Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GGA2 Gene

Aliases for GGA2 Gene

  • Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2 2 3 5
  • Golgi-Localized, Gamma Ear-Containing, ARF-Binding Protein 2 3 4
  • VHS Domain And Ear Domain Of Gamma-Adaptin 3 4
  • Gamma-Adaptin-Related Protein 2 3 4
  • VEAR 3 4
  • Golgi-Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2 2
  • ADP-Ribosylation Factor-Binding Protein GGA2 3
  • VHS Domain And Ear Domain-Containing Protein 3
  • KIAA1080 4

External Ids for GGA2 Gene

Previous GeneCards Identifiers for GGA2 Gene

  • GC16M022884
  • GC16M023563
  • GC16M023403
  • GC16M023442
  • GC16M023383
  • GC16M021565

Summaries for GGA2 Gene

Entrez Gene Summary for GGA2 Gene

  • This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGA2 Gene

GGA2 (Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Lysosome. GO annotations related to this gene include ADP-ribosylation factor binding. An important paralog of this gene is GGA1.

UniProtKB/Swiss-Prot for GGA2 Gene

  • Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Gene Wiki entry for GGA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGA2 Gene

Genomics for GGA2 Gene

Regulatory Elements for GGA2 Gene

Enhancers for GGA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F023496 1.8 FANTOM5 Ensembl ENCODE 8.6 +22.7 22658 6.0 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 COG7 DCTN5 LOC100419017 ENSG00000260751 PALB2 ENSG00000260905 GGA2 UBFD1 GC16M023463
GH16F023527 1.3 Ensembl ENCODE 7.6 -6.5 -6492 2.3 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 SLC30A9 FOS SP5 NFYC DCTN5 NDUFAB1 UBFD1 GGA2 SUB1P4
GH16F023536 1.3 Ensembl ENCODE 7.5 -17.3 -17289 4.8 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 FOS SP5 ZHX2 PALB2 DCTN5 COG7 ENSG00000260482 ENSG00000260905 NDUFAB1 ENSG00000261723 GGA2 SUB1P4 GC16M023544
GH16F023556 1.2 ENCODE 7.5 -35.7 -35652 3.2 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ENSG00000260482 ENSG00000260751 NDUFAB1 UBFD1 GGA2 EARS2
GH16F023516 1.1 Ensembl ENCODE 8 +2.9 2895 5.4 SOX13 KLF1 PKNOX1 USF1 SAP130 ZNF121 POLR2A NFYB SCRT2 ETV6 DCTN5 LOC100419017 NDUFAB1 UBFD1 GGA2 PIR42085
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GGA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GGA2 Gene

Chromosome:
16
Start:
23,463,542 bp from pter
End:
23,521,995 bp from pter
Size:
58,454 bases
Orientation:
Minus strand

Genomic View for GGA2 Gene

Genes around GGA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGA2 Gene

Proteins for GGA2 Gene

  • Protein details for GGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJY4-GGA2_HUMAN
    Recommended name:
    ADP-ribosylation factor-binding protein GGA2
    Protein Accession:
    Q9UJY4
    Secondary Accessions:
    • D3DWF0
    • O14564
    • Q9NYN2
    • Q9UPS2

    Protein attributes for GGA2 Gene

    Size:
    613 amino acids
    Molecular mass:
    67150 Da
    Quaternary structure:
    • Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity). Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2.
    SequenceCaution:
    • Sequence=AAK38634.1; Type=Frameshift; Positions=193; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GGA2 Gene

neXtProt entry for GGA2 Gene

Post-translational modifications for GGA2 Gene

No data available for DME Specific Peptides for GGA2 Gene

Domains & Families for GGA2 Gene

Suggested Antigen Peptide Sequences for GGA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJY4

UniProtKB/Swiss-Prot:

GGA2_HUMAN :
  • The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).
  • Belongs to the GGA protein family.
Domain:
  • The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).
  • The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.
  • The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs.
  • The GAE domain binds accessory proteins regulating GGAs function.
  • Contains 1 GAE domain.
  • Contains 1 GAT domain.
  • Contains 1 VHS domain.
Family:
  • Belongs to the GGA protein family.
genes like me logo Genes that share domains with GGA2: view

Function for GGA2 Gene

Molecular function for GGA2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Gene Ontology (GO) - Molecular Function for GGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12429846
GO:0030306 ADP-ribosylation factor binding IDA 10749927
genes like me logo Genes that share ontologies with GGA2: view
genes like me logo Genes that share phenotypes with GGA2: view

Animal Model Products

miRNA for GGA2 Gene

miRTarBase miRNAs that target GGA2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GGA2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GGA2 Gene

