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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GGH Gene

protein-coding   GIFtS: 60
GCID: GC08M063977

gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl...

 Explore 41 diseases affiliated with
GGH via our new
 Human Malady Compendium 
Biological research products
for GGH
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl Hydrolase)1 2
Gamma-Glu-X Carboxypeptidase2 3
GH2 3
Gamma-Glutamyl Hydrolase2
Conjugase3
EC 3.4.19.93

External Ids:    HGNC: 42481   Entrez Gene: 88362   Ensembl: ENSG000001375637   OMIM: 6015095   UniProtKB: Q928203   

Export aliases for GGH gene to outside databases

Previous GC identifers: GC08M063291 GC08M063867 GC08M063650 GC08M064090 GC08M059415


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GGH:
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of
gamma-linked polyglutamates and glutamate. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820
Function: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl
residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play
an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of
pteroylpolyglutamates and antifolates

Gene Wiki entry for GGH


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GGH gene promoter:
         HFH-3   Sox5   ATF-2   CUTL1   LCR-F1   POU3F2   Evi-1   Nkx6-1   Chx10   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGGH promoter sequence
   Search SABiosciences Chromatin IP Primers for GGH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GGH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.3   Ensembl cytogenetic band:  8q12.3   HGNC cytogenetic band: 8q12.3

GGH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GGH gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M063977:  view genomic region     (about GC identifiers)

Start:
63,927,638 bp from pter      End:
63,951,730 bp from pter
Size:
24,093 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820 (See protein sequence)
Recommended Name: Gamma-glutamyl hydrolase precursor  
Size: 318 amino acids; 35964 Da
Subunit: Homodimer
Subcellular location: Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is
primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome
fractions from stage I to stage IV
1 PDB 3D structure from and Proteopedia for GGH:
1L9X (3D)    

Explore the universe of human proteins at neXtProt for GGH: NX_Q92820

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92820

  • GGH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003869.1  
    ENSEMBL proteins: 
     ENSP00000260118   ENSP00000430206  

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    Uscn Proteins for GGH

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005764lysosome IEA--
    GO:0005829cytosol IEA--
    GO:0042470melanosome IEA--


    GGH for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GGH for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015527 Pept_C26_g-glut_hydrolase
     IPR011697 Peptidase_C26

    Graphical View of Domain Structure for InterPro Entry Q92820

    ProtoNet protein and cluster: Q92820

    1 Blocks protein family: IPB011697 Peptidase C26

    UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820
    Similarity: Belongs to the peptidase C26 family
    Similarity: Contains 1 gamma-glutamyl hydrolase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: GGH_HUMAN, Q92820
    Function: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl
    residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play
    an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of
    pteroylpolyglutamates and antifolates
    Catalytic activity: Hydrolysis of a gamma-glutamyl bond

         Genatlas biochemistry entry for GGH:
    gammaglutamyl hydrolase,involved in the metabolism of folic acid

    Enzyme Number (IUBMB): EC 3.4.19.91

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    SwitchGear 3'UTR luciferase reporter plasmidGGH 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008238exopeptidase activity TAS8816764
    GO:0008242omega peptidase activity TAS8816764
    GO:0034722gamma-glutamyl-peptidase activity IDA11005824


    GGH for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Fluoropyrimidine Activity
    Fluoropyrimidine Activity1.00
    Fluoropyrimidine Pathway, Pharmacodynamics0.30
    2glutamate removal from folates
    glutamate removal from folates1.00
    3Folate biosynthesis
    Folate biosynthesis1.00
    4Glutathione metabolism
    glutathione-mediated detoxification I0.53
    5Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics0.45

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for GGH 
        Fluoropyrimidine Activity
    glutathione-mediated detoxification I
    glutamate removal from folates

    2 PharmGKB Pathways for GGH
        Fluoropyrimidine Pathway, Pharmacodynamics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for GGH):
        Folate biosynthesis


    GGH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GGH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/27 Interacting proteins for GGH (Q928203 ENSP000002601184) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    ATG4BQ9Y4P13I2D: score=1 
    C12orf44Q9BSB43I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006541glutamine metabolic process IEA--
    GO:0010043response to zinc ion IEA--
    GO:0032868response to insulin stimulus IEA--
    GO:0042493response to drug IEA--
    GO:0045471response to ethanol IEA--


