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Aliases for GGNBP2 Gene

Aliases for GGNBP2 Gene

  • Gametogenetin Binding Protein 2 2 3 5
  • Laryngeal Carcinoma-Related Protein 1 3 4
  • Zinc Finger Protein 403 2 3
  • ZNF403 3 4
  • LCRG1 3 4
  • LZK1 3 4
  • Laryngeal Carcinoma Related Gene 1 3
  • Gametogenetin-Binding Protein 2 3
  • C3HC4-Type Zinc Finger Protein 3
  • Protein ZNF403 4
  • ZFP403 3
  • DIF-3 3
  • DIF3 3

External Ids for GGNBP2 Gene

Previous HGNC Symbols for GGNBP2 Gene

  • ZNF403

Previous GeneCards Identifiers for GGNBP2 Gene

  • GC17P031974
  • GC17P034900
  • GC17P030837

Summaries for GGNBP2 Gene

GeneCards Summary for GGNBP2 Gene

GGNBP2 (Gametogenetin Binding Protein 2) is a Protein Coding gene. Diseases associated with GGNBP2 include Chromosome 17Q12 Deletion Syndrome.

UniProtKB/Swiss-Prot for GGNBP2 Gene

  • May be involved in spermatogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGNBP2 Gene

Genomics for GGNBP2 Gene

Regulatory Elements for GGNBP2 Gene

Enhancers for GGNBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F036102 1.5 FANTOM5 Ensembl ENCODE 2.3 -439.2 -439246 6.9 PKNOX1 ATF1 KLF17 BMI1 SCRT2 CREM EGR2 CEBPB TBX21 ZNF518A CCL4 CCL3 CCL3L3 CCL5 CCL18 CCL15 ENSG00000270871 PIGW SLFN12L MYO19
GH17F036086 1.6 FANTOM5 Ensembl ENCODE 1.8 -454.8 -454844 6.3 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 NSD2 YBX1 BMI1 RAD21 ZNF335 CCL3 CCL4 CCL3L3 CCL18 TAF5LP1 SLFN12L CCL5 GGNBP2 ENSG00000277089
GH17F036149 1.5 FANTOM5 Ensembl ENCODE 1.9 -395.4 -395442 1.1 PKNOX1 TBL1XR1 ZNF76 ZNF2 RAD21 ZBTB40 YY1 RFX5 ZNF366 ZNF143 CCL4 CCL3 CCL3L3 CCL5 CCL23 GGNBP2 LOC101927369 ENSG00000282738 LOC100420851
GH17F036543 1.1 ENCODE 0.8 +0.9 892 4.9 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 ZNF143 ZNHIT3 MYO19 ENSG00000274756 ENSG00000270871 DHRS11 GC17P036546 GGNBP2
GH17F036154 0.5 FANTOM5 1.5 -390.4 -390416 0.4 ZNF316 TBX21 CCL4 CCL3 CCL3L3 CCL4L2 CCL5 CCL23 GGNBP2 ENSG00000282738 LOC100420851 LOC101927369
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GGNBP2 on UCSC Golden Path with GeneCards custom track

Promoters for GGNBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001345019 612 4201 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 ZNF143

Genomic Location for GGNBP2 Gene

Chromosome:
17
Start:
36,544,888 bp from pter
End:
36,589,848 bp from pter
Size:
44,961 bases
Orientation:
Plus strand

Genomic View for GGNBP2 Gene

Genes around GGNBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGNBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGNBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGNBP2 Gene

Proteins for GGNBP2 Gene

  • Protein details for GGNBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3C7-GGNB2_HUMAN
    Recommended name:
    Gametogenetin-binding protein 2
    Protein Accession:
    Q9H3C7
    Secondary Accessions:
    • B2RPK7
    • Q96T90
    • Q9GZR8
    • Q9H767

    Protein attributes for GGNBP2 Gene

    Size:
    697 amino acids
    Molecular mass:
    79086 Da
    Quaternary structure:
    • Interacts with GGN.
    Miscellaneous:
    • Strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines.
    SequenceCaution:
    • Sequence=BAB15031.1; Type=Frameshift; Positions=387; Evidence={ECO:0000305}; Sequence=BAB15397.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC18878.1; Type=Frameshift; Positions=433; Evidence={ECO:0000305};

    Alternative splice isoforms for GGNBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGNBP2 Gene

Post-translational modifications for GGNBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GGNBP2 Gene

No data available for DME Specific Peptides for GGNBP2 Gene

Domains & Families for GGNBP2 Gene

Protein Domains for GGNBP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGNBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GGNBP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GGNBP2 Gene

Function for GGNBP2 Gene

Molecular function for GGNBP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.
genes like me logo Genes that share phenotypes with GGNBP2: view

Animal Models for GGNBP2 Gene

MGI Knock Outs for GGNBP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GGNBP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GGNBP2 Gene

Localization for GGNBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGNBP2 Gene

Cytoplasmic vesicle. Note=Associated with vesicular structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GGNBP2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GGNBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IBA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with GGNBP2: view

Pathways & Interactions for GGNBP2 Gene

SuperPathways for GGNBP2 Gene

No Data Available

Interacting Proteins for GGNBP2 Gene

Gene Ontology (GO) - Biological Process for GGNBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GGNBP2: view

No data available for Pathways by source and SIGNOR curated interactions for GGNBP2 Gene

Transcripts for GGNBP2 Gene

Unigene Clusters for GGNBP2 Gene

Gametogenetin binding protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGNBP2 Gene

No ASD Table

Relevant External Links for GGNBP2 Gene

GeneLoc Exon Structure for
GGNBP2
ECgene alternative splicing isoforms for
GGNBP2

Expression for GGNBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GGNBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GGNBP2 Gene

This gene is overexpressed in Testis (38.9) and Peripheral blood mononuclear cells (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GGNBP2 Gene



Protein tissue co-expression partners for GGNBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GGNBP2 Gene:

GGNBP2

SOURCE GeneReport for Unigene cluster for GGNBP2 Gene:

Hs.514116

mRNA Expression by UniProt/SwissProt for GGNBP2 Gene:

Q9H3C7-GGNB2_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed more abundantly in heart, pancreas and skeletal muscle.
genes like me logo Genes that share expression patterns with GGNBP2: view

Primer Products

No data available for mRNA differential expression in normal tissues for GGNBP2 Gene

Orthologs for GGNBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GGNBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGNBP2 34
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia GGNBP2 34
  • 95.34 (n)
cow
(Bos Taurus)
Mammalia GGNBP2 34
  • 95.16 (n)
rat
(Rattus norvegicus)
Mammalia Ggnbp2 34
  • 93.73 (n)
mouse
(Mus musculus)
Mammalia Ggnbp2 34 16
  • 92.91 (n)
chicken
(Gallus gallus)
Aves GGNBP2 34
  • 85.54 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ggnbp2 34
  • 68.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15356 34
zebrafish
(Danio rerio)
Actinopterygii ggnbp2 34
  • 66.89 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14063 34
Species where no ortholog for GGNBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GGNBP2 Gene

ENSEMBL:
Gene Tree for GGNBP2 (if available)
TreeFam:
Gene Tree for GGNBP2 (if available)

Paralogs for GGNBP2 Gene

No data available for Paralogs for GGNBP2 Gene

Variants for GGNBP2 Gene

Sequence variations from dbSNP and Humsavar for GGNBP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10544073 -- 36,556,780(+) TTTTT(-/T)GTGAG intron-variant
rs10584099 -- 36,552,538(+) TGCTT(-/ATAA)CAATG intron-variant
rs10637268 -- 36,586,642(+) AGATG(-/AAG)GAGTC intron-variant
rs10707226 -- 36,560,614(+) GAAAT(-/A)ACGTG intron-variant
rs1076184 -- 36,586,320(-) CTGCA(A/T)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGNBP2 Gene

Variant ID Type Subtype PubMed ID
nsv978416 CNV duplication 23825009
nsv833428 CNV loss 17160897
nsv574909 CNV gain 21841781
nsv516100 CNV gain+loss 19592680
nsv476134 CNV novel sequence insertion 20440878
nsv471697 CNV gain 15918152
nsv469853 CNV gain+loss 16826518
nsv469760 CNV loss 16826518
nsv457734 CNV gain 19166990
esv3640474 CNV gain 21293372
esv3640472 CNV gain 21293372
esv3640471 CNV gain 21293372
esv2763162 CNV gain 21179565
esv2758686 CNV gain+loss 17122850
dgv3155n100 CNV gain 25217958

Variation tolerance for GGNBP2 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGNBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGNBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGNBP2 Gene

Disorders for GGNBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GGNBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q12 deletion syndrome
  • 17q12 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GGNBP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGNBP2
genes like me logo Genes that share disorders with GGNBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GGNBP2 Gene

Publications for GGNBP2 Gene

  1. Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930. (PMID: 15145523) Li Y. … Chen Z. (Cancer Lett. 2004) 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. (PMID: 11728448) Ohbayashi T. … Mukai K. (FEBS Lett. 2001) 2 3 64
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 64
  5. DNA Damage Regulates Translation through I^-TRCP Targeting of CReP. (PMID: 26091241) Loveless T.B. … Toczyski D.P. (PLoS Genet. 2015) 3 64

Products for GGNBP2 Gene

Sources for GGNBP2 Gene

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