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GGT7 Gene

protein-coding   GIFtS: 60
GCID: GC20M033435

Gamma-Glutamyltransferase 7

(Previous name: gamma-glutamyltransferase-like 3)
(Previous symbols: GGTL5, GGTL3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Gamma-Glutamyltransferase 71 2     EC 2.3.2.23 8
GGTL31 2 3 5     GGT42 5
GGTL51 2 3 5     D20S1012
Gamma-Glutamyltransferase-Like 31 2 3     dJ18C9.22
Gamma-Glutamyltransferase-Like 52 3     Gamma-Glutamyltransferase 42
Gamma-Glutamyltranspeptidase 72 3     Gamma-Glutamyltranspeptidase-Like 32
Glutathione Hydrolase 72 3     EC 3.4.19.133
GGT 72 3     

External Ids:    HGNC: 42591   Entrez Gene: 26862   Ensembl: ENSG000001310677   OMIM: 6123425   UniProtKB: Q9UJ143   

Export aliases for GGT7 gene to outside databases

Previous GC identifers: GC20M032897 GC20M030198


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GGT7 Gene:
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in
the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal
preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy
and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved
in lung carcinogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for GGT7 Gene:
GGT7 (gamma-glutamyltransferase 7) is a protein-coding gene. GO annotations related to this gene include glutathione hydrolase activity and gamma-glutamyltransferase activity. An important paralog of this gene is GGT6.

UniProtKB/Swiss-Prot: GGT7_HUMAN, Q9UJ14
Function: Cleaves glutathione conjugates (By similarity)

Gene Wiki entry for GGT7 (GGTL3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the GGT7 gene promoter:
         Bach1   c-Fos   AP-1   JunB   Fra-1   FosB   MZF-1   JunD   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGGT7 promoter sequence
   Search Chromatin IP Primers for GGT7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GGT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

GGT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GGT7 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M033435:  view genomic region     (about GC identifiers)

Start:
33,432,523 bp from pter      End:
33,460,663 bp from pter
Size:
28,141 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GGT7_HUMAN, Q9UJ14 (See protein sequence)
Recommended Name: Gamma-glutamyltransferase 7 precursor  
Size: 662 amino acids; 70467 Da
Subunit: Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By
similarity). Isoform 3 interacts with FAM57A
Sequence caution: Sequence=BAC03394.1; Type=Erroneous initiation;
Secondary accessions: Q8N899 Q8NF66 Q9BYP5 Q9BYP6
Alternative splicing: 4 isoforms:  Q9UJ14-1   Q9UJ14-4   Q9UJ14-5   Q9UJ14-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GGT7: NX_Q9UJ14

Explore proteomics data for GGT7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GGT7 (Q9UJ14) (see all 7)
     PGKRPLS  PPLPGSLL  MQIYFGDPQIF  EKPVCGVYRGHLVLSP 


    See GGT7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_821158.2  
    ENSEMBL proteins: 
     ENSP00000338964   ENSP00000394993  
    Reactome Protein details: Q9UJ14

    GGT7 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for GGT7

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    antibodies-online antibodies for GGT7 (17 products) 

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    antibodies-online kits for GGT7 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GGT: Gamma-glutamyltransferases

    1 InterPro protein domain:
     IPR000101 GGT_peptidase

    Graphical View of Domain Structure for InterPro Entry Q9UJ14

    ProtoNet protein and cluster: Q9UJ14

    1 Blocks protein domain: IPB000101 Gamma-glutamyltranspeptidase

    UniProtKB/Swiss-Prot: GGT7_HUMAN, Q9UJ14
    Similarity: Belongs to the gamma-glutamyltransferase family


    Find genes that share domains with GGT7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GGT7_HUMAN, Q9UJ14
    Function: Cleaves glutathione conjugates (By similarity)
    Catalytic activity: A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid
    Catalytic activity: Glutathione + H(2)O = L-cysteinylglycine + L-glutamate

         Enzyme Numbers (IUBMB): EC 2.3.2.21 2 EC 3.4.19.131

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003840gamma-glutamyltransferase activity TAS18357469
    GO:0036374glutathione hydrolase activity IEA--
         
    Find genes that share ontologies with GGT7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GGT7:
     Big cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GGT7

    miRNA
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    miRTarBase miRNAs that target GGT7:
    hsa-mir-331-3p (MIRT043545)

