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Aliases for GGT1 Gene

Aliases for GGT1 Gene

  • Gamma-Glutamyltransferase 1 2 3 4 5
  • Leukotriene-C4 Hydrolase 3 4
  • Glutathione Hydrolase 1 3 4
  • EC 2.3.2.2 4 61
  • GGT 1 3 4
  • GGT 3 4
  • Testicular Tissue Protein Li 73 3
  • Gamma-Glutamyltranspeptidase 1 3
  • CD224 Antigen 4
  • EC 3.4.19.13 4
  • EC 3.4.19.14 4
  • D22S672 3
  • D22S732 3
  • CD224 3
  • GTG 3

External Ids for GGT1 Gene

Previous HGNC Symbols for GGT1 Gene

  • GGT

Previous GeneCards Identifiers for GGT1 Gene

  • GC22P021675
  • GC22M021675
  • GC22P023304
  • GC22P024980
  • GC22P007929

Summaries for GGT1 Gene

Entrez Gene Summary for GGT1 Gene

  • The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]

GeneCards Summary for GGT1 Gene

GGT1 (Gamma-Glutamyltransferase 1) is a Protein Coding gene. Diseases associated with GGT1 include Glutathionuria and Alcohol Abuse. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include gamma-glutamyltransferase activity and glutathione hydrolase activity. An important paralog of this gene is GGT2.

UniProtKB/Swiss-Prot for GGT1 Gene

  • Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.

Gene Wiki entry for GGT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT1 Gene

Genomics for GGT1 Gene

Regulatory Elements for GGT1 Gene

Enhancers for GGT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F024600 1 ENCODE 30.7 +19.2 19166 4.1 HDGF ZNF133 ARID4B FEZF1 DMAP1 ZNF48 ZNF121 GLIS2 ZNF263 SP3 GGT1 LRRC75B CHCHD10 ENSG00000230947 BCRP3
GH22F024591 1 ENCODE 27.9 +9.6 9554 2.7 MLX SIN3A ARID4B ZNF48 YY1 GLIS2 PAF1 SP3 SP5 MIER2 GGT1 ENSG00000230947 LRRC75B
GH22F024630 1.3 Ensembl ENCODE 19.3 +49.3 49251 6.0 HDGF PKNOX1 ARNT ARID4B GLI4 ZNF121 ZNF207 ZNF143 KLF7 KDM4B GGT1 LOC105372966 ZNF70 ENSG00000272578 SNRPD3 ENSG00000232545 CRYBB2P1 POM121L10P BCRP3 PIRC111
GH22F024548 1.8 FANTOM5 Ensembl ENCODE 12.7 -30.3 -30289 8.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF70 SNRPD3 GGTLC4P POM121L9P MIF-AS1 ARL5AP4 LOC100421614 CRIP1P4 RPS10P29 ENSG00000228039
GH22F024606 1.1 Ensembl ENCODE 19.7 +23.8 23752 2.2 HDGF PKNOX1 ATF1 KLF17 SIN3A ZNF121 GLIS2 CREM ZNF263 USF2 GGT1 ENSG00000230947 BCRP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GGT1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GGT1 gene promoter:

Genomic Location for GGT1 Gene

Chromosome:
22
Start:
24,583,750 bp from pter
End:
24,629,005 bp from pter
Size:
45,256 bases
Orientation:
Plus strand

Genomic View for GGT1 Gene

Genes around GGT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGT1 Gene

Proteins for GGT1 Gene

  • Protein details for GGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19440-GGT1_HUMAN
    Recommended name:
    Gamma-glutamyltranspeptidase 1
    Protein Accession:
    P19440
    Secondary Accessions:
    • Q08247
    • Q14404
    • Q8TBS1
    • Q9UMK1

    Protein attributes for GGT1 Gene

    Size:
    569 amino acids
    Molecular mass:
    61410 Da
    Quaternary structure:
    • Heterodimer composed of the light and heavy chains. The active site is located in the light chain.
    Miscellaneous:
    • Chloride ions bound in the active site cavity may contribute to stabilize the protein fold.
    • Cys-454 was thought to bind the gamma-glutamyl moiety, but mutagenesis of this residue had no effect on activity.
    SequenceCaution:
    • Sequence=AAA35899.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GGT1 Gene

    Alternative splice isoforms for GGT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGT1 Gene

Selected DME Specific Peptides for GGT1 Gene

P19440:
  • LCEVFCR
  • VVQAIVRT
  • PGKQPLSSMCP
  • ATSTINLYFGSKV
  • VTEVVRNM
  • LILNILKGYNFS
  • DDGGTAHLS
  • GFPVGKGLA
  • PSPANFI
  • VDAAIAAL
  • PEFYTPDD
  • LTYHRIVEAFRFAYAKRT
  • GGLSVAVPGEI
  • GLCLWLPS
  • TIYNSTT

Post-translational modifications for GGT1 Gene

  • Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.
  • N-glycosylated on both chains. Contains hexoses, hexosamines and sialic acid residues. Glycosylation profiles tested in kidney and liver tissues reveal the presence of tissue-specific and site-specific glycan composition, despite the overlap in composition among the N-glycans. A total of 36 glycan compositions, with 40 unique structures are observed. Up to 15 different glycans are observed at a single site, with site-specific variation in glycan composition. The difference in glycosylation profiles in the 2 tissues do not affect the enzyme activity.
  • Ubiquitination at Lys 181
  • Glycosylation at Asn 95, Asn 120, Asn 230, Asn 266, Asn 297, Asn 344, and Asn 511
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for GGT1 Gene

Gene Families for GGT1 Gene

Protein Domains for GGT1 Gene

Graphical View of Domain Structure for InterPro Entry

P19440

UniProtKB/Swiss-Prot:

GGT1_HUMAN :
  • Belongs to the gamma-glutamyltransferase family.
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGT1: view

Function for GGT1 Gene

Molecular function for GGT1 Gene

GENATLAS Biochemistry:
gamma-glutamyltransferase 1,expressed in placenta,sigmoid tissues,gamma-glutamyl cycle
UniProtKB/Swiss-Prot CatalyticActivity:
A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione + H(2)O = L-cysteinylglycine + L-glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
Leukotriene C(4) + H(2)O = leukotriene D(4) + L-glutamate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autocatalytic cleavage.
UniProtKB/Swiss-Prot Function:
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.

Enzyme Numbers (IUBMB) for GGT1 Gene

Gene Ontology (GO) - Molecular Function for GGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003840 gamma-glutamyltransferase activity IEA,TAS 18357469
GO:0005515 protein binding IPI 15528406
GO:0008233 peptidase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with GGT1: view
genes like me logo Genes that share phenotypes with GGT1: view

Human Phenotype Ontology for GGT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GGT1 Gene

MGI Knock Outs for GGT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GGT1

Inhibitory RNA Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for GGT1 Gene

Localization for GGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT1 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GGT1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031362 anchored component of external side of plasma membrane TAS 18357469
genes like me logo Genes that share ontologies with GGT1: view

Pathways & Interactions for GGT1 Gene

genes like me logo Genes that share pathways with GGT1: view

UniProtKB/Swiss-Prot P19440-GGT1_HUMAN

  • Pathway: Sulfur metabolism; glutathione metabolism.

