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Aliases for GGTLC1 Gene

Aliases for GGTLC1 Gene

  • Gamma-Glutamyltransferase Light Chain 1 2 3 5
  • Gamma-Glutamyltransferase-Like Activity 4 2 3 4
  • Gamma-Glutamyltransferase-Like Activity 3 2 3
  • Gamma-Glutamyltransferase-Like Protein 6 3 4
  • GGTLA4 3 4
  • Gamma-Glutamyl Transpeptidase 3
  • DJ831C21.1 3
  • DJ831C21.2 3
  • EC 2.3.2.2 63
  • GGTLA3 3
  • GGTL6 3

External Ids for GGTLC1 Gene

Previous HGNC Symbols for GGTLC1 Gene

  • GGTLA4
  • GGTLA3

Summaries for GGTLC1 Gene

Entrez Gene Summary for GGTLC1 Gene

  • This gene encodes a member of the gamma-glutamyl transpeptidase (GGT) family, which are important in the metabolism of glutathione. The most ubiquitously expressed human GGT gene, GGT1, encodes a single transmembrane polypeptide that is post-translationally processed to form a heavy and a light chain. In contrast, the product of this gene only contains homology to the light chain region, and lacks a transmembrane domain. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]

GeneCards Summary for GGTLC1 Gene

GGTLC1 (Gamma-Glutamyltransferase Light Chain 1) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include gamma-glutamyltransferase activity. An important paralog of this gene is GGT1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGTLC1 Gene

Genomics for GGTLC1 Gene

Genomic Location for GGTLC1 Gene

Chromosome:
20
Start:
23,985,050 bp from pter
End:
23,988,779 bp from pter
Size:
3,730 bases
Orientation:
Minus strand

Genomic View for GGTLC1 Gene

Genes around GGTLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGTLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGTLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGTLC1 Gene

No data available for Regulatory Elements for GGTLC1 Gene

Proteins for GGTLC1 Gene

  • Protein details for GGTLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX51-GGTL1_HUMAN
    Recommended name:
    Gamma-glutamyltransferase light chain 1
    Protein Accession:
    Q9BX51
    Secondary Accessions:
    • D3DW43
    • Q08246

    Protein attributes for GGTLC1 Gene

    Size:
    225 amino acids
    Molecular mass:
    24274 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity.

neXtProt entry for GGTLC1 Gene

Proteomics data for GGTLC1 Gene at MOPED

Selected DME Specific Peptides for GGTLC1 Gene

Post-translational modifications for GGTLC1 Gene

No Post-translational modifications

Other Protein References for GGTLC1 Gene

Domains & Families for GGTLC1 Gene

Gene Families for GGTLC1 Gene

Protein Domains for GGTLC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGTLC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BX51

UniProtKB/Swiss-Prot:

GGTL1_HUMAN :
  • Belongs to the gamma-glutamyltransferase family.
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGTLC1: view

Function for GGTLC1 Gene

Enzyme Numbers (IUBMB) for GGTLC1 Gene

genes like me logo Genes that share phenotypes with GGTLC1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGTLC1 Gene

Localization for GGTLC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGTLC1 Gene COMPARTMENTS Subcellular localization image for GGTLC1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GGTLC1 Gene

Pathways & Interactions for GGTLC1 Gene

genes like me logo Genes that share pathways with GGTLC1: view

Interacting Proteins for GGTLC1 Gene

Gene Ontology (GO) - Biological Process for GGTLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019370 leukotriene biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGTLC1: view

No data available for SIGNOR curated interactions for GGTLC1 Gene

Drugs & Compounds for GGTLC1 Gene

No Compound Related Data Available

Transcripts for GGTLC1 Gene

mRNA/cDNA for GGTLC1 Gene

(11) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GGTLC1 Gene

Gamma-glutamyltransferase light chain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GGTLC1 Gene

No ASD Table

Relevant External Links for GGTLC1 Gene

GeneLoc Exon Structure for
GGTLC1
ECgene alternative splicing isoforms for
GGTLC1

Expression for GGTLC1 Gene

mRNA expression in normal human tissues for GGTLC1 Gene

mRNA differential expression in normal tissues according to GTEx for GGTLC1 Gene

This gene is overexpressed in Lung (x30.3) and Testis (x19.4).

SOURCE GeneReport for Unigene cluster for GGTLC1 Gene Hs.355394

genes like me logo Genes that share expression patterns with GGTLC1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GGTLC1 Gene

Orthologs for GGTLC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GGTLC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGTLC1 35
  • 98.67 (n)
  • 99.11 (a)
GGTLC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 32 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 33 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
OneToMany
mouse
(Mus musculus)
Mammalia Ggt1 36
  • 30 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
ManyToMany
-- 36
  • 1 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ggt1a 36
  • 25 (a)
ManyToMany
ggt1b 36
  • 22 (a)
ManyToMany
ggt1l2.1 36
  • 15 (a)
ManyToMany
ggt1l2.2 36
  • 17 (a)
ManyToMany
si:ch73-236c18.3 36
  • 16 (a)
ManyToMany
si:dkey-222h21.12 36
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1492 36
  • 14 (a)
ManyToMany
CG4829 36
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C53D5.5 36
  • 17 (a)
ManyToMany
H14N18.4 36
  • 14 (a)
ManyToMany
T03D8.6 36
  • 12 (a)
ManyToMany
Y7A9A.1 36
  • 15 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM38 36
  • 12 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.14319 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
CSA.7538 36
  • 20 (a)
ManyToMany
Species with no ortholog for GGTLC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GGTLC1 Gene

ENSEMBL:
Gene Tree for GGTLC1 (if available)
TreeFam:
Gene Tree for GGTLC1 (if available)

Paralogs for GGTLC1 Gene

Paralogs for GGTLC1 Gene

(6) SIMAP similar genes for GGTLC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GGTLC1: view

Variants for GGTLC1 Gene

Sequence variations from dbSNP and Humsavar for GGTLC1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3865760 -- 23,985,886(+) ATCTG(C/T)GTGCC reference, synonymous-codon
rs3875213 -- 23,984,702(-) GCGTC(C/T)AGCTC downstream-variant-500B
rs3954815 -- 23,985,741(+) GGCCC(A/G)CTTCA reference, missense
rs3954817 -- 23,987,459(+) TAAAC(C/T)CTGCA intron-variant, upstream-variant-2KB
rs4009392 -- 23,984,726(+) AAGGC(A/G/T)CCCGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GGTLC1 Gene

Variant ID Type Subtype PubMed ID
nsv833944 CNV Gain 17160897
nsv522873 CNV Gain 19592680
nsv9793 CNV Gain+Loss 18304495
esv26651 CNV Gain 19812545
nsv820636 CNV Deletion 20802225
esv2673741 CNV Deletion 23128226

Variation tolerance for GGTLC1 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGTLC1 Gene

HapMap Linkage Disequilibrium report
GGTLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGTLC1 Gene

Disorders for GGTLC1 Gene

Relevant External Links for GGTLC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGTLC1

No disorders were found for GGTLC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGTLC1 Gene

Publications for GGTLC1 Gene

  1. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3 4 67
  2. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. (PMID: 10843999) Luong A. … Goldstein J.L. (J. Biol. Chem. 2000) 2 3
  3. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns S.L. … Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. The identification of myocilin-associated proteins in the human trabecular meshwork. (PMID: 16289162) Fautsch M.P. … Johnson D.H. (Exp. Eye Res. 2006) 3

Products for GGTLC1 Gene

Sources for GGTLC1 Gene

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