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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GH2 Gene

protein-coding   GIFtS: 56
GCID: GC17M061957

Growth Hormone 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Growth Hormone 21 2 3     GHV2 5
Placenta-Specific Growth Hormone1 2 3     GHL2
Placental-Specific Growth Hormone1 2     Growth Hormone Variant2
GH-V2 3     hGH-V2

External Ids:    HGNC: 42621   Entrez Gene: 26892   Ensembl: ENSG000001364877   OMIM: 1392405   UniProtKB: P012423   

Export aliases for GH2 gene to outside databases

Previous GC identifers: GC17U990035 GC17M064383 GC17M062425 GC17M062430 GC17M059304 GC17M059311 GC17M057325


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GH2 Gene:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an
important role in growth control. The gene, along with four other related genes, is located at the growth hormone
locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which
is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of
sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones,
leading to further diversity and potential for specialization. As in the case of its pituitary counterpart,
growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity,
with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GH2 Gene: 
GH2 (growth hormone 2) is a protein-coding gene. Diseases associated with GH2 include isolated growth hormone deficiency, and growth hormone deficiency, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include hormone activity. An important paralog of this gene is CSH2.

UniProtKB/Swiss-Prot: SOM2_HUMAN, P01242
Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the
liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts.
It also stimulates amino acid uptake and protein synthesis in muscle and other tissues

Gene Wiki entry for GH2 (Growth hormone 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GH2 gene promoter:
         POU3F1   COMP1   CUTL1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q22-q24

GH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061957:  view genomic region     (about GC identifiers)

Start:
61,957,572 bp from pter      End:
61,959,295 bp from pter
Size:
1,724 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SOM2_HUMAN, P01242 (See protein sequence)
Recommended Name: Growth hormone variant precursor  
Size: 217 amino acids; 25000 Da
Subunit: Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in
homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the
alpha2-macroglobulin complex
Subcellular location: Secreted
Secondary accessions: B1A4H5 B1A4H7 O14643 O14644 P09587
Alternative splicing: 4 isoforms:  P01242-1   P01242-2   P01242-3   P01242-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GH2: NX_P01242

Explore proteomics data for GH2 at MOPED 

GH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

GH2 Protein Expression

REFSEQ proteins (4 alternative transcripts): 
NP_002050.1  NP_072050.1  NP_072051.1  NP_072052.1  

ENSEMBL proteins: 
 ENSP00000410618   ENSP00000394122   ENSP00000409294   ENSP00000333157  
Reactome Protein details: P01242
Human Recombinant Protein Products for GH2: 
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R&D Systems Recombinant & Natural Proteins for GH2 (Growth Hormone 2)
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OriGene Protein Over-expression Lysate for GH2
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Novus Biologicals GH2 Proteins
Novus Biologicals GH2 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for GH2 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--

GH2 for ontologies           About GeneDecksing



GH2 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for GH2 

Assay Products for GH2: 
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Cloud-Clone Corp. ELISAs for GH2 
Cloud-Clone Corp. CLIAs for GH2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR018116 Somatotropin_CS
 IPR012351 4_helix_cytokine_core
 IPR009079 4_helix_cytokine-like_core
 IPR001400 Somatotropin

Graphical View of Domain Structure for InterPro Entry P01242

ProtoNet protein and cluster: P01242

1 Blocks protein domain: IPB001400 Somatotropin hormone

UniProtKB/Swiss-Prot: SOM2_HUMAN, P01242
Similarity: Belongs to the somatotropin/prolactin family


GH2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SOM2_HUMAN, P01242
Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the
liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts.
It also stimulates amino acid uptake and protein synthesis in muscle and other tissues

     Genatlas biochemistry entry for GH2:
growth hormone 2 (V,variant),placental,22kDa,with two alternatively spliced isoforms (GHV3) without a
transmembrane domain,20kDa (GHV2 with a transmembrane domain

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
     
GH2 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for GH2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GH2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GH2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GH2 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GH2
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SwitchGear 3'UTR luciferase reporter plasmidGH2 3' UTR sequence
Inhib. RNA
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Gene Editing
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GH2
Sirion Biotech Customized lentivirus for stable overexpression of GH2 
                     Customized lentivirus expression plasmids for stable overexpression of GH2 

