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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GGA2 Gene

protein-coding   GIFtS: 59
GCID: GC16M023474

Golgi-Associated, Gamma Adaptin Ear Containing, ARF Binding...

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Golgi-Associated, Gamma Adaptin Ear Containing, ARF Binding Protein
21 2
     ADP-Ribosylation Factor-Binding Protein GGA22
Gamma-Adaptin-Related Protein 22 3     Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 22
Golgi-Localized, Gamma Ear-Containing, ARF-Binding Protein 22 3     VHS Domain And Ear Domain-Containing Protein2
VHS Domain And Ear Domain Of Gamma-Adaptin2 3     KIAA10803
VEAR2     Vear3

External Ids:    HGNC: 160641   Entrez Gene: 230622   Ensembl: ENSG000001033657   OMIM: 6060055   UniProtKB: Q9UJY43   

Export aliases for GGA2 gene to outside databases

Previous GC identifers: GC16M022884 GC16M023563 GC16M023403 GC16M023442 GC16M023383 GC16M021565


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GGA2 Gene:
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This
family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi
network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose
6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to
the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation
and clathrin-coated vesicle assembly. (provided by RefSeq, Jul 2008)

GeneCards Summary for GGA2 Gene: 
GGA2 (golgi-associated, gamma adaptin ear containing, ARF binding protein 2) is a protein-coding gene. Diseases associated with GGA2 include colon cancer. GO annotations related to this gene include protein binding and ADP-ribosylation factor binding. An important paralog of this gene is GGA1.

UniProtKB/Swiss-Prot: GGA2_HUMAN, Q9UJY4
Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes.
Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo
molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif

Gene Wiki entry for GGA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GGA2 gene promoter:
         GR   Max1   TBP   USF1   FOXF2   C/EBPalpha   USF-1   GR-alpha   MRF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGGA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GGA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GGA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12

GGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GGA2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M023474:  view genomic region     (about GC identifiers)

Start:
23,474,863 bp from pter      End:
23,533,316 bp from pter
Size:
58,454 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GGA2_HUMAN, Q9UJY4 (See protein sequence)
Recommended Name: ADP-ribosylation factor-binding protein GGA2  
Size: 613 amino acids; 67150 Da
Subunit: Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity).
Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the
type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins
CCDC91, P200, SYNRG, EPN4 and NECAP2
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome
membrane; Peripheral membrane protein
Sequence caution: Sequence=AAK38634.1; Type=Frameshift; Positions=193;
1 PDB 3D structure from and Proteopedia for GGA2:
1MHQ (3D)    
Secondary accessions: D3DWF0 O14564 Q9NYN2 Q9UPS2

Explore the universe of human proteins at neXtProt for GGA2: NX_Q9UJY4

Explore proteomics data for GGA2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJY4

  • GGA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GGA2 Protein Expression
    REFSEQ proteins: NP_055859.1  
    ENSEMBL proteins: 
     ENSP00000311962   ENSP00000454455   ENSP00000454469   ENSP00000456247   ENSP00000455331  
     ENSP00000460975   ENSP00000455293   ENSP00000459560   ENSP00000459414  

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    Novus Biologicals GGA2 Protein
    Novus Biologicals GGA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IDA10749927
    GO:0010008endosome membrane IEA--
    GO:0030131clathrin adaptor complex IEA--

    GGA2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR002014 VHS
     IPR004152 GAT
     IPR018205 VHS_subgr
     IPR013041 Coatomer/clathrin_app_Ig-like
     IPR008152 Clathrin_a/b/g-adaptin_app_Ig

    Graphical View of Domain Structure for InterPro Entry Q9UJY4

    ProtoNet protein and cluster: Q9UJY4

    4 Blocks protein domains:
    IPB002014 VHS
    IPB004152 GAT domain
    IPB008152 Alpha/gamma adaptin
    IPB008153 Gamma-adaptin


    UniProtKB/Swiss-Prot: GGA2_HUMAN, Q9UJY4
    Domain: The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster
    followed by two leucines (AC-LL motif)
    Domain: The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to
    the TGN it prevents ARF-GTP hydrolysis
    Domain: The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs
    Domain: The GAE domain binds accessory proteins regulating GGAs function
    Similarity: Belongs to the GGA protein family
    Similarity: Contains 1 GAE domain
    Similarity: Contains 1 GAT domain
    Similarity: Contains 1 VHS domain


