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Aliases for GGT5 Gene

Aliases for GGT5 Gene

  • Gamma-Glutamyltransferase 5 2 3 5
  • Gamma-Glutamyltransferase-Like Activity 1 2 3 4
  • Gamma-Glutamyl Transpeptidase-Related Enzyme 3 4
  • Gamma-Glutamyltranspeptidase 5 3 4
  • Leukotriene-C4 Hydrolase 3 4
  • Glutathione Hydrolase 5 3 4
  • GGT-REL 3 4
  • GGTLA1 3 4
  • GGT 5 3 4
  • Gamma-Glutamyl Transpeptidase-Related Protein 3
  • Gamma-Glutamyl Cleaving Enzyme 3
  • EC 3.4.19.13 4
  • EC 3.4.19.14 4
  • EC 2.3.2.2 4
  • GGL 3

External Ids for GGT5 Gene

Previous HGNC Symbols for GGT5 Gene

  • GGTLA1

Previous GeneCards Identifiers for GGT5 Gene

  • GC22M022945
  • GC22M024615
  • GC22M007564

Summaries for GGT5 Gene

Entrez Gene Summary for GGT5 Gene

  • This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for GGT5 Gene

GGT5 (Gamma-Glutamyltransferase 5) is a Protein Coding gene. Diseases associated with GGT5 include Fructose-1,6-Bisphosphatase Deficiency and Trigeminal Nerve Disease. Among its related pathways are Glutathione metabolism and Taurine and hypotaurine metabolism. GO annotations related to this gene include gamma-glutamyltransferase activity and glutathione hydrolase activity. An important paralog of this gene is GGT1.

UniProtKB/Swiss-Prot for GGT5 Gene

  • Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).

Gene Wiki entry for GGT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT5 Gene

Genomics for GGT5 Gene

Regulatory Elements for GGT5 Gene

Enhancers for GGT5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GGT5 on UCSC Golden Path with GeneCards custom track

Promoters for GGT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GGT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GGT5 Gene

Chromosome:
22
Start:
24,219,654 bp from pter
End:
24,245,142 bp from pter
Size:
25,489 bases
Orientation:
Minus strand

Genomic View for GGT5 Gene

Genes around GGT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGT5 Gene

Proteins for GGT5 Gene

  • Protein details for GGT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36269-GGT5_HUMAN
    Recommended name:
    Gamma-glutamyltransferase 5
    Protein Accession:
    P36269
    Secondary Accessions:
    • Q53XM9
    • Q6GMP0
    • Q96FC1
    • Q9UFM5

    Protein attributes for GGT5 Gene

    Size:
    586 amino acids
    Molecular mass:
    62261 Da
    Quaternary structure:
    • Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).
    SequenceCaution:
    • Sequence=CAB55910.1; Type=Frameshift; Positions=446; Evidence={ECO:0000305};

    Alternative splice isoforms for GGT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGT5 Gene

Post-translational modifications for GGT5 Gene

  • Cleaved by autocatalysis into a large and a small subunit.
  • Glycosylation at Asn 98, Asn 204, Asn 303, Asn 347, Asn 535, and Asn 550
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GGT5 Gene

Domains & Families for GGT5 Gene

Gene Families for GGT5 Gene

Protein Domains for GGT5 Gene

Graphical View of Domain Structure for InterPro Entry

P36269

UniProtKB/Swiss-Prot:

GGT5_HUMAN :
  • Belongs to the gamma-glutamyltransferase family.
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGT5: view

Function for GGT5 Gene

Molecular function for GGT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione + H(2)O = L-cysteinylglycine + L-glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
Leukotriene C(4) + H(2)O = leukotriene D(4) + L-glutamate.
UniProtKB/Swiss-Prot Function:
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).

Enzyme Numbers (IUBMB) for GGT5 Gene

Gene Ontology (GO) - Molecular Function for GGT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003840 gamma-glutamyltransferase activity TAS 18357469
GO:0036374 glutathione hydrolase activity IEA --
genes like me logo Genes that share ontologies with GGT5: view
genes like me logo Genes that share phenotypes with GGT5: view

Animal Models for GGT5 Gene

MGI Knock Outs for GGT5:

Animal Model Products

CRISPR Products

miRNA for GGT5 Gene

miRTarBase miRNAs that target GGT5

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GGT5 Gene

Localization for GGT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT5 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGT5 Gene COMPARTMENTS Subcellular localization image for GGT5 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GGT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016021 integral component of membrane IEA --
GO:0031362 anchored component of external side of plasma membrane TAS 18357469
genes like me logo Genes that share ontologies with GGT5: view

Pathways & Interactions for GGT5 Gene

genes like me logo Genes that share pathways with GGT5: view

UniProtKB/Swiss-Prot P36269-GGT5_HUMAN

  • Pathway: Lipid metabolism; leukotriene D4 biosynthesis.
  • Pathway: Sulfur metabolism; glutathione metabolism.

