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GH2 Gene

protein-coding   GIFtS: 58
GCID: GC17M061957

Growth Hormone 2

  See GH2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Growth Hormone 21 2 3     GHV2 5
Placenta-Specific Growth Hormone1 2 3     GHL2
Placental-Specific Growth Hormone1 2     Growth Hormone Variant2
GH-V2 3     hGH-V2

External Ids:    HGNC: 42621   Entrez Gene: 26892   Ensembl: ENSG000001364877   OMIM: 1392405   UniProtKB: P012423   

Export aliases for GH2 gene to outside databases

Previous GC identifers: GC17U990035 GC17M064383 GC17M062425 GC17M062430 GC17M059304 GC17M059311 GC17M057325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GH2 Gene:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an
important role in growth control. The gene, along with four other related genes, is located at the growth hormone
locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which
is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of
sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones,
leading to further diversity and potential for specialization. As in the case of its pituitary counterpart,
growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity,
with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GH2 Gene:
GH2 (growth hormone 2) is a protein-coding gene. Diseases associated with GH2 include isolated growth hormone deficiency, and trophoblastic neoplasm. GO annotations related to this gene include hormone activity. An important paralog of this gene is CSH2.

UniProtKB/Swiss-Prot: SOM2_HUMAN, P01242
Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the
liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts.
It also stimulates amino acid uptake and protein synthesis in muscle and other tissues

Gene Wiki entry for GH2 (Growth hormone 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GH2 gene promoter:
         POU3F1   COMP1   CUTL1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGH2 promoter sequence
   Search Chromatin IP Primers for GH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q22-q24

GH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061957:  view genomic region     (about GC identifiers)

Start:
61,957,572 bp from pter      End:
61,959,295 bp from pter
Size:
1,724 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SOM2_HUMAN, P01242 (See protein sequence)
Recommended Name: Growth hormone variant precursor  
Size: 217 amino acids; 25000 Da
Subunit: Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in
homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the
alpha2-macroglobulin complex
Secondary accessions: B1A4H5 B1A4H7 O14643 O14644 P09587
Alternative splicing: 4 isoforms:  P01242-1   P01242-2   P01242-3   P01242-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GH2: NX_P01242

Explore proteomics data for GH2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn166
  • Modification sites at PhosphoSitePlus

  • See GH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_002050.1  NP_072050.1  NP_072051.1  NP_072052.1  

    ENSEMBL proteins: 
     ENSP00000410618   ENSP00000394122   ENSP00000409294   ENSP00000333157  
    Reactome Protein details: P01242

    GH2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant GH2 Protein
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    Novus Biologicals GH2 Proteins
    Novus Biologicals GH2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for GH2

     
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    GH2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for GH2

    GH2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR018116 Somatotropin_CS
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR001400 Somatotropin

    Graphical View of Domain Structure for InterPro Entry P01242

    ProtoNet protein and cluster: P01242

    1 Blocks protein domain: IPB001400 Somatotropin hormone

    UniProtKB/Swiss-Prot: SOM2_HUMAN, P01242
    Similarity: Belongs to the somatotropin/prolactin family


    Find genes that share domains with GH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOM2_HUMAN, P01242
    Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the
    liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts.
    It also stimulates amino acid uptake and protein synthesis in muscle and other tissues

         Genatlas biochemistry entry for GH2:
    growth hormone 2 (V,variant),placental,22kDa,with two alternatively spliced isoforms (GHV3) without a
    transmembrane domain,20kDa (GHV2 with a transmembrane domain

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
         
    Find genes that share ontologies with GH2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GH2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GH2

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GH2

    Gene Editing
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    Sino Biological Human cDNA Clone for GH2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GH2

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SOM2_HUMAN, P01242: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with GH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GH2 About   (see all 23)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51


    Find genes that share SuperPaths with GH2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GH2 (see all 56)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    2 Reactome Pathways for GH2
        Growth hormone receptor signaling
    Prolactin receptor signaling


