|
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gamma-glutamyltransferase 3 pseudogene(Previous name: gamma-glutamyltransferase 3 )
(Previous symbol: GGT3)
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Aliases
for GGT3P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Gamma-Glutamyltransferase 3 Pseudogene1 2 | | EC 3.4.19.133 | | GGT31 2 3 | | GGT 33 | | Gamma-Glutamyltransferase 31 3 | | Glutathione Hydrolase 33 | | EC 2.3.2.23 8 | | |
Export aliases for GGT3P gene to outside databasesPrevious GC identifer: GC22M017143 |
Summaries
for GGT3P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GGT3_HUMAN, A6NGU5Function: Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety ofglutathione to amino acids and dipeptide acceptors (By similarity)
|
Genomic Views
for GGT3P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011519.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GGT3P gene promoter:
AhR HOXA9 HOXA9B GATA-2 Arnt Meis-1b IRF-2 CBF-A CBF(2) Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GGT3P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GGT3P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21GGT3P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M018765: view genomic region
(about GC identifiers)
Start:
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18,761,178 bp from pter |
End:
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18,830,912 bp from pter |
Size:
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69,735 bases |
Orientation:
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minus strand |
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Proteins
for GGT3P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GGT3_HUMAN, A6NGU5 (See
protein sequence)Recommended Name: Putative gamma-glutamyltranspeptidase 3 precursor Size: 568 amino acids; 61502 Da
Subcellular location: Membrane; Single-pass type II membrane protein (By similarity)
Miscellaneous: In some epileptic patients treated with phenytoin, phenobarbital and carbamazepin, GGT3 is found, as anadditional form of GGT. This group of patients has levels of ceruloplasmin and oxidase activity that weresignificantly higher than in the group of patients without GGT3. However, levels of ceruloplasmin and oxidase activityare significantly higher in this group of patients without GGT3 than those of the control group
Caution: Could be the product of a pseudogene. According to PubMed:18357469, it is not functionalExplore the universe of human proteins at neXtProt for GGT3P: NX_A6NGU5
4/14 DME Specific Peptides for GGT3P (A6NGU5) (see all 14)
GGT3P Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- | | GO:0031362 | anchored to external side of plasma membrane |
TAS | 18357469 |
GGT3P for ontologies About GeneDecksing
GGT3P Antibody Products:
Assay Products for GGT3P: |
Protein
Domains /
Families
for GGT3P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GGT3P for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NGU5ProtoNet protein and cluster: A6NGU5 UniProtKB/Swiss-Prot: GGT3_HUMAN, A6NGU5Similarity: Belongs to the gamma-glutamyltransferase family |
Function
for GGT3P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GGT3_HUMAN, A6NGU5Function: Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety ofglutathione to amino acids and dipeptide acceptors (By similarity)Catalytic activity: A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acidCatalytic activity: Glutathione + H(2)O = L-cysteinylglycine + L-glutamateEnzyme Numbers (IUBMB): EC 2.3.2.21 2 EC 3.4.19.131
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGT3P |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
GGT3P for ontologies About GeneDecksing
|
Pathways & Interactions
for GGT3P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | gamma-glutamyl cycle | | | 2 | leukotriene biosynthesis | |
2  BioSystems Pathways for GGT3P
UniProtKB/Swiss-Prot: GGT3_HUMAN, A6NGU5Pathway: Sulfur metabolism; glutathione metabolismInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GGT3P
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
GGT3P for ontologies About GeneDecksing
|
Drugs & Compounds
for GGT3P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GGT3P
2 HMDB Compounds for GGT3P About this table
Search CenterWatch for drugs/clinical trials and news about GGT3P
|
Transcripts
for GGT3P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for GGT3P: Gamma-glutamyltransferase 3 pseudogene Hs.595809 [show with all ESTs]Unigene Representative Sequence: NR_0032674 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000412448(uc010gri.1 uc011ago.1 uc011agp.1 uc002zob.1)
ENST00000453783 ENST00000445651 ENST00000430306
Additional cDNA sequence: BC108264.1 BC143607.1 NR_003267.1 13 DOTS entries: DT.120642084 DT.100034647 DT.120642058 DT.120642063 DT.75136348 DT.100669183 DT.100843149 DT.102839611 DT.120668227 DT.87016250 DT.100016221 DT.100669181 DT.70103474 24/35 AceView cDNA sequences (see all 35): CR613324 BU584289 BV199127 BV198359 BV193587 BF884661 M30474 BQ016232 AA775790 BV181075 BV176035 BV196122 BV198360 BV198943 BV185406 BU584622 CD620126 AA917932 BE171984 AW611477 AW242750 BF515607 H27285 BV194493
GeneLoc Exon Structure
|
Expression
for GGT3P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GGT3P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for GGT3P
SOURCE GeneReport for Unigene cluster: Hs.595809
SABiosciences Custom PCR Arrays for GGT3P
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GGT3P
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat GGT3P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GGT3P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GGT3P | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGT3P |
Orthologs
for GGT3P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GGT3P gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
CF593197.12 |
-- |
74.16(n) |
|
CF593197.1 |
Species with no ortholog for GGT3P
ENSEMBL Gene Tree for GGT3P (if available)
TreeFam Gene Tree for GGT3P (if available) |
Paralogs
for GGT3P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GGT3P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GGT3P (18761178 - 18830912 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 21 variations for GGT3P
15/21 CNVs (see all 21): 5450 3237 79445 90878 34485 73703 90879 4116 79446 0815 73706 2260 73708 31070 2259 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for GGT3P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GGT3P for disorders About GeneDecksing
17  diseases for GGT3P: About MalaCardsopen-angle glaucoma benign recurrent intrahepatic cholestasis primary open angle glaucoma intrahepatic cholestasis
familial adenomatous polyposis cholestasis stickler syndrome hyperthyroxinemia
glaucoma digeorge syndrome insulin resistance gastroduodenitis
polyposis medulloblastoma alzheimer's disease hepatitis
alcoholism
1 Novoseek disease relationship for GGT3P gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cholestasis intrahepatic |
72 |
5 |
20038848 (4), 11867191 (1) |
Export disorders for GGT3P gene to outside databases
|
Publications
for GGT3P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GGT3P gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with GGT3P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human gamma-glutamyltransferase gene family. (PubMed id 18357469)1, 2, 3 Heisterkamp N.... Sneddon T.P. (2008)
- Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. (PubMed id 8104871)1, 3 Figlewicz D.A....Rouleau G.A. (1993)
- siRNA knock-down of gamma-glutamyl transpeptidase does not affect hypoxic K+ channel inhibition. (PubMed id 14715246)1 Williams S.E....Kemp P.J. (2004)
- Assessment of copper status in epileptic patients treated with anticonvulsant drugs by measuring the specific oxidase activity of ceruloplasmin. (PubMed id 14642999)2 Tutor-Crespo M.J....Tutor J.C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
- Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney. (PubMed id 2573352)1 Pawlak A.... Guellaen G. (1989)
- Characterization of ATP8B1 gene mutations and a hot-l inked mutation found in Chinese children with progressive intrahepatic cholesta sis and low GGT. (PubMed id 20038848)9 Liu L.Y....Wang J.S. (2010)
- Characterization of the extracellular gamma-glutamyl transpeptidases, GGT1 and GGT2, in Arabidopsis. (PubMed id 17316175)9 Ohkama-Ohtsu N....Oliver D.J. (2007)
|
External Searches for GGT3P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GGT3P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GGT3P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GGT3P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GGT3P gene:
Search GeneIP for patents involving GGT3P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GGT3P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GGT3P | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GGT3P | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GGT3P | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GGT3P | | Browse OriGene Myc/DDK tagged cDNA clones in CMV expression vector | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GGT3P | | OriGene Custom Protein Services for GGT3P | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GGT3P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GGT3P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GGT3P | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GGT3P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GGT3P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GGT3P |
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 |  |  |  | |
| | | | Search Tocris compounds for GGT3P |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGT3P |
|  |  |  | | | | Search ThermoFisher Antibodies for GGT3P |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GGT3P |
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