Localization for GGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGA2 Gene

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GGA2 gene
Compartment Confidence
golgi apparatus 5
endosome 5
cytosol 3
lysosome 2
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005802 trans-Golgi network IDA 10749927
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with GGA2: view

Pathways & Interactions for GGA2 Gene

genes like me logo Genes that share pathways with GGA2: view

Pathways by source for GGA2 Gene

1 KEGG pathway for GGA2 Gene

Gene Ontology (GO) - Biological Process for GGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA,NAS 10749927
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GGA2: view

No data available for SIGNOR curated interactions for GGA2 Gene

Drugs & Compounds for GGA2 Gene

(1) Drugs for GGA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GGA2: view

Transcripts for GGA2 Gene

Unigene Clusters for GGA2 Gene

Golgi-associated, gamma adaptin ear containing, ARF binding protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GGA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7: -
SP8: - -
SP9: -
SP10:
SP11:

ExUns: 16b · 16c ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
SP1: -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for GGA2 Gene

GeneLoc Exon Structure for
GGA2
ECgene alternative splicing isoforms for
GGA2

Expression for GGA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GGA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GGA2 Gene

This gene is overexpressed in Fetal gut (11.7), Frontal cortex (8.2), Blymphocyte (6.9), and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GGA2 Gene



Protein tissue co-expression partners for GGA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GGA2 Gene:

GGA2

SOURCE GeneReport for Unigene cluster for GGA2 Gene:

Hs.460336

mRNA Expression by UniProt/SwissProt for GGA2 Gene:

Q9UJY4-GGA2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with GGA2: view

Primer Products

No data available for mRNA differential expression in normal tissues for GGA2 Gene

Orthologs for GGA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGA2 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia GGA2 34 35
  • 90.05 (n)
cow
(Bos Taurus)
Mammalia GGA2 34 35
  • 89.7 (n)
rat
(Rattus norvegicus)
Mammalia Gga2 34
  • 85.2 (n)
mouse
(Mus musculus)
Mammalia Gga2 34 16 35
  • 84.1 (n)
oppossum
(Monodelphis domestica)
Mammalia GGA2 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves GGA2 34 35
  • 61.5 (n)
lizard
(Anolis carolinensis)
Reptilia GGA2 35
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3002 36
  • 32 (a)
Gga 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apt-9 35
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GGA2 35
  • 18 (a)
ManyToMany
GGA1 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8997 34
Species where no ortholog for GGA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for GGA2 Gene

ENSEMBL:
Gene Tree for GGA2 (if available)
TreeFam:
Gene Tree for GGA2 (if available)

Paralogs for GGA2 Gene

Paralogs for GGA2 Gene

(4) SIMAP similar genes for GGA2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GGA2: view

Variants for GGA2 Gene

Sequence variations from dbSNP and Humsavar for GGA2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10153059 -- 23,501,062(+) AGATA(C/T)GCAAA intron-variant, utr-variant-5-prime
rs1056961 -- 23,464,625(-) GTTTT(C/T)TAAAT utr-variant-3-prime
rs1056962 -- 23,464,531(-) CAATT(C/T)TGAGT utr-variant-3-prime
rs10686275 -- 23,475,954(+) ACAAA(-/GAAA)AGCAC intron-variant
rs10716091 -- 23,497,111(+) AAAAC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGA2 Gene

Variant ID Type Subtype PubMed ID
dgv2826n100 CNV gain 25217958
dgv485e199 CNV deletion 23128226
esv2536944 CNV deletion 19546169
esv275554 CNV gain+loss 21479260
esv3553238 CNV deletion 23714750
esv3582101 CNV loss 25503493
esv3638228 CNV loss 21293372
nsv1066078 CNV gain 25217958
nsv1108993 CNV deletion 24896259
nsv1116121 CNV deletion 24896259
nsv1768 CNV insertion 18451855

Variation tolerance for GGA2 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGA2 Gene

Disorders for GGA2 Gene

Relevant External Links for GGA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGA2

No disorders were found for GGA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGA2 Gene

Publications for GGA2 Gene

  1. Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. (PMID: 12606052) Zhu G. … Zhang X.C. (FEBS Lett. 2003) 3 4 22 64
  2. Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. (PMID: 14567678) He X. … Tang J. (Biochemistry 2003) 3 4 22 64
  3. A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. (PMID: 10747088) Hirst J. … Robinson M.S. (J. Cell Biol. 2000) 2 3 4 64
  4. A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi. (PMID: 10749927) Boman A.L. … Kahn R.A. (Mol. Biol. Cell 2000) 2 3 4 64
  5. Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells. (PMID: 18431031) Hida T. … Waguri S. (Arch. Histol. Cytol. 2007) 3 22 64

Products for GGA2 Gene

Sources for GGA2 Gene

Content
Loading form....