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Aliases for GGN Gene

Aliases for GGN Gene

  • Gametogenetin 2 3

External Ids for GGN Gene

Previous GeneCards Identifiers for GGN Gene

  • GC19M043551
  • GC19M043566
  • GC19M038874
  • GC19M035322

Summaries for GGN Gene

Entrez Gene Summary for GGN Gene

  • This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGN Gene

GGN (Gametogenetin) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot for GGN Gene

  • May be involved in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGN Gene

Genomics for GGN Gene

Regulatory Elements for GGN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GGN Gene

Start:
38,384,265 bp from pter
End:
38,388,455 bp from pter
Size:
4,191 bases
Orientation:
Minus strand

Genomic View for GGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGN Gene

Proteins for GGN Gene

  • Protein details for GGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UU5-GGN_HUMAN
    Recommended name:
    Gametogenetin
    Protein Accession:
    Q86UU5
    Secondary Accessions:
    • Q7RTU6
    • Q86UU4
    • Q8NAA1

    Protein attributes for GGN Gene

    Size:
    652 amino acids
    Molecular mass:
    66699 Da
    Quaternary structure:
    • Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.

    Alternative splice isoforms for GGN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGN Gene

Proteomics data for GGN Gene at MOPED

Post-translational modifications for GGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GGN Gene

No data available for DME Specific Peptides for GGN Gene

Domains for GGN Gene

Protein Domains for GGN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for GGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GGN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GGN Gene

Function for GGN Gene

Molecular function for GGN Gene

UniProtKB/Swiss-Prot Function: May be involved in spermatogenesis.

Gene Ontology (GO) - Molecular Function for GGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with GGN: view

Phenotypes for GGN Gene

genes like me logo Genes that share phenotypes with GGN: view

Animal Models for GGN Gene

MGI Knock Outs for GGN:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GGN Gene

Localization for GGN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGN Gene COMPARTMENTS Subcellular localization image for GGN gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for GGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with GGN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GGN Gene

Pathways for GGN Gene

SuperPathways for GGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for GGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007276 gamete generation ISS --
GO:0007283 spermatogenesis IEA --
GO:0008104 protein localization IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GGN: view

No data available for Pathways by source for GGN Gene

Transcripts for GGN Gene

Unigene Clusters for GGN Gene

Gametogenetin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GGN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: - -
SP3: -
SP4: - - - - - -
SP5:
SP6: -

Relevant External Links for GGN Gene

GeneLoc Exon Structure for
GGN
ECgene alternative splicing isoforms for
GGN

Expression for GGN Gene

mRNA expression in normal human tissues for GGN Gene

mRNA differential expression in normal tissues according to GTEx for GGN Gene

This gene is overexpressed in Testis (39.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GGN Gene

SOURCE GeneReport for Unigene cluster for GGN Gene Hs.447948

genes like me logo Genes that share expressions with GGN: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GGN Gene

Orthologs for GGN Gene

This gene was present in the common ancestor of mammals.

Orthologs for GGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGN 35
  • 97.59 (n)
  • 96.15 (a)
GGN 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GGN 35
  • 82.15 (n)
  • 76.63 (a)
GGN 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GGN 35
  • 79.26 (n)
  • 73.37 (a)
GGN 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ggn 35
  • 76.11 (n)
  • 71.52 (a)
Ggn 16
Ggn 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ggn 35
  • 76.87 (n)
  • 71.72 (a)
Species with no ortholog for GGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GGN Gene

ENSEMBL:
Gene Tree for GGN (if available)
TreeFam:
Gene Tree for GGN (if available)

Paralogs for GGN Gene

No data available for Paralogs for GGN Gene

Variants for GGN Gene

Sequence variations from dbSNP and Humsavar for GGN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7248540 -- 38,387,283(+) AGACT(A/G)GTCAG intron-variant
rs7248780 -- 38,387,393(+) AGATC(A/C)GATCA intron-variant
rs11083454 -- 38,384,842(+) TTGTC(C/T)CCCTG intron-variant
rs11083455 -- 38,385,824(+) GGCTG(C/G)GGTGG missense, reference
rs12977287 -- 38,387,204(+) GTCCG(A/C)GGGCT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for GGN Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV Loss 17160897
nsv911658 CNV Loss 21882294
nsv470140 CNV Gain 18288195
nsv911659 CNV Loss 21882294
nsv911660 CNV Gain 21882294
nsv833823 CNV Loss 17160897
dgv3857n71 CNV Loss 21882294

Relevant External Links for GGN Gene

HapMap Linkage Disequilibrium report
GGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGN Gene

Disorders for GGN Gene

(1) University of Copenhagen DISEASES for GGN Gene

Relevant External Links for GGN

Human Genome Epidemiology (HuGE) Navigator
GGN
genes like me logo Genes that share disorders with GGN: view

No data available for UniProtKB/Swiss-Prot for GGN Gene

Publications for GGN Gene

  1. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. (PMID: 12574169) Lu B. … Bishop C.E. (J. Biol. Chem. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. (PMID: 15642376) Zhang J. … Lu B. (FEBS Lett. 2005) 3
  5. GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population. (PMID: 21114676) Jamsai D. … O'Bryan M.K. (Int. J. Androl. 2011) 3

Products for GGN Gene

Sources for GGN Gene

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