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Aliases for GGTLC2 Gene

Aliases for GGTLC2 Gene

  • Gamma-Glutamyltransferase Light Chain 2 2 3
  • Gamma-Glutamyltransferase-Like Protein 4 3 4
  • Gamma-Glutamyltransferase-Like 4 2 3
  • GGTL4 3 4
  • EC 2.3.2.2 63

External Ids for GGTLC2 Gene

Previous HGNC Symbols for GGTLC2 Gene

  • GGTL4

Previous GeneCards Identifiers for GGTLC2 Gene

  • GC22P021320
  • GC22P022986
  • GC22P005956
  • GC22P022989

Summaries for GGTLC2 Gene

Entrez Gene Summary for GGTLC2 Gene

  • This gene encodes a protein related to enzymes that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides. Unlike similar proteins, the encoded protein contains only the light chain portion and may not have catalytic activity. Alternative splicing results in multiple transcript variants. There are several related family members and related pseudogene for this gene situated in the same region of chromosome 22. [provided by RefSeq, Sep 2013]

GeneCards Summary for GGTLC2 Gene

GGTLC2 (Gamma-Glutamyltransferase Light Chain 2) is a Protein Coding gene. Among its related pathways are Metabolism and Arachidonic acid metabolism. GO annotations related to this gene include gamma-glutamyltransferase activity. An important paralog of this gene is GGT1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGTLC2 Gene

Genomics for GGTLC2 Gene

Regulatory Elements for GGTLC2 Gene

Genomic Location for GGTLC2 Gene

Chromosome:
22
Start:
22,644,475 bp from pter
End:
22,647,903 bp from pter
Size:
3,429 bases
Orientation:
Plus strand

Genomic View for GGTLC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGTLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGTLC2 Gene

Proteins for GGTLC2 Gene

  • Protein details for GGTLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14390-GGTL2_HUMAN
    Recommended name:
    Gamma-glutamyltransferase light chain 2
    Protein Accession:
    Q14390
    Secondary Accessions:
    • A1A516
    • A2VCM9
    • Q5NV76
    • Q6ISH0

    Protein attributes for GGTLC2 Gene

    Size:
    218 amino acids
    Molecular mass:
    23661 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity
    SequenceCaution:
    • Sequence=BAA20001.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA67421.1; Type=Frameshift; Positions=217; Evidence={ECO:0000305}; Sequence=CAA67421.1; Type=Miscellaneous discrepancy; Note=Contains an unspliced intron inserted in position 120.; Evidence={ECO:0000305};

neXtProt entry for GGTLC2 Gene

Proteomics data for GGTLC2 Gene at MOPED

Selected DME Specific Peptides for GGTLC2 Gene

Post-translational modifications for GGTLC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GGTLC2 Gene

Domains & Families for GGTLC2 Gene

Gene Families for GGTLC2 Gene

Protein Domains for GGTLC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGTLC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14390

UniProtKB/Swiss-Prot:

GGTL2_HUMAN :
  • Belongs to the gamma-glutamyltransferase family.
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGTLC2: view

Function for GGTLC2 Gene

Enzyme Numbers (IUBMB) for GGTLC2 Gene

Gene Ontology (GO) - Molecular Function for GGTLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003840 gamma-glutamyltransferase activity TAS 18357469
genes like me logo Genes that share ontologies with GGTLC2: view
genes like me logo Genes that share phenotypes with GGTLC2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGTLC2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGTLC2 Gene

Localization for GGTLC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGTLC2 Gene COMPARTMENTS Subcellular localization image for GGTLC2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
vacuole 1

Gene Ontology (GO) - Cellular Components for GGTLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031362 anchored component of external side of plasma membrane TAS 18357469
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GGTLC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GGTLC2 Gene

Pathways & Interactions for GGTLC2 Gene

genes like me logo Genes that share pathways with GGTLC2: view

Interacting Proteins for GGTLC2 Gene

Gene Ontology (GO) - Biological Process for GGTLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process NAS 18357469
GO:0019370 leukotriene biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGTLC2: view

No data available for SIGNOR curated interactions for GGTLC2 Gene

Drugs & Compounds for GGTLC2 Gene

No Compound Related Data Available

Transcripts for GGTLC2 Gene

mRNA/cDNA for GGTLC2 Gene

(7) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GGTLC2 Gene

Gamma-glutamyltransferase light chain 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGTLC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGTLC2 Gene

No ASD Table

Relevant External Links for GGTLC2 Gene

GeneLoc Exon Structure for
GGTLC2
ECgene alternative splicing isoforms for
GGTLC2

Expression for GGTLC2 Gene

mRNA expression in normal human tissues for GGTLC2 Gene

mRNA differential expression in normal tissues according to GTEx for GGTLC2 Gene

This gene is overexpressed in Testis (x42.8).

Protein differential expression in normal tissues from HIPED for GGTLC2 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGTLC2 Gene



SOURCE GeneReport for Unigene cluster for GGTLC2 Gene Hs.632765

mRNA Expression by UniProt/SwissProt for GGTLC2 Gene

Q14390-GGTL2_HUMAN
Tissue specificity: Placenta and sigmoid tissues
genes like me logo Genes that share expression patterns with GGTLC2: view

Protein tissue co-expression partners for GGTLC2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GGTLC2 Gene

Orthologs for GGTLC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGTLC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610580 35
  • 98.32 (n)
  • 97.25 (a)
GGTLC2 36
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 30 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 31 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
OneToMany
mouse
(Mus musculus)
Mammalia Ggt1 36
  • 29 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 1 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ggt1a 36
  • 23 (a)
ManyToMany
ggt1b 36
  • 20 (a)
ManyToMany
ggt1l2.1 36
  • 13 (a)
ManyToMany
ggt1l2.2 36
  • 16 (a)
ManyToMany
si:ch73-236c18.3 36
  • 14 (a)
ManyToMany
si:dkey-222h21.12 36
  • 16 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1492 36
  • 12 (a)
ManyToMany
CG4829 36
  • 9 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C53D5.5 36
  • 16 (a)
ManyToMany
H14N18.4 36
  • 13 (a)
ManyToMany
T03D8.6 36
  • 11 (a)
ManyToMany
Y7A9A.1 36
  • 14 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM38 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
CSA.7538 36
  • 18 (a)
ManyToMany
Species with no ortholog for GGTLC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GGTLC2 Gene

ENSEMBL:
Gene Tree for GGTLC2 (if available)
TreeFam:
Gene Tree for GGTLC2 (if available)

Paralogs for GGTLC2 Gene

Paralogs for GGTLC2 Gene

(6) SIMAP similar genes for GGTLC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GGTLC2: view

Variants for GGTLC2 Gene

Sequence variations from dbSNP and Humsavar for GGTLC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2330126 - 22,646,800(+) TCAAT(A/G)ATGAA missense, reference
rs2877059 -- 22,646,850(+) GGGGT(A/G)CCCCC synonymous-codon, reference
rs2904923 - 22,646,786(+) CAGCG(A/G/T)GATCC reference, missense
rs3966249 -- 22,648,102(+) CCCTC(A/G)GACTT downstream-variant-500B
rs3966348 -- 22,646,828(+) TCCCA(A/G)CATCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GGTLC2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv817937 CNV Loss 17921354
dgv548n27 CNV Loss 19166990
nsv828979 CNV Gain+Loss 20364138
dgv731n67 CNV Loss 20364138
dgv550n27 CNV Loss 19166990
dgv38n64 CNV Loss 17921354
dgv551n27 CNV Loss 19166990
nsv438338 CNV Loss 16468122
dgv39n64 CNV Loss 17921354
dgv555n27 CNV Loss 19166990
dgv557n27 CNV Loss 19166990
nsv819428 CNV Gain 19587683
nsv514963 CNV Complex 21397061
nsv821694 CNV Loss 15273396
dgv560n27 CNV Loss 19166990
nsv469742 CNV Complex 16826518
nsv433337 CNV Loss 18776910
nsv459553 CNV Loss 19166990
nsv834151 CNV Loss 17160897
dgv4900n71 CNV Gain 21882294
esv2662193 CNV Deletion 23128226

Variation tolerance for GGTLC2 Gene

Residual Variation Intolerance Score: 85.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.15; 84.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGTLC2 Gene

HapMap Linkage Disequilibrium report
GGTLC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGTLC2 Gene

Disorders for GGTLC2 Gene

Relevant External Links for GGTLC2

Human Genome Epidemiology (HuGE) Navigator
GGTLC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGTLC2
genes like me logo Genes that share disorders with GGTLC2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGTLC2 Gene

Publications for GGTLC2 Gene

  1. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 67
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 2 67
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67
  4. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 67
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67

Products for GGTLC2 Gene

Sources for GGTLC2 Gene

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