Aliases for GGT3P Gene
Aliases for GGT3P Gene
External Ids for GGT3P Gene
- HGNC: 4252
- Entrez Gene: 2679
- Ensembl: ENSG00000197421
- UniProtKB: A6NGU5
Previous HGNC Symbols for GGT3P Gene
- GGT3
Previous GeneCards Identifiers for GGT3P Gene
- GC22M017143
- GC22M018765
Summaries for GGT3P Gene
GeneCards Summary for GGT3P Gene
GGT3P (Gamma-Glutamyltransferase 3 Pseudogene) is a Pseudogene. Diseases associated with GGT3P include Intrahepatic Cholestasis. Among its related pathways are Glutathione metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include obsolete gamma-glutamyltransferase activity and glutathione hydrolase activity.
UniProtKB/Swiss-Prot for GGT3P Gene
-
Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT3P Gene
Genomics for GGT3P Gene
GeneHancer (GH) Regulatory Elements for GGT3P Gene
Promoters and enhancers for GGT3P Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH22I018833 | Promoter | 0.5 | Ensembl | 0.4 | +9.9 | 9898 | 0.2 | E2F6P1 PIRC107 GGT3P |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GGT3P on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GGT3P Gene
Genomic Locations for GGT3P Gene
- chr22:18,773,665-18,843,399
- (GRCh38/hg38)
- Size:
- 69,735 bases
- Orientation:
- Minus strand
- chr22:18,761,178-18,830,912
- (GRCh37/hg19)
Genomic View for GGT3P Gene
Genes around GGT3P on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by Ensembl
- 22q11.21 by Entrez Gene
- 22q11.21 by HGNC
GGT3P Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GGT3P Gene
Proteins for GGT3P Gene
-
Protein details for GGT3P Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NGU5-GGT3_HUMAN
- Recommended name:
- Putative glutathione hydrolase 3 proenzyme
- Protein Accession:
- A6NGU5
Protein attributes for GGT3P Gene
- Size:
- 568 amino acids
- Molecular mass:
- 61502 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- In some epileptic patients treated with phenytoin, phenobarbital and carbamazepin, GGT3 is found, as an additional form of GGT. This group of patients has levels of ceruloplasmin and oxidase activity that were significantly higher than in the group of patients without GGT3. However, levels of ceruloplasmin and oxidase activity are significantly higher in this group of patients without GGT3 than those of the control group.
Selected DME Specific Peptides for GGT3P Gene
- A6NGU5:
-
- GFPVGKGLA
- LCEVFCR
- PSPANFI
- VDAAIAAL
- PEFYTPDD
- LTYHRIVEAFRFAYAKRT
- VVQAIVRT
- GGLSVAVPGEI
- GLCLWLPS
- TIYNSTT
- ATSTINLYFGSKV
- VTEVVRNM
- LILNILKGYNFS
- DDGGTAHLS
Post-translational modifications for GGT3P Gene
- Cleaved by autocatalysis into a large and a small subunit.
- Glycosylation at isoforms=95, isoforms=120, isoforms=230, isoforms=266, posLast=297297, posLast=344344, and isoforms=510
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Assay Products
Domains & Families for GGT3P Gene
Gene Families for GGT3P Gene
Protein Domains for GGT3P Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GGT3P Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A6NGU5- Family:
-
- Belongs to the gamma-glutamyltransferase family.
Function for GGT3P Gene
Molecular function for GGT3P Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Glutathione + H(2)O = L-cysteinylglycine + L-glutamate.
- UniProtKB/Swiss-Prot Function:
- Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.
Enzyme Numbers (IUBMB) for GGT3P Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0036374 | glutathione hydrolase activity | IEA | -- |
| GO:0102953 | hypoglycin A gamma-glutamyl transpeptidase activity | IEA | -- |
Phenotypes for GGT3P Gene
- GenomeRNAi human phenotypes for GGT3P:
Animal Model Products
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-
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Vectors and viruses for KO, Activation, Repression, and more
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GGT3P gene related products
- orf clones - Search results for available GGT3P gene related products
- Applied Biological Materials Clones for GGT3P
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGT3P Gene
Localization for GGT3P Gene
Subcellular locations from UniProtKB/Swiss-Prot for GGT3P Gene
- Membrane; Single-pass type II membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GGT3P Gene
Pathways & Interactions for GGT3P Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type | ||
| 2 | Glutathione metabolism | ||
| 3 | Aflatoxin activation and detoxification | ||
| 4 | Metabolism |
.37
|
|
Pathways by source for GGT3P Gene
6 Reactome pathways for GGT3P Gene
UniProtKB/Swiss-Prot A6NGU5-GGT3_HUMAN
- Pathway: Sulfur metabolism; glutathione metabolism.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006750 | glutathione biosynthetic process | IEA | -- |
| GO:0006751 | glutathione catabolic process | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:1901750 | leukotriene D4 biosynthetic process | ISS | -- |
No data available for SIGNOR curated interactions for GGT3P Gene
Drugs & Compounds for GGT3P Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| cysteinylglycine |
|
19246-18-5 |
|
Transcripts for GGT3P Gene
mRNA/cDNA for GGT3P Gene
- (3) Additional mRNA sequences :
- (35) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GGT3P Gene
CRISPR Products
- Browse CRISPR knockouts for GGT3P
- genomics-online: gRNA clones - Search results for available GGT3P gene related products
- Applied Biological Materials CRISPR for GGT3P
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for GGT3P
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for GGT3P
- Browse OriGene Inhibitory RNA Products For GGT3P
- genomics-online: shRNA clones - Search results for available GGT3P gene related products
- Search ViGene Biosciences for GGT3P
Clone Products
- GenScript: Custom all cDNA clones Services for GGT3P
- VectorBuilder custom plasmid, inducible vectors for GGT3P
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GGT3P
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GGT3P gene related products
- orf clones - Search results for available GGT3P gene related products
- Applied Biological Materials Clones for GGT3P
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GGT3P Gene
mRNA differential expression in normal tissues according to GTEx for GGT3P Gene
This gene is overexpressed in Kidney - Cortex (x24.3) and Thyroid (x15.9).
NURSA nuclear receptor signaling pathways regulating expression of GGT3P Gene:
GGT3PSOURCE GeneReport for Unigene cluster for GGT3P Gene:
Hs.595809Primer Products
- genomics-online: primer clones - Search results for available GGT3P gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGT3P Gene
Orthologs for GGT3P Gene
No data available for Orthologs for GGT3P Gene
Paralogs for GGT3P Gene
(8) SIMAP similar genes for GGT3P Gene using alignment to 1 proteins:
No data available for Paralogs for GGT3P Gene
Variants for GGT3P Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000175684 | -- | 18,776,403(-) | T/C | intron_variant | |
| rs1000227865 | -- | 18,775,174(-) | G/A | non_coding_transcript_variant | |
| rs1001134131 | -- | 18,783,715(-) | G/T | intron_variant | |
| rs1001227425 | -- | 18,781,859(-) | GG/G | intron_variant | |
| rs1005483885 | -- | 18,780,480(-) | T/G | intron_variant |
Additional Variant Information for GGT3P Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GGT3P
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GGT3P Gene
Disorders for GGT3P Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| intrahepatic cholestasis |
|
Search GGT3P in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GGT3P
No data available for UniProtKB/Swiss-Prot and Genatlas for GGT3P Gene
Publications for GGT3P Gene
- The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N … Sneddon TP (Human genetics 2008) 2 3 4 58
- Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. (PMID: 8104871) Figlewicz DA … Rouleau GA (Genomics 1993) 2 3 58
- In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
- Characterization of ATP8B1 gene mutations and a hot-linked mutation found in Chinese children with progressive intrahepatic cholestasis and low GGT. (PMID: 20038848) Liu LY … Wang JS (Journal of pediatric gastroenterology and nutrition 2010) 22 58
- Refining the 22q11.2 deletion breakpoints in DiGeorge syndrome by aCGH. (PMID: 19420922) Bittel DC … Cooley LD (Cytogenetic and genome research 2009) 22 58
Products for GGT3P Gene
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- VectorBuilder custom plasmid, inducible vectors for GGT3P
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available GGT3P related products ranked by validation data
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Sources for GGT3P Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
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- (63) Novus Biologicals
- (64) ProSpec
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- (66) GenScript
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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- (92) COMPARTMENTS
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- (95) ApexBio
- (96) Addgene
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- (98) CYP
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- (100) SwitchGear Genomics
- (101) TreeFam
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- (105) Taconic Biosciences
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- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew