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Aliases for GGCT Gene

Aliases for GGCT Gene

  • Gamma-Glutamylcyclotransferase 2 3
  • Cytochrome C-Releasing Factor 21 3 4
  • C7orf24 3 4
  • CRF21 3 4
  • Chromosome 7 Open Reading Frame 24 2
  • Gamma -Glutamyl Cyclotransferase 3
  • EC 2.3.2.4 4
  • GCTG 3
  • GGC 3

External Ids for GGCT Gene

Previous HGNC Symbols for GGCT Gene

  • C7orf24
  • GCTG

Previous GeneCards Identifiers for GGCT Gene

  • GC07M030503
  • GC07M030536
  • GC07M030418

Summaries for GGCT Gene

Entrez Gene Summary for GGCT Gene

  • The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for GGCT Gene

GGCT (Gamma-Glutamylcyclotransferase) is a Protein Coding gene. Among its related pathways are Metabolism and Glutathione metabolism. GO annotations related to this gene include protein homodimerization activity and gamma-glutamylcyclotransferase activity.

UniProtKB/Swiss-Prot for GGCT Gene

  • Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGCT Gene

Genomics for GGCT Gene

Regulatory Elements for GGCT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GGCT Gene

Chromosome:
7
Start:
30,496,621 bp from pter
End:
30,504,844 bp from pter
Size:
8,224 bases
Orientation:
Minus strand

Genomic View for GGCT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGCT Gene

Proteins for GGCT Gene

  • Protein details for GGCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75223-GGCT_HUMAN
    Recommended name:
    Gamma-glutamylcyclotransferase
    Protein Accession:
    O75223
    Secondary Accessions:
    • B2RDN0
    • B8ZZN4
    • B8ZZR8
    • Q9BS37

    Protein attributes for GGCT Gene

    Size:
    188 amino acids
    Molecular mass:
    21008 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GGCT Gene

    Alternative splice isoforms for GGCT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGCT Gene

Proteomics data for GGCT Gene at MOPED

Post-translational modifications for GGCT Gene

  • Ubiquitination at Lys 140
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for GGCT (gamma-Glutamylcyclotransferase/CRF21)

No data available for DME Specific Peptides for GGCT Gene

Domains & Families for GGCT Gene

Gene Families for GGCT Gene

Protein Domains for GGCT Gene

Suggested Antigen Peptide Sequences for GGCT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75223

UniProtKB/Swiss-Prot:

GGCT_HUMAN :
  • Belongs to the gamma-glutamylcyclotransferase family.
Family:
  • Belongs to the gamma-glutamylcyclotransferase family.
genes like me logo Genes that share domains with GGCT: view

Function for GGCT Gene

Molecular function for GGCT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.0 mM for gamma-glutamyl-L-alanine; Vmax=50.3 umol/min/mg enzyme;
UniProtKB/Swiss-Prot CatalyticActivity:
(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
UniProtKB/Swiss-Prot Induction:
By geranylgeraniol.

Enzyme Numbers (IUBMB) for GGCT Gene

Gene Ontology (GO) - Molecular Function for GGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003839 gamma-glutamylcyclotransferase activity TAS --
GO:0042803 protein homodimerization activity IDA 17932939
genes like me logo Genes that share ontologies with GGCT: view

Phenotypes for GGCT Gene

GenomeRNAi human phenotypes for GGCT:
genes like me logo Genes that share phenotypes with GGCT: view

Animal Model Products

miRNA for GGCT Gene

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for GGCT Gene

Localization for GGCT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGCT Gene COMPARTMENTS Subcellular localization image for GGCT gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for GGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GGCT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GGCT Gene

Pathways & Interactions for GGCT Gene

genes like me logo Genes that share pathways with GGCT: view

Pathways by source for GGCT Gene

1 GeneGo (Thomson Reuters) pathway for GGCT Gene

Interacting Proteins for GGCT Gene

Gene Ontology (GO) - Biological Process for GGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001836 release of cytochrome c from mitochondria IMP 16765912
GO:0006750 glutathione biosynthetic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GGCT: view

No data available for SIGNOR curated interactions for GGCT Gene

Drugs & Compounds for GGCT Gene

(3) Drugs for GGCT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Cysteine Approved Nutra 0
Gamma-Glutamylcysteine Experimental Pharma 0
Pyroglutamic acid Experimental Pharma 0

(1) Additional Compounds for GGCT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Pyrrolidonecarboxylic acid
  • (+)-2-Pyrrolidone-5-carboxylate
  • (+)-2-Pyrrolidone-5-carboxylic acid
  • (+)-Pyroglutamate
  • (+)-Pyroglutamic acid
  • (2R)-2-Carboxy-5-pyrrolidinone
4042-36-8
genes like me logo Genes that share compounds with GGCT: view

Transcripts for GGCT Gene

Unigene Clusters for GGCT Gene

Gamma-glutamylcyclotransferase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGCT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGCT Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - -
SP2: -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - -
SP7: - -

Relevant External Links for GGCT Gene

GeneLoc Exon Structure for
GGCT
ECgene alternative splicing isoforms for
GGCT

Expression for GGCT Gene

mRNA expression in normal human tissues for GGCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GGCT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0) and Oral epithelium (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GGCT Gene



SOURCE GeneReport for Unigene cluster for GGCT Gene Hs.530024

genes like me logo Genes that share expression patterns with GGCT: view

Protein tissue co-expression partners for GGCT Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GGCT Gene

Orthologs for GGCT Gene

This gene was present in the common ancestor of animals.

Orthologs for GGCT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GGCT 35
  • 89.3 (n)
  • 85.56 (a)
GGCT 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GGCT 35
  • 89.13 (n)
  • 86.63 (a)
GGCT 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ggct 35
  • 84.95 (n)
  • 82.8 (a)
Ggct 16
Ggct 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GGCT 35
  • 100 (n)
  • 100 (a)
GGCT 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ggct 35
  • 84.22 (n)
  • 82.98 (a)
oppossum
(Monodelphis domestica)
Mammalia GGCT 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GGCT 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GGCT 35
  • 75.4 (n)
  • 69.64 (a)
GGCT 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GGCT 36
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ggctb 35
  • 58.28 (n)
  • 60.23 (a)
ggcta 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010447 35
  • 51.55 (n)
  • 44.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32196 35
  • 52.15 (n)
  • 44.9 (a)
CG32196 36
  • 34 (a)
OneToMany
CG4306 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C44B7.7 35
  • 52.35 (n)
  • 48.08 (a)
C44B7.7 36
  • 39 (a)
OneToOne
Species with no ortholog for GGCT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GGCT Gene

ENSEMBL:
Gene Tree for GGCT (if available)
TreeFam:
Gene Tree for GGCT (if available)

Paralogs for GGCT Gene

Pseudogenes.org Pseudogenes for GGCT Gene

genes like me logo Genes that share paralogs with GGCT: view

No data available for Paralogs for GGCT Gene

Variants for GGCT Gene

Sequence variations from dbSNP and Humsavar for GGCT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4259 -- 30,504,118(+) ACATG(A/G)TCCCA intron-variant
rs4260 -- 30,504,148(+) TGAGG(A/C)GCGAA intron-variant
rs4270 -- 30,496,995(+) GAAAA(C/G/T)GGATC utr-variant-3-prime, nc-transcript-variant
rs28679 -- 30,502,181(+) atgca(A/G)gaact intron-variant
rs38405 -- 30,497,258(+) AAACA(A/G)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGCT Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
esv2456067 CNV Deletion 19546169
nsv5684 CNV Insertion 18451855

Variation tolerance for GGCT Gene

Residual Variation Intolerance Score: 58.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGCT Gene

HapMap Linkage Disequilibrium report
GGCT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGCT Gene

Disorders for GGCT Gene

Relevant External Links for GGCT

Genetic Association Database (GAD)
GGCT
Human Genome Epidemiology (HuGE) Navigator
GGCT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGCT
genes like me logo Genes that share disorders with GGCT: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGCT Gene

Publications for GGCT Gene

  1. Crystal structure of Homo sapiens protein LOC79017. (PMID: 17932939) Bae E. … Phillips G.N. Jr. (Proteins 2008) 2 67
  2. The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase: an essential enzyme in the gamma- glutamyl cycle. (PMID: 18515354) Oakley A.J. … Board P.G. (J. Biol. Chem. 2008) 2 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment. (PMID: 26339607) Kageyama S. … Kawauchi A. (Biomed Res Int 2015) 67
  5. I^-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors. (PMID: 24342434) Takemura K. … Board P.G. (Hum. Pathol. 2014) 67

Products for GGCT Gene

Sources for GGCT Gene

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