    GGA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GGA2_HUMAN, Q9UJY4
    Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes.
    Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo
    molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12429846
    GO:0030306ADP-ribosylation factor binding IDA10749927
         
    GGA2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GGA2:
     Decreased cilium length after  

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gga2):
     growth/size  homeostasis/metabolism  mortality/aging 

    GGA2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GGA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GGA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GGA2 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GGA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for GGA2):
        Lysosome


    GGA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GGA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for GGA2 (Q9UJY41, 2, 3 ENSP000003119624) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPG21Q9NZD82, 3, ENSP000002045664MINT-66286 I2D: score=5 STRING: ENSP00000204566
    SORT1Q995232, 3, ENSP000002566374MINT-15490 MINT-18373 MINT-15491 MINT-18374 I2D: score=3 STRING: ENSP00000256637
    IGF2RP117172, 3, ENSP000003494374MINT-14276 MINT-18511 I2D: score=2 STRING: ENSP00000349437
    RABEP1Q152761, 2, 3, ENSP000002624774EBI-447646,EBI-447043 MINT-14026 I2D: score=5 STRING: ENSP00000262477
    SORL1Q926732, 3, ENSP000002601974MINT-18468 MINT-18467 I2D: score=5 STRING: ENSP00000260197
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport NAS10749927
    GO:0016192vesicle-mediated transport IEA--

    GGA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GGA2

    1 HMDB Compound for GGA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GGA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GGA2 gene: 
    NM_015044.4  

    Unigene Cluster for GGA2:

    Golgi-associated, gamma adaptin ear containing, ARF binding protein 2
    Hs.460336  [show with all ESTs]
    Unigene Representative Sequence: NM_015044
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309859(uc002dlq.3 uc010bxo.2) ENST00000567468 ENST00000567339
    ENST00000568922 ENST00000566685 ENST00000569182 ENST00000567201 ENST00000570111
    ENST00000568799 ENST00000563494 ENST00000569300 ENST00000569189 ENST00000563047
    ENST00000562944 ENST00000562117 ENST00000566651 ENST00000566547
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB029003.1 AF165531.1 AF190863.1 AF233522.1 AK024619.1 AK026350.1 AK130752.1 AK308425.1 
    BC000284.1 BC050620.1 

    21 DOTS entries:

    DT.97802848  DT.75137542  DT.91703648  DT.100753863  DT.92449212  DT.97791884  DT.99980049  DT.100823002 
    DT.120690982  DT.87017539  DT.99963378  DT.100823000  DT.102832972  DT.92055093  DT.100842910  DT.120691026 
    DT.40222209  DT.75135518  DT.91850677  DT.92449221  DT.100823003 

    24/486 AceView cDNA sequences (see all 486):

    AI090605 AA663909 BF196572 CB322058 C00613 AK026350 CR594963 F11972 
    AW500706 AA046459 BC050620 AA033756 AW576534 CB529520 AA679417 BQ425185 
    BM564307 AI418016 BM973987 NM_015044 AB029003 CA868048 AW627397 CA868297 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for GGA2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                -           -     -     -     -                                   -                             -                           
    SP2:                                -           -     -     -     -                                                                 -                           
    SP3:                                                                                                                                                            
    SP4:                                -           -     -     -     -                                                                                             
    SP5:                                -           -     -     -                                                                                                   

    ExUns: 16b · 16c ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
    SP1:                          -                     
    SP2:  -     -     -           -                     
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for GGA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GGA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GGA2 Expression
    About this image