Cell Line
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Search LifeMap BioReagents cell lines for GH2
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GH2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GH2 About   (see all 23)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Apoptotic Pathways in Synovial Fibroblasts
Mitochondrial Apoptosis0.85
Rac1 Pathway0.65
Cellular Apoptosis Pathway0.85
Glioma Invasiveness0.64
Apoptotic Pathways in Synovial Fibroblasts0.84
Actin-Based Motility by Rho Family GTPases0.62
p53 Mediated Apoptosis0.84
ERK5 Signaling0.61
2GPCR Pathway
Ras Pathway0.73
Breast Cancer Regulation by Stathmin10.58
Paxillin Interactions0.73
NFAT in Immune Response0.58
GPCR Pathway0.62
Estrogen Pathway0.55
Pancreatic Adenocarcinoma0.59
3Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
ILK Signaling0.49
MAPK Signaling0.58
4Nanog in Mammalian ESC Pluripotency
Nanog in Mammalian ESC Pluripotency0.61
14-3-3 Induced Intracellular Signaling0.59
GSK3 Signaling0.61
eNOS Signaling0.48
5TGF-Beta Pathway
TGF-Beta Pathway0.60
JAK-STAT Pathway0.57
MAPK Family Pathway0.60
JNK Pathway0.51

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GH2 (see all 56)
    Nuclear Receptor Activation by Vitamin-A
Paxillin Interactions
Telomerase Components in Cell Signaling
Mitochondrial Apoptosis
Molecular Mechanisms of Cancer

5/7        Reactome Pathways for GH2 (see all 7)
    Cytokine Signaling in Immune system
Signal Transduction
Growth hormone receptor signaling
Prolactin receptor signaling
Signaling by ERBB4


4         Kegg Pathways  (Kegg details for GH2):
    Cytokine-cytokine receptor interaction
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway


GH2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GH2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for GH2 (ENSP000003331574) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
GHRENSP000002308824STRING: ENSP00000230882
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway TAS--

GH2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GH2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GH2 (SOM2)

3 Novoseek inferred chemical compound relationships for GH2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ribonucleic acid 37.6 1 9329365 (1)
glucose 15.3 11 20005926 (5), 10776988 (1), 18473352 (1)
testosterone 2.95 1 9203060 (1)

Search CenterWatch for drugs/clinical trials and news about GH2 / SOM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GH2 gene (4 alternative transcripts): 
NM_002059.4  NM_022556.3  NM_022557.3  NM_022558.3  

Unigene Cluster for GH2:

Growth hormone 2
Hs.406754  [show with all ESTs]
Unigene Representative Sequence: NM_022557
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000449787 ENST00000456543 ENST00000423893(uc002jcn.1 uc002jco.1 uc002jcm.1)
ENST00000332800(uc002jcl.1)
miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GH2
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GH2
SwitchGear 3'UTR luciferase reporter plasmidGH2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GH2
Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): GH2 (NM_022556)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GH2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GH2
Sirion Biotech Customized lentivirus for stable overexpression of GH2 
                     Customized lentivirus expression plasmids for stable overexpression of GH2 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for GH2
OriGene qSTAR qPCR primer pairs in human, mouse for GH2
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GH2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GH2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GH2

Additional mRNA sequence: 

AB451332.1 AB451477.1 AF006060.1 AF006061.1 AK312194.1 BC020760.1 CR541902.1 CR541924.1 
J03756.1 M38451.1 

24/39 DOTS entries (see all 39):

DT.91964566  DT.100715568  DT.100862608  DT.95278599  DT.91840785  DT.92405319  DT.92434087  DT.100651113 
DT.100838861  DT.92012584  DT.100715496  DT.100715551  DT.100715591  DT.100715602  DT.91728134  DT.100715524 
DT.100839230  DT.100842187  DT.100848246  DT.100863701  DT.120951731  DT.91861058  DT.92054920  DT.92434084 

24/442 AceView cDNA sequences (see all 442):

CR614423 CR603528 CR623264 CR613416 CR594619 CR608232 CR596365 NM_022556 
CR623298 CR620157 NM_022557 CR615133 CR625149 CR599897 CR626031 CR618653 
CR619674 CR619103 CR605118 CR608146 CR621109 CR613696 CR623451 CR605609 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACAAGGTCG
GH2 Expression
About this image


See GH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GH2

SOURCE GeneReport for Unigene cluster: Hs.406754

UniProtKB/Swiss-Prot: SOM2_HUMAN, P01242
Tissue specificity: Expressed in the placenta

    SABiosciences Expression via Pathway-Focused PCR Array including GH2: 
          Obesity in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GH2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GH2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GH2 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves GH16
Somatotropin
41(a)
1 → many
27(1616706-1620213)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
37(a)
1 → many
6(63428935-63436554)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5872 Xenopus laevis growth hormone A mRNA, complete cds 76.65(n)    AF193797.1 
zebrafish
(Danio rerio)
Actinopterygii gh16
smtla6
(see all 3)
somatolactin alpha
(see all 3)
29(a)
18(a)
(see all 3)
1 ↔ many
possible ortholog
(see all 3)
3(22540799-22545974)
18(46620558-46629935)
        Species with no ortholog for GH2

ENSEMBL Gene Tree for GH2 (if available)
TreeFam Gene Tree for GH2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for GH2 gene
CSH22  CSH12  GH12  CSHL12  
4 SIMAP similar genes for GH2 using alignment to 3 protein entries:     SOM2_HUMAN (see all proteins):
GH1    CSHL1    CSH1    CSH2