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    Selected qRT-PCR Assays for microRNAs that regulate GGT7 (see all 24):
    hsa-miR-485-5p hsa-miR-125a-5p hsa-miR-330-5p hsa-miR-3653 hsa-miR-4314 hsa-miR-3658 hsa-miR-3150b-3p hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidGGT7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GGT7_HUMAN, Q9UJ14: Membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0031362anchored component of external side of plasma membrane TAS18357469

    Find genes that share ontologies with GGT7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GGT7 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    Glutathione synthesis and recycling0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Biological oxidations
    Biological oxidations0.56
    Phase II conjugation0.56
    4Taurine and hypotaurine metabolism
    Taurine and hypotaurine metabolism0.31
    Cyanoamino acid metabolism0.31
    5Arachidonic acid metabolism
    Arachidonic acid metabolism0.41


    Find genes that share SuperPaths with GGT7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GGT7
        Glutathione metabolism

    1 Reactome Pathway for GGT7
        Glutathione synthesis and recycling


    5 Kegg Pathways  (Kegg details for GGT7):
        Taurine and hypotaurine metabolism
    Cyanoamino acid metabolism
    Glutathione metabolism
    Arachidonic acid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: GGT7_HUMAN, Q9UJ14
    Pathway: Sulfur metabolism; glutathione metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GGT7
    Interactions:

        Search GeneGlobe Interaction Network for GGT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GGT7 (Q9UJ143 ENSP000003389644) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    CAMKK2Q96RR43I2D: score=1 
    MAXP612443I2D: score=1 
    ANPEPENSP000003000604STRING: ENSP00000300060
    CSADENSP000002670854STRING: ENSP00000267085
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process TAS18357469
    GO:0006750glutathione biosynthetic process IEA--
    GO:0019370leukotriene biosynthetic process ISS--

    Find genes that share ontologies with GGT7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GGT7

    Selected HMDB Compounds for GGT7 (see all 15)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Leukotriene F4LTF4 (see all 3)--3001504
    5-L-Glutamyl-taurine5-Glutamyl-taurine ----
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    CysteinylglycineL-Cysteinylglycine (see all 5)19246-18-5--
    FamotidineAmfamox (see all 83)76824-35-6--
    Gamma-Glutamyl-Se-methylselenocysteine ----
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
    Leukotriene C4(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine (see all 12)72025-60-6--
    Leukotriene C5LTC(,5) 75207-09-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GGT7 gene: 
    NM_178026.2  

    Unigene Cluster for GGT7:

    Gamma-glutamyltransferase 7
    Hs.433738  [show with all ESTs]
    Unigene Representative Sequence: BC141843
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336431(uc010gex.3 uc002xay.3 uc002xaz.1 uc002xba.1)
    ENST00000469018 ENST00000470952 ENST00000427420
    miRNA
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    hsa-miR-485-5p hsa-miR-125a-5p hsa-miR-330-5p hsa-miR-3653 hsa-miR-4314 hsa-miR-3658 hsa-miR-3150b-3p hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidGGT7 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat GGT7

    Additional mRNA sequence: 

    AK299494.1 BC033745.1 BC040030.1 BC101370.1 BC101371.1 BC101372.1 BC141843.1 

    18 DOTS entries:

    DT.100824759  DT.100824763  DT.110157  DT.120806359  DT.120806361  DT.40196965  DT.100824760  DT.100824758 
    DT.40212974  DT.97858122  DT.86837268  DT.100028936  DT.100824752  DT.120806438  DT.40295573  DT.91925832 
    DT.95099534  DT.95122178 

    Selected AceView cDNA sequences (see all 226):

    AI292097 AI475595 BE857735 AI017876 BQ632013 BX420432 BM923294 AI423493 
    AI801996 AI498140 AW134534 AI333990 T25011 CA841905 AA995210 BQ067650 
    NM_178026 BM906292 BM668484 AK124788 W19243 BF477776 BU790233 BM703730 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GGT7 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
    SP1:                    -     -                                                     -     -     -                             -     -                           
    SP2:                                                                                -     -     -                                                               
    SP3:                                                                                -     -     -                             -     -                           
    SP4:                                                                                -     -     -                             -                                 
    SP5:                                                                                                                                                        -   

    ExUns: 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:  -                                                                           


    ECgene alternative splicing isoforms for GGT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GGT7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCCCGA
    GGT7 Expression
    About this image


