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GHDC Gene

protein-coding GIFtS: 44

GC17M037596

GH3 domain containing
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
D11LGP1 ^²
D11LGP1E ^³
D11lgp1e-like ^²
LGP1 ^¹, ², ³

Descriptions
GH3 domain containing ^²
LGP1 homolog ^²
homolog of mouse LGP1 ^²

External Ids
HGNC: 24438¹
Entrez Gene: 84514²
UniProtKB: Q8N2G8³
Ensembl: ENSG00000167925⁷

Search outside databases for aliases for GHDC gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2

GHDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M037596: (about GC identifiers)

Start:	37,594,632 bp from pter
End:	37,599,739 bp from pter
Size:	5,108 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010755.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GHDC_HUMAN, Q8N2G8 (See protein sequence)

Recommended Name: GH3 domain-containing protein precursor

Size: 530 amino acids; 57523 Da

Subcellular location: Endoplasmic reticulum. Nucleus envelope (By similarity)

Secondary accessions: Q9BXM6

Alternative splicing: 2 isoforms: Q8N2G8-1 Q8N2G8-2

REFSEQ proteins (3 alternative transcripts):

NP_001136094.1 NP_001136095.1 NP_115873.1

ENSEMBL proteins:

ENSP00000366692 ENSP00000377436 ENSP00000301671

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GHDC)
	Human Recombinant Proteins from Abnova (LGP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--
GO:0005635	nuclear envelope	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--

About this table

Antibodies for GHDC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GHDC
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GHDC), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LGP1)
	Novus Biologicals Antibodies for GHDC

Assays for GHDC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8N2G8

ProtoNet protein and cluster: Q8N2G8

UniProtKB/Swiss-Prot: GHDC_HUMAN, Q8N2G8

Similarity: Belongs to the GH3 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GHDC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LGP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NR_024573

Applied Biosystems Silencer® siRNAs for GHDC

Sigma-Aldrich siRNA for GHDC

Sigma-Aldrich shRNA for GHDC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GHDC
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001142622
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001142622
untagged cDNA clones in CMV expression vector (see all 4): NM_001142622

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032484

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GHDC

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GHDC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LGP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NR_024573

Sigma-Aldrich siRNA for GHDC

Sigma-Aldrich shRNA for GHDC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001142622 NM_001142623 NM_032484

REFSEQ mRNAs for GHDC gene (3 alternative transcripts):

NM_001142622.1 NM_001142623.1 NM_032484.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001142622 NM_001142623 NM_032484

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001142622
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001142622
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001142622

Additional cDNA sequence:

AF316997.1 AK074700.1 AK075277.1 AK122777.1 AK298933.1 AK307058.1 AK307628.1 BC011056.1

BC022784.1 CR603987.1

11 DOTS entries:

DT.100027667 DT.100790724 DT.411768 DT.95274544 DT.101983803 DT.95196201 DT.120990863 DT.100790719

DT.120990851 DT.120990862 DT.95274545

24/141 AceView cDNA sequences (see all 141 ):

AL602550 BX458799 AI168398 BG818542 BM986956 AK122777 BM694873 BQ960598

BX336853 AI360128 BG762344 BM710232 BC022784 AI679973 CR603987 BM787212

CF995604 BQ944055 AF316997 BX280955 AL535155 BI907313 BM852704 BM711959

highest scoring ESTs for GHDC:

AF316997 AK074700 AK075277 AL037412 AL550970 AU279802 BC011056 BC022784 BE867596 BF304327

Unigene Cluster for GHDC:

GH3 domain containing

Hs.38039 [show with all ESTs]

Unigene Representative Sequence: AK074700

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GHDC (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	^	12
SP1:																			-																								-				-
SP2:																			-																												-
SP3:																			-																								-				-
SP4:																			-				-		-		-		-
SP5:																			-

About this scheme

ECgene alternative splicing isoforms for GHDC

3 Ensembl transcripts including schematic representations:

ENST00000377472 ENST00000393854 ENST00000301671

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GHDC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GHDC

¹ / ² / ³

3 probe-sets matching GHDC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
52826_at²^{, 3}	U95-B	1	0.94	1.00	1.00	1.00	AL037412	0.80	1.00	0.91	1
227159_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI827015	0.60	1.00	0.82	1
227159_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GHDC for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACTTCCTGC

SOURCE GeneReport for Unigene cluster: Hs.38039

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GHDC gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GHDC¹	--	GH3 domain containing	85.21(n) 83.24(a)	607630 XM_844387.1 XP_849480.1
chimpanzee (Pan troglodytes)	GHDC¹	--	GH3 domain containing	99.18(n) 98.49(a)	742493 XM_001166383.1 XP_001166383.1
cow (Bos taurus)	GHDC¹	--	GH3 domain containing	84.56(n) 82.23(a)	515225 NM_001075703.1 NP_001069171.1
rat (Rattus norvegicus)	Ghdc¹	--	GH3 domain containing	80.15(n) 75(a)	303542 XM_220981.4 XP_220981.4
mouse (Mus musculus)	Ghdc^{1, 5}	11 (61.10 cM)⁵	GH3 domain containing^{1, 5}	79.87(n)¹ 73.4(a)¹	80860¹ NM_031871.1¹ NP_114077.1¹ AF316996⁵ AF316998⁵ (see all 10)

