Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GGN Gene

Aliases for GGN Gene

  • Gametogenetin 2 3 3 5

External Ids for GGN Gene

Previous GeneCards Identifiers for GGN Gene

  • GC19M043551
  • GC19M043566
  • GC19M038874
  • GC19M035322

Summaries for GGN Gene

Entrez Gene Summary for GGN Gene

  • This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGN Gene

GGN (Gametogenetin) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot for GGN Gene

  • May be involved in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGN Gene

Genomics for GGN Gene

Regulatory Elements for GGN Gene

Enhancers for GGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F038453 0.9 ENCODE 11.9 -64.6 -64573 0.2 TBP ATF1 PKNOX1 CBX3 CREB3L1 CREM CEBPB HDAC8 SP1 TFDP1 FAM98C SPRED3 GGN CATSPERG PPP1R14A GC19P038435 GC19P038502
GH19F038361 0.5 ENCODE 11 +26.2 26232 1.6 HDGF ATF1 PKNOX1 ZNF133 SIN3A ZNF2 ZNF48 YY1 ZNF121 GLIS2 C19orf33 ENSG00000266963 CATSPERG ENSG00000269445 ENSG00000267375 ENSG00000269172 ENSG00000267892 SPRED3 GGN FAM98C
GH19F038269 1.1 Ensembl ENCODE 10.4 +117.9 117879 1.7 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 GATA2 KLF7 YY2 C19orf33 CATSPERG ENSG00000269688 ENSG00000266963 ENSG00000269445 ENSG00000267375 ENSG00000269172 ZNF573 KCNK6 DPF1
GH19F038272 1.1 Ensembl ENCODE 10.4 +114.9 114920 3.0 SOX13 ELF3 DRAP1 SAP130 DMAP1 ZNF384 BCL11B YY1 RARA ZNF121 C19orf33 CATSPERG ENSG00000266963 ENSG00000269445 ENSG00000267375 ENSG00000269172 DPF1 YIF1B KCNK6 SPRED3
GH19F038233 0.2 ENCODE 10.3 +154.6 154588 0.2 PKNOX1 KLF17 ARID4B ZNF48 ZNF2 RAD21 ZNF121 GLIS2 SCRT2 ZNF143 YIF1B PPP1R14A KCNK6 CATSPERG RASGRP4 RYR1 GGN SPRED3 FAM98C GC19M038235
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GGN on UCSC Golden Path with GeneCards custom track

Promoters for GGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000346273 -17 2801 HDGF ZNF133 ZNF2 ZNF48 ZNF121 GLIS2 ZNF143 KLF7 ZNF263 SP3

Genomic Location for GGN Gene

38,384,265 bp from pter
38,388,583 bp from pter
4,319 bases
Minus strand

Genomic View for GGN Gene

Genes around GGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGN Gene

Proteins for GGN Gene

  • Protein details for GGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q7RTU6
    • Q86UU4
    • Q8NAA1

    Protein attributes for GGN Gene

    652 amino acids
    Molecular mass:
    66699 Da
    Quaternary structure:
    • Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.

    Alternative splice isoforms for GGN Gene


neXtProt entry for GGN Gene

Post-translational modifications for GGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GGN Gene

No data available for DME Specific Peptides for GGN Gene

Domains & Families for GGN Gene

Protein Domains for GGN Gene


Suggested Antigen Peptide Sequences for GGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GGN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GGN Gene

Function for GGN Gene

Molecular function for GGN Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.

Gene Ontology (GO) - Molecular Function for GGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GGN: view
genes like me logo Genes that share phenotypes with GGN: view

Animal Models for GGN Gene

MGI Knock Outs for GGN:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GGN Gene

Localization for GGN Gene

Subcellular locations from

Jensen Localization Image for GGN Gene COMPARTMENTS Subcellular localization image for GGN gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GGN Gene

Pathways & Interactions for GGN Gene

SuperPathways for GGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for GGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair IEA --
GO:0007275 multicellular organism development IEA --
GO:0007276 gamete generation IEA,ISS --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GGN: view

No data available for Pathways by source and SIGNOR curated interactions for GGN Gene

Transcripts for GGN Gene

Unigene Clusters for GGN Gene

Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: - -
SP3: -
SP4: - - - - - -
SP6: -

Relevant External Links for GGN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GGN Gene

mRNA differential expression in normal tissues according to GTEx for GGN Gene

This gene is overexpressed in Testis (x39.1).

Protein differential expression in normal tissues from HIPED for GGN Gene

This gene is overexpressed in Pancreatic juice (47.1), Adipocyte (12.7), and Testis (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGN Gene

Protein tissue co-expression partners for GGN Gene

NURSA nuclear receptor signaling pathways regulating expression of GGN Gene:


SOURCE GeneReport for Unigene cluster for GGN Gene:

genes like me logo Genes that share expression patterns with GGN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GGN Gene

Orthologs for GGN Gene

This gene was present in the common ancestor of mammals.

Orthologs for GGN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GGN 34 35
  • 97.59 (n)
(Bos Taurus)
Mammalia GGN 34 35
  • 82.15 (n)
(Canis familiaris)
Mammalia GGN 34 35
  • 79.26 (n)
(Rattus norvegicus)
Mammalia Ggn 34
  • 76.87 (n)
(Mus musculus)
Mammalia Ggn 34 16 35
  • 76.11 (n)
Species where no ortholog for GGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GGN Gene

Gene Tree for GGN (if available)
Gene Tree for GGN (if available)

Paralogs for GGN Gene

No data available for Paralogs for GGN Gene

Variants for GGN Gene

Sequence variations from dbSNP and Humsavar for GGN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11083454 -- 38,384,842(+) TTGTC(C/T)CCCTG intron-variant
rs11083455 -- 38,385,824(+) GGCTG(C/G)GGTGG reference, missense
rs112138627 -- 38,385,946(+) GCAGC(G/T)GTGGT reference, missense
rs112267921 -- 38,384,354(+) GCATC(G/T)GGATT utr-variant-3-prime
rs112875988 -- 38,389,627(+) GTCTT(C/T)GGTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GGN Gene

Variant ID Type Subtype PubMed ID
nsv1064275 CNV loss 25217958
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for GGN Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.27; 88.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGN Gene

Disorders for GGN Gene

Relevant External Links for GGN

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGN Gene

Publications for GGN Gene

  1. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. (PMID: 12574169) Lu B. … Bishop C.E. (J. Biol. Chem. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3 64

Products for GGN Gene

Sources for GGN Gene

Loading form....