Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GGH Gene

protein-coding   GIFtS: 61
GCID: GC08M063977

Gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl
Hydrolase)1 2
Gamma-Glu-X Carboxypeptidase2 3
GH2 3
Gamma-Glutamyl Hydrolase2
Conjugase3
EC 3.4.19.93

External Ids:    HGNC: 42481   Entrez Gene: 88362   Ensembl: ENSG000001375637   OMIM: 6015095   UniProtKB: Q928203   

Export aliases for GGH gene to outside databases

Previous GC identifers: GC08M063291 GC08M063867 GC08M063650 GC08M064090 GC08M059415


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GGH Gene:
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal
of gamma-linked polyglutamates and glutamate. (provided by RefSeq, Jul 2008)

GeneCards Summary for GGH Gene: 
GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)) is a protein-coding gene. Diseases associated with GGH include pulmonary neuroendocrine tumor, and balanitis, and among its related super-pathways are Antimetabolite Pathway - Folate Cycle, Pharmacodynamics and Fluoropyrimidine Pathway, Pharmacokinetics. GO annotations related to this gene include gamma-glutamyl-peptidase activity and omega peptidase activity.

UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820
Function: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl
residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May
play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of
pteroylpolyglutamates and antifolates

Gene Wiki entry for GGH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GGH gene promoter:
         HFH-3   Sox5   ATF-2   CUTL1   LCR-F1   POU3F2   Evi-1   Nkx6-1   Chx10   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGGH promoter sequence
   Search SABiosciences Chromatin IP Primers for GGH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GGH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.3   Ensembl cytogenetic band:  8q12.3   HGNC cytogenetic band: 8q12.3

GGH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GGH gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M063977:  view genomic region     (about GC identifiers)

Start:
63,927,638 bp from pter      End:
63,951,730 bp from pter
Size:
24,093 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820 (See protein sequence)
Recommended Name: Gamma-glutamyl hydrolase precursor  
Size: 318 amino acids; 35964 Da
Subunit: Homodimer
Subcellular location: Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location
is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome
fractions from stage I to stage IV
1 PDB 3D structure from and Proteopedia for GGH:
1L9X (3D)    

Explore the universe of human proteins at neXtProt for GGH: NX_Q92820

Explore proteomics data for GGH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92820

  • GGH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GGH Protein Expression
    REFSEQ proteins: NP_003869.1  
    ENSEMBL proteins: 
     ENSP00000260118  

    Human Recombinant Protein Products for GGH: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GGH
    OriGene Protein Over-expression Lysate for GGH
    OriGene MassSpec for GGH 
    OriGene Custom Protein Services for GGH
    GenScript Custom Purified and Recombinant Proteins Services for GGH
    Novus Biologicals GGH Proteins
    Novus Biologicals GGH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GGH
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005764lysosome IEA--
    GO:0005829cytosol IEA--
    GO:0042470melanosome IEA--

    GGH for ontologies           About GeneDecksing



    GGH Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GGH
    GenScript Custom Superior Antibodies Services for GGH
    Novus Biologicals GGH Antibodies
    Abcam antibodies for GGH
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for GGH
    LSBio Antibodies in human, mouse, rat for GGH 

    Assay Products for GGH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GGH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GGH
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR015527 Pept_C26_g-glut_hydrolase
     IPR011697 Peptidase_C26

    Graphical View of Domain Structure for InterPro Entry Q92820

    ProtoNet protein and cluster: Q92820

    1 Blocks protein domain: IPB011697 Peptidase C26

    UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820
    Similarity: Belongs to the peptidase C26 family
    Similarity: Contains 1 gamma-glutamyl hydrolase domain


    GGH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GGH_HUMAN, Q92820
    Function: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl
    residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May
    play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of
    pteroylpolyglutamates and antifolates
    Catalytic activity: Hydrolysis of a gamma-glutamyl bond

         Genatlas biochemistry entry for GGH:
    gammaglutamyl hydrolase,involved in the metabolism of folic acid

         Enzyme Number (IUBMB): EC 3.4.19.91

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008238exopeptidase activity TAS8816764
    GO:0008242omega peptidase activity TAS8816764
    GO:0016787hydrolase activity ----
    GO:0034722gamma-glutamyl-peptidase activity IDA11005824
         
    GGH for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GGH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GGH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GGH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GGH 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GGH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GGH
    SwitchGear 3'UTR luciferase reporter plasmidGGH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GGH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GGH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GGH
    Sirion Biotech Customized adenovirus for overexpression of GGH

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GGH (see all 7)
    OriGene ORF clones in mouse, rat for GGH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GGH (NM_003878)
    Sino Biological Human cDNA Clone for GGH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GGH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GGH
    Sirion Biotech Customized lentivirus for stable overexpression of GGH 
                         Customized lentivirus expression plasmids for stable overexpression of GGH 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GGH
    Search LifeMap BioReagents cell lines for GGH
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GGH About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics0.87
    2Fluoropyrimidine Activity
    Fluoropyrimidine Activity0.69
    3Glutathione metabolism
    glutathione-mediated detoxification I0.42
    4glutamate removal from folates
    glutamate removal from folates
    5Folate biosynthesis
    Folate biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for GGH
        Fluoropyrimidine Activity
    glutathione-mediated detoxification I
    glutamate removal from folates


    2 PharmGKB Pathways for GGH
        Fluoropyrimidine Pathway, Pharmacodynamics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for GGH):
        Folate biosynthesis


    GGH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GGH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/27 Interacting proteins for GGH (Q928203 ENSP000002601184) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    ATG4BQ9Y4P13I2D: score=1 
    C12orf44Q9BSB43I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006541glutamine metabolic process IEA--
    GO:0010043response to zinc ion IEA--
    GO:0032868response to insulin stimulus IEA--
    GO:0042493response to drug IEA--
    GO:0045471response to ethanol IEA--

    GGH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GGH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GGH

    2 HMDB Compounds for GGH    About this table
    CompoundSynonyms CAS #PubMed Ids
    Tetrahydrofolic acid(6S)-Tetrahydrofolate (see all 10)135-16-0--
    Tetrahydrofolyl-[Glu](n)Tetrahydrofolyl-[Glu](n+1) (see all 5)----

    2 DrugBank Compounds for GGH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Folic AcidFolate (see all 9)59-30-3enzymesubstrate17439143 16859665 16945597
    MethotrexateAmethopterin (see all 12)59-05-2enzymesubstrate17586865

    10/18 Novoseek inferred chemical compound relationships for GGH gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    folate 69 62 18499665 (3), 16859665 (2), 18414409 (2), 14676127 (2) (see all 26)
    hdmtx 67.5 5 15284538 (2), 15564880 (1)
    glycinamide ribonucleotide 62 1 11469716 (1)
    methotrexate 62 61 11389096 (8), 9306433 (4), 8691640 (3), 9080326 (2) (see all 16)
    thymidylate 48.7 2 11469716 (1), 19307503 (1)
    dihydrofolate 41.6 2 1713122 (1), 8343522 (1)
    iodoacetate 30.3 3 10527932 (2)
    octreotide 20.9 2 16114269 (1), 18440607 (1)
    cysteine 14.4 9 10527932 (3), 8812353 (2), 10739875 (1), 10441559 (1)
    glutamate 14.2 5 11389096 (1), 9306433 (1)

    1 PharmGKB related drug/compound annotation for GGH gene    About this table
    Drug/compound PharmGKB Annotation
    methotrexateCA  

    Search CenterWatch for drugs/clinical trials and news about GGH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GGH gene: 
    NM_003878.2  

    Unigene Cluster for GGH:

    Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
    Hs.78619  [show with all ESTs]
    Unigene Representative Sequence: NM_003878
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518466 ENST00000260118(uc003xuw.3) ENST00000522852 ENST00000520609
    ENST00000518113 ENST00000518966 ENST00000523479 ENST00000523788
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GGH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GGH
    SwitchGear 3'UTR luciferase reporter plasmidGGH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GGH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GGH
    Clone
    Products:
         
    OriGene clones in human, mouse for GGH (see all 7)
    OriGene ORF clones in mouse, rat for GGH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GGH (NM_003878)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GGH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GGH
    Sirion Biotech Customized lentivirus for stable overexpression of GGH 
                         Customized lentivirus expression plasmids for stable overexpression of GGH 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GGH
    OriGene qSTAR qPCR primer pairs in human, mouse for GGH
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GGH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GGH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GGH

    Additional mRNA sequence: 

    AK290450.1 BC025025.1 U55206.1 

    11 DOTS entries:

    DT.442854  DT.95274746  DT.121489432  DT.75190958  DT.100815112  DT.121489442  DT.95274745  DT.100815110 
    DT.40229831  DT.95345634  DT.99983564 

    24/190 AceView cDNA sequences (see all 190):

    CB162917 CB159430 BM830853 BM698149 BE896954 CA412351 BU620618 BQ775365 
    CR605764 BE018193 BG676176 BG024311 BM667314 AA455800 BU741768 CB162715 
    AA193412 CR612261 AW015292 AL545539 BM763982 BM836329 CB108194 BM699166 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GGH expression in normal human tissues (normalized intensities)      GGH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAGCCTT
    GGH Expression
    About this image


    GGH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Peripheral Nervous System (Nervous System)
             Human Schwann Cells (HSC)   
     
     Umbilical Cord (Extraembryonic Tissues)
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
     
     Endothelium (Extraembryonic Tissues)
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad

    See GGH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GGH

    SOURCE GeneReport for Unigene cluster: Hs.78619
        SABiosciences Custom PCR Arrays for GGH
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GGH
    OriGene qSTAR qPCR primer pairs in human, mouse for GGH
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GGH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GGH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GGH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GGH gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ggh1 , 5 gamma-glutamyl hydrolase1, 5 77.39(n)1
    70.03(a)1
      4 (7.79 cM)5
    145901  NM_010281.21  NP_034411.21 
     200420525 
    chicken
    (Gallus gallus)
    Aves GGH1 gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl more 62.57(n)
    56.15(a)
      421144  XM_419226.3  XP_419226.3 
    lizard
    (Anolis carolinensis)
    Reptilia GGH6
    gamma-glutamyl hydrolase (conjugase, folylpolygamm...
    58(a)
    1 ↔ 1
    4(29409207-29426604)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119872 Transcribed sequence with weak similarity to protein more 77.4(n)    CF591646.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ggh1 gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl more 59.17(n)
    56.68(a)
      406624  NM_213322.1  NP_998487.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)72Dp1 lethal (3) 72Dp 49.65(n)
    39.01(a)
      317887  NM_168655.3  NP_730119.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GGH31 gamma-glutamyl hydrolase 3 47.96(n)
    40.29(a)
      844203  NM_106514.3  NP_177988.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05175001 hypothetical protein 46.14(n)
    35.94(a)
      4339329  NM_001062587.1  NP_001056052.1 


    ENSEMBL Gene Tree for GGH (if available)
    TreeFam Gene Tree for GGH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/561 SNPs in GGH are shown (see all 561)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506437391,2
    C--59416260(+) TCAAA-/GTGGCTATGTG/T
    ATGTG
    /TGGCTATGTG
    TACAC
    2 -- int1 cds10--------
    rs345653431,2
    C--59418401(+) CTCCC-/CTGTCTT 1 -- int10--------
    rs1486257791,2
    C--59418793(+) AAAAA-/ACAAAT 1 -- int10--------
    rs593914481,2
    C--59433965(+) AGTTT-/CTTG  
     T
    /TCTTG
    AAGTA
    1 -- int10--------
    rs678975161,2
    C--63927456(+) ACACA-/CACA  
            
    AATAC
    1 -- ds50011Minor allele frequency- CACA:0.00NA 2
    rs3729915971,2
    C--63928200(+) CTTTC-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs674858061,2
    C--63935071(+) TAACC-/CT    
       T
    /TCT
    TGATT
    2 -- cds10--------
    rs712553721,2
    C--63935072(+) AACCTTCT/-GATTA 1 -- cds11Minor allele frequency- -:0.00NA 2
    rs2014684491,2
    C--63937298(+) AAAAA-/AGAAAC 1 -- int10--------
    rs106710331,2
    C--63946543(+) CTCCT-/AT/TA 
            
    TATAT
    1 -- int11NA 2

    HapMap Linkage Disequilibrium report for GGH (63927638 - 63951730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GGH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6227CNV Loss18451855


    Human Gene Mutation Database (HGMD): GGH
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GGH
    DNA2.0 Custom Variant and Variant Library Synthesis for GGH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601509    OMIM disorders: --

    20/41 diseases for GGH (see all 41):    About MalaCards
    pulmonary neuroendocrine tumor    balanitis    tropical sprue    herpes simplex
    neuroendocrine tumor    acromegaly    gastrinoma    acute leukemia
    vaccinia    follicular lymphoma    lymphoblastic leukemia    growth hormone deficiency
    spina bifida    panic disorder    diffuse large b-cell lymphoma    acute lymphoblastic leukemia
    esophageal adenocarcinoma    hypoglycemia    mood disorder    b-cell lymphomas

    1 disease from the University of Copenhagen DISEASES database for GGH:
    Tropical sprue