About this table Species with no ortholog for GHDC

ENSEMBL Gene Tree for GHDC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/21 NCBI SNPs in GHDC are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 17)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3744485^1,2	F,H	37595200(+)	`GGAGGG/AGCGAG`	4	--	ut3¹ ese³ trp³		5		EA EU WA	1912
	rs7226205^1,2	H	37594481(+)	`CTAGGA/TTGTGC`	1	--	ng5¹ ese³		4		EU EA WA	416
	rs12603630^1,2	H	37599988(+)	`CTGGGT/AGACTC`	4	--	ut5¹ tfbs³		4		EU EA WA	418
--	rs3210456^1,2	C	37594808(-)	`CAATTC/TTGAAG`	4	--	ut3¹		0	--	--	--	--
--	rs9909995^1,2	C	37601118(+)	`agtgcG/Tgggat`	1	--	ng3¹		0	--	--	--	--
--	rs1047299^1,2	--	37594714(-)	`TCCTGC/GGGGGG`	4	--	ut3¹		1		MN	184
--	rs34271933^1,2	--	37599446(+)	`GTGGG-/CCCGGG`	1	--	ut5¹		0	--	--	--	--
--	rs11548416^1,2	--	37599046(-)	`GGATGC/TCAGGC`	4	A/V	mis¹ ese³		0	--	--	--	--
--	rs28573203^1,2	--	37601648(+)	`TTTTTG/TGTTTT`	1	--	ng3¹ trp³		0	--	--	--	--
--	rs71377266^1,2	--	37594315(+)	`TCTTTA/CTTTTA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for GHDC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608587

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for GHDC gene:

Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. (PubMed id 11161808)^{2, 3, 4} Miyoshi K.... Hennighausen L. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. (PubMed id 11735219)^{2, 3} Cui Y....Hennighausen L. (2001)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)³ Otsuki T....Isogai T. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 84514	HGNC: 24438	AceView: LGP1	Ensembl:ENSG00000167925	euGenes: HUgn84514
ECgene: GHDC	H-InvDB: GHDC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for GHDC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GHDC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GHDC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GHDC		Antibodies for GHDC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GHDC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LGP1)
	Antibodies (LGP1)
	Chimera RNAi (LGP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (GHDC)
	Antibodies (GHDC)

Search OriGene for GHDC

Search Tocris compounds for GHDC

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GHDC

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GHDC Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for GHDC

Summaries
for GHDC

Genomic Location
for GHDC

Proteins
for GHDC

Protein Domains/
Families
for GHDC

Gene Function
for GHDC

Pathways & Interactions
for GHDC

Drugs & Compounds
for GHDC

Transcripts
for GHDC

Expression
for GHDC

Orthologs
for GHDC

Paralogs
for GHDC

SNPs/Variants
for GHDC

Disorders & Mutations
for GHDC

Medical News
for GHDC

Publications
for GHDC

Search for GHDC

Genome Databases showing GHDC

Other Databases showing GHDC

Specialized Databases showing GHDC

Licensable Technologies
for GHDC

Services
for GHDC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GHDC Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor GHDC

Summariesfor GHDC

Genomic Locationfor GHDC

Proteinsfor GHDC

Protein Domains/Familiesfor GHDC

Gene Functionfor GHDC

Pathways & Interactionsfor GHDC

Drugs & Compoundsfor GHDC

Transcriptsfor GHDC

Expression for GHDC

Orthologsfor GHDC

Paralogsfor GHDC

SNPs/Variantsfor GHDC

Disorders & Mutationsfor GHDC

Medical Newsfor GHDC

Publicationsfor GHDC

Search for GHDC

Genome Databases showing GHDC

Other Databases showing GHDC

Specialized Databases showing GHDC

Licensable Technologiesfor GHDC

Servicesfor GHDC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GHDC

Summaries
for GHDC

Genomic Location
for GHDC

Proteins
for GHDC

Protein Domains/
Families
for GHDC

Gene Function
for GHDC

Pathways & Interactions
for GHDC

Drugs & Compounds
for GHDC

Transcripts
for GHDC

Expression
for GHDC

Orthologs
for GHDC

Paralogs
for GHDC

SNPs/Variants
for GHDC

Disorders & Mutations
for GHDC

Medical News
for GHDC

Publications
for GHDC

Licensable Technologies
for GHDC

Services
for GHDC