    See GGA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GGA2

    SOURCE GeneReport for Unigene cluster: Hs.460336

    UniProtKB/Swiss-Prot: GGA2_HUMAN, Q9UJY4
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GGA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GGA2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gga21 , 5 golgi associated, gamma adaptin ear containing, ARF more1, 5 84.5(n)1
    86.67(a)1
      7 (65.21 cM)5
    741051  NM_028758.21  NP_083034.11 
     1219867225 
    chicken
    (Gallus gallus)
    Aves GGA21 golgi-associated, gamma adaptin ear containing, ARF more 62.13(n)
    55.94(a)
      416577  XM_414878.2  XP_414878.2 
    lizard
    (Anolis carolinensis)
    Reptilia GGA26
    Uncharacterized protein
    67(a)
    1 ↔ 1
    AAWZ02038145(36-5867)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG30023   -- 32(a)   8F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea apt-96
    Protein APT-9
    19(a)
    1 → many
    X(11068527-11071925)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GGA16
    GGA26
    Golgi-localized protein with homology to gamma-ada...
    Protein that interacts with and regulates Arf1p an...
    17(a)
    17(a)
    many ↔ many
    many ↔ many
    IV(1190059-1191732)
    VIII(328303-330060)


    ENSEMBL Gene Tree for GGA2 (if available)
    TreeFam Gene Tree for GGA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GGA2 gene
    GGA12  GGA32  
    4 SIMAP similar genes for GGA2 using alignment to 7 protein entries:     GGA2_HUMAN (see all proteins):
    GGA1    TOM1L1    GGA3    TOM1

    GGA2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GGA2
    PGOHUM00000262283


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/990 SNPs in GGA2 are shown (see all 990)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414843481,2
    --23474474(+) GAGGGC/TTGCCA 1 -- ds50010--------
    rs2012893901,2
    --23474567(+) ACCCC-/AGAGTT 1 -- ds50010--------
    rs1475100561,2
    C--23474596(+) AACACA/GTAAGT 1 -- ds50010--------
    rs1400404891,2
    --23474597(+) ACACAG/TAAGTG 1 -- ds50010--------
    rs1165380491,2
    C,F--23474634(+) GAAGAG/CAGCGG 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1857489071,2
    --23474641(+) GCGGGA/GTTATG 1 -- ds50010--------
    rs3698561,2
    C,F,O,A,H--23474664(+) TCATAC/TTGATA 1 -- ds500129Minor allele frequency- G:0.01EA NA NS WA CSA 2983
    rs1914892821,2
    --23474734(+) ATACTA/GTATTT 1 -- ds50010--------
    rs786061981,2
    --23474897(+) TTTTAG/TAAAGC 1 -- ut310--------
    rs1153083941,2
    C,F--23474990(+) TGCATC/TGCTTG 1 -- ut311Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for GGA2 (23474863 - 23533316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GGA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2536944CNV Deletion19546169
    dgv485e199CNV Deletion23128226
    nsv1768CNV Insertion18451855
    esv275554CNV Gain+Loss21479260

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606005    OMIM disorders: --

    2 diseases for GGA2:    About MalaCards
    colon cancer    


    GGA2 for disorders           About GeneDecksing


    Export disorders for GGA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GGA2 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with GGA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi. (PubMed id 10749927)1, 2, 3 Boman A.L.... Kahn R.A. (2000)
    2. A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. (PubMed id 10747088)1, 2, 3 Hirst J....Robinson M.S. (2000)
    3. Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. (PubMed id 12606052)1, 2, 9 Zhu G.... Zhang X.C. (2003)
    4. Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. (PubMed id 14567678)1, 2, 9 He X.... Tang J. (2003)
    5. Interactions of GGA3 with the ubiquitin sorting machinery. (PubMed id 15039775)1, 2 Puertollano R. and Bonifacino J.S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Definition of the consensus motif recognized by gamma-adaptin ear domains. (PubMed id 14665628)1, 2 Mattera R.... Bonifacino J.S. (2004)
    8. Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. (PubMed id 12808037)1, 2 Lui W.W.Y.... Robinson M.S. (2003)
    9. Mammalian GGAs act together to sort mannose 6-phosphate receptors. (PubMed id 14638859)1, 2 Ghosh P.... Kornfeld S. (2003)
    10. Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. (PubMed id 12505986)1, 2 Mattera R.... Bonifacino J.S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23062 HGNC: 16064 AceView: GGA2 Ensembl:ENSG00000103365 euGenes: HUgn23062
    ECgene: GGA2 Kegg: 23062 H-InvDB: GGA2

    (According to HUGE)
    About This Section
    HUGE: KIAA1080

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GGA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GGA2 gene:
    Search GeneIP for patents involving GGA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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