Gene Ontology (GO) - Biological Process for GGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002682 regulation of immune system process ISS --
GO:0006508 proteolysis IEA --
GO:0006520 cellular amino acid metabolic process TAS 2904146
GO:0006536 glutamate metabolic process IDA 24047895
GO:0006691 leukotriene metabolic process TAS --
genes like me logo Genes that share ontologies with GGT1: view

No data available for SIGNOR curated interactions for GGT1 Gene

Drugs & Compounds for GGT1 Gene

(96) Drugs for GGT1 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Carbon dioxide Approved, Vet_approved Pharma 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 59
Water Approved Pharma 0
Taurine Experimental Nutra Non-selective, endogenous glycine receptor partial agonist 27

(57) Additional Compounds for GGT1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cysteinylglycine
  • Cys-Gly
  • L-Cysteinylglycine
  • N-Cysteinyl Glycine
  • N-Cysteinyl-Glycine
  • N-L-Cysteinyl-Glycine
19246-18-5
5-L-Glutamyl-taurine
  • 5-Glutamyl-taurine
beta-Aminopropionitrile
  • 2-Cyanoethylamine
  • 3-Aminopropanenitrile
  • 3-Aminopropionitrile
  • 3-Aminopropiononitrile
  • Aminopropionitrile
151-18-8
gamma-Glutamyl-beta-aminopropiononitrile
gamma-Glutamyl-beta-cyanoalanine

(1) ApexBio Compounds for GGT1 Gene

Compound Action Cas Number
GGsTop γ-glutamyl transpeptidase (GGT) inhibitor, novel and irreversible 926281-37-0
genes like me logo Genes that share compounds with GGT1: view

Transcripts for GGT1 Gene

Unigene Clusters for GGT1 Gene

Gamma-glutamyltransferase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGT1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2:
SP3: -

Relevant External Links for GGT1 Gene

GeneLoc Exon Structure for
GGT1
ECgene alternative splicing isoforms for
GGT1

Expression for GGT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GGT1 Gene

mRNA differential expression in normal tissues according to GTEx for GGT1 Gene

This gene is overexpressed in Kidney - Cortex (x12.5), Liver (x5.1), and Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for GGT1 Gene

This gene is overexpressed in Urine (17.6), Kidney (17.5), Pancreatic juice (13.4), and Fetal gut (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GGT1 Gene



NURSA nuclear receptor signaling pathways regulating expression of GGT1 Gene:

GGT1

SOURCE GeneReport for Unigene cluster for GGT1 Gene:

Hs.645535

mRNA Expression by UniProt/SwissProt for GGT1 Gene:

P19440-GGT1_HUMAN
Tissue specificity: Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
genes like me logo Genes that share expression patterns with GGT1: view

No data available for Protein tissue co-expression partners for GGT1 Gene

Orthologs for GGT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GGT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGT1 34
  • 98.83 (n)
dog
(Canis familiaris)
Mammalia GGT1 34
  • 85.56 (n)
-- 35
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia GGT1 34
  • 84.15 (n)
-- 35
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ggt1 34 16 35
  • 80.83 (n)
rat
(Rattus norvegicus)
Mammalia Ggt1 34
  • 80.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 67 (a)
OneToMany
GGT1 34
  • 66.6 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ggt1 34
  • 62.61 (n)
zebrafish
(Danio rerio)
Actinopterygii ggt1a 34 35
  • 61.05 (n)
ggt1b 35
  • 56 (a)
ManyToMany
ggt1l2.2 35
  • 50 (a)
ManyToMany
si:dkey-222h21.12 35
  • 48 (a)
ManyToMany
si:ch73-236c18.3 35
  • 45 (a)
ManyToMany
ggt1l2.1 35
  • 41 (a)
ManyToMany
zgc64172 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000853 34
  • 53.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4829 36 34 35
  • 51.45 (n)
CG6461 36
  • 45 (a)
EG:23E12.1 36
  • 42 (a)
CG1492 36 35
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea C53D5.5 36 34 35
  • 48.7 (n)
Y7A9A.1 36 35
  • 36 (a)
T03D8.6 36 35
  • 34 (a)
H14N18.4 35
  • 34 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR144W 34
  • 50.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM38 34 35 37
  • 43.48 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05236g 34
  • 42.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GGT2 34
  • 46.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
ManyToMany
CSA.7538 35
  • 50 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01753 34
  • 49.45 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ggt1 34
  • 45.93 (n)
Species where no ortholog for GGT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GGT1 Gene

ENSEMBL:
Gene Tree for GGT1 (if available)
TreeFam:
Gene Tree for GGT1 (if available)

Paralogs for GGT1 Gene

Variants for GGT1 Gene

Sequence variations from dbSNP and Humsavar for GGT1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1041987 -- 24,627,909(+) ATGGA(C/T)GACTT reference, synonymous-codon
rs1041998 -- 24,627,936(+) ACCAA(C/T)GAGTT reference, synonymous-codon
rs1042004 -- 24,627,948(+) GGGGT(A/C/G)CCCCC reference, synonymous-codon
rs1042062 -- 24,628,830(+) CCTGC(C/T)GGCTA reference, synonymous-codon
rs1062459 -- 24,627,947(+) TGGGG(C/T)ACCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GGT1 Gene

Variant ID Type Subtype PubMed ID
nsv9884 CNV gain+loss 18304495
nsv962775 CNV duplication 23825009
nsv7350 OTHER inversion 18451855
nsv588744 CNV gain 21841781
nsv526567 CNV gain 19592680
nsv482076 CNV gain 20164927
nsv1114314 CNV deletion 24896259
nsv1110863 OTHER inversion 24896259
nsv1057819 CNV gain 25217958
nsv1055830 CNV gain 25217958
esv3893463 CNV gain 25118596
esv3575443 CNV gain 25503493
esv2724069 CNV deletion 23290073
esv2724068 CNV deletion 23290073
esv2724041 CNV deletion 23290073
esv25356 CNV gain 19812545
esv2530395 CNV loss 19546169
esv1162534 CNV deletion 17803354
dgv8039n54 CNV gain 21841781
dgv4528n100 CNV gain 25217958

Variation tolerance for GGT1 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGT1 Gene

Disorders for GGT1 Gene

MalaCards: The human disease database

(50) MalaCards diseases for GGT1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glutathionuria
  • gamma-glutamyltransferase deficiency
alcohol abuse
  • alcoholism
extrahepatic cholestasis
  • extrahepatic biliary stasis
liver disease
  • disorder of liver
obstructive jaundice
  • cholestatic jaundice
- elite association - COSMIC cancer census association via MalaCards
Search GGT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GGT1_HUMAN
  • Glutathionuria (GLUTH) [MIM:231950]: Autosomal recessive disease. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GGT1

Genetic Association Database (GAD)
GGT1
Human Genome Epidemiology (HuGE) Navigator
GGT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGT1
genes like me logo Genes that share disorders with GGT1: view

No data available for Genatlas for GGT1 Gene

Publications for GGT1 Gene

  1. Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species. (PMID: 10392451) Chikhi N. … Laperche Y. (Comp. Biochem. Physiol. 1999) 3 4 22 64
  2. Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit. (PMID: 7759490) Ikeda Y. … Meister A. (J. Biol. Chem. 1995) 3 4 22 64
  3. Involvement of Ser-451 and Ser-452 in the catalysis of human gamma- glutamyl transpeptidase. (PMID: 7673200) Ikeda Y. … Meister A. (J. Biol. Chem. 1995) 3 4 22 64
  4. Human GGT2 does not autocleave into a functional enzyme: a cautionary tale for interpretation of microarray data on redox signaling. (PMID: 23682772) West M.B. … Hanigan M.H. (Antioxid. Redox Signal. 2013) 3 4 64
  5. Novel insights into eukaryotic gamma-glutamyl transpeptidase 1 from the crystal structure of the glutamate-bound human enzyme. (PMID: 24047895) West M.B. … Mooers B.H. (J. Biol. Chem. 2013) 3 4 64

Products for GGT1 Gene

Sources for GGT1 Gene

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