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Aliases for GGT3P Gene

Aliases for GGT3P Gene

  • Gamma-Glutamyltransferase 3 Pseudogene 2 3 5
  • Gamma-Glutamyltransferase 3 2 4
  • EC 2.3.2.2 4 63
  • GGT3 3 4
  • Glutathione Hydrolase 3 4
  • EC 3.4.19.13 4
  • GGT 3 4

External Ids for GGT3P Gene

Previous HGNC Symbols for GGT3P Gene

  • GGT3

Previous GeneCards Identifiers for GGT3P Gene

  • GC22M017143
  • GC22M018765

Summaries for GGT3P Gene

GeneCards Summary for GGT3P Gene

GGT3P (Gamma-Glutamyltransferase 3 Pseudogene) is a Pseudogene. Diseases associated with GGT3P include intrahepatic cholestasis. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include gamma-glutamyltransferase activity and glutathione hydrolase activity.

UniProtKB/Swiss-Prot for GGT3P Gene

  • Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT3P Gene

Genomics for GGT3P Gene

Regulatory Elements for GGT3P Gene

Genomic Location for GGT3P Gene

Chromosome:
22
Start:
18,773,665 bp from pter
End:
18,843,399 bp from pter
Size:
69,735 bases
Orientation:
Minus strand

Genomic View for GGT3P Gene

Genes around GGT3P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGT3P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGT3P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGT3P Gene

Proteins for GGT3P Gene

  • Protein details for GGT3P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGU5-GGT3_HUMAN
    Recommended name:
    Putative gamma-glutamyltranspeptidase 3
    Protein Accession:
    A6NGU5

    Protein attributes for GGT3P Gene

    Size:
    568 amino acids
    Molecular mass:
    61502 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • In some epileptic patients treated with phenytoin, phenobarbital and carbamazepin, GGT3 is found, as an additional form of GGT. This group of patients has levels of ceruloplasmin and oxidase activity that were significantly higher than in the group of patients without GGT3. However, levels of ceruloplasmin and oxidase activity are significantly higher in this group of patients without GGT3 than those of the control group.

neXtProt entry for GGT3P Gene

Proteomics data for GGT3P Gene at MOPED

Post-translational modifications for GGT3P Gene

  • Cleaved by autocatalysis into a large and a small subunit.
  • Glycosylation at Asn 95, Asn 120, Asn 230, Asn 266, Asn 297, Asn 344, and Asn 510

Domains & Families for GGT3P Gene

Gene Families for GGT3P Gene

Protein Domains for GGT3P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGT3P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGU5

UniProtKB/Swiss-Prot:

GGT3_HUMAN :
  • Belongs to the gamma-glutamyltransferase family.
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGT3P: view

Function for GGT3P Gene

Molecular function for GGT3P Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione + H(2)O = L-cysteinylglycine + L-glutamate.
UniProtKB/Swiss-Prot Function:
Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.

Enzyme Numbers (IUBMB) for GGT3P Gene

Phenotypes for GGT3P Gene

genes like me logo Genes that share phenotypes with GGT3P: view

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGT3P Gene

Localization for GGT3P Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT3P Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GGT3P: view

No data available for Subcellular locations from COMPARTMENTS for GGT3P Gene

Pathways & Interactions for GGT3P Gene

genes like me logo Genes that share pathways with GGT3P: view

UniProtKB/Swiss-Prot A6NGU5-GGT3_HUMAN

  • Pathway: Sulfur metabolism; glutathione metabolism.

Interacting Proteins for GGT3P Gene

Gene Ontology (GO) - Biological Process for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006749 glutathione metabolic process TAS 18357469
GO:0019370 leukotriene biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGT3P: view

No data available for SIGNOR curated interactions for GGT3P Gene

Drugs & Compounds for GGT3P Gene

(2) Drugs for GGT3P Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra 0
L-Glutamic Acid Nutra Full agonist, Agonist 0

(2) Additional Compounds for GGT3P Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cysteinylglycine
  • Cys-Gly
  • L-Cysteinylglycine
  • N-Cysteinyl Glycine
  • N-Cysteinyl-Glycine
  • N-L-Cysteinyl-Glycine
19246-18-5
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with GGT3P: view

Transcripts for GGT3P Gene

mRNA/cDNA for GGT3P Gene

Unigene Clusters for GGT3P Gene

Gamma-glutamyltransferase 3 pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GGT3P Gene

No ASD Table

Relevant External Links for GGT3P Gene

GeneLoc Exon Structure for
GGT3P
ECgene alternative splicing isoforms for
GGT3P

Expression for GGT3P Gene

mRNA expression in normal human tissues for GGT3P Gene

mRNA differential expression in normal tissues according to GTEx for GGT3P Gene

This gene is overexpressed in Kidney - Cortex (x24.3) and Thyroid (x15.9).

SOURCE GeneReport for Unigene cluster for GGT3P Gene Hs.595809

genes like me logo Genes that share expression patterns with GGT3P: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GGT3P Gene

Orthologs for GGT3P Gene

Evolution for GGT3P Gene

ENSEMBL:
Gene Tree for GGT3P (if available)
TreeFam:
Gene Tree for GGT3P (if available)

No data available for Orthologs for GGT3P Gene

Paralogs for GGT3P Gene

(8) SIMAP similar genes for GGT3P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GGT3P: view

No data available for Paralogs for GGT3P Gene

Variants for GGT3P Gene

Sequence variations from dbSNP and Humsavar for GGT3P Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs25254 -- 18,773,568(+) CAGTG(C/T)CCGCA downstream-variant-500B
rs645874 -- 18,791,313(+) AAGTC(A/G)GGCCT intron-variant
rs645912 -- 18,791,334(+) AGGCC(G/T)GTGTC intron-variant
rs647657 -- 18,778,577(+) CCCAC(A/C/G)AGTCC intron-variant
rs429047 -- 18,786,302(+) ctcac(A/T)gcaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGT3P Gene

Variant ID Type Subtype PubMed ID
nsv428385 CNV Gain+Loss 18775914
dgv1380e1 CNV Complex 17122850
nsv471594 CNV Gain+Loss 15918152
nsv516997 CNV Gain+Loss 19592680
esv2751935 CNV Loss 17911159
dgv173e55 CNV Gain 17911159
esv32687 CNV Gain+Loss 17666407
dgv4820n71 CNV Gain 21882294
nsv471339 CNV Duplication 19718026
nsv914164 CNV Gain 21882294
esv22247 CNV Gain+Loss 19812545
dgv4821n71 CNV Gain 21882294
nsv469578 CNV Gain 16826518
nsv469851 CNV Gain 16826518
dgv4822n71 CNV Gain 21882294
esv2422290 CNV Deletion 17116639
dgv19e196 CNV Duplication 17116639
nsv821058 CNV Duplication 20802225

Relevant External Links for GGT3P Gene

HapMap Linkage Disequilibrium report
GGT3P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GGT3P Gene

Disorders for GGT3P Gene

MalaCards: The human disease database

(1) MalaCards diseases for GGT3P Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
- elite association - COSMIC cancer census association via MalaCards
Search GGT3P in MalaCards View complete list of genes associated with diseases

Relevant External Links for GGT3P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGT3P
genes like me logo Genes that share disorders with GGT3P: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GGT3P Gene

Publications for GGT3P Gene

  1. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3 4 67
  2. Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. (PMID: 8104871) Figlewicz D.A. … Rouleau G.A. (Genomics 1993) 2 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. Characterization of ATP8B1 gene mutations and a hot-linked mutation found in Chinese children with progressive intrahepatic cholestasis and low GGT. (PMID: 20038848) Liu L.Y. … Wang J.S. (J. Pediatr. Gastroenterol. Nutr. 2010) 23
  5. Refining the 22q11.2 deletion breakpoints in DiGeorge syndrome by aCGH. (PMID: 19420922) Bittel D.C. … Cooley L.D. (Cytogenet. Genome Res. 2009) 23

Products for GGT3P Gene

Sources for GGT3P Gene

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