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Aliases for GGA3 Gene

Aliases for GGA3 Gene

  • Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 3 2
  • Golgi-Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 3 2 3 5
  • Golgi-Localized, Gamma Ear-Containing, ARF-Binding Protein 3 4
  • KIAA0154 4

External Ids for GGA3 Gene

Previous GeneCards Identifiers for GGA3 Gene

  • GC17M073229
  • GC17M076291
  • GC17M073696
  • GC17M073829
  • GC17M070744
  • GC17M068642

Summaries for GGA3 Gene

Entrez Gene Summary for GGA3 Gene

  • This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for GGA3 Gene

GGA3 (Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Lysosome. GO annotations related to this gene include ADP-ribosylation factor binding. An important paralog of this gene is GGA1.

UniProtKB/Swiss-Prot for GGA3 Gene

  • Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Gene Wiki entry for GGA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGA3 Gene

Genomics for GGA3 Gene

Regulatory Elements for GGA3 Gene

Promoters for GGA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GGA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GGA3 Gene

Chromosome:
17
Start:
75,225,480 bp from pter
End:
75,262,393 bp from pter
Size:
36,914 bases
Orientation:
Minus strand

Genomic View for GGA3 Gene

Genes around GGA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGA3 Gene

Proteins for GGA3 Gene

  • Protein details for GGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ52-GGA3_HUMAN
    Recommended name:
    ADP-ribosylation factor-binding protein GGA3
    Protein Accession:
    Q9NZ52
    Secondary Accessions:
    • B7Z7E2
    • B7Z7M9
    • J3KRN0
    • Q15017
    • Q6IS16
    • Q9UJY3

    Protein attributes for GGA3 Gene

    Size:
    723 amino acids
    Molecular mass:
    78315 Da
    Quaternary structure:
    • Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200 (By similarity). Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC.
    SequenceCaution:
    • Sequence=BAA09926.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GGA3 Gene

    Alternative splice isoforms for GGA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGA3 Gene

Proteomics data for GGA3 Gene at MOPED

Post-translational modifications for GGA3 Gene

  • Phosphorylated by CK2 and dephosphorylated by PP2A (By similarity). Phosphorylation of GGA3 allows the internal AC-LL motif to bind the VHS domain and to inhibit the recognition of cargo signals.
  • Ubiquitinated.
  • Ubiquitination at Lys 15, Lys 38, Lys 100, Lys 165, Lys 174, Lys 176, Lys 183, Lys 185, Lys 195, and Lys 264
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GGA3 (GGA3)

No data available for DME Specific Peptides for GGA3 Gene

Domains & Families for GGA3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZ52

UniProtKB/Swiss-Prot:

GGA3_HUMAN :
  • The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).
  • Belongs to the GGA protein family.
Domain:
  • The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).
  • The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.
  • The unstructured hinge region contains clathrin-binding and an autoinhibitory (AC-LL) motifs.
  • The GAE domain binds accessory proteins regulating GGAs function.
  • Contains 1 GAE domain.
  • Contains 1 GAT domain.
  • Contains 1 VHS domain.
Family:
  • Belongs to the GGA protein family.
genes like me logo Genes that share domains with GGA3: view

Function for GGA3 Gene

Molecular function for GGA3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
genes like me logo Genes that share phenotypes with GGA3: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GGA3 Gene

Localization for GGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGA3 Gene

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGA3 Gene COMPARTMENTS Subcellular localization image for GGA3 gene
Compartment Confidence
endosome 5
golgi apparatus 5
cytosol 2
lysosome 2
nucleus 2
vacuole 2

Gene Ontology (GO) - Cellular Components for GGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with GGA3: view

Pathways & Interactions for GGA3 Gene

genes like me logo Genes that share pathways with GGA3: view

Pathways by source for GGA3 Gene

1 BioSystems pathway for GGA3 Gene
2 Reactome pathways for GGA3 Gene
1 KEGG pathway for GGA3 Gene

Gene Ontology (GO) - Biological Process for GGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA,NAS 10749927
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GGA3: view

No data available for SIGNOR curated interactions for GGA3 Gene

Drugs & Compounds for GGA3 Gene

(1) Drugs for GGA3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GGA3: view

Transcripts for GGA3 Gene

Unigene Clusters for GGA3 Gene

Golgi-associated, gamma adaptin ear containing, ARF binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GGA3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8: - -
SP9: - - -
SP10:
SP11:
SP12:

Relevant External Links for GGA3 Gene

GeneLoc Exon Structure for
GGA3
ECgene alternative splicing isoforms for
GGA3

Expression for GGA3 Gene

mRNA expression in normal human tissues for GGA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GGA3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.3), Lymph node (8.9), and Fetal Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GGA3 Gene



SOURCE GeneReport for Unigene cluster for GGA3 Gene Hs.87726

mRNA Expression by UniProt/SwissProt for GGA3 Gene

Q9NZ52-GGA3_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with GGA3: view

Protein tissue co-expression partners for GGA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GGA3 Gene

Orthologs for GGA3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGA3 35
  • 99.39 (n)
  • 99.5 (a)
GGA3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GGA3 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GGA3 36
  • 86 (a)
OneToOne
GGA3 35
  • 87.04 (n)
  • 87.64 (a)
mouse
(Mus musculus)
Mammalia Gga3 36
  • 86 (a)
OneToOne
Gga3 35
  • 85.66 (n)
  • 87.73 (a)
Gga3 16
oppossum
(Monodelphis domestica)
Mammalia GGA3 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gga3 35
  • 85.49 (n)
  • 89.51 (a)
chicken
(Gallus gallus)
Aves GGA3 36
  • 72 (a)
OneToOne
GGA3 35
  • 72.39 (n)
  • 75.07 (a)
lizard
(Anolis carolinensis)
Reptilia GGA3 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6656 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gga3 35
  • 66.04 (n)
  • 66.52 (a)
Str.14778 35
zebrafish
(Danio rerio)
Actinopterygii gga3 36
  • 54 (a)
OneToMany
GGA3 (2 of 2) 36
  • 54 (a)
OneToMany
gga3 35
  • 62.35 (n)
  • 64.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gga 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apt-9 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GGA1 36
  • 19 (a)
ManyToMany
GGA2 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for GGA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GGA3 Gene

ENSEMBL:
Gene Tree for GGA3 (if available)
TreeFam:
Gene Tree for GGA3 (if available)

Paralogs for GGA3 Gene

Paralogs for GGA3 Gene

genes like me logo Genes that share paralogs with GGA3: view

Variants for GGA3 Gene

Sequence variations from dbSNP and Humsavar for GGA3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_036524 A breast cancer sample
rs117805695 - 75,243,476(+) CGTCT(C/T)TGATC reference, missense, utr-variant-5-prime
rs146877619 - 75,241,043(+) GTTAC(C/T)GCACT reference, missense
rs963547 -- 75,246,076(+) CAGTG(C/T)GACAC intron-variant
rs1473428 -- 75,249,322(+) ACAGG(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGA3 Gene

Variant ID Type Subtype PubMed ID
nsv908758 CNV Loss 21882294
nsv908760 CNV Loss 21882294
nsv510727 CNV Loss 20534489
nsv908761 CNV Loss 21882294

Variation tolerance for GGA3 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGA3 Gene

HapMap Linkage Disequilibrium report
GGA3
Human Gene Mutation Database (HGMD)
GGA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGA3 Gene

Disorders for GGA3 Gene

Relevant External Links for GGA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGA3

No disorders were found for GGA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGA3 Gene

Publications for GGA3 Gene

  1. GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. (PMID: 10747089) Dell'Angelica E.C. … Bonifacino J.S. (J. Cell Biol. 2000) 2 3 4 67
  2. Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis. (PMID: 19815556) SarajAorvi T. … Hiltunen M. (J. Biol. Chem. 2009) 3 23
  3. A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. (PMID: 16977309) Scott G.K. … Thomas G. (EMBO J. 2006) 3 23
  4. Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. (PMID: 17116753) Pak Y. … Rotin D. (J. Cell Biol. 2006) 3 23
  5. Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes. (PMID: 16135791) Kametaka S. … Bonifacino J.S. (Mol. Cell. Biol. 2005) 3 23

Products for GGA3 Gene

Sources for GGA3 Gene

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