Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GHRH Gene

protein-coding   GIFtS: 60
GCID: GC20M035880

Growth Hormone Releasing Hormone


(Previous symbol: GHRF)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Growth Hormone Releasing Hormone1 2     GRF2 3
GHRF1 2 3 5     INN2
sermorelin1 2     somatorelin2
somatocrinin1 2     Sermorelin3
somatoliberin1 2     Somatocrinin3
Growth Hormone-Releasing Factor2 3     Somatorelin3
Growth Hormone-Releasing Hormone2 3     

External Ids:    HGNC: 42651   Entrez Gene: 26912   Ensembl: ENSG000001187027   OMIM: 1391905   UniProtKB: P012863   

Export aliases for GHRH gene to outside databases

Previous GC identifers: GC20M035608 GC20M036517 GC20M036564 GC20M035312 GC20M032616


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GHRH Gene:
The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the
hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to
stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in
several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this
gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. (provided by
RefSeq, Jul 2008)

GeneCards Summary for GHRH Gene:
GHRH (growth hormone releasing hormone) is a protein-coding gene. Diseases associated with GHRH include isolated growth hormone deficiency due to defect in ghrf, and gigantism due to ghrf hypersecretion. GO annotations related to this gene include growth hormone-releasing hormone receptor binding and growth hormone-releasing hormone activity.

UniProtKB/Swiss-Prot: SLIB_HUMAN, P01286
Function: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth
hormone




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the GHRH gene promoter:
         c-Fos   AP-1   ATF-2   NF-kappaB   CREB   deltaCREB   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGHRH promoter sequence
   Search Chromatin IP Primers for GHRH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GHRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.2

GHRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GHRH gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M035880:  view genomic region     (about GC identifiers)

Start:
35,879,489 bp from pter      End:
35,890,238 bp from pter
Size:
10,750 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SLIB_HUMAN, P01286 (See protein sequence)
Recommended Name: Somatoliberin precursor  
Size: 108 amino acids; 12447 Da
Secondary accessions: Q4KN10 Q5JYR1
Alternative splicing: 2 isoforms:  P01286-1   P01286-2   

Explore the universe of human proteins at neXtProt for GHRH: NX_P01286

Explore proteomics data for GHRH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GHRH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171660.1  NP_066567.1  

    ENSEMBL proteins: 
     ENSP00000362716   ENSP00000362713   ENSP00000237527  
    Reactome Protein details: P01286

    GHRH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GHRH
    GenScript Custom Purified and Recombinant Proteins Services for GHRH
    Novus Biologicals GHRH Proteins
    Novus Biologicals GHRH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GHRH
    Cloud-Clone Corp. Proteins for GHRH

    GHRH Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GHRH
    OriGene Custom Antibody Services for GHRH
    Novus Biologicals GHRH Antibodies
    Abcam antibodies for GHRH
    Cloud-Clone Corp. Antibodies for GHRH
    ThermoFisher Antibodies for GHRH
    LSBio Antibodies in human, mouse, rat for GHRH

    GHRH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GHRH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GHRH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GHRH
    Cloud-Clone Corp. CLIAs for GHRH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR000532 Glucagon_GIP_secretin_VIP

    Graphical View of Domain Structure for InterPro Entry P01286

    ProtoNet protein and cluster: P01286

    1 Blocks protein domain: IPB000532 Glucagon/GIP/secretin/VIP

    UniProtKB/Swiss-Prot: SLIB_HUMAN, P01286
    Similarity: Belongs to the glucagon family


    GHRH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLIB_HUMAN, P01286
    Function: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth
    hormone

         Genatlas biochemistry entry for GHRH:
    growth hormone releasing factor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity ----
    GO:0005515protein binding ----
    GO:0016608growth hormone-releasing hormone activity IDA18329818
    GO:0031770growth hormone-releasing hormone receptor binding IPI1333056
         
    GHRH for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ghrh):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  immune system  liver/biliary system 
     nervous system  reproductive system 

    GHRH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ghrhtm1Salv for GHRH

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GHRH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GHRH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GHRH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GHRH

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GHRH using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GHRH:
    hsa-miR-625 hsa-miR-590-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidGHRH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GHRH
    Predesigned siRNA for gene silencing in human, mouse, rat GHRH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GHRH

    Clone
    Products:
         
    OriGene clones in human, mouse for GHRH (see all 10)
    OriGene ORF clones in mouse, rat for GHRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GHRH (NM_021081)
    Sino Biological Human cDNA Clone for GHRH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GHRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GHRH

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GHRH
    Browse ESI BIO Cell Lines and PureStem Progenitors for GHRH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GHRH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SLIB_HUMAN, P01286: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    endoplasmic reticulum2
    plasma membrane2
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--
    GO:0043195terminal bouton ISS--

    GHRH for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GHRH About   (see all 17)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GHRH (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    2 Reactome Pathways for GHRH
        Glucagon-type ligand receptors
    G alpha (s) signalling events



    GHRH for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GHRH
    Interactions:

        GeneGlobe Interaction Network for GHRH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GHRH (P012862, 3 ENSP000002375274) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8090823 I2D: score=1 STRING: ENSP00000353731
    FAPQ128842, 3, ENSP000001887904MINT-8090620 I2D: score=1 STRING: ENSP00000188790
    GHRHRQ026433, ENSP000003201804I2D: score=1 STRING: ENSP00000320180
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS--
    GO:0007267cell-cell signaling TAS6192430
    GO:0008284positive regulation of cell proliferation IDA12867592
    GO:0019933cAMP-mediated signaling IDA7680413
    GO:0021984adenohypophysis development ISS--

    GHRH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GHRH (SLIB)

    UniProtKB/Swiss-Prot: SLIB_HUMAN, P01286
    Pharmaceutical: Available under the names Groliberin (Pharmacia) or Somatrel (Ferring). Also available under the
    name Geref (Serono). Geref is a synthetic acetylated form of residues 1 to 29 of GHRH. Used for the treatment of
    growth hormone deficiency

    Selected Novoseek inferred chemical compound relationships for GHRH gene (see all 66)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ghrp 86.4 100 9768668 (7), 11322505 (6), 9053785 (6), 15634714 (5) (see all 15)
    hexarelin 83.3 82 8977750 (11), 9186817 (7), 11238504 (6), 8799695 (6) (see all 14)
    pyridostigmine 79.1 68 8370132 (5), 11106919 (5), 2220258 (5), 10754475 (4) (see all 18)
    leucinamide 70.7 1 1478784 (1)
    acipimox 61 5 10848875 (3), 11085190 (1)
    arginine 54.7 113 12864804 (5), 8736266 (5), 10754475 (4), 1617799 (4) (see all 36)
    adenylate 54.5 36 7962343 (2), 19215372 (2), 8721987 (1), 10698193 (1) (see all 23)
    acth 54.4 9 11238504 (1), 1591027 (1), 16832586 (1), 10084578 (1) (see all 8)
    clonidine 53.4 59 2087535 (9), 9267532 (4), 2147600 (3), 1543013 (3) (see all 15)
    gnrh 53.3 23 1683565 (1), 1425484 (1), 9078497 (1), 1359604 (1) (see all 19)



    GHRH for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GHRH gene (2 alternative transcripts): 
    NM_001184731.1  NM_021081.4  

    Unigene Cluster for GHRH:

    Growth hormone releasing hormone
    Hs.37023  [show with all ESTs]
    Unigene Representative Sequence: BX102214
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373614(uc021wdc.1 uc002xgr.3 uc002xgt.3 uc002xgs.3)
    ENST00000373611 ENST00000237527
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GHRH using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GHRH:
    hsa-miR-625 hsa-miR-590-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidGHRH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GHRH
    Predesigned siRNA for gene silencing in human, mouse, rat GHRH
    Clone
    Products:
         