    4 Kegg Pathways  (Kegg details for GH2):
        Cytokine-cytokine receptor interaction
    Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including GH2: 
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GH2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for GH2 (ENSP000003331574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRENSP000002308824STRING: ENSP00000230882
    TFENSP000002649984STRING: ENSP00000264998
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway TAS--

    Find genes that share ontologies with GH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GH2 (SOM2)

    3 Novoseek inferred chemical compound relationships for GH2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribonucleic acid 37.6 1 9329365 (1)
    glucose 15.3 11 20005926 (5), 10776988 (1), 18473352 (1)
    testosterone 2.95 1 9203060 (1)



    Find genes that share compounds with GH2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GH2 gene (4 alternative transcripts): 
    NM_002059.4  NM_022556.3  NM_022557.3  NM_022558.3  

    Unigene Cluster for GH2:

    Growth hormone 2
    Hs.406754  [show with all ESTs]
    Unigene Representative Sequence: NM_022557
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449787 ENST00000456543 ENST00000423893(uc002jcn.1 uc002jco.1 uc002jcm.1)
    ENST00000332800(uc002jcl.1)
    miRNA
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    Products:
         
    OriGene RNAi products in human, mouse, rat for GH2
    Predesigned siRNA for gene silencing in human, mouse, rat GH2
    Clone
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    OriGene clones in human, mouse for GH2 (see all 24)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): GH2 (NM_022556)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GH2
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat GH2
      QuantiFast Probe-based Assays in human, mouse, rat GH2

    Additional mRNA sequence: 

    AB451332.1 AB451477.1 AF006060.1 AF006061.1 AK312194.1 BC020760.1 CR541902.1 CR541924.1 
    J03756.1 M38451.1 

    Selected DOTS entries (see all 39):

    DT.91964566  DT.100715568  DT.100862608  DT.95278599  DT.91840785  DT.92405319  DT.92434087  DT.100651113 
    DT.100838861  DT.92012584  DT.100715496  DT.100715551  DT.100715591  DT.100715602  DT.91728134  DT.100715524 
    DT.100839230  DT.100842187  DT.100848246  DT.100863701  DT.120951731  DT.91861058  DT.92054920  DT.92434084 

    Selected AceView cDNA sequences (see all 442):

    CR604462 CR623264 CR615097 CR594237 CR621181 CR624985 CR601892 CR624472 
    CR610286 CR626011 CR596365 CR622152 CR597767 CR593959 CR615316 CR609696 
    CR602268 NM_022640 CR605508 CR614693 CR626463 CR624109 CR592885 CR619425 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGGTCG
    GH2 Expression
    About this image


    GH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Placenta (Extraembryonic Tissues)
    GH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406754

    UniProtKB/Swiss-Prot: SOM2_HUMAN, P01242
    Tissue specificity: Expressed in the placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including GH2: 
              Obesity in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for GH2
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    QuantiFast Probe-based Assays in human, mouse, rat GH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GH2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GH16
    Gallus gallus growth hormone (GH), mRNA.
    42(a)
    1 → many
    27(1616706-1620213)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    6(63428935-63436554)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5872 Xenopus laevis growth hormone A mRNA, complete cds 76.65(n)    AF193797.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gh16
    growth hormone 1
    30(a)
    1 → many
    3(22540799-22545974) ENSDARG00000038185
            Species with no ortholog for GH2

    ENSEMBL Gene Tree for GH2 (if available)
    TreeFam Gene Tree for GH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GH2 gene
    CSH22  CSH12  GH12  CSHL12  
    4 SIMAP similar genes for GH2 using alignment to 3 protein entries:     SOM2_HUMAN (see all proteins):
    GH1    CSHL1    CSH1    CSH2

