Aliases for GGPS1 Gene
External Ids for GGPS1 Gene
Previous GeneCards Identifiers for GGPS1 Gene
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
GeneCards Summary for GGPS1 Gene
GGPS1 (Geranylgeranyl Diphosphate Synthase 1) is a Protein Coding gene. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include dimethylallyltranstransferase activity and geranyltranstransferase activity.
UniProtKB/Swiss-Prot for GGPS1 Gene
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.