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Aliases for GGT3P Gene

Aliases for GGT3P Gene

  • Gamma-Glutamyltransferase 3 Pseudogene 2 3
  • Gamma-Glutamyltransferase 3 2 4
  • EC 2.3.2.2 4 63
  • GGT3 3 4
  • Glutathione Hydrolase 3 4
  • EC 3.4.19.13 4
  • GGT 3 4

External Ids for GGT3P Gene

Previous HGNC Symbols for GGT3P Gene

  • GGT3

Previous GeneCards Identifiers for GGT3P Gene

  • GC22M017143

Summaries for GGT3P Gene

GeneCards Summary for GGT3P Gene

GGT3P (Gamma-Glutamyltransferase 3 Pseudogene) is a Pseudogene. Diseases associated with GGT3P include hyperthyroxinemia and stickler syndrome. GO annotations related to this gene include gamma-glutamyltransferase activity and glutathione hydrolase activity.

UniProtKB/Swiss-Prot for GGT3P Gene

  • Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT3P Gene

Genomics for GGT3P Gene

Regulatory Elements for GGT3P Gene

Genomic Location for GGT3P Gene

Start:
18,773,665 bp from pter
End:
18,843,399 bp from pter
Size:
69,735 bases
Orientation:
Minus strand

Genomic View for GGT3P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGT3P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGT3P Gene

Proteins for GGT3P Gene

  • Protein details for GGT3P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGU5-GGT3_HUMAN
    Recommended name:
    Putative gamma-glutamyltranspeptidase 3
    Protein Accession:
    A6NGU5
    Secondary Accessions:

    Protein attributes for GGT3P Gene

    Size:
    568 amino acids
    Molecular mass:
    61502 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • In some epileptic patients treated with phenytoin, phenobarbital and carbamazepin, GGT3 is found, as an additional form of GGT. This group of patients has levels of ceruloplasmin and oxidase activity that were significantly higher than in the group of patients without GGT3. However, levels of ceruloplasmin and oxidase activity are significantly higher in this group of patients without GGT3 than those of the control group

neXtProt entry for GGT3P Gene

Proteomics data for GGT3P Gene at MOPED

Post-translational modifications for GGT3P Gene

  • Cleaved by autocatalysis into a large and a small subunit.
  • Glycosylation at Asn95, Asn120, Asn230, Asn266, Asn297, Asn344, and Asn510

Domains for GGT3P Gene

Gene Families for GGT3P Gene

HGNC:
  • GGT :Gamma-glutamyltransferases

Protein Domains for GGT3P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGT3P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGU5

UniProtKB/Swiss-Prot:

GGT3_HUMAN :
  • A6NGU5
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGT3P: view

Function for GGT3P Gene

Molecular function for GGT3P Gene

UniProtKB/Swiss-Prot CatalyticActivity: A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid
UniProtKB/Swiss-Prot CatalyticActivity: Glutathione + H(2)O = L-cysteinylglycine + L-glutamate
UniProtKB/Swiss-Prot Function: Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.

Enzyme Numbers (IUBMB) for GGT3P Gene

Gene Ontology (GO) - Molecular Function for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003840 gamma-glutamyltransferase activity TAS 18357469
GO:0036374 glutathione hydrolase activity IEA --
genes like me logo Genes that share ontologies with GGT3P: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GGT3P Gene

Localization for GGT3P Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT3P Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031362 anchored component of external side of plasma membrane TAS 18357469
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GGT3P: view

No data available for Subcellular locations from COMPARTMENTS for GGT3P Gene

Pathways for GGT3P Gene

SuperPathways for GGT3P Gene

No Data Available

UniProtKB/Swiss-Prot A6NGU5-GGT3_HUMAN

  • Pathway: Sulfur metabolism; glutathione metabolism

Interacting Proteins for GGT3P Gene

Gene Ontology (GO) - Biological Process for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006749 glutathione metabolic process TAS 18357469
GO:0006750 glutathione biosynthetic process IEA --
GO:0019370 leukotriene biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGT3P: view

No data available for Pathways by source for GGT3P Gene

Compounds for GGT3P Gene

(2) HMDB Compounds for GGT3P Gene

Compound Synonyms Cas Number PubMed IDs
Leukotriene C5
  • LTC(,5)
75207-09-9
Leukotriene D5
  • LTD(,5)
Not Available
genes like me logo Genes that share compounds with GGT3P: view

Transcripts for GGT3P Gene

Unigene Clusters for GGT3P Gene

Gamma-glutamyltransferase 3 pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GGT3P Gene

No ASD Table

Relevant External Links for GGT3P Gene

GeneLoc Exon Structure for
GGT3P
ECgene alternative splicing isoforms for
GGT3P

Expression for GGT3P Gene

mRNA expression in normal human tissues for GGT3P Gene

mRNA differential expression in normal tissues according to GTEx for GGT3P Gene

This gene is overexpressed in Kidney - Cortex (24.3) and Thyroid (15.9).

SOURCE GeneReport for Unigene cluster for GGT3P Gene Hs.595809

genes like me logo Genes that share expressions with GGT3P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for GGT3P Gene

Orthologs for GGT3P Gene

Evolution for GGT3P Gene

ENSEMBL:
Gene Tree for GGT3P (if available)
TreeFam:
Gene Tree for GGT3P (if available)

No data available for Orthologs for GGT3P Gene

Paralogs for GGT3P Gene

Selected SIMAP similar genes for GGT3P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GGT3P: view

No data available for Paralogs for GGT3P Gene

Variants for GGT3P Gene

Sequence variations from dbSNP and Humsavar for GGT3P Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs25254 -- 18,773,568(+) CAGTG(C/T)CCGCA downstream-variant-500B
rs173388 -- 18,789,497(+) agcta(G/T)gatca intron-variant
rs243422 -- 18,790,081(+) Aagcc(A/G)ggcgt intron-variant
rs243423 -- 18,790,611(+) cgctt(G/T)aactt intron-variant
rs243424 -- 18,790,643(+) actga(A/G)attgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGT3P Gene

Variant ID Type Subtype PubMed ID
nsv428385 CNV Gain+Loss 18775914
dgv1380e1 CNV Complex 17122850
nsv471594 CNV Gain+Loss 15918152
nsv516997 CNV Gain+Loss 19592680
esv2751935 CNV Loss 17911159
dgv173e55 CNV Gain 17911159
esv32687 CNV Gain+Loss 17666407
dgv4820n71 CNV Gain 21882294
nsv471339 CNV Duplication 19718026
nsv914164 CNV Gain 21882294
esv22247 CNV Gain+Loss 19812545
dgv4821n71 CNV Gain 21882294
nsv469578 CNV Gain 16826518
nsv469851 CNV Gain 16826518
dgv4822n71 CNV Gain 21882294
esv2422290 CNV Deletion 17116639
dgv19e196 CNV Duplication 17116639
nsv821058 CNV Duplication 20802225

Relevant External Links for GGT3P Gene

HapMap Linkage Disequilibrium report
GGT3P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGT3P Gene

Disorders for GGT3P Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for GGT3P Gene including...

Search for GGT3P Gene in MalaCards »

(1) Novoseek inferred disease relationships for GGT3P Gene

Disease -log(P) Hits PubMed IDs
cholestasis intrahepatic 72 5
genes like me logo Genes that share disorders with GGT3P: view

No data available for UniProtKB/Swiss-Prot for GGT3P Gene

Publications for GGT3P Gene

  1. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3 4
  2. Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. (PMID: 8104871) Figlewicz D.A. … Rouleau G.A. (Genomics 1993) 2 3
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. siRNA knock-down of gamma-glutamyl transpeptidase does not affect hypoxic K+ channel inhibition. (PMID: 14715246) Williams S.E. … Kemp P.J. (Biochem. Biophys. Res. Commun. 2004) 3

Products for GGT3P Gene

Sources for GGT3P Gene

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