Aliases for GGN Gene
External Ids for GGN Gene
- HGNC: 18869
- Entrez Gene: 199720
- Ensembl: ENSG00000179168
- OMIM: 609966
- UniProtKB: Q86UU5
Previous GeneCards Identifiers for GGN Gene
- GC19M043551
- GC19M043566
- GC19M038874
- GC19M035322
- GC19M038385
- GC19M038548
Summaries for GGN Gene
-
This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for GGN Gene
GGN (Gametogenetin) is a Protein Coding gene. Diseases associated with GGN include Androgenic Alopecia. Gene Ontology (GO) annotations related to this gene include protein dimerization activity.
UniProtKB/Swiss-Prot for GGN Gene
-
May be involved in spermatogenesis.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGN Gene
Genomics for GGN Gene
GeneHancer (GH) Regulatory Elements for GGN Gene
Regulatory Element Products
Genomic Locations for GGN Gene
- chr19:38,384,265-38,388,583
- (GRCh38/hg38)
- Size:
- 4,319 bases
- Orientation:
- Minus strand
- chr19:38,874,905-38,878,722
- (GRCh37/hg19)
Genomic View for GGN Gene
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC


RefSeq DNA sequence for GGN Gene
Proteins for GGN Gene
-
Protein details for GGN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UU5-GGN_HUMAN
- Recommended name:
- Gametogenetin
- Protein Accession:
- Q86UU5
- Q7RTU6
- Q86UU4
- Q8NAA1
Protein attributes for GGN Gene
- Size:
- 652 amino acids
- Molecular mass:
- 66699 Da
- Quaternary structure:
-
- Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.
Protein Expression for GGN Gene
Post-translational modifications for GGN Gene
Other Protein References for GGN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GGN
-
Abcam antibodies for GGN
- Invitrogen Antibodies for GGN
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Protein Products
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-
Quality Products:
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-
Abcam proteins for GGN
Assay Products
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No data available for DME Specific Peptides for GGN Gene
Domains & Families for GGN Gene
Gene Families for GGN Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for GGN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for GGN Gene
Function for GGN Gene
Molecular function for GGN Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in spermatogenesis.
Phenotypes From GWAS Catalog for GGN Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for GGN Gene
- MGI mutant phenotypes for GGN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GGN:
Animal Models for GGN Gene
- MGI Knock Outs for GGN:
-
- Ggn tm1Dpj
Animal Model Products
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-
-
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-
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
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- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GGN Gene
Localization for GGN Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GGN Gene
Pathways & Interactions for GGN Gene
Interacting Proteins for GGN Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006302 | double-strand break repair | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007276 | gamete generation | IEA,ISS | -- |
GO:0007283 | spermatogenesis | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GGN Gene
Transcripts for GGN Gene
mRNA/cDNA for GGN Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GGN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||
SP2: | - | - | |||||||||||||||||||
SP3: | - | ||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||
SP5: | |||||||||||||||||||||
SP6: | - |
Expression for GGN Gene
mRNA differential expression in normal tissues according to GTEx for GGN Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGN Gene
NURSA nuclear receptor signaling pathways regulating expression of GGN Gene:
GGNSOURCE GeneReport for Unigene cluster for GGN Gene:
Hs.447948Primer Products
-
OriGene qPCR primer pairs for GGN
- genomics-online: primer clones - Search results for 113 available GGN gene related products
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGN Gene
Orthologs for GGN Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GGN 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | GGN 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | GGN 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ggn 33 |
|
||
mouse (Mus musculus) |
Mammalia | Ggn 33 16 34 |
|
- Species where no ortholog for GGN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for GGN Gene
No data available for Paralogs for GGN Gene
Variants for GGN Gene
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000265697 | -- | 38,387,887(-) | T/G | 5_prime_UTR_variant, intron_variant | |
rs1000495198 | -- | 38,388,820(-) | G/T | upstream_transcript_variant | |
rs1000674996 | -- | 38,388,072(-) | C/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1001576983 | -- | 38,390,190(-) | G/A | upstream_transcript_variant | |
rs1001683632 | -- | 38,384,158(-) | T/C | downstream_transcript_variant |
Additional Variant Information for GGN Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGN Gene
Disorders for GGN Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
androgenic alopecia |
|
|
Additional Disease Information for GGN
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GGN Gene
Publications for GGN Gene
- Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. (PMID: 12574169) Lu B … Bishop CE (The Journal of biological chemistry 2003) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 58
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 13 available GGN Antibodies ranked by validation data
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- Overview of 113 available GGN gene related products
Sources for GGN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
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- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew