Aliases for GGACT Gene
External Ids for GGACT Gene
Previous HGNC Symbols for GGACT Gene
Previous GeneCards Identifiers for GGACT Gene
The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010]
GeneCards Summary for GGACT Gene
GGACT (Gamma-Glutamylamine Cyclotransferase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include gamma-glutamylcyclotransferase activity.
UniProtKB/Swiss-Prot for GGACT Gene
Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.