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Aliases for GGNBP2 Gene

Aliases for GGNBP2 Gene

  • Gametogenetin Binding Protein 2 2 3 5
  • Laryngeal Carcinoma-Related Protein 1 3 4
  • Zinc Finger Protein 403 2 3
  • ZNF403 3 4
  • LCRG1 3 4
  • LZK1 3 4
  • Laryngeal Carcinoma Related Gene 1 3
  • Gametogenetin-Binding Protein 2 3
  • C3HC4-Type Zinc Finger Protein 3
  • Protein ZNF403 4
  • ZFP403 3
  • DIF-3 3
  • DIF3 3

External Ids for GGNBP2 Gene

Previous HGNC Symbols for GGNBP2 Gene

  • ZNF403

Previous GeneCards Identifiers for GGNBP2 Gene

  • GC17P031974
  • GC17P034900
  • GC17P030837

Summaries for GGNBP2 Gene

GeneCards Summary for GGNBP2 Gene

GGNBP2 (Gametogenetin Binding Protein 2) is a Protein Coding gene. Diseases associated with GGNBP2 include Chromosome 17Q12 Deletion Syndrome.

UniProtKB/Swiss-Prot for GGNBP2 Gene

  • May be involved in spermatogenesis.

Additional gene information for GGNBP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGNBP2 Gene

Genomics for GGNBP2 Gene

GeneHancer (GH) Regulatory Elements for GGNBP2 Gene

Promoters and enhancers for GGNBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I036543 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 892 4.9 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 SLC30A9 POLR2B GGNBP2 GC17P036546 ZNHIT3 MYO19 DHRS11 GC17M036499
GH17I036102 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 2.3 -438.9 -438883 6.2 PKNOX1 ATF1 SMAD1 KLF17 BMI1 SCRT2 ZNF143 ATF7 IKZF2 RUNX3 CCL4 CCL3 CCL3L3 CCL5 CCL18 CCL15 PIGW SLFN12L MYO19 GGNBP2
GH17I036149 Enhancer 1.4 FANTOM5 Ensembl ENCODE 1.9 -395.5 -395522 0.9 PKNOX1 ZNF2 IRF4 YY1 ZNF213 ZNF207 ZNF143 DEK YY2 REST LOC101927369 CCL4 CCL3 CCL3L3 CCL5 CCL23 GGNBP2 GC17P036146 LOC100420851 ENSG00000282738
GH17I036092 Enhancer 0.9 FANTOM5 ENCODE 1.8 -452.5 -452536 0.5 SRF BACH1 MAFG BATF ATF2 RELA IKZF1 ATF7 NFE2 ETV6 CCL3 CCL3L3 CCL4 CCL18 CCL5 GGNBP2
GH17I036589 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.2 +51.7 51658 13.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B E2F8 DHRS11 GC17P036618 MRM1 ZNHIT3 MYO19 CCL4L2 GGNBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GGNBP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GGNBP2 gene promoter:

Genomic Locations for GGNBP2 Gene

Genomic Locations for GGNBP2 Gene
chr17:36,544,888-36,589,848
(GRCh38/hg38)
Size:
44,961 bases
Orientation:
Plus strand
chr17:34,900,737-34,946,278
(GRCh37/hg19)

Genomic View for GGNBP2 Gene

Genes around GGNBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGNBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGNBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGNBP2 Gene

Proteins for GGNBP2 Gene

  • Protein details for GGNBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3C7-GGNB2_HUMAN
    Recommended name:
    Gametogenetin-binding protein 2
    Protein Accession:
    Q9H3C7
    Secondary Accessions:
    • B2RPK7
    • Q96T90
    • Q9GZR8
    • Q9H767

    Protein attributes for GGNBP2 Gene

    Size:
    697 amino acids
    Molecular mass:
    79086 Da
    Quaternary structure:
    • Interacts with GGN.
    Miscellaneous:
    • Strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines.
    SequenceCaution:
    • Sequence=BAB15031.1; Type=Frameshift; Positions=387; Evidence={ECO:0000305}; Sequence=BAB15397.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC18878.1; Type=Frameshift; Positions=433; Evidence={ECO:0000305};

    Alternative splice isoforms for GGNBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGNBP2 Gene

Post-translational modifications for GGNBP2 Gene

No Post-translational modifications

Other Protein References for GGNBP2 Gene

No data available for DME Specific Peptides for GGNBP2 Gene

Domains & Families for GGNBP2 Gene

Gene Families for GGNBP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GGNBP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGNBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GGNBP2: view

No data available for UniProtKB/Swiss-Prot for GGNBP2 Gene

Function for GGNBP2 Gene

Molecular function for GGNBP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.

Phenotypes From GWAS Catalog for GGNBP2 Gene

genes like me logo Genes that share phenotypes with GGNBP2: view

Animal Models for GGNBP2 Gene

MGI Knock Outs for GGNBP2:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GGNBP2 Gene

Localization for GGNBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGNBP2 Gene

Cytoplasmic vesicle. Note=Associated with vesicular structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GGNBP2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GGNBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA,IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with GGNBP2: view

Pathways & Interactions for GGNBP2 Gene

SuperPathways for GGNBP2 Gene

No Data Available

Interacting Proteins for GGNBP2 Gene

Gene Ontology (GO) - Biological Process for GGNBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010629 negative regulation of gene expression IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GGNBP2: view

No data available for Pathways by source and SIGNOR curated interactions for GGNBP2 Gene

Drugs & Compounds for GGNBP2 Gene

No Compound Related Data Available

Transcripts for GGNBP2 Gene

Unigene Clusters for GGNBP2 Gene

Gametogenetin binding protein 2:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGNBP2 Gene

No ASD Table

Relevant External Links for GGNBP2 Gene

GeneLoc Exon Structure for
GGNBP2
ECgene alternative splicing isoforms for
GGNBP2

Expression for GGNBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GGNBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GGNBP2 Gene

This gene is overexpressed in Testis (38.9) and Peripheral blood mononuclear cells (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GGNBP2 Gene



Protein tissue co-expression partners for GGNBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GGNBP2 Gene:

GGNBP2

SOURCE GeneReport for Unigene cluster for GGNBP2 Gene:

Hs.514116

mRNA Expression by UniProt/SwissProt for GGNBP2 Gene:

Q9H3C7-GGNB2_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed more abundantly in heart, pancreas and skeletal muscle.

Evidence on tissue expression from TISSUES for GGNBP2 Gene

  • Intestine(4.3)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with GGNBP2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGNBP2 Gene

Orthologs for GGNBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GGNBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGNBP2 33
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia GGNBP2 33
  • 95.34 (n)
cow
(Bos Taurus)
Mammalia GGNBP2 33
  • 95.16 (n)
rat
(Rattus norvegicus)
Mammalia Ggnbp2 33
  • 93.73 (n)
mouse
(Mus musculus)
Mammalia Ggnbp2 33 16
  • 92.91 (n)
chicken
(Gallus gallus)
Aves GGNBP2 33
  • 85.54 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ggnbp2 33
  • 68.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15356 33
zebrafish
(Danio rerio)
Actinopterygii ggnbp2 33
  • 66.89 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14063 33
Species where no ortholog for GGNBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GGNBP2 Gene

ENSEMBL:
Gene Tree for GGNBP2 (if available)
TreeFam:
Gene Tree for GGNBP2 (if available)

Paralogs for GGNBP2 Gene

No data available for Paralogs for GGNBP2 Gene

Variants for GGNBP2 Gene

Sequence variations from dbSNP and Humsavar for GGNBP2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000267841 -- 36,546,905(+) G/A intron_variant
rs1000292268 -- 36,582,438(+) G/A intron_variant
rs1000515130 -- 36,558,615(+) T/G intron_variant
rs1000550715 -- 36,563,217(+) G/T intron_variant
rs1000557863 -- 36,569,287(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GGNBP2 Gene

Variant ID Type Subtype PubMed ID
dgv3155n100 CNV gain 25217958
esv2758686 CNV gain+loss 17122850
esv2763162 CNV gain 21179565
esv3640471 CNV gain 21293372
esv3640472 CNV gain 21293372
esv3640474 CNV gain 21293372
nsv457734 CNV gain 19166990
nsv469760 CNV loss 16826518
nsv469853 CNV gain+loss 16826518
nsv471697 CNV gain 15918152
nsv476134 CNV novel sequence insertion 20440878
nsv516100 CNV gain+loss 19592680
nsv574909 CNV gain 21841781
nsv833428 CNV loss 17160897
nsv978416 CNV duplication 23825009

Variation tolerance for GGNBP2 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GGNBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGNBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGNBP2 Gene

Disorders for GGNBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GGNBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q12 deletion syndrome
  • 17q12 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GGNBP2

genes like me logo Genes that share disorders with GGNBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GGNBP2 Gene

Publications for GGNBP2 Gene

  1. Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930. (PMID: 15145523) Li Y … Chen Z (Cancer letters 2004) 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. (PMID: 11728448) Ohbayashi T … Mukai K (FEBS letters 2001) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer. (PMID: 28864131) Zhu Z … Zhao H (Gynecologic oncology 2017) 3 58

Products for GGNBP2 Gene

Sources for GGNBP2 Gene

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