GGNBP2 Gene
protein-coding GIFtS: 46
GCID: GC17P034900
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|
gametogenetin binding protein 2(Previous name: zinc finger protein 403 )
(Previous symbol: ZNF403)
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Aliases
for GGNBP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Gametogenetin Binding Protein 21 2 | | Laryngeal Carcinoma-Related Protein 12 3 | | LZK11 2 3 5 | | FLJ212301 | | ZNF4031 2 3 | | FLJ225611 | | DIF31 2 5 | | C3HC4-Type Zinc Finger Protein2 | | LCRG12 3 5 | | Gametogenetin-Binding Protein 22 | | DIF-31 2 | | Laryngeal Carcinoma Related Gene 12 | | ZFP4031 2 | | Protein ZNF4033 | | Zinc Finger Protein 4031 2 | | |
Export aliases for GGNBP2 gene to outside databasesPrevious GC identifers: GC17P031974 GC17P030837 |
Summaries
for GGNBP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GGNB2_HUMAN, Q9H3C7Function: May be involved in spermatogenesis
|
Genomic Views
for GGNBP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GGNBP2 gene promoter:
Elk-1 HTF Nkx2-5 NF-AT AREB6 NF-AT4 NF-AT2 HOXA5 NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GGNBP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GGNBP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21.1GGNBP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P034900: view genomic region
(about GC identifiers)
Start:
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34,900,737 bp from pter |
End:
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34,946,278 bp from pter |
Size:
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45,542 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr17+,PATCHES 34,886,491-34,932,042 |
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Proteins
for GGNBP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GGNB2_HUMAN, Q9H3C7 (See
protein sequence)Recommended Name: Gametogenetin-binding protein 2 Size: 697 amino acids; 79086 Da
Subunit: Interacts with GGN (By similarity)
Subcellular location: Cytoplasmic vesicle (By similarity). Note=Associated with vesicular structures (By similarity)
Miscellaneous: Strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines
Sequence caution: Sequence=BAB15031.1; Type=Frameshift; Positions=387; Sequence=BAB15397.1; Type=Erroneous initiation;Sequence=CAC18878.1; Type=Frameshift; Positions=433;
Secondary accessions: B2RPK7 Q96T90 Q9GZR8 Q9H767Alternative splicing: 3 isoforms: Q9H3C7-1 Q9H3C7-2 Q9H3C7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GGNBP2: NX_Q9H3C7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H3C7
GGNBP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079111.1
ENSEMBL proteins: ENSP00000307617 ENSP00000465502 ENSP00000465989 ENSP00000467114
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
GGNBP2 for ontologies About GeneDecksing
GGNBP2 Antibody Products:
Assay Products for GGNBP2: |
Protein
Domains /
Families
for GGNBP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GGNBP2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H3C7ProtoNet protein and cluster: Q9H3C7 |
Function
for GGNBP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GGNB2_HUMAN, Q9H3C7Function: May be involved in spermatogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GGNBP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GGNBP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for GGNBP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GGNBP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGNBP2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
GGNBP2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GGNBP2:
Animal Models:
1 MGI phenotypic allele  for Ggnbp2 (no phenotypes)
GGNBP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GGNBP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GGNBP2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for GGNBP2 (Q9H3C73 ENSP000003076174) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
GGNBP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for GGNBP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GGNBP2
Search CenterWatch for drugs/clinical trials and news about GGNBP2 / GGNB2
|
Transcripts
for GGNBP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GGNBP2 gene: NM_024835.3 Unigene Cluster for GGNBP2: Gametogenetin binding protein 2 Hs.514116 [show with all ESTs]Unigene Representative Sequence: AF2683879 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304718(uc002hnb.3) ENST00000485685 ENST00000486208 ENST00000495023(uc002hna.3)
ENST00000593016 ENST00000483256(uc002hnc.1) ENST00000586045 ENST00000588222
ENST00000589269
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GGNBP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GGNBP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GGNBP2 (NM_024835) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GGNBP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GGNBP2 |
Additional cDNA sequence: AF126964.1 AF268387.1 AJ404670.2 AK026214.1 AK124053.1 AK124084.1 AK290687.1 AK292161.1 AK301614.1 BC137491.1 23 DOTS entries: DT.100793846 DT.40307232 DT.120893948 DT.316864 DT.95174169 DT.97795555 DT.120894045 DT.91757097 DT.120894096 DT.97820211 DT.100793854 DT.100793852 DT.97821561 DT.120893861 DT.100793853 DT.100793847 DT.120893868 DT.91757107 DT.120894025 DT.120894143 DT.91757111 DT.95174172 DT.87002681 24/227 AceView cDNA sequences (see all 227): AK124053 CA442581 AA459595 CK430110 CB136227 BM702633 NM_024835 BU620875 BM455195 BM974064 AW079538 AW966890 AW079530 BX106489 BU615197 BE873472 CA446285 AI660616 AA908797 AI696932 AA811697 BQ720812 AF126964 BU688140
GeneLoc Exon Structure
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Expression
for GGNBP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GGNBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GGNBP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GGNBP2
SOURCE GeneReport for Unigene cluster: Hs.514116
UniProtKB/Swiss-Prot: GGNB2_HUMAN, Q9H3C7Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressedmore abundantly in heart, pancreas and skeletal muscle
SABiosciences Custom PCR Arrays for GGNBP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GGNBP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GGNBP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GGNBP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GGNBP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGNBP2 |
Orthologs
for GGNBP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GGNBP2 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for GGNBP2 (if available)
TreeFam Gene Tree for GGNBP2 (if available) |
Paralogs
for GGNBP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GGNBP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GGNBP2 (34900737 - 34946278 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for GGNBP2
8 CNVs: 3143 2223 3142 49849 8843 0800 4031 2222
1 Inversion: 37189 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GGNBP2 |
|
Disorders
/ Diseases
for GGNBP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GGNBP2 for disorders About GeneDecksing
OMIM gene information: 612275
OMIM disorders: --
3  diseases for GGNBP2: About MalaCardslaryngeal carcinoma laryngitis carcinoma
1 disease from the University of Copenhagen DISEASES database for GGNBP2:Laryngeal carcinoma Export disorders for GGNBP2 gene to outside databases
|
Publications
for GGNBP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GGNBP2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GGNBP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930. (PubMed id 15145523)1, 2, 9 Li Y. and Chen Z. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. (PubMed id 11728448)1, 3 Ohbayashi T....Mukai K. (2001)
- Knockdown of ZNF403 inhibits cell proliferation and in duces G2/M arrest by modulating cell-cycle mediators. (PubMed id 22350815)1 Guan R....Chen Z. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. (PubMed id 15642376)1 Zhang J....Lu B. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for GGNBP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GGNBP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GGNBP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GGNBP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GGNBP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GGNBP2 gene:
Search GeneIP for patents involving GGNBP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GGNBP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GGNBP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GGNBP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GGNBP2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GGNBP2 | | OriGene 3'-UTR Clone for GGNBP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GGNBP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GGNBP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GGNBP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GGNBP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GGNBP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GGNBP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GGNBP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GGNBP2 |
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| | | | Search Tocris compounds for GGNBP2 |
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 | | | GGNBP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGNBP2 |
|  |  |  | | | | ThermoFisher Antibody for GGNBP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GGNBP2 |
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