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Aliases for GGT5 Gene

Aliases for GGT5 Gene

  • Gamma-Glutamyltransferase 5 2 3 5
  • Gamma-Glutamyltransferase-Like Activity 1 2 3 4
  • Gamma-Glutamyl Transpeptidase-Related Enzyme 3 4
  • Gamma-Glutamyltranspeptidase 5 3 4
  • Leukotriene-C4 Hydrolase 3 4
  • Glutathione Hydrolase 5 3 4
  • GGT-REL 3 4
  • GGTLA1 3 4
  • GGT 5 3 4
  • Gamma-Glutamyl Transpeptidase-Related Protein 3
  • Gamma-Glutamyl Cleaving Enzyme 3
  • EC 4
  • EC 4
  • EC 4
  • GGL 3

External Ids for GGT5 Gene

Previous HGNC Symbols for GGT5 Gene

  • GGTLA1

Previous GeneCards Identifiers for GGT5 Gene

  • GC22M022945
  • GC22M024615
  • GC22M007564

Summaries for GGT5 Gene

Entrez Gene Summary for GGT5 Gene

  • This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for GGT5 Gene

GGT5 (Gamma-Glutamyltransferase 5) is a Protein Coding gene. Among its related pathways are Aflatoxin activation and detoxification and Taurine and hypotaurine metabolism. GO annotations related to this gene include gamma-glutamyltransferase activity and glutathione hydrolase activity. An important paralog of this gene is GGT1.

UniProtKB/Swiss-Prot for GGT5 Gene

  • Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).

Gene Wiki entry for GGT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT5 Gene

Genomics for GGT5 Gene

Regulatory Elements for GGT5 Gene

Enhancers for GGT5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GGT5 on UCSC Golden Path with GeneCards custom track

Promoters for GGT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GGT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GGT5 Gene

24,219,654 bp from pter
24,245,142 bp from pter
25,489 bases
Minus strand

Genomic View for GGT5 Gene

Genes around GGT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGT5 Gene

Proteins for GGT5 Gene

  • Protein details for GGT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-glutamyltransferase 5
    Protein Accession:
    Secondary Accessions:
    • Q53XM9
    • Q6GMP0
    • Q96FC1
    • Q9UFM5

    Protein attributes for GGT5 Gene

    586 amino acids
    Molecular mass:
    62261 Da
    Quaternary structure:
    • Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).
    • Sequence=CAB55910.1; Type=Frameshift; Positions=446; Evidence={ECO:0000305};

    Alternative splice isoforms for GGT5 Gene


neXtProt entry for GGT5 Gene

Proteomics data for GGT5 Gene at MOPED

Post-translational modifications for GGT5 Gene

  • Cleaved by autocatalysis into a large and a small subunit.
  • Glycosylation at Asn 98, Asn 204, Asn 303, Asn 347, Asn 535, and Asn 550
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GGT5 Gene

Domains & Families for GGT5 Gene

Gene Families for GGT5 Gene

Protein Domains for GGT5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the gamma-glutamyltransferase family.
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGT5: view

Function for GGT5 Gene

Molecular function for GGT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione + H(2)O = L-cysteinylglycine + L-glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
Leukotriene C(4) + H(2)O = leukotriene D(4) + L-glutamate.
UniProtKB/Swiss-Prot Function:
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).

Enzyme Numbers (IUBMB) for GGT5 Gene

genes like me logo Genes that share phenotypes with GGT5: view

Animal Models for GGT5 Gene

MGI Knock Outs for GGT5:

Animal Model Products

miRNA for GGT5 Gene

miRTarBase miRNAs that target GGT5

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GGT5 Gene

Localization for GGT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT5 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for GGT5 Gene COMPARTMENTS Subcellular localization image for GGT5 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GGT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with GGT5: view

Pathways & Interactions for GGT5 Gene

genes like me logo Genes that share pathways with GGT5: view

UniProtKB/Swiss-Prot P36269-GGT5_HUMAN

  • Pathway: Lipid metabolism; leukotriene D4 biosynthesis.
  • Pathway: Sulfur metabolism; glutathione metabolism.

Interacting Proteins for GGT5 Gene

Gene Ontology (GO) - Biological Process for GGT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006520 cellular amino acid metabolic process TAS 1676842
GO:0006749 glutathione metabolic process IEA,TAS 18357469
GO:0006954 inflammatory response IEA --
GO:0019370 leukotriene biosynthetic process IEA,ISS --
genes like me logo Genes that share ontologies with GGT5: view

No data available for SIGNOR curated interactions for GGT5 Gene

Drugs & Compounds for GGT5 Gene

(4) Drugs for GGT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Famotidine Approved Pharma Histamine H2-receptor antagonist 57
Glutathione Approved Nutra 0
Taurine Experimental Nutra Non-selective, endogenous glycine receptor partial agonist 26
L-Glutamic Acid Nutra Full agonist, Agonist 0

(12) Additional Compounds for GGT5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5-Glutamyl-taurine
  • 2-Cyanoethylamine
  • 3-Aminopropanenitrile
  • 3-Aminopropionitrile
  • 3-Aminopropiononitrile
  • Aminopropionitrile
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
  • Cys-Gly
  • L-Cysteinylglycine
  • N-Cysteinyl Glycine
  • N-Cysteinyl-Glycine
  • N-L-Cysteinyl-Glycine
genes like me logo Genes that share compounds with GGT5: view

Transcripts for GGT5 Gene

Unigene Clusters for GGT5 Gene

Gamma-glutamyltransferase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GGT5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: -
SP2: -
SP4: - -
SP5: -

Relevant External Links for GGT5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GGT5 Gene

mRNA expression in normal human tissues for GGT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GGT5 Gene

This gene is overexpressed in Kidney (8.4) and Adrenal (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGT5 Gene

SOURCE GeneReport for Unigene cluster for GGT5 Gene Hs.437156

genes like me logo Genes that share expression patterns with GGT5: view

Protein tissue co-expression partners for GGT5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GGT5 Gene

Orthologs for GGT5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGT5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GGT5 35
  • 82.06 (n)
  • 80.07 (a)
GGT5 36
  • 80 (a)
(Canis familiaris)
Mammalia GGT5 35
  • 80.92 (n)
  • 78 (a)
-- 36
  • 79 (a)
-- 36
  • 85 (a)
(Mus musculus)
Mammalia Ggt5 35
  • 81.05 (n)
  • 80.35 (a)
Ggt5 16
Ggt5 36
  • 80 (a)
(Pan troglodytes)
Mammalia GGT5 35
  • 99.09 (n)
  • 98.81 (a)
GGT5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ggt5 35
  • 81.35 (n)
  • 78.95 (a)
(Monodelphis domestica)
Mammalia GGT5 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia GGT5 36
  • 54 (a)
(Gallus gallus)
Aves GGT5 35
  • 56.04 (n)
  • 50.09 (a)
GGT5 36
  • 48 (a)
(Anolis carolinensis)
Reptilia GGT5 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497518 35
  • 55.99 (n)
  • 51.37 (a)
(Danio rerio)
Actinopterygii LOC100333757 35
  • 55.62 (n)
  • 49.51 (a)
CABZ01059291.1 36
  • 35 (a)
GGT5 (2 of 3) 36
  • 46 (a)
ggt5a 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ggt-1 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM38 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3709 36
  • 33 (a)
Species with no ortholog for GGT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GGT5 Gene

Gene Tree for GGT5 (if available)
Gene Tree for GGT5 (if available)

Paralogs for GGT5 Gene

Paralogs for GGT5 Gene

(5) SIMAP similar genes for GGT5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GGT5: view

Variants for GGT5 Gene

Sequence variations from dbSNP and Humsavar for GGT5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs7288201 - 24,225,325(+) CAAGA(C/T)GGAGG reference, missense
rs5760274 - 24,244,695(+) GACTA(G/T)GCTGA reference, missense, utr-variant-5-prime
rs2275984 - 24,226,680(+) GCCCC(C/T)TGGCA reference, missense
VAR_028008 -
rs2078191 -- 24,245,235(-) GCGGG(C/T)GGTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GGT5 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv914599 CNV Gain 21882294
nsv914629 CNV Gain 21882294
nsv834157 CNV Gain 17160897
nsv483072 CNV Loss 15286789
nsv914630 CNV Loss 21882294
nsv834158 CNV Gain 17160897
nsv528842 CNV Loss 19592680
nsv914631 CNV Loss 21882294
nsv528009 CNV Loss 19592680
nsv9882 CNV Gain+Loss 18304495
esv24290 CNV Gain 19812545
esv2493035 CNV Deletion 19546169

Variation tolerance for GGT5 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 60.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGT5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGT5 Gene

Disorders for GGT5 Gene

Relevant External Links for GGT5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GGT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGT5 Gene

Publications for GGT5 Gene

  1. Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase. (PMID: 1676842) Heisterkamp N. … Groffen J. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 67
  2. Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22. (PMID: 8095916) Morris C. … Groffen J. (Hum. Genet. 1993) 2 3 23
  3. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3
  4. Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme. (PMID: 11063908) Enoiu M. … Wellman M. (Free Radic. Biol. Med. 2000) 3 23
  5. Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells. (PMID: 9374738) Potdar P.D. … Ostrowski L.E. (Am. J. Physiol. 1997) 3 23

Products for GGT5 Gene

Sources for GGT5 Gene