Gene Ontology (GO) - Biological Process for GGT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006520 cellular amino acid metabolic process TAS 1676842
GO:0006691 leukotriene metabolic process TAS --
GO:0006749 glutathione metabolic process TAS 18357469
GO:0006750 glutathione biosynthetic process IEA --
genes like me logo Genes that share ontologies with GGT5: view

No data available for SIGNOR curated interactions for GGT5 Gene

Drugs & Compounds for GGT5 Gene

(7) Drugs for GGT5 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon dioxide Approved, Vet_approved Pharma 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 57
Water Approved Pharma 0
Glutathione Approved Nutra 0
Taurine Experimental Nutra Non-selective, endogenous glycine receptor partial agonist 26

(10) Additional Compounds for GGT5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-L-Glutamyl-taurine
  • 5-Glutamyl-taurine
beta-Aminopropionitrile
  • 2-Cyanoethylamine
  • 3-Aminopropanenitrile
  • 3-Aminopropionitrile
  • 3-Aminopropiononitrile
  • Aminopropionitrile
151-18-8
cysteinylglycine
  • Cys-Gly
  • L-Cysteinylglycine
  • N-Cysteinyl Glycine
  • N-Cysteinyl-Glycine
  • N-L-Cysteinyl-Glycine
19246-18-5
gamma-Glutamyl-beta-aminopropiononitrile
gamma-Glutamyl-beta-cyanoalanine

(1) ApexBio Compounds for GGT5 Gene

Compound Action Cas Number
GGsTop γ-glutamyl transpeptidase (GGT) inhibitor, novel and irreversible 926281-37-0
genes like me logo Genes that share compounds with GGT5: view

Transcripts for GGT5 Gene

Unigene Clusters for GGT5 Gene

Gamma-glutamyltransferase 5:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGT5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: -
SP2: -
SP3:
SP4: - -
SP5: -

Relevant External Links for GGT5 Gene

GeneLoc Exon Structure for
GGT5
ECgene alternative splicing isoforms for
GGT5

Expression for GGT5 Gene

mRNA expression in normal human tissues for GGT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GGT5 Gene

This gene is overexpressed in Kidney (8.4) and Adrenal (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGT5 Gene



Protein tissue co-expression partners for GGT5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GGT5 Gene:

GGT5

SOURCE GeneReport for Unigene cluster for GGT5 Gene:

Hs.437156
genes like me logo Genes that share expression patterns with GGT5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GGT5 Gene

Orthologs for GGT5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGT5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GGT5 34
  • 82.06 (n)
  • 80.07 (a)
GGT5 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GGT5 34
  • 80.92 (n)
  • 78 (a)
-- 35
  • 79 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ggt5 34
  • 81.05 (n)
  • 80.35 (a)
Ggt5 16
Ggt5 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GGT5 34
  • 99.09 (n)
  • 98.81 (a)
GGT5 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ggt5 34
  • 81.35 (n)
  • 78.95 (a)
oppossum
(Monodelphis domestica)
Mammalia GGT5 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GGT5 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves GGT5 34
  • 56.04 (n)
  • 50.09 (a)
GGT5 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GGT5 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497518 34
  • 55.99 (n)
  • 51.37 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333757 34
  • 55.62 (n)
  • 49.51 (a)
CABZ01059291.1 35
  • 35 (a)
OneToMany
GGT5 (2 of 3) 35
  • 46 (a)
OneToMany
ggt5a 35
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ggt-1 35
  • 33 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM38 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3709 35
  • 33 (a)
ManyToMany
Species where no ortholog for GGT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GGT5 Gene

ENSEMBL:
Gene Tree for GGT5 (if available)
TreeFam:
Gene Tree for GGT5 (if available)

Paralogs for GGT5 Gene

Paralogs for GGT5 Gene

(5) SIMAP similar genes for GGT5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GGT5: view

Variants for GGT5 Gene

Sequence variations from dbSNP and Humsavar for GGT5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs7288201 - 24,225,325(+) CAAGA(C/T)GGAGG reference, missense
rs5760274 - 24,244,695(+) GACTA(G/T)GCTGA reference, missense, utr-variant-5-prime
rs2275984 - 24,226,680(+) GCCCC(C/T)TGGCA reference, missense
VAR_028008 -
rs738810 -- 24,219,538(+) GGTCC(A/G)CGAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GGT5 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv24290 CNV gain 19812545
esv2493035 CNV deletion 19546169
esv2724041 CNV deletion 23290073
esv3557987 CNV deletion 23714750
esv3575443 CNV gain 25503493
esv3647429 CNV loss 21293372
esv3893463 CNV gain 25118596
nsv1055830 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv1116947 CNV deletion 24896259
nsv1144020 CNV deletion 24896259
nsv483072 CNV loss 15286789
nsv526567 CNV gain 19592680
nsv528009 CNV loss 19592680
nsv528842 CNV loss 19592680
nsv7350 OTHER inversion 18451855
nsv834157 CNV gain 17160897
nsv834158 CNV gain 17160897
nsv953059 CNV deletion 24416366
nsv979723 CNV duplication 23825009
nsv9882 CNV gain+loss 18304495

Variation tolerance for GGT5 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 60.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGT5 Gene

Human Gene Mutation Database (HGMD)
GGT5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGT5 Gene

Disorders for GGT5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GGT5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fructose-1,6-bisphosphatase deficiency
  • fructose 1 phosphate aldolase deficiency
trigeminal nerve disease
  • trigeminal nerve diseases
- elite association - COSMIC cancer census association via MalaCards
Search GGT5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GGT5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGT5
genes like me logo Genes that share disorders with GGT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GGT5 Gene

Publications for GGT5 Gene

  1. Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22. (PMID: 8095916) Morris C. … Groffen J. (Hum. Genet. 1993) 2 3 22 65
  2. Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase. (PMID: 1676842) Heisterkamp N. … Groffen J. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 65
  3. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3 65
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for GGT5 Gene

Sources for GGT5 Gene

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