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Aliases for GGN Gene

Aliases for GGN Gene

  • Gametogenetin 2 3 3 5

External Ids for GGN Gene

Previous GeneCards Identifiers for GGN Gene

  • GC19M043551
  • GC19M043566
  • GC19M038874
  • GC19M035322
  • GC19M038385

Summaries for GGN Gene

Entrez Gene Summary for GGN Gene

  • This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGN Gene

GGN (Gametogenetin) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot for GGN Gene

  • May be involved in spermatogenesis.

Additional gene information for GGN Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGN Gene

Genomics for GGN Gene

Regulatory Elements for GGN Gene

Enhancers for GGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H038269 1.5 Ensembl ENCODE dbSUPER 10.4 +117.9 117879 1.7 ATF1 ARNT SIN3A FEZF1 ZNF2 TCF12 ZNF121 GLIS2 GATA2 KLF7 CATSPERG C19orf33 HNRNPL ENSG00000266963 HKR1 ZNF607 ENSG00000269445 ENSG00000267375 ENSG00000269172 ZNF793
GH19H038030 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.6 +354.2 354170 7.6 HDGF PKNOX1 ATF1 RB1 KLF17 RAD21 ZNF143 ZNF207 ATF7 RUNX3 ZNF585B ZNF527 ZNF585A ZFP30 ZNF607 HKR1 ZNF793 ZNF570 ENSG00000267682 ZNF573
GH19H038361 1 ENCODE 11 +26.2 26232 1.6 PKNOX1 ATF1 ZNF133 SIN3A ZNF2 ZBTB7B ZNF121 GLIS2 ELK1 KLF7 C19orf33 CATSPERG ENSG00000266963 ENSG00000269445 ENSG00000267375 ENSG00000269172 GGN SPRED3 FAM98C DPF1
GH19H038453 0.9 ENCODE 11.9 -64.6 -64573 0.2 HDAC1 TBP PKNOX1 ATF1 RB1 ZNF350 ATF7 CREM CEBPB HDAC8 HNRNPL FAM98C SPRED3 GGN ENSG00000269688 PAF1 CATSPERG PPP1R14A GC19P038435 GC19P038502
GH19H038002 2 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +383.8 383772 4.8 HDGF PKNOX1 SIN3A ARID4B ZNF2 ZNF302 ZNF548 FOS SP3 MXD4 ZNF383 ZNF585A HNRNPL ZNF585B ZNF527 ZNF420 ZNF607 ZNF793 ZFP30 ZNF573
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GGN on UCSC Golden Path with GeneCards custom track

Promoters for GGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109275 -217 2401 HDGF ATF1 ZNF2 TCF12 ZNF121 GLIS2 ZNF143 KLF7 SP3 TSHZ1

Genomic Locations for GGN Gene

Genomic Locations for GGN Gene
4,319 bases
Minus strand

Genomic View for GGN Gene

Genes around GGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGN Gene

Proteins for GGN Gene

  • Protein details for GGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q7RTU6
    • Q86UU4
    • Q8NAA1

    Protein attributes for GGN Gene

    652 amino acids
    Molecular mass:
    66699 Da
    Quaternary structure:
    • Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.

    Alternative splice isoforms for GGN Gene


neXtProt entry for GGN Gene

Post-translational modifications for GGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GGN Gene

No data available for DME Specific Peptides for GGN Gene

Domains & Families for GGN Gene

Gene Families for GGN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GGN Gene


Suggested Antigen Peptide Sequences for GGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GGN: view

No data available for UniProtKB/Swiss-Prot for GGN Gene

Function for GGN Gene

Molecular function for GGN Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.

Phenotypes From GWAS Catalog for GGN Gene

Gene Ontology (GO) - Molecular Function for GGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GGN: view
genes like me logo Genes that share phenotypes with GGN: view

Animal Models for GGN Gene

MGI Knock Outs for GGN:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GGN Gene

Localization for GGN Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GGN gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GGN Gene

Pathways & Interactions for GGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for GGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair IEA --
GO:0007275 multicellular organism development IEA --
GO:0007276 gamete generation ISS,IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GGN: view

No data available for Pathways by source and SIGNOR curated interactions for GGN Gene

Drugs & Compounds for GGN Gene

No Compound Related Data Available

Transcripts for GGN Gene

Unigene Clusters for GGN Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: - -
SP3: -
SP4: - - - - - -
SP6: -

Relevant External Links for GGN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GGN Gene

mRNA differential expression in normal tissues according to GTEx for GGN Gene

This gene is overexpressed in Testis (x39.1).

Protein differential expression in normal tissues from HIPED for GGN Gene

This gene is overexpressed in Pancreatic juice (47.1), Adipocyte (12.7), and Testis (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGN Gene

Protein tissue co-expression partners for GGN Gene

NURSA nuclear receptor signaling pathways regulating expression of GGN Gene:


SOURCE GeneReport for Unigene cluster for GGN Gene:

genes like me logo Genes that share expression patterns with GGN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGN Gene

Orthologs for GGN Gene

This gene was present in the common ancestor of mammals.

Orthologs for GGN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GGN 33 34
  • 97.59 (n)
(Bos Taurus)
Mammalia GGN 33 34
  • 82.15 (n)
(Canis familiaris)
Mammalia GGN 33 34
  • 79.26 (n)
(Rattus norvegicus)
Mammalia Ggn 33
  • 76.87 (n)
(Mus musculus)
Mammalia Ggn 33 16 34
  • 76.11 (n)
Species where no ortholog for GGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GGN Gene

Gene Tree for GGN (if available)
Gene Tree for GGN (if available)

Paralogs for GGN Gene

No data available for Paralogs for GGN Gene

Variants for GGN Gene

Sequence variations from dbSNP and Humsavar for GGN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000265697 -- 38,387,887(+) ACAAC(G/T)AGGGC intron-variant, utr-variant-5-prime
rs1000495198 -- 38,388,820(+) CCGAG(G/T)GGGGC upstream-variant-2KB
rs1000674996 -- 38,388,072(+) CCCTC(A/C)CCTTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001576983 -- 38,390,190(+) TGGAC(A/G)TGAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001683632 -- 38,384,158(+) CAGAA(C/T)TGGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GGN Gene

Variant ID Type Subtype PubMed ID
nsv953296 CNV deletion 24416366
nsv833823 CNV loss 17160897
nsv833822 CNV loss 17160897
nsv470140 CNV gain 18288195
nsv1064275 CNV loss 25217958

Variation tolerance for GGN Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.27; 88.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGN Gene

Disorders for GGN Gene

Relevant External Links for GGN

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGN Gene

Publications for GGN Gene

  1. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. (PMID: 12574169) Lu B … Bishop CE (The Journal of biological chemistry 2003) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 60

Products for GGN Gene

Sources for GGN Gene

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