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GGH Gene

protein-coding   GIFtS: 63
GCID: GC08M063928

Gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl...

  See GGH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl
Hydrolase)1 2
Gamma-Glu-X Carboxypeptidase2 3
GH2 3
Gamma-Glutamyl Hydrolase2
Conjugase3
EC 3.4.19.93

External Ids:    HGNC: 42481   Entrez Gene: 88362   Ensembl: ENSG000001375637   OMIM: 6015095   UniProtKB: Q928203   

Export aliases for GGH gene to outside databases

Previous GC identifers: GC08M063291 GC08M063867 GC08M063650 GC08M063977 GC08M064090 GC08M059415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GGH Gene:
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal
of gamma-linked polyglutamates and glutamate. (provided by RefSeq, Jul 2008)

GeneCards Summary for GGH Gene:
GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)) is a protein-coding gene. Diseases associated with GGH include tropical sprue, and pulmonary neuroendocrine tumor. GO annotations related to this gene include gamma-glutamyl-peptidase activity and omega peptidase activity.

UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820
Function: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl
residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May
play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of
pteroylpolyglutamates and antifolates

Gene Wiki entry for GGH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the GGH gene promoter:
         HFH-3   Sox5   ATF-2   CUTL1   LCR-F1   POU3F2   Evi-1   Nkx6-1   Chx10   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGGH promoter sequence
   Search Chromatin IP Primers for GGH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GGH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.3   Ensembl cytogenetic band:  8q12.3   HGNC cytogenetic band: 8q12.3

GGH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GGH gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M063928:  view genomic region     (about GC identifiers)

Start:
63,927,638 bp from pter      End:
63,951,730 bp from pter
Size:
24,093 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820 (See protein sequence)
Recommended Name: Gamma-glutamyl hydrolase precursor  
Size: 318 amino acids; 35964 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for GGH:
1L9X (3D)    

Explore the universe of human proteins at neXtProt for GGH: NX_Q92820

Explore proteomics data for GGH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys212, Lys235, Lys253, Lys287
  • Glycosylation2 at Asn116, Asn163, Asn203, Asn307
  • Modification sites at PhosphoSitePlus

  • See GGH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003869.1  
    ENSEMBL proteins: 
     ENSP00000260118  

    GGH Human Recombinant Protein Products:

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    antibodies-online proteins for GGH (11 products) 

     
    antibodies-online peptides for GGH

    GGH Antibody Products:

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    antibodies-online antibodies for GGH (39 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015527 Pept_C26_g-glut_hydrolase
     IPR011697 Peptidase_C26

    Graphical View of Domain Structure for InterPro Entry Q92820

    ProtoNet protein and cluster: Q92820

    1 Blocks protein domain: IPB011697 Peptidase C26

    UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820
    Similarity: Belongs to the peptidase C26 family
    Similarity: Contains 1 gamma-glutamyl hydrolase domain


    Find genes that share domains with GGH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GGH_HUMAN, Q92820
    Function: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl
    residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May
    play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of
    pteroylpolyglutamates and antifolates
    Catalytic activity: Hydrolysis of a gamma-glutamyl bond

         Genatlas biochemistry entry for GGH:
    gammaglutamyl hydrolase,involved in the metabolism of folic acid

         Enzyme Number (IUBMB): EC 3.4.19.91

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008238exopeptidase activity TAS8816764
    GO:0008242omega peptidase activity TAS8816764
    GO:0016787hydrolase activity ----
    GO:0034722gamma-glutamyl-peptidase activity IDA11005824
         
    Find genes that share ontologies with GGH           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GGH

    miRNA
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    miRTarBase miRNAs that target GGH:
    hsa-mir-26b-5p (MIRT029881)

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    SwitchGear 3'UTR luciferase reporter plasmidGGH 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GGH_HUMAN, Q92820: Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location
    is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome5
    vacuole5
    cytosol2
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005764lysosome IEA--
    GO:0005829cytosol IEA--
    GO:0042470melanosome IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with GGH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GGH About    
    See pathways by source

    SuperPathContained pathways About
    1Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacodynamics0.00
    glutamate removal from folates0.00
    2Glutathione metabolism
    glutathione-mediated detoxification I0.42
    3One carbon pool by folate
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics0.35
    4Folate biosynthesis
    Folate biosynthesis


    Find genes that share SuperPaths with GGH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for GGH
        Fluoropyrimidine Activity
    glutathione-mediated detoxification I
    glutamate removal from folates


    2 PharmGKB Pathways for GGH
        Fluoropyrimidine Pathway, Pharmacodynamics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for GGH):
        Folate biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GGH
    Interactions:

        Search GeneGlobe Interaction Network for GGH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for GGH (Q928203 ENSP000002601184) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    ATG101Q9BSB43I2D: score=1 
    ATG4BQ9Y4P13I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS8816764
    GO:0006541glutamine metabolic process IEA--
    GO:0010043response to zinc ion IEA--
    GO:0032868response to insulin IEA--
    GO:0042493response to drug IEA--

    Find genes that share ontologies with GGH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GGH

    2 HMDB Compounds for GGH    About this table
    CompoundSynonyms CAS #PubMed Ids
    Tetrahydrofolic acid(6S)-Tetrahydrofolate (see all 10)135-16-0--
    Tetrahydrofolyl-[Glu](n)Tetrahydrofolyl-[Glu](n+1) (see all 5)----

    2 DrugBank Compounds for GGH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Folic AcidFolate (see all 9)59-30-3enzymesubstrate17439143 16859665 16945597
    MethotrexateAmethopterin (see all 12)59-05-2enzymesubstrate17586865

    Selected Novoseek inferred chemical compound relationships for GGH gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    folate 69 62 18499665 (3), 16859665 (2), 18414409 (2), 14676127 (2) (see all 26)
    hdmtx 67.5 5 15284538 (2), 15564880 (1)
    glycinamide ribonucleotide 62 1 11469716 (1)
    methotrexate 62 61 11389096 (8), 9306433 (4), 8691640 (3), 9080326 (2) (see all 16)
    thymidylate 48.7 2 11469716 (1), 19307503 (1)
    dihydrofolate 41.6 2 1713122 (1), 8343522 (1)
    iodoacetate 30.3 3 10527932 (2)
    octreotide 20.9 2 16114269 (1), 18440607 (1)
    cysteine 14.4 9 10527932 (3), 8812353 (2), 10739875 (1), 10441559 (1)
    glutamate 14.2 5 11389096 (1), 9306433 (1)

    1 PharmGKB related drug/compound annotation for GGH gene    About this table
    Drug/compound PharmGKB Annotation
    methotrexateCA  



    Find genes that share compounds with GGH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GGH gene: 
    NM_003878.2  

    Unigene Cluster for GGH:

    Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
    Hs.78619  [show with all ESTs]
    Unigene Representative Sequence: NM_003878
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518466 ENST00000260118(uc003xuw.3) ENST00000522852 ENST00000520609
    ENST00000518113 ENST00000518966 ENST00000523479 ENST00000523788
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat GGH

    Additional mRNA sequence: 

    AK290450.1 BC025025.1 U55206.1 

    11 DOTS entries:

    DT.442854  DT.95274746  DT.121489432  DT.75190958  DT.100815112  DT.121489442  DT.95274745  DT.100815110 
    DT.40229831  DT.95345634  DT.99983564 

    Selected AceView cDNA sequences (see all 190):

    BM699166 AA699798 BU752041 CR600078 CB045441 BG676176 CB147996 AI133503 
    AI591087 BM836329 AA455800 AI051617 BU741768 AI952830 BG024311 CB108194 
    CA412351 CR592214 AU077130 BM698149 AW015292 BM667314 AU107886 CB159430 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GGH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAGCCTT
    GGH Expression
    About this image


    GGH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
     
     Placenta (Extraembryonic Tissues)
    GGH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GGH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78619
        Custom PCR Arrays for GGH
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GGH gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ggh1 , 5 gamma-glutamyl hydrolase1, 5 77.74(n)1
    70.51(a)1
      4 (7.79 cM)5
    145901  NM_010281.21  NP_034411.21 
     200420525 
    chicken
    (Gallus gallus)
    Aves GGH1 gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl more 63.79(n)
    57.81(a)
      421144  XM_419226.4  XP_419226.4 
    lizard
    (Anolis carolinensis)
    Reptilia GGH6
    gamma-glutamyl hydrolase (conjugase, folylpolygamm...
    58(a)
    1 ↔ 1
    4(29409207-29426604)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119872 Transcribed sequence with weak similarity to protein more 77.4(n)    CF591646.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ggh1 gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl more 60(n)
    58.28(a)
      406624  NM_213322.1  NP_998487.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)72Dp1 lethal (3) 72Dp 49.53(n)
    39.01(a)
      317887  NM_168655.3  NP_730119.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GGH31 GGH3 48.2(n)
    40.29(a)
      844203  NM_106514.3  NP_177988.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05175001 Os05g0517500 46.26(n)
    35.94(a)
      4339329  NM_001062587.1  NP_001056052.1 


    ENSEMBL Gene Tree for GGH (if available)
    TreeFam Gene Tree for GGH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GGH (see all 561)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506437391,2
    C--59416260(+) TCAAA-/GTGGCTATGTG/T
    ATGTG
    /TGGCTATGTG
    TACAC
    2 -- int1 cds10--------
    rs345653431,2
    C--59418401(+) CTCCC-/CTGTCTT 1 -- int10--------
    rs1486257791,2
    C--59418793(+) AAAAA-/ACAAAT 1 -- int10--------
    rs593914481,2
    C--59433965(+) AGTTT-/CTTG  
     T
    /TCTTG
    AAGTA
    1 -- int10--------
    rs678975161,2
    C--63927456(+) ACACA-/CACA  
            
    AATAC
    1 -- ds50011Minor allele frequency- CACA:0.00NA 2
    rs3729915971,2
    C--63928200(+) CTTTC-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs674858061,2
    C--63935071(+) TAACC-/CT    
       T
    /TCT
    TGATT
    2 -- cds10--------
    rs712553721,2
    C--63935072(+) AACCTTCT/-GATTA 1 -- cds11Minor allele frequency- -:0.00NA 2
    rs2014684491,2
    C--63937298(+) AAAAA-/AGAAAC 1 -- int10--------
    rs106710331,2
    C--63946543(+) CTCCT-/AT/TA 
            
    TATAT
    1 -- int11NA 2

    HapMap Linkage Disequilibrium report for GGH (63927638 - 63951730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GGH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6227CNV Loss18451855

    Human Gene Mutation Database (HGMD): GGH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GGH
    DNA2.0 Custom Variant and Variant Library Synthesis for GGH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601509    OMIM disorders: --

    6 diseases for GGH:    
    About MalaCards
    tropical sprue    pulmonary neuroendocrine tumor    genital herpes    neuroendocrine tumor
    herpes simplex    acromegaly

    1 disease from the University of Copenhagen DISEASES database for GGH:
    Tropical sprue

    Find genes that share disorders with GGH           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GGH gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 66.4 22 17670828 (2), 14750441 (1), 18003913 (1), 2167933 (1) (see all 19)
    acromegaly 35.3 2 16114269 (1), 18440607 (1)
    leukemia 22.7 17 16826517 (3), 8691640 (2), 16041371 (2), 15284538 (2) (see all 6)
    cmv infection 22.2 1 9302197 (1)
    lymphoblastic leukemia acute childhood 21.5 1 16999998 (1)
    herpes 20.1 3 15604426 (1), 10543617 (1)
    neuroendocrine tumors 15.5 3 15492986 (2)
    lymphoblastic leukemia acute 6.92 5 16826517 (2), 20197200 (1)
    rheumatoid arthritis 5.79 2 15564880 (1), 17409534 (1)
    adenoma 5.38 4 18440607 (2), 12516247 (1), 16114269 (1)

    Genetic Association Database (GAD): GGH
    Human Genome Epidemiology (HuGE) Navigator: GGH (29 documents)

    Export disorders for GGH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GGH gene, integrated from 10 sources (see all 185):
    (articles sorted by number of sources associating them with GGH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. (PubMed id 8816764)1, 2, 3, 9 Yao R.... Galivan J. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Characterization of human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. (PubMed id 16945597)1, 2, 7, 9 Eisele L.E.... Ryan T.J. (Biochim. Biophys. Acta 2006)
    3. Structural organization of the human gamma-glutamyl hydrolase gene. (PubMed id 10570974)1, 2, 3, 9 Yin D.... Yao R. (Gene 1999)
    4. Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population. (PubMed id 17409534)1, 4, 9 Hayashi H....Itoh K. (amp 2007)
    5. Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. (PubMed id 19841321)1, 4, 9 Adjei A.A....Zinner R.G. (J. Clin. Oncol. 2010)
    6. Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase. (PubMed id 11005824)1, 2, 9 Chave K.J.... Ryan T.J. (J. Biol. Chem. 2000)
    7. Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico. (PubMed id 20197200)1, 4, 9 Organista-Nava J....Leyva-VA!zquez M.A. (Leuk. Res. 2010)
    8. Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer. (PubMed id 19307503)1, 4, 9 Smit E.F....Groen H.J. (J. Clin. Oncol. 2009)
    9. Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms. (PubMed id 19016697)1, 4, 9 Warren R.B....Griffiths C.E. (Br. J. Dermatol. 2009)
    10. Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. (PubMed id 18842806)1, 4, 9 DeVos L....Crott J.W. (Am. J. Clin. Nutr. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8836 HGNC: 4248 AceView: GGH Ensembl:ENSG00000137563 euGenes: HUgn8836
    ECgene: GGH Kegg: 8836 H-InvDB: GGH

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GGH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GGH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GGH gene:
    Search GeneIP for patents involving GGH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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