    Find genes that share paralogs with GH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GH2 (see all 178)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433373931,2
    --61957084(+) CCCAAC/TGCATG 4 -- ds50010--------
    rs1467588751,2
    --61957102(+) AGTGCA/CAAGCA 4 -- ds50010--------
    rs1126629701,2
    C,F--61957133(+) GGCTGG/AGCATG 4 -- ds50012Minor allele frequency- A:0.10WA 120
    rs1403692451,2
    C--61957165(+) CTGGAC/TGTCCT 4 -- ds50010--------
    rs1816901071,2
    --61957207(+) ACAGGA/GAAGGG 4 -- ds50010--------
    rs1863940461,2
    --61957402(+) AGAATC/TGCTTG 4 -- ds50010--------
    rs1455560621,2
    --61957434(+) AGCGAA/GCCAAG 4 -- ds50010--------
    rs575613251,2
    C,F--61957566(+) CTAGTA/C/GAAACA 4 -- ds50015EU WA EA 260
    rs586961301,2
    C--61957610(+) TGGTGC/G/TGCACT 9 T P A ut31 mis14EU WA EA 142
    rs28541911,2
    C,H--61957633(-) CTGGTC/GGTGGA 5 S W ut31 mis14Minor allele frequency- G:0.00NS EA 406

    HapMap Linkage Disequilibrium report for GH2 (61957572 - 61959295 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716099CNV Deletion23290073
    nsv436234CNV Deletion17901297
    esv2716098CNV Deletion23290073
    nsv510720CNV Loss20534489
    nsv111804CNV Loss16902084
    esv26789CNV Loss19812545
    nsv833510CNV Loss17160897
    nsv833511CNV Loss17160897
    nsv517272CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): GH2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139240    OMIM disorders: --

    4 diseases for GH2:    
    About MalaCards
    isolated growth hormone deficiency    trophoblastic neoplasm    pituitary tumors    choriocarcinoma

    1 disease from the University of Copenhagen DISEASES database for GH2:
    Choriocarcinoma

    Find genes that share disorders with GH2           About GenesLikeMe

    4 Novoseek inferred disease relationships for GH2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 68.1 6 7515000 (2), 1708334 (1), 10534168 (1), 8472847 (1) (see all 5)
    pituitary tumors 33.9 4 1922020 (1), 2298178 (1)
    tumors 0 4 9563788 (2), 10534168 (1), 10987258 (1)
    lymphoma 0 1 2298178 (1)

    Genetic Association Database (GAD): GH2
    Human Genome Epidemiology (HuGE) Navigator: GH2 (2 documents)

    Export disorders for GH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GH2 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with GH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of two novel growth hormone transcripts expressed in human placenta. (PubMed id 9709963)1, 2, 9 Boguszewski C.L.... Carlsson B. (J. Clin. Endocrinol. Metab. 1998)
    2. Identification of placental human growth hormone as the growth hormone-V gene expression product. (PubMed id 2196278)1, 2, 9 Frankenne F.... Hennen G. (J. Clin. Endocrinol. Metab. 1990)
    3. A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence. (PubMed id 20403354)1, 4 McElholm A.R....Murray L.J. (Gastroenterology 2010)
    4. Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. (PubMed id 15531513)1, 4 Day I.N....Phillips D.I. (J. Clin. Endocrinol. Metab. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The human growth hormone locus: nucleotide sequence, biology, and evolution. (PubMed id 2744760)1, 2 Chen E.Y....Seeburg P.H. (Genomics 1989)
    7. Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins. (PubMed id 3379057)1, 2 Cooke N.E.... Liebhaber S.A. (J. Biol. Chem. 1988)
    8. Cloning and nucleotide sequence of placental hGH-V cDNA. (PubMed id 2460050)1, 2 Igout A.... Hennen G. (Arch. Int. Physiol. Biochim. 1988)
    9. The human growth hormone gene family: structure and evolution of the chromosomal locus. (PubMed id 6306568)1, 3 Barsh G.S....Gelinas R.E. (Nucleic Acids Res. 1983)
    10. The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. (PubMed id 7169009)1, 2 Seeburg P.H. (DNA 1982)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2689 HGNC: 4262 AceView: CSH1andGH2andCSH2 Ensembl:ENSG00000136487 euGenes: HUgn2689
    ECgene: GH2 Kegg: 2689 H-InvDB: GH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GH2 gene:
    Search GeneIP for patents involving GH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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