Aliases for GGH Gene
External Ids for GGH Gene
Previous GeneCards Identifiers for GGH Gene
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]
GeneCards Summary for GGH Gene
GGH (Gamma-Glutamyl Hydrolase) is a Protein Coding gene. Diseases associated with GGH include tropical sprue and methotrexate toxicity or dose selection. Among its related pathways are Pyrimidine metabolism (REACTOME) and One carbon pool by folate. GO annotations related to this gene include hydrolase activity and exopeptidase activity.
UniProtKB/Swiss-Prot for GGH Gene
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.