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Aliases for GGTLC1 Gene

Aliases for GGTLC1 Gene

  • Gamma-Glutamyltransferase Light Chain 1 2 3 5
  • Gamma-Glutamyltransferase-Like Activity 4 2 3 4
  • Gamma-Glutamyltransferase-Like Activity 3 2 3
  • Gamma-Glutamyltransferase-Like Protein 6 3 4
  • GGTLA4 3 4
  • Gamma-Glutamyl Transpeptidase 3
  • DJ831C21.1 3
  • DJ831C21.2 3
  • EC 61
  • GGTLA3 3
  • GGTL6 3

External Ids for GGTLC1 Gene

Previous HGNC Symbols for GGTLC1 Gene

  • GGTLA4
  • GGTLA3

Summaries for GGTLC1 Gene

Entrez Gene Summary for GGTLC1 Gene

  • This gene encodes a member of the gamma-glutamyl transpeptidase (GGT) family, which are important in the metabolism of glutathione. The most ubiquitously expressed human GGT gene, GGT1, encodes a single transmembrane polypeptide that is post-translationally processed to form a heavy and a light chain. In contrast, the product of this gene only contains homology to the light chain region, and lacks a transmembrane domain. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]

GeneCards Summary for GGTLC1 Gene

GGTLC1 (Gamma-Glutamyltransferase Light Chain 1) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Eicosanoid Synthesis. GO annotations related to this gene include gamma-glutamyltransferase activity. An important paralog of this gene is GGT1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGTLC1 Gene

Genomics for GGTLC1 Gene

Regulatory Elements for GGTLC1 Gene

Enhancers for GGTLC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G024025 1.2 FANTOM5 Ensembl ENCODE 5.4 -38.4 -38378 2.5 JUN MAX FOS FOXP2 MYC GABPA GGTLC1 PIR52234 GC20P023996
GH20G023980 0.6 Ensembl 5.6 +7.4 7378 1.6 TFAP4 NFIA NFIB NR3C1 ZFHX2 ZNF652 EGR2 SALL1 GGTLC1 ENSG00000236168
GH20G024109 0.7 FANTOM5 ENCODE 2.4 -120.4 -120443 0.2 NFYB NFYC GGTLC1 LOC105372576 PIR52234
GH20G023984 0.5 Ensembl 0.7 +4.0 3979 0.4 CTCF FOXA2 FOXA1 GGTLC1 ENSG00000236168
GH20G023982 0.5 ENCODE 0.4 +6.0 5981 0.2 SOX13 GATAD2A HNF1A FOXA3 ENSG00000236168 GGTLC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GGTLC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GGTLC1 Gene

23,985,050 bp from pter
23,988,779 bp from pter
3,730 bases
Minus strand

Genomic View for GGTLC1 Gene

Genes around GGTLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGTLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGTLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGTLC1 Gene

Proteins for GGTLC1 Gene

  • Protein details for GGTLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-glutamyltransferase light chain 1
    Protein Accession:
    Secondary Accessions:
    • D3DW43
    • Q08246

    Protein attributes for GGTLC1 Gene

    225 amino acids
    Molecular mass:
    24274 Da
    Quaternary structure:
    No Data Available
    • Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity.

neXtProt entry for GGTLC1 Gene

Selected DME Specific Peptides for GGTLC1 Gene


Post-translational modifications for GGTLC1 Gene

No Post-translational modifications

Domains & Families for GGTLC1 Gene

Gene Families for GGTLC1 Gene

Protein Domains for GGTLC1 Gene

Suggested Antigen Peptide Sequences for GGTLC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the gamma-glutamyltransferase family.
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGTLC1: view

Function for GGTLC1 Gene

Enzyme Numbers (IUBMB) for GGTLC1 Gene

Gene Ontology (GO) - Molecular Function for GGTLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003840 gamma-glutamyltransferase activity TAS 18357469
GO:0036374 glutathione hydrolase activity IEA --
genes like me logo Genes that share ontologies with GGTLC1: view
genes like me logo Genes that share phenotypes with GGTLC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGTLC1 Gene

Localization for GGTLC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GGTLC1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GGTLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031362 anchored component of external side of plasma membrane TAS 18357469
genes like me logo Genes that share ontologies with GGTLC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GGTLC1 Gene

Pathways & Interactions for GGTLC1 Gene

genes like me logo Genes that share pathways with GGTLC1: view

Pathways by source for GGTLC1 Gene

Interacting Proteins for GGTLC1 Gene

Gene Ontology (GO) - Biological Process for GGTLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006749 glutathione metabolic process TAS 18357469
GO:0006751 glutathione catabolic process IEA --
GO:0019370 leukotriene biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGTLC1: view

