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Aliases for GGA2 Gene

Aliases for GGA2 Gene

  • Golgi-Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2 2 3
  • Golgi-Localized, Gamma Ear-Containing, ARF-Binding Protein 2 3 4
  • VHS Domain And Ear Domain Of Gamma-Adaptin 3 4
  • Gamma-Adaptin-Related Protein 2 3 4
  • VEAR 3 4
  • Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2 3
  • ADP-Ribosylation Factor-Binding Protein GGA2 3
  • VHS Domain And Ear Domain-Containing Protein 3
  • KIAA1080 4

External Ids for GGA2 Gene

Summaries for GGA2 Gene

Entrez Gene Summary for GGA2 Gene

  • This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGA2 Gene

GGA2 (Golgi-Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2) is a Protein Coding gene. Among its related pathways are Lysosome. GO annotations related to this gene include ADP-ribosylation factor binding. An important paralog of this gene is GGA1.

UniProtKB/Swiss-Prot for GGA2 Gene

  • Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif

Gene Wiki entry for GGA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGA2 Gene

Genomics for GGA2 Gene

Genomic Location for GGA2 Gene

Start:
23,462,225 bp from pter
End:
23,521,995 bp from pter
Size:
59,771 bases
Orientation:
Minus strand

Genomic View for GGA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGA2 Gene

Regulatory Elements for GGA2 Gene

Proteins for GGA2 Gene

  • Protein details for GGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJY4-GGA2_HUMAN
    Recommended name:
    ADP-ribosylation factor-binding protein GGA2
    Protein Accession:
    Q9UJY4
    Secondary Accessions:
    • D3DWF0
    • O14564
    • Q9NYN2
    • Q9UPS2

    Protein attributes for GGA2 Gene

    Size:
    613 amino acids
    Molecular mass:
    67150 Da
    Quaternary structure:
    • Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity). Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2.
    SequenceCaution:
    • Sequence=AAK38634.1; Type=Frameshift; Positions=193; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GGA2 Gene

neXtProt entry for GGA2 Gene

Proteomics data for GGA2 Gene at MOPED

Post-translational modifications for GGA2 Gene

No data available for DME Specific Peptides for GGA2 Gene

Domains for GGA2 Gene

UniProtKB/Swiss-Prot:

GGA2_HUMAN
Domain:
  • The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif):
    • Q9UJY4
  • The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis:
    • Q9UJY4
  • The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs:
    • Q9UJY4
  • The GAE domain binds accessory proteins regulating GGAs function:
    • Q9UJY4
  • Contains 1 GAE domain.:
    • Q9UJY4
  • Contains 1 GAT domain.:
    • Q9UJY4
  • Contains 1 VHS domain.:
    • Q9UJY4
Family:
  • Belongs to the GGA protein family.:
    • Q9UJY4
genes like me logo Genes that share domains with GGA2: view

No data available for Gene Families for GGA2 Gene

Function for GGA2 Gene

Molecular function for GGA2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif

Gene Ontology (GO) - Molecular Function for GGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12429846
GO:0030306 ADP-ribosylation factor binding IDA 10749927
genes like me logo Genes that share ontologies with GGA2: view

Phenotypes for GGA2 Gene

genes like me logo Genes that share phenotypes with GGA2: view

miRNA for GGA2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GGA2 Gene

Localization for GGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGA2 Gene

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGA2 Gene COMPARTMENTS Subcellular localization image for GGA2 gene
Compartment Confidence
endosome 5
cytosol 3
golgi apparatus 3
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005768 endosome --
GO:0005794 Golgi apparatus IDA --
GO:0005802 trans-Golgi network IDA 10749927
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with GGA2: view

Pathways for GGA2 Gene

SuperPathways for GGA2 Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with GGA2: view

Pathways by source for GGA2 Gene

1 KEGG pathway for GGA2 Gene

Gene Ontology (GO) - Biological Process for GGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport NAS 10749927
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with GGA2: view

Compounds for GGA2 Gene

(1) HMDB Compounds for GGA2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GGA2: view

Transcripts for GGA2 Gene

Unigene Clusters for GGA2 Gene

Golgi-associated, gamma adaptin ear containing, ARF binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GGA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7: -
SP8: - -
SP9: -
SP10:
SP11:

ExUns: 16b · 16c ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
SP1: -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for GGA2 Gene

GeneLoc Exon Structure for
GGA2
ECgene alternative splicing isoforms for
GGA2

Expression for GGA2 Gene

mRNA expression in normal human tissues for GGA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GGA2 Gene

SOURCE GeneReport for Unigene cluster for GGA2 Gene Hs.460336

mRNA Expression by UniProt/SwissProt for GGA2 Gene

Q9UJY4-GGA2_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with GGA2: view

Orthologs for GGA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGA2 36
  • 99.44 (n)
  • 99.26 (a)
GGA2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GGA2 36
  • 89.7 (n)
  • 90.2 (a)
GGA2 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GGA2 36
  • 90.05 (n)
  • 93.14 (a)
GGA2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gga2 36
  • 84.1 (n)
  • 85.74 (a)
Gga2 16
Gga2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GGA2 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 53 (a)
OneToMany
-- 37
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gga2 36
  • 85.2 (n)
  • 87.29 (a)
chicken
(Gallus gallus)
Aves GGA2 36
  • 61.5 (n)
  • 55.54 (a)
GGA2 37
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GGA2 37
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gga 37
  • 21 (a)
OneToMany
CG3002 38
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea apt-9 37
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GGA1 37
  • 17 (a)
ManyToMany
GGA2 37
  • 18 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8997 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for GGA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for GGA2 Gene

ENSEMBL:
Gene Tree for GGA2 (if available)
TreeFam:
Gene Tree for GGA2 (if available)

Paralogs for GGA2 Gene

Paralogs for GGA2 Gene

Selected SIMAP similar genes for GGA2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for GGA2 Gene

genes like me logo Genes that share paralogs with GGA2: view

Variants for GGA2 Gene

Sequence variations from dbSNP and Humsavar for GGA2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs250550 -- 23,461,854(-) TCCCA(A/G)GTAGC downstream-variant-500B
rs369856 -- 23,463,343(+) TCATA(C/T)TGATA downstream-variant-500B, nc-transcript-variant
rs488131 -- 23,463,819(-) CAGCT(A/G)ATGTT utr-variant-3-prime, nc-transcript-variant
rs494279 -- 23,467,315(+) AGATG(A/G/T)TGATG utr-variant-3-prime, nc-transcript-variant
rs722069 -- 23,495,619(-) CAAGA(C/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGA2 Gene

Variant ID Type Subtype PubMed ID
nsv1768 CNV Insertion 18451855
esv2536944 CNV Deletion 19546169
dgv485e199 CNV Deletion 23128226
esv275554 CNV Gain+Loss 21479260

Relevant External Links for GGA2 Gene

HapMap Linkage Disequilibrium report
GGA2

Disorders for GGA2 Gene

No disorders were found for GGA2 Gene.

No data available for UniProtKB/Swiss-Prot for GGA2 Gene

Publications for GGA2 Gene

  1. Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. (PMID: 12606052) Zhu G. … Zhang X.C. (FEBS Lett. 2003) 3 4 23
  2. Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. (PMID: 14567678) He X. … Tang J. (Biochemistry 2003) 3 4 23
  3. A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi. (PMID: 10749927) Boman A.L. … Kahn R.A. (Mol. Biol. Cell 2000) 2 3 4
  4. A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. (PMID: 10747088) Hirst J. … Robinson M.S. (J. Cell Biol. 2000) 2 3 4
  5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4

Products for GGA2 Gene

  • Addgene plasmids for GGA2

Sources for GGA2 Gene

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