    OriGene clones in human, mouse for GHRH (see all 10)
    OriGene ORF clones in mouse, rat for GHRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GHRH (NM_021081)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GHRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GHRH
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GHRH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GHRH
      QuantiTect SYBR Green Assays in human, mouse, rat GHRH
      QuantiFast Probe-based Assays in human, mouse, rat GHRH

    Additional mRNA sequence: 

    BC098109.1 BC098161.1 BC099727.1 

    1 DOTS entry:

    DT.404432 

    7 AceView cDNA sequences:

    AW134884 BX102214 AI631051 NM_021081 BE219117 BE348700 X00094 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GHRH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGCAGAAC
    GHRH Expression
    About this image


    GHRH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)
             Diencephalon
    GHRH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GHRH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37023
        Custom PCR Arrays for GHRH
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GHRH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GHRH
    QuantiTect SYBR Green Assays in human, mouse, rat GHRH
    QuantiFast Probe-based Assays in human, mouse, rat GHRH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GHRH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for GHRH gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ghrh1 , 5 growth hormone releasing hormone1, 5 76.56(n)1
    65.93(a)1
      2 (78.25 cM)5
    146011  NM_010285.21  NP_034415.11 
     1573294975 


    ENSEMBL Gene Tree for GHRH (if available)
    TreeFam Gene Tree for GHRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GHRH (see all 191)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888246551,2
    --35879006(+) GGAGGC/TGGAGG 2 -- ds50010--------
    rs1432482851,2
    --35879069(+) AAACTC/GTGTCT 2 -- ds50010--------
    rs782530351,2
    F--35879227(+) CCAGCG/ACTCTC 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1468586501,2
    --35879240(+) TTGCAC/TGGTGT 2 -- ds50010--------
    rs61042631,2
    C,F,A,H--35879350(+) gagatC/Tctatg 2 -- ds500117Minor allele frequency- T:0.02NS EA NA EU CSAM WA 2191
    rs60176401,2
    F,H--35879353(+) ATCCTA/C/GTGCAT 2 -- ds50014NS EA 404
    rs49884911,2
    C,F,H--35879404(+) AGCTTT/CAAAAA 2 -- ds500119Minor allele frequency- C:0.12NA EU CSAM EA NS WA 2148
    rs61042641,2
    C,F,H--35879422(+) ACCTCG/ATAATA 2 -- ds500110Minor allele frequency- A:0.01NS EA NA EU CSAM WA 900
    rs61042671,2
    C,H--35879609(+) CAGGAG/AGAATC 2 -- ut31 ese36Minor allele frequency- A:0.00NS EA NA 422
    rs1998813741,2
    C--35879679(+) GTAAGG/TGTGGC 2 -- int11Minor allele frequency- T:0.00EU 1313

    HapMap Linkage Disequilibrium report for GHRH (35879489 - 35890238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GHRH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524059CNV Loss19592680

    Human Gene Mutation Database (HGMD): GHRH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GHRH
    DNA2.0 Custom Variant and Variant Library Synthesis for GHRH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 139190    OMIM disorders: --

    Selected diseases for GHRH (see all 98):    
    About MalaCards
    isolated growth hormone deficiency due to defect in ghrf    gigantism due to ghrf hypersecretion    adenohypophysitis    gigantism
    pancreatic islet cell tumors    carcinoid syndrome    adrenocorticotropic hormone deficiency    fetal adenoma
    vipoma    central neurocytoma    mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes    somatostatinoma
    recessive dystrophic epidermolysis bullosa    dwarfism    zollinger-ellison syndrome    liver cirrhosis
    acromegaly    serotonin syndrome    hypopituitarism    alcoholic liver cirrhosis

    11 diseases from the University of Copenhagen DISEASES database for GHRH:
    Acromegaly     Hypopituitarism     Adenoma     Hypoglycemia
    Pituitary adenoma     Cushing's syndrome     Hypothyroidism     Hyperprolactinemia
    Pituitary hypoplasia     Diabetes insipidus     Neuroendocrine tumor

