Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GHITM Gene

Aliases for GHITM Gene

  • Growth Hormone Inducible Transmembrane Protein 2 3
  • Transmembrane BAX Inhibitor Motif-Containing Protein 5 3 4
  • Mitochondrial Morphology And Cristae Structure 1 3 4
  • Transmembrane BAX Inhibitor Motif Containing 5 2 3
  • Dermal Papilla-Derived Protein 2 3 4
  • TMBIM5 3 4
  • DERP2 3 4
  • MICS1 3 4
  • HSPC282 3
  • PTD010 3
  • My021 3

External Ids for GHITM Gene

Previous GeneCards Identifiers for GHITM Gene

  • GC10P084856
  • GC10P085121
  • GC10P086030
  • GC10P085563
  • GC10P085889
  • GC10P079745

Summaries for GHITM Gene

GeneCards Summary for GHITM Gene

GHITM (Growth Hormone Inducible Transmembrane Protein) is a Protein Coding gene. Diseases associated with GHITM include nasal cavity disease.

UniProtKB/Swiss-Prot for GHITM Gene

  • Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.

Gene Wiki entry for GHITM Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GHITM Gene

Genomics for GHITM Gene

Regulatory Elements for GHITM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GHITM Gene

Chromosome:
10
Start:
84,139,429 bp from pter
End:
84,153,555 bp from pter
Size:
14,127 bases
Orientation:
Plus strand

Genomic View for GHITM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GHITM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GHITM Gene

Proteins for GHITM Gene

  • Protein details for GHITM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3K2-GHITM_HUMAN
    Recommended name:
    Growth hormone-inducible transmembrane protein
    Protein Accession:
    Q9H3K2
    Secondary Accessions:
    • A8K9Z9
    • D3DWE0
    • O95894
    • Q5VT95
    • Q9H0P2

    Protein attributes for GHITM Gene

    Size:
    345 amino acids
    Molecular mass:
    37205 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GHITM Gene

Proteomics data for GHITM Gene at MOPED

Post-translational modifications for GHITM Gene

  • Ubiquitination at Lys 63
  • Modification sites at PhosphoSitePlus

Other Protein References for GHITM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GHITM Gene

Domains & Families for GHITM Gene

Protein Domains for GHITM Gene

Suggested Antigen Peptide Sequences for GHITM Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3K2

UniProtKB/Swiss-Prot:

GHITM_HUMAN :
  • Belongs to the BI1 family.
Family:
  • Belongs to the BI1 family.
genes like me logo Genes that share domains with GHITM: view

No data available for Gene Families for GHITM Gene

Function for GHITM Gene

Molecular function for GHITM Gene

UniProtKB/Swiss-Prot Function:
Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.

Gene Ontology (GO) - Molecular Function for GHITM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with GHITM: view

Phenotypes for GHITM Gene

GenomeRNAi human phenotypes for GHITM:
genes like me logo Genes that share phenotypes with GHITM: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GHITM Gene

Localization for GHITM Gene

Subcellular locations from UniProtKB/Swiss-Prot for GHITM Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GHITM Gene COMPARTMENTS Subcellular localization image for GHITM gene
Compartment Confidence
extracellular 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for GHITM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GHITM: view

Pathways & Interactions for GHITM Gene

SuperPathways for GHITM Gene

No Data Available

Interacting Proteins for GHITM Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361207%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000405965%0d%0a
Selected Interacting proteins: Q9H3K2-GHITM_HUMAN ENSP00000361207 for GHITM Gene via UniProtKB I2D STRING

Gene Ontology (GO) - Biological Process for GHITM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GHITM: view

No data available for Pathways by source and SIGNOR curated interactions for GHITM Gene

Drugs & Compounds for GHITM Gene

No Compound Related Data Available

Transcripts for GHITM Gene

mRNA/cDNA for GHITM Gene

Unigene Clusters for GHITM Gene

Growth hormone inducible transmembrane protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GHITM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GHITM Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: -
SP9: - - -

Relevant External Links for GHITM Gene

GeneLoc Exon Structure for
GHITM
ECgene alternative splicing isoforms for
GHITM

Expression for GHITM Gene

mRNA expression in normal human tissues for GHITM Gene

Protein differential expression in normal tissues from HIPED for GHITM Gene

This gene is overexpressed in Nasal epithelium (58.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GHITM Gene



SOURCE GeneReport for Unigene cluster for GHITM Gene Hs.352656

genes like me logo Genes that share expression patterns with GHITM: view

Protein tissue co-expression partners for GHITM Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GHITM Gene

Orthologs for GHITM Gene

This gene was present in the common ancestor of animals.