    GGH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GGH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GGH

    2 HMDB Compounds for GGH    About this table
    CompoundSynonyms CAS #PubMed Ids
    Tetrahydrofolic acid(6S)-Tetrahydrofolate (see all 10)135-16-0--
    Tetrahydrofolyl-[Glu](n)Tetrahydrofolyl-[Glu](n+1) (see all 5)----

    2 DrugBank Compounds for GGH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Folic AcidFolate (see all 9)59-30-3enzymesubstrate17439143 16859665 16945597
    MethotrexateAmethopterin (see all 12)59-05-2enzymesubstrate17586865

    10/18 Novoseek chemical compound relationships for GGH gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    folate 69 62 18499665 (3), 16859665 (2), 18414409 (2), 14676127 (2) (see all 26)
    hdmtx 67.5 5 15284538 (2), 15564880 (1)
    glycinamide ribonucleotide 62 1 11469716 (1)
    methotrexate 62 61 11389096 (8), 9306433 (4), 8691640 (3), 9080326 (2) (see all 16)
    thymidylate 48.7 2 11469716 (1), 19307503 (1)
    dihydrofolate 41.6 2 1713122 (1), 8343522 (1)
    iodoacetate 30.3 3 10527932 (2)
    octreotide 20.9 2 16114269 (1), 18440607 (1)
    cysteine 14.4 9 10527932 (3), 8812353 (2), 10739875 (1), 10441559 (1)
    glutamate 14.2 5 11389096 (1), 9306433 (1)

    1 PharmGKB related drug/compound annotation for GGH gene
    Drug/compound PharmGKB Annotation
    methotrexateCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about GGH 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GGH gene: 
    NM_003878.2  

    Unigene Cluster for GGH:

    Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
    Hs.78619  [show with all ESTs]
    Unigene Representative Sequence: NM_003878
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518466 ENST00000260118(uc003xuw.3) ENST00000522852 ENST00000520609
    ENST00000518113 ENST00000517622 ENST00000518966 ENST00000523479 ENST00000523788


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    Inhib. RNA
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    Additional cDNA sequence: 

    AK290450.1 BC025025.1 U55206.1 

    11 DOTS entries:

    DT.442854  DT.95274746  DT.121489432  DT.75190958  DT.100815112  DT.121489442  DT.95274745  DT.100815110 
    DT.40229831  DT.95345634  DT.99983564 

    24/190 AceView cDNA sequences (see all 190):

    CR612261 BE018193 AA456621 AA193412 BQ212309 AW015292 BX399736 BM923881 
    AI051617 AI591087 AI625832 BE896954 CD369679 AA699798 BU741768 BM763982 
    BM699166 CB108194 BG024311 CB147996 BM836329 CD368089 AI097260 AL545539 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GGH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAAGCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GGH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GGH

    SOURCE GeneReport for Unigene cluster: Hs.78619
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GGH gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ggh1 , 5 gamma-glutamyl hydrolase1, 5 77.39(n)1
    70.03(a)1
      4 (7.79 cM)5
    145901  NM_010281.21  NP_034411.21 
     200420525 
    chicken
    (Gallus gallus)
    Aves GGH1 gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl more 62.57(n)
    56.15(a)
      421144  XM_419226.3  XP_419226.3 
    lizard
    (Anolis carolinensis)
    Reptilia GGH6
    --
    63(a)
    1 ↔ 1
    4(29410832-29419778)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119872 Transcribed sequence with weak similarity to protein more 77.4(n)    CF591646.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ggh1 gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl more 59.17(n)
    56.68(a)
      406624  NM_213322.1  NP_998487.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)72Dp1 lethal (3) 72Dp 49.65(n)
    39.01(a)
      317887  NM_168655.3  NP_730119.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GGH31 gamma-glutamyl hydrolase 3 47.96(n)
    40.29(a)
      844203  NM_106514.3  NP_177988.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05175001 hypothetical protein 46.14(n)
    35.94(a)
      4339329  NM_001062587.1  NP_001056052.1 


    ENSEMBL Gene Tree for GGH (if available)
    TreeFam Gene Tree for GGH (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/472 NCBI SNPs in GGH are shown (see all 472    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756947061,2
    F,--59415372(+) AAGGAC/TGGAGA 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs736843261,2
    C,F,--59416231(+) CACTCC/TGCAAC 1 -- int13Minor allele frequency- T:0.11WA CSA 122
    rs793921881,2
    C,--59416990(+) CAGCTA/TGTCTT 1 -- int11Minor allele frequency- T:0.01NA 120
    rs726583451,2
    C,--59417350(+) CAATTT/GGTATC 1 -- int11Minor allele frequency- G:0.01NA 120
    rs11244091,2
    F,H--59417751(+) TACATC/TTTGAT 1 -- int17Minor allele frequency- G:0.06NA NS EA 538
    rs754971591,2
    F,--59418224(+) ATGTGA/GAAATT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1147460011,2
    C,F,--59419018(+) CCTGCC/TTCATG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs726583551,2
    C,--59420537(+) AGTAAC/TGAGTG 1 -- int10--------
    rs726583581,2
    C,--59420675(+) TAAAGC/TATCTC 1 -- int10--------
    rs1152012551,2
    C,F,--59420943(+) CACAGC/TACAAA 1 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for GGH (63927638 - 63951730 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GGH: --
    Human Gene Mutation Database (HGMD): GGH

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GGH for disorders           About GeneDecksing

    OMIM gene information: 601509    OMIM disorders: --

    20/41 diseases for GGH (see all 41):    About MalaCards
    diffuse large b-cell lymphoma    tropical sprue    b-cell lymphomas    growth hormone deficiency
    spina bifida    neuroendocrine tumor    lymphoblastic leukemia    herpes simplex
    pulmonary neuroendocrine tumor    inflammatory bowel disease    acromegaly    acute lymphoblastic leukemia
    panic disorder    rheumatoid arthritis    pituitary adenoma    gastrinoma
    follicular lymphoma    acute leukemia    balanitis    hodgkin's lymphoma

    1 disease from the University of Copenhagen DISEASES database for GGH:
    Tropical sprue

    10/20 Novoseek disease relationships for GGH gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 66.4 22 17670828 (2), 14750441 (1), 18003913 (1), 2167933 (1) (see all 19)
    acromegaly 35.3 2 16114269 (1), 18440607 (1)
    leukemia 22.7 17 16826517 (3), 8691640 (2), 16041371 (2), 15284538 (2) (see all 6)
    cmv infection 22.2 1 9302197 (1)
    lymphoblastic leukemia acute childhood 21.5 1 16999998 (1)
    herpes 20.1 3 15604426 (1), 10543617 (1)
    neuroendocrine tumors 15.5 3 15492986 (2)
    lymphoblastic leukemia acute 6.92 5 16826517 (2), 20197200 (1)
    rheumatoid arthritis 5.79 2 15564880 (1), 17409534 (1)
    adenoma 5.38 4 18440607 (2), 12516247 (1), 16114269 (1)

    Genetic Association Database (GAD): GGH
    Human Genome Epidemiology (HuGE) Navigator: GGH (29 documents)

    Export disorders for GGH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GGH gene, integrated from 9 sources (see all 179):
    (articles sorted by number of sources associating them with GGH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. (PubMed id 8816764)1, 2, 3, 9 Yao R.... Galivan J. (1996)
    2. Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. (PubMed id 16945597)1, 2, 7, 9 Eisele L.E....Ryan T.J. (2006)
    3. Structural organization of the human gamma-glutamyl hydrolase gene. (PubMed id 10570974)1, 2, 3, 9 Yin D....Yao R. (1999)
    4. Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase. (PubMed id 11005824)1, 2, 9 Chave K.J.... Ryan T.J. (2000)
    5. The pharmacogenetics of methotrexate in inflammatory bowel disease. (PubMed id 16141796)1, 4, 9 Herrlinger K.R....Jewell D.P. (2005)
    6. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (2003)
    9. Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate. (PubMed id 11953431)1, 2 Li H.... Van Roey P. (2002)
    10. Site-directed mutagenesis establishes cysteine-110 as essential for enzyme activity in human gamma-glutamyl hydrolase. (PubMed id 10527932)2, 9 Chave K.J.... Ryan T.J. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8836 HGNC: 4248 AceView: GGH Ensembl:ENSG00000137563 euGenes: HUgn8836
    ECgene: GGH Kegg: 8836 H-InvDB: GGH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GGH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GGH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GGH gene:
    Search GeneIP for patents involving GGH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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