.4 9 11238504 (1), 1591027 (1), 16832586 (1), 10084578 (1) (see all 8)
    clonidine 53.4 59 2087535 (9), 9267532 (4), 2147600 (3), 1543013 (3) (see all 15)
    gnrh 53.3 23 1683565 (1), 1425484 (1), 9078497 (1), 1359604 (1) (see all 19)

    Search CenterWatch for drugs/clinical trials and news about GHRH / SLIB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GHRH gene (2 alternative transcripts): 
    NM_001184731.1  NM_021081.4  

    Unigene Cluster for GHRH:

    Growth hormone releasing hormone
    Hs.37023  [show with all ESTs]
    Unigene Representative Sequence: BX102214
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373614(uc021wdc.1 uc002xgr.3 uc002xgt.3 uc002xgs.3)
    ENST00000373611 ENST00000237527

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    SwitchGear 3'UTR luciferase reporter plasmidGHRH 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GHRH

    Additional mRNA sequence: 

    BC098109.1 BC098161.1 BC099727.1 

    1 DOTS entry:

    DT.404432 

    7 AceView cDNA sequences:

    AW134884 AI631051 NM_021081 BX102214 BE219117 BE348700 X00094 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GHRH expression in normal human tissues (normalized intensities)      GHRH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGCAGAAC
    GHRH Expression
    About this image


    GHRH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
             brain/midbrain   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Neural Tube (Nervous System)
             Diencephalon

     -- (Nervous System)
             mouse/organ system/nervous system/central nervous system   

    See GHRH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GHRH

    SOURCE GeneReport for Unigene cluster: Hs.37023
        SABiosciences Custom PCR Arrays for GHRH
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GHRH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GHRH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GHRH gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ghrh1 , 5 growth hormone releasing hormone1, 5 76.56(n)1
    65.93(a)1
      2 (78.25 cM)5
    146011  NM_010285.21  NP_034415.11 
     1573294975 
    chicken
    (Gallus gallus)
    Aves GHRH6
    growth hormone releasing hormone precursor
    23(a)
    1 ↔ 1
    20(5387580-5395077)
    lizard
    (Anolis carolinensis)
    Reptilia GHRH6
    growth hormone releasing hormone
    22(a)
    1 ↔ 1
    GL343291.1(1375899-1383368)
    zebrafish
    (Danio rerio)
    Actinopterygii ghrh6
    growth hormone releasing hormone
    30(a)
    1 ↔ 1
    11(15707808-15797645)


    ENSEMBL Gene Tree for GHRH (if available)
    TreeFam Gene Tree for GHRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/191 SNPs in GHRH are shown (see all 191)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888246551,2
    --35879006(+) GGAGGC/TGGAGG 2 -- ds50010--------
    rs1432482851,2
    --35879069(+) AAACTC/GTGTCT 2 -- ds50010--------
    rs782530351,2
    F--35879227(+) CCAGCG/ACTCTC 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1468586501,2
    --35879240(+) TTGCAC/TGGTGT 2 -- ds50010--------
    rs61042631,2
    C,F,A,H--35879350(+) gagatC/Tctatg 2 -- ds500117Minor allele frequency- T:0.02NS EA NA EU CSAM WA 2191
    rs60176401,2
    F,H--35879353(+) ATCCTA/C/GTGCAT 2 -- ds50014NS EA 404
    rs49884911,2
    C,F,H--35879404(+) AGCTTT/CAAAAA 2 -- ds500119Minor allele frequency- C:0.12NA EU CSAM EA NS WA 2148
    rs61042641,2
    C,F,H--35879422(+) ACCTCG/ATAATA 2 -- ds500110Minor allele frequency- A:0.01NS EA NA EU CSAM WA 900
    rs61042671,2
    C,H--35879609(+) CAGGAG/AGAATC 2 -- ut31 ese36Minor allele frequency- A:0.00NS EA NA 422
    rs1998813741,2
    C--35879679(+) GTAAGG/TGTGGC 2 -- int11Minor allele frequency- T:0.00EU 1313

    HapMap Linkage Disequilibrium report for GHRH (35879489 - 35890238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GHRH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv524059CNV Loss19592680


    Human Gene Mutation Database (HGMD): GHRH
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GHRH
    DNA2.0 Custom Variant and Variant Library Synthesis for GHRH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139190    OMIM disorders: --

    20/94 diseases for GHRH (see all 94):    About MalaCards
    gigantism    carcinoid syndrome    growth disorders    isolated growth hormone deficiency
    fetal adenoma    pancreatic islet cell tumors    central neurocytoma    mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes
    vipoma    adenohypophysitis    somatostatinoma    dwarfism
    recessive dystrophic epidermolysis bullosa    zollinger-ellison syndrome    growth hormone deficiency    acromegaly
    hypopituitarism    liver cirrhosis    alcoholic liver cirrhosis    anorexia nervosa

    11 diseases from the University of Copenhagen DISEASES database for GHRH:
    Acromegaly     Hypopituitarism     Adenoma     Hypoglycemia
    Pituitary adenoma     Cushing's syndrome     Hypothyroidism     Hyperprolactinemia
    Pituitary hypoplasia     Diabetes insipidus     Neuroendocrine tumor

    GHRH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/63 Novoseek inferred disease relationships for GHRH gene (see all 63)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acromegaly 71.3 26 10483668 (5), 1683501 (2), 19017754 (2), 16968791 (2) (see all 12)
    growth hormone deficiency 65.2 11 18031173 (5), 12864804 (1), 12536371 (1), 9924487 (1) (see all 5)
    pituitary adenoma 60.1 12 1350590 (3), 1683501 (2), 9392350 (1), 1923952 (1) (see all 8)
    hypopituitarism 57.5 1 11676163 (1)
    dwarfism 55.1 4 2239085 (1), 9002989 (1), 10084578 (1), 1296432 (1)
    short stature 52.6 1 9467553 (1)
    vipoma 50.6 3 10436815 (1), 11445245 (1)
    adenoma 43.9 23 7745020 (5), 1350590 (3), 1363983 (2), 9109848 (2) (see all 8)
    pituitary tumors 43.9 2 9392350 (1), 7911814 (1)
    hypothyroidism primary 41.6 4 8961133 (2), 9156038 (1)

    Genetic Association Database (GAD): GHRH
    Human Genome Epidemiology (HuGE) Navigator: GHRH (17 documents)

    Export disorders for GHRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GHRH gene, integrated from 9 sources (see all 529):
    (articles sorted by number of sources associating them with GHRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment. (PubMed id 3918305)1, 2, 3 Mayo K.E....Evans R.M. (1985)
    2. A study of relationships between single nucleotide po lymorphisms from the growth hormone-insulin-like growth factor axis and bone ma ss: the Hertfordshire cohort study. (PubMed id 19487270)1, 4, 9 Dennison E.M....Lips M.A. (2009)
    3. Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation. (PubMed id 17546465)1, 4, 9 Lettre G....Hirschhorn J.N. (2007)
    4. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4, 9 Canzian F....Kaaks R. (2005)
    5. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
    6. Eighteen insulin-like growth factor pathway genes, ci rculating levels of IGF-I and its binding protein, and risk of prostate and bre ast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (2010)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    8. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    9. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolis m and breast cancer risk in the NCI breast and prostate cancer cohort consortiu m. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (2010)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2691 HGNC: 4265 AceView: GHRH Ensembl:ENSG00000118702 euGenes: HUgn2691
    ECgene: GHRH H-InvDB: GHRH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GHRH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GHRH Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Growth_hormone_releasing_hormone

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GHRH gene:
    Search GeneIP for patents involving GHRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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