GH2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/178 SNPs in GH2 are shown (see all 178)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1433373931,2
--61957084(+) CCCAAC/TGCATG 4 -- ds50010--------
rs1467588751,2
--61957102(+) AGTGCA/CAAGCA 4 -- ds50010--------
rs1126629701,2
C,F--61957133(+) GGCTGG/AGCATG 4 -- ds50012Minor allele frequency- A:0.10WA 120
rs1403692451,2
C--61957165(+) CTGGAC/TGTCCT 4 -- ds50010--------
rs1816901071,2
--61957207(+) ACAGGA/GAAGGG 4 -- ds50010--------
rs1863940461,2
--61957402(+) AGAATC/TGCTTG 4 -- ds50010--------
rs1455560621,2
--61957434(+) AGCGAA/GCCAAG 4 -- ds50010--------
rs575613251,2
C,F--61957566(+) CTAGTA/C/GAAACA 4 -- ds50015EU WA EA 260
rs586961301,2
C--61957610(+) TGGTGC/G/TGCACT 9 T P A ut31 mis14EU WA EA 142
rs28541911,2
C,H--61957633(-) CTGGTC/GGTGGA 5 S W ut31 mis14Minor allele frequency- G:0.00NS EA 406

HapMap Linkage Disequilibrium report for GH2 (61957572 - 61959295 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for GH2:    About this table     
Variant IDTypeSubtypePubMed ID
esv2716099CNV Deletion23290073
nsv436234CNV Deletion17901297
esv2716098CNV Deletion23290073
nsv510720CNV Loss20534489
nsv111804CNV Loss16902084
esv26789CNV Loss19812545
nsv833510CNV Loss17160897
nsv833511CNV Loss17160897
nsv517272CNV Gain+Loss19592680


Human Gene Mutation Database (HGMD): GH2
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing GH2
DNA2.0 Custom Variant and Variant Library Synthesis for GH2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 139240    OMIM disorders: --

18 diseases for GH2:    About MalaCards
isolated growth hormone deficiency    growth hormone deficiency    trophoblastic neoplasm    choriocarcinoma
pituitary tumors    transitional cell carcinoma    gestational diabetes    down syndrome
pre-eclampsia    eclampsia    type 1 diabetes    diabetes mellitus
esophagitis    obesity    thyroiditis    adenocarcinoma
pancreatitis    breast cancer

1 disease from the University of Copenhagen DISEASES database for GH2:
Choriocarcinoma

GH2 for disorders           About GeneDecksing

4 Novoseek inferred disease relationships for GH2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma 68.1 6 7515000 (2), 1708334 (1), 10534168 (1), 8472847 (1) (see all 5)
pituitary tumors 33.9 4 1922020 (1), 2298178 (1)
tumors 0 4 9563788 (2), 10534168 (1), 10987258 (1)
lymphoma 0 1 2298178 (1)

Genetic Association Database (GAD): GH2
Human Genome Epidemiology (HuGE) Navigator: GH2 (2 documents)

Export disorders for GH2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for GH2 gene, integrated from 9 sources (see all 96):
(articles sorted by number of sources associating them with GH2)
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  1. Cloning of two novel growth hormone transcripts expressed in human placenta. (PubMed id 9709963)1, 2, 9 Boguszewski C.L.... Carlsson B. (1998)
  2. Identification of placental human growth hormone as the growth hormone-V gene expression product. (PubMed id 2196278)1, 2, 9 Frankenne F.... Hennen G. (1990)
  3. A population-based study of IGF axis polymorphisms an d the esophageal inflammation, metaplasia, adenocarcinoma sequence. (PubMed id 20403354)1, 4 McElholm A.R....Murray L.J. (2010)
  4. Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. (PubMed id 15531513)1, 4 Day I.N....Phillips D.I. (2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. The human growth hormone locus: nucleotide sequence, biology, and evolution. (PubMed id 2744760)1, 2 Chen E.Y....Seeburg P.H. (1989)
  7. Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins. (PubMed id 3379057)1, 2 Cooke N.E.... Liebhaber S.A. (1988)
  8. Cloning and nucleotide sequence of placental hGH-V cDNA. (PubMed id 2460050)1, 2 Igout A.... Hennen G. (1988)
  9. The human growth hormone gene family: structure and evolution of the chromosomal locus. (PubMed id 6306568)1, 3 Barsh G.S....Gelinas R.E. (1983)
  10. The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. (PubMed id 7169009)1, 2 Seeburg P.H. (1982)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2689 HGNC: 4262 AceView: CSH1andGH2andCSH2 Ensembl:ENSG00000136487 euGenes: HUgn2689
ECgene: GH2 Kegg: 2689 H-InvDB: GH2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for GH2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for GH2 gene:
Search GeneIP for patents involving GH2

GeneCards and IP:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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