Orthologs for GHITM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GHITM 35
  • 90.24 (n)
  • 93.91 (a)
GHITM 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GHITM 35
  • 90.92 (n)
  • 92.17 (a)
GHITM 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ghitm 35
  • 90.53 (n)
  • 91.88 (a)
Ghitm 16
Ghitm 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GHITM 35
  • 99.52 (n)
  • 99.42 (a)
GHITM 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ghitm 35
  • 88.79 (n)
  • 90.14 (a)
oppossum
(Monodelphis domestica)
Mammalia GHITM 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GHITM 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GHITM 35
  • 71.01 (n)
  • 72.75 (a)
GHITM 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GHITM 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ghitm 35
  • 70.63 (n)
  • 75.07 (a)
Str.6400 35
African clawed frog
(Xenopus laevis)
Amphibia ghitm-prov 35
zebrafish
(Danio rerio)
Actinopterygii ghitm 35
  • 59.96 (n)
  • 63.91 (a)
zgc66108 35
ghitm 36
  • 65 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10257 35
fruit fly
(Drosophila melanogaster)
Insecta CG1287 37
  • 49 (a)
CG2076 37
  • 54 (a)
CG2076 35
  • 53.64 (n)
  • 52.98 (a)
CG1287 36
  • 45 (a)
OneToMany
CG2076 36
  • 46 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009883 35
  • 55.63 (n)
  • 53.31 (a)
worm
(Caenorhabditis elegans)
Secernentea K11H12.8 35
  • 56.69 (n)
  • 54.93 (a)
K11H12.8 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for GHITM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GHITM Gene

ENSEMBL:
Gene Tree for GHITM (if available)
TreeFam:
Gene Tree for GHITM (if available)

Paralogs for GHITM Gene

(1) SIMAP similar genes for GHITM Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GHITM: view

No data available for Paralogs for GHITM Gene

Variants for GHITM Gene

Sequence variations from dbSNP and Humsavar for GHITM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7576 -- 84,152,850(+) TGAGG(A/C)GCCAG utr-variant-3-prime
rs1064705 -- 84,152,509(+) CTGCC(A/T)TTTTT utr-variant-3-prime
rs1136944 -- 84,139,591(+) GGACC(G/T)AGGTA utr-variant-5-prime
rs1137056 -- 84,152,527(+) AATAA(A/C)TGCAG utr-variant-3-prime
rs1137057 -- 84,152,529(+) TAAAT(A/G/T)CAGTA utr-variant-3-prime

Variation tolerance for GHITM Gene

Residual Variation Intolerance Score: 31.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GHITM Gene

HapMap Linkage Disequilibrium report
GHITM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GHITM Gene

Disorders for GHITM Gene

MalaCards: The human disease database

(1) MalaCards diseases for GHITM Gene - From: DISEASES

Disorder Aliases PubMed IDs
nasal cavity disease
  • nasal cavity disease nos
- elite association
Search GHITM in MalaCards View complete list of genes associated with diseases

Relevant External Links for GHITM

Genetic Association Database (GAD)
GHITM
Human Genome Epidemiology (HuGE) Navigator
GHITM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GHITM
genes like me logo Genes that share disorders with GHITM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GHITM Gene

Publications for GHITM Gene

  1. LFG: a candidate apoptosis regulatory gene family. (PMID: 19784873) Hu L. … Goldberger G. (Apoptosis 2009) 23 67
  2. The growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family. (PMID: 18071587) Reimers K. … Vogt P.M. (Int. J. Biol. Sci. 2007) 23 67
  3. Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10. (PMID: 15296517) Nagel J.E. … Taub D.D. (BMC Immunol. 2004) 23 67
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 67
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 67

Products for GHITM Gene

Sources for GHITM Gene

Back to Top

Content