Aliases for GGN Gene
External Ids for GGN Gene
- HGNC: 18869
- Entrez Gene: 199720
- Ensembl: ENSG00000179168
- OMIM: 609966
- UniProtKB: Q86UU5
Previous GeneCards Identifiers for GGN Gene
- GC19M043551
- GC19M043566
- GC19M038874
- GC19M035322
Summaries for GGN Gene
-
This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for GGN Gene
GGN (Gametogenetin) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity.
UniProtKB/Swiss-Prot for GGN Gene
-
May be involved in spermatogenesis.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGN Gene
Genomics for GGN Gene
Regulatory Elements for GGN Gene
Enhancers for GGN Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GGN on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for GGN Gene
- Chromosome:
- 19
- Start:
- 38,384,265 bp from pter
- End:
- 38,388,583 bp from pter
- Size:
- 4,319 bases
- Orientation:
- Minus strand
Genomic View for GGN Gene
Genes around GGN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
GGN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GGN Gene
Proteins for GGN Gene
-
Protein details for GGN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UU5-GGN_HUMAN
- Recommended name:
- Gametogenetin
- Protein Accession:
- Q86UU5
- Q7RTU6
- Q86UU4
- Q8NAA1
Protein attributes for GGN Gene
- Size:
- 652 amino acids
- Molecular mass:
- 66699 Da
- Quaternary structure:
-
- Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.
Protein Expression for GGN Gene
Post-translational modifications for GGN Gene
Other Protein References for GGN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GGN
- Invitrogen Antibodies for GGN
- antibodies-online Antibodies for GGN: See all 11
- GeneTex GGN antibody for GGN
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GGN
- Origene Custom Protein Services for GGN
- antibodies-online Proteins for GGN: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for GGN
Assay Products
No data available for DME Specific Peptides for GGN Gene
Domains & Families for GGN Gene
Suggested Antigen Peptide Sequences for GGN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for GGN Gene
Function for GGN Gene
Molecular function for GGN Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in spermatogenesis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for GGN Gene
- MGI mutant phenotypes for GGN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GGN:
Animal Models for GGN Gene
- MGI Knock Outs for GGN:
-
- Ggn tm1Dpj
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GGN
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GGN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
- Search ViGene Biosciences for GGN
CRISPR Products
-
OriGene CRISPR knockouts for GGN
-
Santa Cruz Biotechnology (SCBT) CRISPR for GGN
- GenScript: Design CRISPR guide RNA sequences for GGN
miRNA Products
- Search ViGene Biosciences for GGN
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GGN
- Browse OriGene Inhibitory RNA Products For GGN
-
ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
Clone Products
- Sino Biological Human cDNA Clone for GGN
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GGN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GGN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for GGN
-
ViGene Biosciences adenoviral particle packaged cDNA for GGN gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GGN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GGN Gene
Localization for GGN Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GGN Gene
Pathways & Interactions for GGN Gene
No Data Available
Interacting Proteins for GGN Gene
Selected Interacting proteins:
ENSP00000334940
Q86UU5-GGN_HUMAN
for GGN Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006302 | double-strand break repair | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007276 | gamete generation | ISS,IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GGN Gene
Transcripts for GGN Gene
mRNA/cDNA for GGN Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for GGN
-
Santa Cruz Biotechnology (SCBT) CRISPR for GGN
- GenScript: Design CRISPR guide RNA sequences for GGN
miRNA Products
- Search ViGene Biosciences for GGN
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GGN
- Browse OriGene Inhibitory RNA Products For GGN
-
ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
Clone Products
- Sino Biological Human cDNA Clone for GGN
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GGN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GGN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | - |
Expression for GGN Gene
mRNA differential expression in normal tissues according to GTEx for GGN Gene
This gene is overexpressed in Testis (x39.1).
This gene is overexpressed in Pancreatic juice (47.1), Adipocyte (12.7), and Testis (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGN Gene
NURSA nuclear receptor signaling pathways regulating expression of GGN Gene:
GGNSOURCE GeneReport for Unigene cluster for GGN Gene:
Hs.447948Primer Products
-
OriGene qPCR primer pairs for GGN
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGN Gene
Orthologs for GGN Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GGN 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | GGN 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GGN 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ggn 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ggn 34 16 35 |
|
- Species where no ortholog for GGN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for GGN Gene
No data available for Paralogs for GGN Gene
Variants for GGN Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000265697 | -- | 38,387,887(+) | ACAAC(G/T)AGGGC | intron-variant, utr-variant-5-prime | |
| rs1000495198 | -- | 38,388,820(+) | CCGAG(G/T)GGGGC | upstream-variant-2KB | |
| rs1000674996 | -- | 38,388,072(+) | CCCTC(A/C)CCTTT | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1001576983 | -- | 38,390,190(+) | TGGAC(A/G)TGAGA | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1001683632 | -- | 38,384,158(+) | CAGAA(C/T)TGGGG | downstream-variant-500B |
Residual Variation Intolerance Score:
78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.27;
88.16% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GGN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GGN
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGN Gene
Disorders for GGN Gene
Relevant External Links for GGN
No disorders were found for GGN Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGN Gene
Publications for GGN Gene
- Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. (PMID: 12574169) Lu B. … Bishop C.E. (J. Biol. Chem. 2003) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3 64
Products for GGN Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GGN
- Origene Custom Protein Services for GGN
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GGN
- Browse OriGene Inhibitory RNA Products For GGN
- OriGene qPCR primer pairs for GGN
- OriGene CRISPR knockouts for GGN
- OriGene ORF clones in human for GGN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GGN
- GenScript: Next-day shipping cDNA ORF clone for GGN in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GGN
- GenScript Custom Assay Services for GGN
- GenScript Custom overexpressing Cell Line Services for GGN
- GenScript: Design CRISPR guide RNA sequences for GGN
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
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- Plasmid Preparation
- GenScript Custom Peptide Services for GGN
- Sino Biological Human cDNA Clone for GGN
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for GGN
- Novus Biologicals proteins and lysates for GGN
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for GGN: See all 11
- Search antibodies-online for kits
- antibodies-online Proteins for GGN: See all 4
- Search antibodies-online for peptides
- GeneTex GGN antibody for GGN
- Search GeneTex for Proteins for GGN
- ViGene Biosciences adenoviral particle packaged cDNA for GGN gene
- ViGene Biosciences lentiviral particle packaged cDNA for GGN gene
- ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
- Search ViGene Biosciences for GGN
- Horizon Cell Lines for GGN
- Cyagen custom Knockout/knockin (KOKI) mouse models for GGN
- VectorBuilder custom plasmid, inducible vectors for GGN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GGN
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GGN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer