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GGT3P Gene(Pseudogene)

Gamma-Glutamyltransferase 3 Pseudogene

GCID:
GC22M018773
GIFtS:
27
Genes Participants
UDN Logo

Aliases for GGT3P Gene

Aliases for GGT3P Gene

  • Gamma-Glutamyltransferase 3 Pseudogene 2 3 5
  • Gamma-Glutamyltransferase 3 2 4
  • EC 2.3.2.2 4 61
  • GGT3 3 4
  • Glutathione Hydrolase 3 4
  • EC 3.4.19.13 4
  • GGT 3 4

External Ids for GGT3P Gene

Previous HGNC Symbols for GGT3P Gene

  • GGT3

Previous GeneCards Identifiers for GGT3P Gene

  • GC22M017143
  • GC22M018765

Summaries for GGT3P Gene

GeneCards Summary for GGT3P Gene

GGT3P (Gamma-Glutamyltransferase 3 Pseudogene) is a Pseudogene. Diseases associated with GGT3P include Intrahepatic Cholestasis. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include gamma-glutamyltransferase activity and glutathione hydrolase activity.

UniProtKB/Swiss-Prot for GGT3P Gene

  • Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT3P Gene

Genomics for GGT3P Gene

Products:

  1. Regulatory Element

Regulatory Elements for GGT3P Gene


Transcription factor binding sites by QIAGEN in the GGT3P gene promoter:

Genomic Location for GGT3P Gene

Chromosome:
22
Start:
18,773,665 bp from pter
End:
18,843,399 bp from pter
Size:
69,735 bases
Orientation:
Minus strand

Genomic View for GGT3P Gene

Genes around GGT3P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGT3P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGT3P Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GGT3P Gene

Proteins for GGT3P Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GGT3P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGU5-GGT3_HUMAN
    Recommended name:
    Putative gamma-glutamyltranspeptidase 3
    Protein Accession:
    A6NGU5

    Protein attributes for GGT3P Gene

    Size:
    568 amino acids
    Molecular mass:
    61502 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • In some epileptic patients treated with phenytoin, phenobarbital and carbamazepin, GGT3 is found, as an additional form of GGT. This group of patients has levels of ceruloplasmin and oxidase activity that were significantly higher than in the group of patients without GGT3. However, levels of ceruloplasmin and oxidase activity are significantly higher in this group of patients without GGT3 than those of the control group.

neXtProt entry for GGT3P Gene

Selected DME Specific Peptides for GGT3P Gene

A6NGU5:
  • GFPVGKGLA
  • LCEVFCR
  • PSPANFI
  • VDAAIAAL
  • PEFYTPDD
  • LTYHRIVEAFRFAYAKRT
  • VVQAIVRT
  • GGLSVAVPGEI
  • GLCLWLPS
  • TIYNSTT
  • ATSTINLYFGSKV
  • VTEVVRNM
  • LILNILKGYNFS
  • DDGGTAHLS

Post-translational modifications for GGT3P Gene

  • Cleaved by autocatalysis into a large and a small subunit.
  • Glycosylation at Asn 95, Asn 120, Asn 230, Asn 266, Asn 297, Asn 344, and Asn 510

Domains & Families for GGT3P Gene

Gene Families for GGT3P Gene

HGNC:

Protein Domains for GGT3P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGT3P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGU5

UniProtKB/Swiss-Prot:

GGT3_HUMAN :
  • Belongs to the gamma-glutamyltransferase family.
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGT3P: view

Function for GGT3P Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GGT3P Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione + H(2)O = L-cysteinylglycine + L-glutamate.
UniProtKB/Swiss-Prot Function:
Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.

Enzyme Numbers (IUBMB) for GGT3P Gene

Gene Ontology (GO) - Molecular Function for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003840 gamma-glutamyltransferase activity TAS 18357469
GO:0036374 glutathione hydrolase activity IEA --
genes like me logo Genes that share ontologies with GGT3P: view

Phenotypes for GGT3P Gene

GenomeRNAi human phenotypes for GGT3P:
genes like me logo Genes that share phenotypes with GGT3P: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGT3P Gene

Localization for GGT3P Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT3P Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031362 anchored component of external side of plasma membrane TAS 18357469
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GGT3P: view

No data available for Subcellular locations from COMPARTMENTS for GGT3P Gene

Pathways & Interactions for GGT3P Gene

genes like me logo Genes that share pathways with GGT3P: view

UniProtKB/Swiss-Prot A6NGU5-GGT3_HUMAN

  • Pathway: Sulfur metabolism; glutathione metabolism.

Interacting Proteins for GGT3P Gene

Selected Interacting proteins: A6NGU5-GGT3_HUMAN for GGT3P Gene via IID

Gene Ontology (GO) - Biological Process for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006749 glutathione metabolic process TAS 18357469
GO:0006750 glutathione biosynthetic process IEA --
GO:0019370 leukotriene biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGT3P: view

No data available for SIGNOR curated interactions for GGT3P Gene

Drugs & Compounds for GGT3P Gene

Products:

  1. Drug

(3) Drugs for GGT3P Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Glutathione Approved Nutra 0
L-Glutamic Acid Nutra Full agonist, Agonist 0

(1) Additional Compounds for GGT3P Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cysteinylglycine
  • Cys-Gly
  • L-Cysteinylglycine
  • N-Cysteinyl Glycine
  • N-Cysteinyl-Glycine
  • N-L-Cysteinyl-Glycine
 19246-18-5
genes like me logo Genes that share compounds with GGT3P: view

Transcripts for GGT3P Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GGT3P Gene

(3) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GGT3P Gene

Gamma-glutamyltransferase 3 pseudogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGT3P Gene

No ASD Table

Relevant External Links for GGT3P Gene

GeneLoc Exon Structure for
GGT3P
ECgene alternative splicing isoforms for
GGT3P

Expression for GGT3P Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GGT3P Gene

mRNA expression in normal human tissues for GGT3P Gene
mRNA expression by BioGPS for GGT3P GenemRNA expression by GTEx for GGT3P Gene

mRNA differential expression in normal tissues according to GTEx for GGT3P Gene

This gene is overexpressed in Kidney - Cortex (x24.3) and Thyroid (x15.9).

NURSA nuclear receptor signaling pathways regulating expression of GGT3P Gene:

GGT3P

SOURCE GeneReport for Unigene cluster for GGT3P Gene:

Hs.595809
genes like me logo Genes that share expression patterns with GGT3P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GGT3P Gene

Orthologs for GGT3P Gene

Evolution for GGT3P Gene

ENSEMBL:
Gene Tree for GGT3P (if available)
TreeFam:
Gene Tree for GGT3P (if available)

No data available for Orthologs for GGT3P Gene

Paralogs for GGT3P Gene

(8) SIMAP similar genes for GGT3P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GGT3P: view

No data available for Paralogs for GGT3P Gene

Variants for GGT3P Gene

Sequence variations from dbSNP and Humsavar for GGT3P Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1055042 -- 18,791,099(-) GGGCT(A/G)CCGTG nc-transcript-variant
rs111245818 -- 18,781,690(+) GCCGC(A/G)GCAGG nc-transcript-variant
rs111275046 -- 18,790,211(+) ATAAT(A/T)AGGCC intron-variant
rs111331306 -- 18,782,455(+) AAAGA(-/TATT)TTTTT intron-variant
rs111332704 -- 18,780,603(+) TTTCT(C/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGT3P Gene

Variant ID Type Subtype PubMed ID
esv3328287 CNV duplication 20981092
esv32687 CNV gain+loss 17666407
esv2758824 CNV gain+loss 17122850
esv2751935 CNV loss 17911159
esv2422290 CNV deletion 17116639
esv22247 CNV gain+loss 19812545
dgv99e203 CNV gain+loss 21179565
dgv7963n54 CNV gain 21841781
dgv4469n100 CNV gain 25217958
dgv4468n100 CNV gain+loss 25217958
dgv4467n100 CNV gain 25217958
dgv4466n100 CNV gain+loss 25217958
dgv2566e59 CNV duplication 20981092
dgv2565e59 CNV duplication 20981092
dgv19e196 CNV duplication 17116639
dgv173e55 CNV gain 17911159
dgv169n111 CNV duplication 26073780
dgv1283e212 CNV gain 25503493
nsv979631 CNV duplication 23825009
nsv966136 CNV duplication 23825009
nsv953688 CNV deletion 24416366
nsv953018 CNV duplication 24416366
nsv821058 CNV duplication 20802225
nsv516997 CNV gain+loss 19592680
nsv471594 CNV gain+loss 15918152
nsv471339 CNV gain 19718026
nsv469851 CNV gain 16826518
nsv469578 CNV gain 16826518
nsv428385 CNV gain+loss 18775914
nsv1151039 CNV duplication 26484159
nsv1141410 CNV duplication 24896259
nsv1128852 CNV duplication 24896259
nsv1118686 CNV duplication 24896259
nsv1078507 CNV duplication 25765185
nsv1077932 CNV duplication 25765185
nsv1061694 CNV gain 25217958
nsv1055756 CNV gain 25217958
esv3893432 CNV gain 25118596
esv3584483 CNV gain 24956385
esv3575418 CNV gain 25503493
esv3432286 CNV duplication 20981092
esv3432226 CNV duplication 20981092
esv3422899 CNV duplication 20981092
esv3385979 CNV duplication 20981092
esv3369963 CNV duplication 20981092
esv3369734 CNV duplication 20981092

Relevant External Links for GGT3P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGT3P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GGT3P Gene

Disorders for GGT3P Gene

MalaCards: The human disease database

(1) MalaCards diseases for GGT3P Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
- elite association - COSMIC cancer census association via MalaCards
Search GGT3P in MalaCards View complete list of genes associated with diseases

Relevant External Links for GGT3P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGT3P
genes like me logo Genes that share disorders with GGT3P: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GGT3P Gene

Publications for GGT3P Gene

  1. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3 4 64
  2. Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. (PMID: 8104871) Figlewicz D.A. … Rouleau G.A. (Genomics 1993) 2 3 64
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  4. Characterization of ATP8B1 gene mutations and a hot-linked mutation found in Chinese children with progressive intrahepatic cholestasis and low GGT. (PMID: 20038848) Liu L.Y. … Wang J.S. (J. Pediatr. Gastroenterol. Nutr. 2010) 22 64
  5. Refining the 22q11.2 deletion breakpoints in DiGeorge syndrome by aCGH. (PMID: 19420922) Bittel D.C. … Cooley L.D. (Cytogenet. Genome Res. 2009) 22 64

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