No data available for SIGNOR curated interactions for GGTLC1 Gene

Drugs & Compounds for GGTLC1 Gene

No Compound Related Data Available

Transcripts for GGTLC1 Gene

mRNA/cDNA for GGTLC1 Gene

(10) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GGTLC1 Gene

Gamma-glutamyltransferase light chain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGTLC1 Gene

No ASD Table

Relevant External Links for GGTLC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GGTLC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GGTLC1 Gene

mRNA differential expression in normal tissues according to GTEx for GGTLC1 Gene

This gene is overexpressed in Lung (x30.3) and Testis (x19.4).

NURSA nuclear receptor signaling pathways regulating expression of GGTLC1 Gene:


SOURCE GeneReport for Unigene cluster for GGTLC1 Gene:


Evidence on tissue expression from TISSUES for GGTLC1 Gene

  • Lung(4.2)
  • Nervous system(4)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with GGTLC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGTLC1 Gene

Orthologs for GGTLC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GGTLC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GGTLC1 34 35
  • 98.67 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
-- 35
  • 1 (a)
(Canis familiaris)
Mammalia -- 35
  • 33 (a)
(Bos Taurus)
Mammalia -- 35
  • 32 (a)
(Mus musculus)
Mammalia Ggt1 35
  • 30 (a)
(Monodelphis domestica)
Mammalia -- 35
(Gallus gallus)
Aves -- 35
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 25 (a)
(Danio rerio)
Actinopterygii ggt1a 35
  • 25 (a)
ggt1b 35
  • 22 (a)
ggt1l2.2 35
  • 17 (a)
si:dkey-222h21.12 35
  • 17 (a)
si:ch73-236c18.3 35
  • 16 (a)
ggt1l2.1 35
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1492 35
  • 14 (a)
CG4829 35
  • 11 (a)
(Caenorhabditis elegans)
Secernentea C53D5.5 35
  • 17 (a)
Y7A9A.1 35
  • 15 (a)
H14N18.4 35
  • 14 (a)
T03D8.6 35
  • 12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM38 35
  • 12 (a)
(Glycine max)
eudicotyledons Gma.14319 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
CSA.7538 35
  • 20 (a)
Species where no ortholog for GGTLC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GGTLC1 Gene

Gene Tree for GGTLC1 (if available)
Gene Tree for GGTLC1 (if available)

Paralogs for GGTLC1 Gene

Paralogs for GGTLC1 Gene

(6) SIMAP similar genes for GGTLC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GGTLC1: view

Variants for GGTLC1 Gene

Sequence variations from dbSNP and Humsavar for GGTLC1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000132813 -- 23,984,607(+) AGGGG(C/T)GTGGC downstream-variant-500B
rs1000467372 -- 23,988,655(+) GCGCC(A/T)TTAAG upstream-variant-2KB, utr-variant-5-prime
rs1000813768 -- 23,988,900(+) GGAGC(C/G/T)GGTTC upstream-variant-2KB, utr-variant-5-prime
rs1001420836 -- 23,987,855(+) CCATC(C/T)TGGCT intron-variant, upstream-variant-2KB
rs1001871991 -- 23,987,631(+) TGGAT(A/G)CCATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GGTLC1 Gene

Variant ID Type Subtype PubMed ID
esv26651 CNV gain 19812545
esv2673741 CNV deletion 23128226
esv3645541 CNV loss 21293372
nsv1063474 CNV loss 25217958
nsv522873 CNV gain 19592680
nsv820636 CNV deletion 20802225
nsv833944 CNV gain 17160897
nsv953004 CNV deletion 24416366
nsv962565 CNV duplication 23825009
nsv962566 CNV duplication 23825009
nsv9793 CNV gain+loss 18304495
nsv979449 CNV duplication 23825009

Variation tolerance for GGTLC1 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGTLC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGTLC1 Gene

Disorders for GGTLC1 Gene

Relevant External Links for GGTLC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GGTLC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGTLC1 Gene

Publications for GGTLC1 Gene

  1. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. (PMID: 10843999) Luong A. … Goldstein J.L. (J. Biol. Chem. 2000) 2 3 64
  5. Human lung expresses unique gamma-glutamyl transpeptidase transcripts. (PMID: 7689219) Wetmore L.A. … Drazen J.M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 64

Products for GGTLC1 Gene

Sources for GGTLC1 Gene

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