    GGH for disorders           About GeneDecksing

    10/20 Novoseek inferred disease relationships for GGH gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 66.4 22 17670828 (2), 14750441 (1), 18003913 (1), 2167933 (1) (see all 19)
    acromegaly 35.3 2 16114269 (1), 18440607 (1)
    leukemia 22.7 17 16826517 (3), 8691640 (2), 16041371 (2), 15284538 (2) (see all 6)
    cmv infection 22.2 1 9302197 (1)
    lymphoblastic leukemia acute childhood 21.5 1 16999998 (1)
    herpes 20.1 3 15604426 (1), 10543617 (1)
    neuroendocrine tumors 15.5 3 15492986 (2)
    lymphoblastic leukemia acute 6.92 5 16826517 (2), 20197200 (1)
    rheumatoid arthritis 5.79 2 15564880 (1), 17409534 (1)
    adenoma 5.38 4 18440607 (2), 12516247 (1), 16114269 (1)

    Genetic Association Database (GAD): GGH
    Human Genome Epidemiology (HuGE) Navigator: GGH (29 documents)

    Export disorders for GGH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GGH gene, integrated from 9 sources (see all 184):
    (articles sorted by number of sources associating them with GGH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. (PubMed id 8816764)1, 2, 3, 9 Yao R.... Galivan J. (1996)
    2. Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. (PubMed id 16945597)1, 2, 7, 9 Eisele L.E....Ryan T.J. (2006)
    3. Structural organization of the human gamma-glutamyl hydrolase gene. (PubMed id 10570974)1, 2, 3, 9 Yin D....Yao R. (1999)
    4. Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population. (PubMed id 17409534)1, 4, 9 Hayashi H....Itoh K. (2007)
    5. Phase II trial of pemetrexed plus bevacizumab for sec ond-line therapy of patients with advanced non-small-cell lung cancer: NCCTG an d SWOG study N0426. (PubMed id 19841321)1, 4, 9 Adjei A.A....Zinner R.G. (2010)
    6. Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase. (PubMed id 11005824)1, 2, 9 Chave K.J.... Ryan T.J. (2000)
    7. Polymorphisms of the gamma-glutamyl hydrolase gene an d risk of relapse to acute lymphoblastic leukemia in Mexico. (PubMed id 20197200)1, 4, 9 Organista-Nava J....Leyva-VA!zquez M.A. (2010)
    8. Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer. (PubMed id 19307503)1, 4, 9 Smit E.F....Groen H.J. (2009)
    9. Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms. (PubMed id 19016697)1, 4, 9 Warren R.B....Griffiths C.E. (2008)
    10. Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. (PubMed id 18842806)1, 4, 9 DeVos L....Crott J.W. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8836 HGNC: 4248 AceView: GGH Ensembl:ENSG00000137563 euGenes: HUgn8836
    ECgene: GGH Kegg: 8836 H-InvDB: GGH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GGH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GGH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GGH gene:
    Search GeneIP for patents involving GGH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GGH  
     OriGene qPCR primer pairs and template standards for GGH   OriGene Protein Over-expression Lysate for GGH  
     OriGene MassSpec something-or-other for GGH   OriGene clones in human, mouse for GGH  
     OriGene qSTAR qPCR primer pairs in human, mouse for GGH   OriGene Purified Protein for GGH  
     OriGene ORF clones in mouse, rat for GGH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GGH   OriGene Custom Protein Services for GGH  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GGH
     QIAGEN SeqTarget long-range PCR primers for resequencing GGH
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GGH
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GGH
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GGH
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GGH
     GenScript Custom Purified and Recombinant Proteins Services for GGH GenScript cDNA clones with any tag delivered in your preferred vector for GGH
     GenScript Custom Assay Services for GGH GenScript Custom Superior Antibodies Services for GGH
     GenScript Custom overexpressing Cell Line Services for GGH CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GGH promoter
     Search Chromatin IP Primers for GGH
     RT2 qPCR Primer Assay in human, mouse / rat GGH
     Search GNC Networks for GGH
     SABiosciences Custom PCR Arrays for GGH
     Search Tocris compounds for GGH
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for GGH
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GGH antibodies
     GGH proteins
     GGH lysates
     Antibodies for GGH
     See all of Abcam's Antibodies, Kits and Proteins for GGH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GGH




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for GGH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGH
     SwitchGear 3'UTR luciferase reporter plasmids for GGH
     SwitchGear Promoter luciferase reporter plasmids for GGH
     ThermoFisher Antibodies for GGH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GGH
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GGH
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GGH
    Customized:
     lentivirus for stable overexpression of GGH
     lentivirus expression plasmids for stable overexpression of GGH
     adenovirus for overexpression of GGH
     LSBio Antibodies in human, mouse, rat for GGH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GGH gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4