Aliases for GGN Gene
External Ids for GGN Gene
- HGNC: 18869
- Entrez Gene: 199720
- Ensembl: ENSG00000179168
- OMIM: 609966
- UniProtKB: Q86UU5
Previous GeneCards Identifiers for GGN Gene
- GC19M043551
- GC19M043566
- GC19M038874
- GC19M035322
- GC19M038385
- GC19M038548
Summaries for GGN Gene
-
This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for GGN Gene
GGN (Gametogenetin) is a Protein Coding gene. Diseases associated with GGN include Androgenic Alopecia. Gene Ontology (GO) annotations related to this gene include protein dimerization activity.
UniProtKB/Swiss-Prot for GGN Gene
-
May be involved in spermatogenesis.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGN Gene
Genomics for GGN Gene
GeneHancer (GH) Regulatory Elements for GGN Gene
Promoters and enhancers for GGN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GGN on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GGN Gene
Genomic Locations for GGN Gene
- chr19:38,384,265-38,388,583
- (GRCh38/hg38)
- Size:
- 4,319 bases
- Orientation:
- Minus strand
- chr19:38,874,905-38,878,722
- (GRCh37/hg19)
Genomic View for GGN Gene
Genes around GGN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
GGN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GGN Gene
Proteins for GGN Gene
-
Protein details for GGN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UU5-GGN_HUMAN
- Recommended name:
- Gametogenetin
- Protein Accession:
- Q86UU5
- Q7RTU6
- Q86UU4
- Q8NAA1
Protein attributes for GGN Gene
- Size:
- 652 amino acids
- Molecular mass:
- 66699 Da
- Quaternary structure:
-
- Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.
Protein Expression for GGN Gene
Post-translational modifications for GGN Gene
No Post-translational modifications
Other Protein References for GGN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GGN
-
Abcam antibodies for GGN
- Invitrogen Antibodies for GGN
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Protein Products
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- antibodies-online: Search results for 4 available GGN Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for GGN
Assay Products
- antibodies-online: Search results for available GGN related products ranked by validation data
No data available for DME Specific Peptides for GGN Gene
Domains & Families for GGN Gene
Gene Families for GGN Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for GGN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for GGN Gene
Function for GGN Gene
Molecular function for GGN Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in spermatogenesis.
Phenotypes From GWAS Catalog for GGN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for GGN Gene
- MGI mutant phenotypes for GGN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GGN:
Animal Models for GGN Gene
- MGI Knock Outs for GGN:
-
- Ggn tm1Dpj
Animal Model Products
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-
-
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-
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-
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-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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Cell Line Products
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GGN Gene
Localization for GGN Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GGN Gene
Pathways & Interactions for GGN Gene
No Data Available
Interacting Proteins for GGN Gene
Selected Interacting proteins:
Q86UU5-GGN_HUMAN
ENSP00000334940
for GGN Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006302 | double-strand break repair | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007276 | gamete generation | IEA,ISS | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GGN Gene
Transcripts for GGN Gene
mRNA/cDNA for GGN Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for GGN
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- Overview of 113 available GGN gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GGN
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for GGN gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GGN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | - |
Expression for GGN Gene
mRNA differential expression in normal tissues according to GTEx for GGN Gene
This gene is overexpressed in Testis (x39.1).
This gene is overexpressed in Pancreatic juice (47.1), Adipocyte (12.7), and Testis (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GGN Gene
NURSA nuclear receptor signaling pathways regulating expression of GGN Gene:
GGNSOURCE GeneReport for Unigene cluster for GGN Gene:
Hs.447948Primer Products
-
OriGene qPCR primer pairs for GGN
- genomics-online: primer clones - Search results for 113 available GGN gene related products
- Overview of 113 available GGN gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGN Gene
Orthologs for GGN Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GGN 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GGN 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GGN 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ggn 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ggn 33 16 34 |
|
- Species where no ortholog for GGN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for GGN Gene
No data available for Paralogs for GGN Gene
Variants for GGN Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000265697 | -- | 38,387,887(-) | T/G | 5_prime_UTR_variant, intron_variant | |
| rs1000495198 | -- | 38,388,820(-) | G/T | upstream_transcript_variant | |
| rs1000674996 | -- | 38,388,072(-) | C/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001576983 | -- | 38,390,190(-) | G/A | upstream_transcript_variant | |
| rs1001683632 | -- | 38,384,158(-) | T/C | downstream_transcript_variant |
Residual Variation Intolerance Score:
78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.27;
88.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GGN Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGN Gene
Disorders for GGN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| androgenic alopecia |
|
|
Search GGN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GGN
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GGN Gene
Publications for GGN Gene
- Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. (PMID: 12574169) Lu B … Bishop CE (The Journal of biological chemistry 2003) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 58
Products for GGN Gene
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- Invitrogen Antibodies for GGN
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 13 available GGN Antibodies ranked by validation data
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- Overview of 113 available GGN gene related products
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- Overview of 113 available GGN gene related products
Sources for GGN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew