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Aliases for GGH Gene

Aliases for GGH Gene

  • Gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl Hydrolase) 2 3
  • Gamma-Glu-X Carboxypeptidase 3 4
  • GH 3 4
  • Gamma-Glutamyl Hydrolase 3
  • EC 3.4.19.9 4
  • Conjugase 4

External Ids for GGH Gene

Previous GeneCards Identifiers for GGH Gene

  • GC08M063291
  • GC08M063867
  • GC08M063650
  • GC08M063977
  • GC08M064090
  • GC08M059415
  • GC08M063928

Summaries for GGH Gene

Entrez Gene Summary for GGH Gene

  • This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGH Gene

GGH (Gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl Hydrolase)) is a Protein Coding gene. Diseases associated with GGH include methotrexate dose selection and tropical sprue. Among its related pathways are Folate biosynthesis and Pyrimidine metabolism. GO annotations related to this gene include omega peptidase activity and gamma-glutamyl-peptidase activity.

UniProtKB/Swiss-Prot for GGH Gene

  • Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates

Gene Wiki entry for GGH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGH Gene

Genomics for GGH Gene

Regulatory Elements for GGH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GGH Gene

Start:
63,015,079 bp from pter
End:
63,039,171 bp from pter
Size:
24,093 bases
Orientation:
Minus strand

Genomic View for GGH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGH Gene

Proteins for GGH Gene

  • Protein details for GGH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92820-GGH_HUMAN
    Recommended name:
    Gamma-glutamyl hydrolase
    Protein Accession:
    Q92820
    Secondary Accessions:

    Protein attributes for GGH Gene

    Size:
    318 amino acids
    Molecular mass:
    35964 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GGH Gene

neXtProt entry for GGH Gene

Proteomics data for GGH Gene at MOPED

Post-translational modifications for GGH Gene

  • Ubiquitination at Lys212, Lys235, Lys253, and Lys287
  • Glycosylation at Asn116, Asn163, Asn203, and Asn307
  • Modification sites at PhosphoSitePlus

Other Protein References for GGH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GGH Gene

Domains for GGH Gene

Protein Domains for GGH Gene

Suggested Antigen Peptide Sequences for GGH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92820

UniProtKB/Swiss-Prot:

GGH_HUMAN :
  • Q92820
Domain:
  • Contains 1 gamma-glutamyl hydrolase domain.
Family:
  • Belongs to the peptidase C26 family.
genes like me logo Genes that share domains with GGH: view

No data available for Gene Families for GGH Gene

Function for GGH Gene

Molecular function for GGH Gene

GENATLAS Biochemistry: gammaglutamyl hydrolase,involved in the metabolism of folic acid
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of a gamma-glutamyl bond
UniProtKB/Swiss-Prot Function: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates

Enzyme Numbers (IUBMB) for GGH Gene

Gene Ontology (GO) - Molecular Function for GGH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008238 exopeptidase activity TAS 8816764
GO:0008242 omega peptidase activity TAS 8816764
GO:0016787 hydrolase activity --
GO:0034722 gamma-glutamyl-peptidase activity IDA 11005824
genes like me logo Genes that share ontologies with GGH: view

Animal Model Products

CRISPR Products

miRNA for GGH Gene

miRTarBase miRNAs that target GGH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGH

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GGH Gene

Localization for GGH Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGH Gene

Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGH Gene COMPARTMENTS Subcellular localization image for GGH gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GGH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IDA 21630459
GO:0005764 lysosome IEA --
GO:0005829 cytosol IEA --
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with GGH: view

Pathways for GGH Gene

genes like me logo Genes that share pathways with GGH: view

Interacting Proteins for GGH Gene

Gene Ontology (GO) - Biological Process for GGH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 8816764
GO:0006541 glutamine metabolic process IEA --
GO:0010043 response to zinc ion IEA --
GO:0032868 response to insulin IEA --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with GGH: view

Compounds for GGH Gene

(2) HMDB Compounds for GGH Gene

Compound Synonyms Cas Number PubMed IDs
Tetrahydrofolic acid
  • (6S)-Tetrahydrofolate
135-16-0
Tetrahydrofolyl-[Glu](n)
  • Tetrahydrofolyl-[Glu](n+1)
Not Available

(2) Drugbank Compounds for GGH Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Folic Acid
  • Folate
59-30-3 enzyme substrate
Methotrexate
  • Amethopterin
59-05-2 enzyme substrate

(18) Novoseek inferred chemical compound relationships for GGH Gene

Compound -log(P) Hits PubMed IDs
folate 69 31
hdmtx 67.5 3
glycinamide ribonucleotide 62 1
methotrexate 62 31
thymidylate 48.7 2

(1) PharmGKB related drug/compound annotations for GGH Gene

Drug/compound Annotation
methotrexate CA
genes like me logo Genes that share compounds with GGH: view

Transcripts for GGH Gene

Unigene Clusters for GGH Gene

Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGH Gene

No ASD Table

Relevant External Links for GGH Gene

GeneLoc Exon Structure for
GGH
ECgene alternative splicing isoforms for
GGH

Expression for GGH Gene

mRNA expression in normal human tissues for GGH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GGH Gene

This gene is overexpressed in Liver (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GGH Gene

SOURCE GeneReport for Unigene cluster for GGH Gene Hs.78619

genes like me logo Genes that share expressions with GGH: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GGH Gene

Orthologs for GGH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GGH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGH 35
  • 99.58 (n)
  • 99.69 (a)
GGH 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GGH 35
  • 82.29 (n)
  • 76.73 (a)
GGH 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GGH 35
  • 86.13 (n)
  • 79.37 (a)
GGH 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ggh 35
  • 77.74 (n)
  • 70.51 (a)
Ggh 16
Ggh 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GGH 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GGH 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ggh 35
  • 76.81 (n)
  • 68.23 (a)
chicken
(Gallus gallus)
Aves GGH 35
  • 63.79 (n)
  • 57.81 (a)
GGH 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GGH 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ggh 35
  • 65.61 (n)
  • 62.81 (a)
Str.11987 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5979 35
zebrafish
(Danio rerio)
Actinopterygii ggh 35
  • 60 (n)
  • 58.28 (a)
ggh 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006670 35
  • 48.62 (n)
  • 42.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)72Dp 35
  • 49.53 (n)
  • 39.01 (a)
l(3)72Dp 36
  • 30 (a)
OneToMany
l(3)72Dr 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GGH3 35
  • 48.2 (n)
  • 40.29 (a)
rice
(Oryza sativa)
Liliopsida Os05g0517500 35
  • 46.26 (n)
  • 35.94 (a)
Species with no ortholog for GGH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GGH Gene

ENSEMBL:
Gene Tree for GGH (if available)
TreeFam:
Gene Tree for GGH (if available)

Paralogs for GGH Gene

No data available for Paralogs for GGH Gene

Variants for GGH Gene

Sequence variations from dbSNP and Humsavar for GGH Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs15073 -- 63,017,519(-) ATTTT(A/T)TTTAG reference, missense
rs15074 -- 63,015,199(-) TCATT(A/C)TGTAT utr-variant-3-prime
rs719235 -- 63,039,122(-) TGACT(G/T)AAGTC upstream-variant-2KB
rs719236 -- 63,039,192(-) CCAAA(A/C)TCGGC upstream-variant-2KB
rs1031552 -- 63,020,631(-) TTTCC(C/T)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGH Gene

Variant ID Type Subtype PubMed ID
nsv6227 CNV Loss 18451855

Relevant External Links for GGH Gene

HapMap Linkage Disequilibrium report
GGH
Human Gene Mutation Database (HGMD)
GGH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGH Gene

Disorders for GGH Gene

(1) University of Copenhagen DISEASES for GGH Gene

(20) Novoseek inferred disease relationships for GGH Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 66.4 20
acromegaly 35.3 2
leukemia 22.7 11
cmv infection 22.2 1
lymphoblastic leukemia acute childhood 21.5 1

Relevant External Links for GGH

Genetic Association Database (GAD)
GGH
Human Genome Epidemiology (HuGE) Navigator
GGH
genes like me logo Genes that share disorders with GGH: view

No data available for UniProtKB/Swiss-Prot for GGH Gene

Publications for GGH Gene

  1. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. (PMID: 8816764) Yao R. … Galivan J. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  2. Structural organization of the human gamma-glutamyl hydrolase gene. (PMID: 10570974) Yin D. … Yao R. (Gene 1999) 2 3 4 23
  3. Characterization of human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. (PMID: 16945597) Eisele L.E. … Ryan T.J. (Biochim. Biophys. Acta 2006) 3 4 23 25
  4. The pharmacogenetics of methotrexate in inflammatory bowel disease. (PMID: 16141796) Herrlinger K.R. … Jewell D.P. (Pharmacogenet. Genomics 2005) 3 23 48
  5. Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population. (PMID: 17409534) Hayashi H. … Itoh K. (Biol. Pharm. Bull. 2007) 3 23 48

Products for GGH Gene

  • Addgene plasmids for GGH

Sources for GGH Gene

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