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Aliases for GGT6 Gene

Aliases for GGT6 Gene

  • Gamma-Glutamyltransferase 6 2 3 5
  • Gamma-Glutamyltransferase 6 Homolog (Rat) 2
  • Gamma-Glutamyltranspeptidase 6 4
  • Glutathione Hydrolase 6 4
  • EC 3.4.19.13 4
  • EC 2.3.2.2 4
  • GGT 6 4

External Ids for GGT6 Gene

Previous GeneCards Identifiers for GGT6 Gene

  • GC17M004407
  • GC17M004460
  • GC17M004349

Summaries for GGT6 Gene

Entrez Gene Summary for GGT6 Gene

  • GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

GeneCards Summary for GGT6 Gene

GGT6 (Gamma-Glutamyltransferase 6) is a Protein Coding gene. Diseases associated with GGT6 include glutathionuria. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include gamma-glutamyltransferase activity and glutathione hydrolase activity. An important paralog of this gene is GGT1.

UniProtKB/Swiss-Prot for GGT6 Gene

  • Cleaves glutathione conjugates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT6 Gene

Genomics for GGT6 Gene

Regulatory Elements for GGT6 Gene

Genomic Location for GGT6 Gene

Chromosome:
17
Start:
4,556,927 bp from pter
End:
4,560,818 bp from pter
Size:
3,892 bases
Orientation:
Minus strand

Genomic View for GGT6 Gene

Genes around GGT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGT6 Gene

Proteins for GGT6 Gene

  • Protein details for GGT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P531-GGT6_HUMAN
    Recommended name:
    Gamma-glutamyltransferase 6
    Protein Accession:
    Q6P531
    Secondary Accessions:
    • B4DUH4
    • Q8NCM0

    Protein attributes for GGT6 Gene

    Size:
    493 amino acids
    Molecular mass:
    50509 Da
    Quaternary structure:
    • Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).

    Alternative splice isoforms for GGT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGT6 Gene

Proteomics data for GGT6 Gene at MOPED

Post-translational modifications for GGT6 Gene

  • Glycosylation at Asn 161 and Asn 370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GGT6 Gene

Domains & Families for GGT6 Gene

Gene Families for GGT6 Gene

Protein Domains for GGT6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGT6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P531

UniProtKB/Swiss-Prot:

GGT6_HUMAN :
  • Belongs to the gamma-glutamyltransferase family.
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGT6: view

Function for GGT6 Gene

Molecular function for GGT6 Gene

GENATLAS Biochemistry:
gamma-glutamyltransferase 6,ubiquitously expressed including fetal liver and brain,gamma-glutamyl cycle
UniProtKB/Swiss-Prot CatalyticActivity:
A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione + H(2)O = L-cysteinylglycine + L-glutamate.
UniProtKB/Swiss-Prot Function:
Cleaves glutathione conjugates.

Enzyme Numbers (IUBMB) for GGT6 Gene

genes like me logo Genes that share phenotypes with GGT6: view

Animal Model Products

miRNA for GGT6 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GGT6 Gene

Localization for GGT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT6 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGT6 Gene COMPARTMENTS Subcellular localization image for GGT6 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GGT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GGT6: view

Pathways & Interactions for GGT6 Gene

genes like me logo Genes that share pathways with GGT6: view

UniProtKB/Swiss-Prot Q6P531-GGT6_HUMAN

  • Pathway: Sulfur metabolism; glutathione metabolism.

Interacting Proteins for GGT6 Gene

Gene Ontology (GO) - Biological Process for GGT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006749 glutathione metabolic process IEA,TAS 18357469
GO:0019370 leukotriene biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGT6: view

No data available for SIGNOR curated interactions for GGT6 Gene

Drugs & Compounds for GGT6 Gene

(4) Drugs for GGT6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Famotidine Approved Pharma Histamine H2-receptor antagonist 57
Glutathione Approved Nutra 0
Taurine Experimental Nutra Non-selective, endogenous glycine receptor partial agonist 26
L-Glutamic Acid Nutra Full agonist, Agonist 0

(13) Additional Compounds for GGT6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-L-Glutamyl-taurine
  • 5-Glutamyl-taurine
beta-Aminopropionitrile
  • 2-Cyanoethylamine
  • 3-Aminopropanenitrile
  • 3-Aminopropionitrile
  • 3-Aminopropiononitrile
  • Aminopropionitrile
151-18-8
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
cysteinylglycine
  • Cys-Gly
  • L-Cysteinylglycine
  • N-Cysteinyl Glycine
  • N-Cysteinyl-Glycine
  • N-L-Cysteinyl-Glycine
19246-18-5
gamma-Glutamyl-beta-aminopropiononitrile
genes like me logo Genes that share compounds with GGT6: view

Transcripts for GGT6 Gene

Unigene Clusters for GGT6 Gene

Gamma-glutamyltransferase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GGT6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5
SP1:
SP2: -
SP3: - - -
SP4: - - - - -
SP5:

Relevant External Links for GGT6 Gene

GeneLoc Exon Structure for
GGT6
ECgene alternative splicing isoforms for
GGT6

Expression for GGT6 Gene

mRNA expression in normal human tissues for GGT6 Gene

mRNA differential expression in normal tissues according to GTEx for GGT6 Gene

This gene is overexpressed in Colon - Transverse (x8.9), Skin - Sun Exposed (Lower leg) (x6.6), Esophagus - Mucosa (x6.5), Skin - Not Sun Exposed (Suprapubic) (x6.2), and Pancreas (x4.3).

Protein differential expression in normal tissues from HIPED for GGT6 Gene

This gene is overexpressed in Urine (45.7) and Prostate (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGT6 Gene



SOURCE GeneReport for Unigene cluster for GGT6 Gene Hs.130749

genes like me logo Genes that share expression patterns with GGT6: view

Protein tissue co-expression partners for GGT6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GGT6 Gene

Orthologs for GGT6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGT6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GGT6 35
  • 81.5 (n)
  • 74.9 (a)
GGT6 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GGT6 35
  • 79.01 (n)
  • 74.09 (a)
GGT6 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ggt6 35
  • 76.16 (n)
  • 69.9 (a)
Ggt6 16
Ggt6 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GGT6 35
  • 99.27 (n)
  • 98.35 (a)
GGT6 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ggt6 35
  • 76.24 (n)
  • 68.47 (a)
oppossum
(Monodelphis domestica)
Mammalia GGT6 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GGT6 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 11 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496507 35
  • 43.11 (n)
  • 35.34 (a)
zebrafish
(Danio rerio)
Actinopterygii GGT6 36
  • 22 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17636 36
  • 14 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM38 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
ManyToMany
Species with no ortholog for GGT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GGT6 Gene

ENSEMBL:
Gene Tree for GGT6 (if available)
TreeFam:
Gene Tree for GGT6 (if available)

Paralogs for GGT6 Gene

Paralogs for GGT6 Gene

genes like me logo Genes that share paralogs with GGT6: view

Variants for GGT6 Gene

Sequence variations from dbSNP and Humsavar for GGT6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs7216284 - 4,560,404(+) CCTCC(A/G)GGGGT reference, missense
rs11657054 - 4,559,728(+) CACGG(A/G)CCCAG reference, missense
rs2100986 -- 4,562,207(-) CAATT(A/G)GGATA upstream-variant-2KB
rs3054325 -- 4,557,640(+) TTATT(-/ATT)TTAAA utr-variant-3-prime
rs4790203 -- 4,560,046(+) AGGAG(A/T)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGT6 Gene

Variant ID Type Subtype PubMed ID
dgv3050n71 CNV Loss 21882294

Variation tolerance for GGT6 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGT6 Gene

HapMap Linkage Disequilibrium report
GGT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGT6 Gene

Disorders for GGT6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GGT6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
glutathionuria
  • gamma-glutamyltransferase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search GGT6 in MalaCards View complete list of genes associated with diseases

Genatlas disease for GGT6 Gene

glutathionuria

Relevant External Links for GGT6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGT6
genes like me logo Genes that share disorders with GGT6: view

No data available for UniProtKB/Swiss-Prot for GGT6 Gene

Publications for GGT6 Gene

  1. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3 4 23 67
  2. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GGT6 Gene

Sources for GGT6 Gene

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