    GGT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    GGT7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GGT7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433738

    UniProtKB/Swiss-Prot: GGT7_HUMAN, Q9UJ14
    Tissue specificity: Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain,
    heart, kidney, liver, lung, spleen, testis and trachea

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGT7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GGT7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ggt71 , 5 gamma-glutamyltransferase 71, 5 89.88(n)1
    96.22(a)1
      2 (77.26 cM)5
    2071821  NM_144786.21  NP_659035.21 
     1554903795 
    chicken
    (Gallus gallus)
    Aves GGT71 gamma-glutamyltransferase 7 68.19(n)
    71.02(a)
      419121  XM_417308.4  XP_417308.3 
    lizard
    (Anolis carolinensis)
    Reptilia GGT76
    gamma-glutamyltransferase 7
    69(a)
    1 ↔ 1
    4(138508823-138542940)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.91262 Xenopus laevis transcribed sequence with weak similarity more 73.99(n)    48023445 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018822951 gamma-glutamyltransferase 7-like 59.58(n)
    53.87(a)
      101882295  XM_005174095.1  XP_005174152.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y97E10AR.26
    Protein Y97E10AR.2, isoform b
    13(a)
    1 ↔ 1
    V(7996178-8000232) WBGene00022397
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECM386
    Gamma-glutamyltranspeptidase, major glutathione-de...
    21(a)
    1 → many
    XII(726069-728051) YLR299W


    ENSEMBL Gene Tree for GGT7 (if available)
    TreeFam Gene Tree for GGT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GGT7 gene
    GGT62  GGTLC12  GGT52  GGT12  GGTLC22  GGTLC32  GGT22  
    1 SIMAP similar gene for GGT7 using alignment to 6 protein entries:     GGT7_HUMAN (see all proteins):
    GGT1

    Find genes that share paralogs with GGT7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GGT7 (see all 594)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444846651,2
    C--33432116(+) ATGACA/GTATAC 1 -- ds50010--------
    rs1466497351,2
    C--33432189(+) GACATA/GCTGAG 1 -- ds50010--------
    rs1838994361,2
    --33432266(+) TGTTTC/TCCATC 1 -- ds50010--------
    rs746395651,2
    C,F--33432300(+) ACCTAC/TTTCAT 1 -- ds50011Minor allele frequency- T:0.10WA 118
    rs1859745171,2
    --33432413(+) TTCAAC/TGTTGA 1 -- ds50010--------
    rs1909300871,2
    --33432415(+) CAACGC/TTGACT 1 -- ds50010--------
    rs736166101,2
    C--33432465(+) CGAGGA/TCTCCT 1 -- ds50010--------
    rs1827397241,2
    --33432491(+) TCAACA/CCAGTT 1 -- ds50010--------
    rs1438379151,2
    C--33432916(+) ACACT-/CACCA 
     CCACCAC
    CACCA
    1 -- cds10--------
    rs115461561,2
    C--33433015(+) ATCCCC/TTCTGG 1 -- ut31 ese31Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for GGT7 (33432523 - 33460663 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GGT7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912860CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GGT7
    DNA2.0 Custom Variant and Variant Library Synthesis for GGT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612342    OMIM disorders: --


    Find genes that share disorders with GGT7           About GenesLikeMe

    Genetic Association Database (GAD): GGT7
    Human Genome Epidemiology (HuGE) Navigator: GGT7 (1 document)

    Export disorders for GGT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GGT7 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with GGT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human gamma-glutamyltransferase gene family. (PubMed id 18357469)1, 2, 3 Heisterkamp N.... Sneddon T.P. (Hum. Genet. 2008)
    2. Molecular cloning and characterization of CT120, a novel membrane- associated gene involved in amino acid transport and glutathione metabolism. (PubMed id 12270127)1, 2, 9 He X.H.... Gu J.R. (Biochem. Biophys. Res. Commun. 2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (DNA Res. 2003)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. (PubMed id 8104871)1, 3 Figlewicz D.A....Rouleau G.A. (Genomics 1993)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2686 HGNC: 4259 AceView: GGTL3 Ensembl:ENSG00000131067 euGenes: HUgn2686
    ECgene: GGT7 Kegg: 2686 H-InvDB: GGT7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GGT7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GGT7 gene:
    Search GeneIP for patents involving GGT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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