Aliases for GGA2 Gene
- Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2 2 3
- Golgi-Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2 2 3 5
- Golgi-Localized, Gamma Ear-Containing, ARF-Binding Protein 2 3 4
- VHS Domain And Ear Domain Of Gamma-Adaptin 3 4
- Gamma-Adaptin-Related Protein 2 3 4
- VEAR 3 4
- VHS Domain And Ear Domain-Containing Protein 3
- KIAA1080 4
External Ids for GGA2 Gene
Previous GeneCards Identifiers for GGA2 Gene
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
GeneCards Summary for GGA2 Gene
GGA2 (Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Lysosome. GO annotations related to this gene include ADP-ribosylation factor binding. An important paralog of this gene is GGA3.
UniProtKB/Swiss-Prot for GGA2 Gene
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.