Aliases for GGN Gene
External Ids for GGN Gene
- HGNC: 18869
- Entrez Gene: 199720
- Ensembl: ENSG00000179168
- OMIM: 609966
- UniProtKB: Q86UU5
Previous GeneCards Identifiers for GGN Gene
- GC19M043551
- GC19M043566
- GC19M038874
- GC19M035322
Summaries for GGN Gene
-
This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for GGN Gene
GGN (Gametogenetin) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity.
UniProtKB/Swiss-Prot for GGN Gene
-
May be involved in spermatogenesis.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGN Gene
Genomics for GGN Gene
Regulatory Elements for GGN Gene
Enhancers for GGN Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around GGN on UCSC Golden Path with GeneCards custom track
Promoters for GGN Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around GGN on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for GGN Gene
- Chromosome:
- 19
- Start:
- 38,384,265 bp from pter
- End:
- 38,388,583 bp from pter
- Size:
- 4,319 bases
- Orientation:
- Minus strand
Genomic View for GGN Gene
Genes around GGN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
GGN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GGN Gene
Proteins for GGN Gene
-
Protein details for GGN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UU5-GGN_HUMAN
- Recommended name:
- Gametogenetin
- Protein Accession:
- Q86UU5
- Q7RTU6
- Q86UU4
- Q8NAA1
Protein attributes for GGN Gene
- Size:
- 652 amino acids
- Molecular mass:
- 66699 Da
- Quaternary structure:
-
- Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.
Protein Expression for GGN Gene
Post-translational modifications for GGN Gene
Other Protein References for GGN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GGN
- antibodies-online Antibodies for GGN: See all 11
- GeneTex GGN antibody for GGN
-
Santa Cruz Biotechnology (SCBT) Antibodies for GGN
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GGN
- Origene Custom Protein Services for GGN
- antibodies-online Proteins for GGN: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for GGN
Assay Products
No data available for DME Specific Peptides for GGN Gene
Domains & Families for GGN Gene
Suggested Antigen Peptide Sequences for GGN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for GGN Gene
Function for GGN Gene
Molecular function for GGN Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in spermatogenesis.
Phenotypes for GGN Gene
- MGI mutant phenotypes for GGN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GGN:
Animal Models for GGN Gene
- MGI Knock Outs for GGN:
-
- Ggn tm1Dpj
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for GGN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
- Search ViGene Biosciences for GGN
CRISPR Products
-
OriGene CRISPR knockouts for GGN
-
Santa Cruz Biotechnology (SCBT) CRISPR for GGN
- GenScript: Design CRISPR guide RNA sequences for GGN
miRNA Products
- Search ViGene Biosciences for GGN
Clone Products
- OriGene clones in human for GGN
- OriGene ORF clones in human,mouse,rat for GGN
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- Sino Biological Human cDNA Clone for GGN
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GGN gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GGN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GGN Gene
Localization for GGN Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GGN Gene
Pathways & Interactions for GGN Gene
More details on SuperPathways for GGN
No Data Available
Interacting Proteins for GGN Gene
Selected Interacting proteins:
ENSP00000334940
Q86UU5-GGN_HUMAN
for GGN Gene via
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GGN Gene
Transcripts for GGN Gene
mRNA/cDNA for GGN Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for GGN
-
Santa Cruz Biotechnology (SCBT) CRISPR for GGN
- GenScript: Design CRISPR guide RNA sequences for GGN
miRNA Products
- Search ViGene Biosciences for GGN
Clone Products
- OriGene clones in human for GGN
- OriGene ORF clones in human,mouse,rat for GGN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GGN
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | - |
Expression for GGN Gene
mRNA differential expression in normal tissues according to GTEx for GGN Gene
This gene is overexpressed in Testis (x39.1).
This gene is overexpressed in Pancreatic juice (47.1), Adipocyte (12.7), and Testis (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGN Gene
SOURCE GeneReport for Unigene cluster for GGN Gene Hs.447948
Primer Products
-
OriGene qPCR primer pairs for GGN
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GGN Gene
Orthologs for GGN Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | GGN 35 |
|
||
| GGN 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | GGN 35 |
|
||
| GGN 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ggn 35 |
|
||
| Ggn 16 |
|
||||
| Ggn 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | GGN 35 |
|
||
| GGN 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ggn 35 |
|
- Species with no ortholog for GGN:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for GGN Gene
No data available for Paralogs for GGN Gene
Variants for GGN Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17853364 | -- | 38,385,687(+) | CTGCG(C/T)GTGCG | reference, synonymous-codon | |
| rs140621639 | -- | 38,385,692(+) | CGTGC(G/T)GGTCT | reference, missense | |
| rs141214200 | -- | 38,385,544(+) | CTGCC(C/T)CAGTC | reference, missense | |
| rs141370671 | -- | 38,385,480(+) | CACTT(C/G)CAGGG | reference, missense | |
| rs141428904 | -- | 38,386,400(+) | CAGGA(C/T)CTCGG | reference, missense |
Residual Variation Intolerance Score:
78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.27;
88.16% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GGN Gene
Disorders for GGN Gene
Relevant External Links for GGN
No disorders were found for GGN Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGN Gene
Publications for GGN Gene
- Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. (PMID: 12574169) Lu B. … Bishop C.E. (J. Biol. Chem. 2003) 2 3 4 67
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
- GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population. (PMID: 21114676) Jamsai D. … O'Bryan M.K. (Int. J. Androl. 2011) 3
- Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. (PMID: 15642376) Zhang J. … Lu B. (FEBS Lett. 2005) 3
Products for GGN Gene
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GGN
- Origene Custom Protein Services for GGN
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for GGN
- Browse OriGene Inhibitory RNA Products For GGN
- OriGene qPCR primer pairs for GGN
- OriGene CRISPR knockouts for GGN
- OriGene clones in human for GGN
- OriGene ORF clones in human,mouse,rat for GGN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
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- Novus Biologicals Antibodies for GGN
- Novus Biologicals proteins and lysates for GGN
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for GGN: See all 11
- Search antibodies-online for kits
- antibodies-online Proteins for GGN: See all 4
- Search antibodies-online for peptides
- GeneTex GGN antibody for GGN
- Search GeneTex for Proteins for GGN
- ViGene Biosciences adenoviral particle packaged cDNA for GGN gene
- ViGene Biosciences lentiviral particle packaged cDNA for GGN gene
- ViGene Biosciences lentiviral particle packaged cDNA for GGN gene
- ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
- ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
- ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
- Search ViGene Biosciences for GGN
- Search ViGene Biosciences for GGN
- Santa Cruz Biotechnology (SCBT) Antibodies for GGN
- Search Santa Cruz Biotechnology (SCBT) for GGN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GGN
Sources for GGN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
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- (130) diseasecard
- (131) NIH Rare Diseases
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- (143) Gene Damage Index
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon