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Aliases for GGNBP2 Gene

Aliases for GGNBP2 Gene

  • Gametogenetin Binding Protein 2 2 3
  • LCRG1 3 4 6
  • LZK1 3 4 6
  • Laryngeal Carcinoma-Related Protein 1 3 4
  • Zinc Finger Protein 403 2 3
  • ZNF403 3 4
  • DIF3 3 6
  • Laryngeal Carcinoma Related Gene 1 3
  • Gametogenetin-Binding Protein 2 3
  • C3HC4-Type Zinc Finger Protein 3
  • Protein ZNF403 4
  • ZFP403 3
  • DIF-3 3

External Ids for GGNBP2 Gene

Previous HGNC Symbols for GGNBP2 Gene

  • ZNF403

Previous GeneCards Identifiers for GGNBP2 Gene

  • GC17P031974
  • GC17P034900
  • GC17P030837

Summaries for GGNBP2 Gene

GeneCards Summary for GGNBP2 Gene

GGNBP2 (Gametogenetin Binding Protein 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for GGNBP2 Gene

  • May be involved in spermatogenesis

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGNBP2 Gene

Genomics for GGNBP2 Gene

Regulatory Elements for GGNBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GGNBP2 Gene

36,544,888 bp from pter
36,589,848 bp from pter
44,961 bases
Plus strand

Genomic View for GGNBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGNBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGNBP2 Gene

Proteins for GGNBP2 Gene

  • Protein details for GGNBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gametogenetin-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RPK7
    • Q96T90
    • Q9GZR8
    • Q9H767

    Protein attributes for GGNBP2 Gene

    697 amino acids
    Molecular mass:
    79086 Da
    Quaternary structure:
    • Interacts with GGN.
    • Strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines
    • Sequence=BAB15031.1; Type=Frameshift; Positions=387; Evidence={ECO:0000305}; Sequence=BAB15397.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC18878.1; Type=Frameshift; Positions=433; Evidence={ECO:0000305};

    Alternative splice isoforms for GGNBP2 Gene


neXtProt entry for GGNBP2 Gene

Proteomics data for GGNBP2 Gene at MOPED

Post-translational modifications for GGNBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GGNBP2 Gene

No data available for DME Specific Peptides for GGNBP2 Gene

Domains for GGNBP2 Gene

Protein Domains for GGNBP2 Gene


Suggested Antigen Peptide Sequences for GGNBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GGNBP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GGNBP2 Gene

Function for GGNBP2 Gene

Molecular function for GGNBP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis

Gene Ontology (GO) - Molecular Function for GGNBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GGNBP2: view

Phenotypes for GGNBP2 Gene

GenomeRNAi human phenotypes for GGNBP2:
genes like me logo Genes that share phenotypes with GGNBP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGNBP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGNBP2 Gene

Localization for GGNBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGNBP2 Gene

Cytoplasmic vesicle. Note=Associated with vesicular structures. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for GGNBP2 Gene COMPARTMENTS Subcellular localization image for GGNBP2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GGNBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with GGNBP2: view

Pathways for GGNBP2 Gene

SuperPathways for GGNBP2 Gene

No Data Available

Interacting Proteins for GGNBP2 Gene

Selected Interacting proteins: Q9H3C7-GGNB2_HUMAN for GGNBP2 Gene via I2D

Gene Ontology (GO) - Biological Process for GGNBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GGNBP2: view

No data available for Pathways by source for GGNBP2 Gene

Transcripts for GGNBP2 Gene

Unigene Clusters for GGNBP2 Gene

Gametogenetin binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGNBP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGNBP2 Gene

No ASD Table

Relevant External Links for GGNBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GGNBP2 Gene

mRNA expression in normal human tissues for GGNBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for GGNBP2 Gene

This gene is overexpressed in Testis (38.9) and Peripheral blood mononuclear cells (24.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GGNBP2 Gene

SOURCE GeneReport for Unigene cluster for GGNBP2 Gene Hs.514116

mRNA Expression by UniProt/SwissProt for GGNBP2 Gene

Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed more abundantly in heart, pancreas and skeletal muscle.
genes like me logo Genes that share expressions with GGNBP2: view

Expression partners for GGNBP2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GGNBP2 Gene

Orthologs for GGNBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GGNBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GGNBP2 35
  • 95.16 (n)
  • 98.28 (a)
(Canis familiaris)
Mammalia GGNBP2 35
  • 95.34 (n)
  • 97.11 (a)
(Mus musculus)
Mammalia Ggnbp2 35
  • 92.91 (n)
  • 96.41 (a)
Ggnbp2 16
(Pan troglodytes)
Mammalia GGNBP2 35
  • 99.86 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ggnbp2 35
  • 93.73 (n)
  • 97.27 (a)
(Gallus gallus)
Aves GGNBP2 35
  • 85.54 (n)
  • 93.82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ggnbp2 35
  • 68.62 (n)
  • 63.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15356 35
(Danio rerio)
Actinopterygii ggnbp2 35
  • 66.89 (n)
  • 74.26 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14063 35
Species with no ortholog for GGNBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GGNBP2 Gene

Gene Tree for GGNBP2 (if available)
Gene Tree for GGNBP2 (if available)

Paralogs for GGNBP2 Gene

No data available for Paralogs for GGNBP2 Gene

Variants for GGNBP2 Gene

Sequence variations from dbSNP and Humsavar for GGNBP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs873944 -- 36,585,642(+) AAAAA(C/T)GAAAA intron-variant
rs1076184 -- 36,586,320(-) CTGCA(A/T)AAAGA intron-variant
rs1106907 -- 36,586,440(-) TATAA(A/T)TTTAA intron-variant
rs1106908 -- 36,586,165(-) TTCTT(C/T)TTCTT synonymous-codon, reference
rs1988033 -- 36,548,532(+) ATCCT(A/G)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGNBP2 Gene

Variant ID Type Subtype PubMed ID
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
esv2751645 CNV Gain 17911159
nsv526727 CNV Gain 19592680
nsv471697 CNV Gain 15918152
essv6619 CNV CNV 17122850
nsv469853 CNV Complex 16826518
nsv457734 CNV Gain 19166990
nsv516100 CNV Gain+Loss 19592680
nsv469760 CNV Loss 16826518
nsv833428 CNV Loss 17160897
essv9000 CNV CNV 17122850
dgv953e1 CNV Complex 17122850

Relevant External Links for GGNBP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGNBP2 Gene

Disorders for GGNBP2 Gene

(1) University of Copenhagen DISEASES for GGNBP2 Gene

genes like me logo Genes that share disorders with GGNBP2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for GGNBP2 Gene

Publications for GGNBP2 Gene

  1. Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930. (PMID: 15145523) Li Y. … Chen Z. (Cancer Lett. 2004) 3 4 23
  2. Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. (PMID: 11728448) Ohbayashi T. … Mukai K. (FEBS Lett. 2001) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. (PMID: 15642376) Zhang J. … Lu B. (FEBS Lett. 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GGNBP2 Gene

Sources for GGNBP2 Gene

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