    GHRH for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for GHRH gene (see all 63)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acromegaly 71.3 26 10483668 (5), 1683501 (2), 19017754 (2), 16968791 (2) (see all 12)
    growth hormone deficiency 65.2 11 18031173 (5), 12864804 (1), 12536371 (1), 9924487 (1) (see all 5)
    pituitary adenoma 60.1 12 1350590 (3), 1683501 (2), 9392350 (1), 1923952 (1) (see all 8)
    hypopituitarism 57.5 1 11676163 (1)
    dwarfism 55.1 4 2239085 (1), 9002989 (1), 10084578 (1), 1296432 (1)
    short stature 52.6 1 9467553 (1)
    vipoma 50.6 3 10436815 (1), 11445245 (1)
    adenoma 43.9 23 7745020 (5), 1350590 (3), 1363983 (2), 9109848 (2) (see all 8)
    pituitary tumors 43.9 2 9392350 (1), 7911814 (1)
    hypothyroidism primary 41.6 4 8961133 (2), 9156038 (1)

    Genetic Association Database (GAD): GHRH
    Human Genome Epidemiology (HuGE) Navigator: GHRH (17 documents)

    Export disorders for GHRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GHRH gene, integrated from 10 sources (see all 530):
    (articles sorted by number of sources associating them with GHRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment. (PubMed id 3918305)1, 2, 3 Mayo K.E....Evans R.M. (Proc. Natl. Acad. Sci. U.S.A. 1985)
    2. A study of relationships between single nucleotide polymorphisms from the growth hormone-insulin-like growth factor axis and bone mass: the Hertfordshire cohort study. (PubMed id 19487270)1, 4, 9 Dennison E.M....Lips M.A. (J. Rheumatol. 2009)
    3. Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation. (PubMed id 17546465)1, 4, 9 Lettre G....Hirschhorn J.N. (Hum. Genet. 2007)
    4. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4, 9 Canzian F....Kaaks R. (amp 2005)
    5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    6. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (amp 2010)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    8. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    9. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2691 HGNC: 4265 AceView: GHRH Ensembl:ENSG00000118702 euGenes: HUgn2691
    ECgene: GHRH H-InvDB: GHRH

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GHRH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GHRH Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Growth_hormone_releasing_hormone

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GHRH gene:
    Search GeneIP for patents involving GHRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GHRH   OriGene RNAi products in human, mouse, rat for GHRH  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GHRH  
     OriGene qSTAR qPCR primer pairs in human, mouse for GHRH   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GHRH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GHRH   OriGene Custom Protein Services for GHRH  

     
     
     Block miRNA regulation of human, mouse, rat GHRH using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GHRH
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GHRH Predesigned siRNA for gene silencing in human, mouse, rat GHRH
     QuantiFast Probe-based Assays in human, mouse, rat GHRH QuantiTect SYBR Green Assays in human, mouse, rat GHRH
     Custom PCR Arrays for GHRH Search Chromatin IP Primers for GHRH
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GHRH  GeneGlobe Interaction Network for GHRH
     Regulatory tfbs in GHRH promoter
     GenScript Custom Purified and Recombinant Proteins Services for GHRH GenScript cDNA clones with any tag delivered in your preferred vector for GHRH
     GenScript Custom Assay Services for GHRH GenScript Custom overexpressing Cell Line Services for GHRH
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GHRH (SLIB)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GHRH
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GHRH antibodies
     GHRH proteins
     GHRH lysates
     Antibodies for GHRH
     See all of Abcam's Antibodies, Kits and Proteins for GHRH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GHRH
     Proteins for GHRH
     Antibodies for GHRH
     ELISAs for GHRH
     CLIAs for GHRH



     Browse ESI BIO Cell Lines and PureStem Progenitors for GHRH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GHRH
     SwitchGear 3'UTR luciferase reporter plasmids for GHRH
     SwitchGear Promoter luciferase reporter plasmids for GHRH
     ThermoFisher Antibodies for GHRH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GHRH
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GHRH
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GHRH
     LSBio Antibodies in human, mouse, rat for GHRH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GHRH gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4